186,512 research outputs found
Musiken i Sverige. [La musique en Suède.] II : Frihetstid och gustaviansk tid, 1720-1810. [Ère de la liberté et époque gustavienne, 1720-1810.] Rédigé par Leif Jonsson et Anna Ivarsdotter-Johnson. 1993
No full textEdling Anders. Musiken i Sverige. [La musique en Suède.] II : Frihetstid och gustaviansk tid, 1720-1810. [Ère de la liberté et époque gustavienne, 1720-1810.] Rédigé par Leif Jonsson et Anna Ivarsdotter-Johnson. 1993. In: Dix-huitième Siècle, n°27, 1995. L'Antiquité. p. 658
Det nya läroriket : från formell vuxenutbildning till lärande regioner
No full textI Det nya läroriket skriver Kenneth Abrahamsson, Jan Edling och Carl Holmberg om vuxnas lärande och om företagens kompetensförsörjning och om vuxenutbildningens skiftande förutsättningar och villkor i landets olika delar och i olika branscher. Det handlar också om individers och gruppers förutsättningar i lärandets landskap utifrån ålder, kön, tidigare utbildning, etnicitet med mera.</p
Conscious and Unconscious Forces in Democratic Relationships : Implications for the Range of Teacher Responsibility
No full textIn this paper Edling and Frelin strive to incorporate the features of complexity in discussions about democracy as a form of life and especially teachers’ moral responsibility for others. By placing the unconscious in relation to mainstream educational policy documents (deliberate democracy) the authors strive to illuminate the conditions these imply for teacher responses. In this paper they discuss the restrictions present in a predefined democratic model and argue for a view of responsibility and learning that takes its beginning in the complexity of the educational process in which the unconscious is a significant force.</p
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Endotoxin-, glutamate- and drug-induced inflammation and cytotoxicity with emphasis on signal transduction mechanisms
No full textInflammatory cells such as monocytes and glial cells play an important role in the pathogenesis of ischemic- or drug-induced brain or liver injury. Excessive concentrations of glutamate is toxic to neural cells, and triggers a series of transcriptional events beginning with the expression of the immediate early genes like c-fos and c-jun, which in turn affect the expression of other genes necessary for the development of brain injury. Glial cells are important mediators in such response as they are responsible for the secretion of proinflammatory cytokines and chemokines which in turn will cause recruitment of immune cells into the brain. Using primary rat glial cell cultures we found that lipopolysaccharide (LPS)- induced c-fos expression was p38 MAPK-dependent and occurred via the activation of the SRE or the CRE elements in the promoter. In contrast to what has been shown in neurons, we found that glutamate-induced c-fos expression in glial cells involves a novel calciumdependent pathway. This mechanism requires the participation of mGluR5, mobilization of ER-calcium and de-repression of DREAM at the DRE element in the c-fos promoter.Similar mechanisms of inflammation as seen in the brain also occur in the liver, where Kupffer cells play a similar role functioning as the hepatic macrophages in their ability to release pro-inflammatory cytokines. Drug-induced hepatotoxicity is a major problem in drug development since preclinical in vitro as well as in vivo animal models usually are of little value for prediction of hepatotoxicity in humans. Pure hepatocyte cultures are generally not a sensitive enough model system to predict drug-induced cytotoxicity. We therefore developed a novel in vitro system containing both monocytes and hepatocytes. Ximelagatran (thrombin inhibitor) as well as the PPAR-gamma agonists troglitazone (hepatotoxic) and rosiglitazone (not hepatotoxic) were used as model compounds.Studies in single cultures of monocytes (THP-1) showed a ximelagatran dependent release of pro-inflammatory chemokines and decreased cell viability, which was shown by inhibitors to involve the JNK- and ERK-signal transduction pathways.A novel human in vitro co-culture model system containing THP-1 and hepatocytes (Huh-7) was established where the cells were separated by a permeable membrane. In such cocultures troglitazone-induced cytotoxicity was more apparent and observed earlier than using single cultures of either Huh-7 or THP-1 cells, whereas rosiglitazone showed no cytotoxicity in either system. The troglitazone effect was accompanied by a much greater expression of genes encoding pro-inflammatory cytokines, chemokines and several other stress-related genes using the co-culture system as compared to single cell type cultures. Conditioned medium from troglitazone-treated THP-1 cells decreased the viability of Huh-7 cells indicate the release of monocyte-derived mediators. It is concluded that such co-culture system might constitute a valuable tool for predictions of drug-induced hepatotoxicity.List of scientific papersI. Simi A, Edling Y, Ingelman-Sundberg M, Tindberg N (2005). Activation of c-fos by lipopolysaccharide in glial cells via p38 mitogen-activated protein kinase-dependent activation of serum or cyclic AMP/calcium response element. J Neurochem. 92(4): 915-24. https://pubmed.ncbi.nlm.nih.gov/15686494II. Edling Y, Ingelman-Sundberg M, Simi A (2007). Glutamate activates c-fos in glial cells via a novel mechanism involving the glutamate receptor subtype mGlu5 and the transcriptional repressor DREAM. Glia. 55(3): 328-40. https://pubmed.ncbi.nlm.nih.gov/17120244III. Edling Y, Andersson T. B., Porsmyr-Palmertz M, Ingelman-Sundberg M (2007). Pro-inflammatory response and adverse drug reactions: mechanisms of action of ximelagatran on chemokine and cytokine activation in a monocyte in vitro model. [Submitted]IV. Edling Y, Sivertsson L, Butura A, Ingelman-Sundberg M, Ek M (2008). Increased sensitivity for drug-induced hepatotoxicity using a novel human in vitro coculture model. [Submitted]</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Det personliga är sociologiskt [Elektronisk resurs] : 14 professorer om svensk sociologi
No full textThis special issue of Sociologisk Forskning contains 14 papers by distinguished Swedish sociologists on the development of sociology in Sweden during the last decades and the forming of their own academic habitus in relation to that development. Contributors are: Göran Ahrne, Boel Berner, Margareta Bertilsson, Ulla Björnberg, Thomas Brante, Hedvig Ekerwald, Rosmarie Eliasson-Lappalainen, Johanna Esseveld, Bengt Furåker, Staffan Lindberg, Gunnar Olofsson, Sune Sunesson, Göran Therborn and Karin Widerberg. The volume is edited by Gunnar Andersson, Thomas Brante and Christofer Edling.</p
Är du mätbar nog, lilla vän? Mätbarhetskultur, ICCS 2009 och ungdomars medborgarkompetens
No full textDe internationella studierna PIRLS, PISA OCH TIMMS har fått stort genomslag i skoldebatten och det förs en diskussion om vilka effekter dessa undersökningar har. Men det finns även en mindre känd studie, ICCS 2009 (International Civic and Citizenship Education Study), som har mätt 14-åringars medborgerliga kompetens i 38 länder. Maria Olson, Silvia Edling, Johan Liljestrand och Erik Andersson har studerat vad ICCS mäter och diskuterar tänkbara konsekvenser för skolans medborgardanande uppgift. </p
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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