1,721,100 research outputs found
Preface: Artificial Intelligence and Oncogenesis
No full textWorldwide, the scientific community is facing a huge increase in medical assistance demand. Ongoing technological progress, along with screening programs, mean that many patients are diagnosed with different kinds of diseases in earlier stages than in past decades, especially neoplastic diseases. And, scientific discoveries continue to widen the current knowledge on cancer’s molecular basis, expanding therapy options for these typically fragile patients. Therefore, physicians such radiologists and pathologists often have to deal with a huge daily workload to render extremely detailed diagnoses to address specific targeted therapies. In this scenario, artificial intelligence (AI) may significantly help physicians cope with the continuous challenging and time-consuming requests that they fac
Negoziazione, partecipazione e trasformazioni della città
No full textIl saggio pone l'attenzione sulle decisioni pubbliche relative alla fruizione delle risorse locali e agli usi del suolo, sempre più spesso soggette al rischio di suscitare opposizioni e conflitti. La diffusione di pratiche negoziali in campo urbanistico, a partire dagli anni '80 del Novecento, viene indagata presentando oggetto, metodi e finalità della negoziazione, con l'auspicio che venga dato sempre maggiore spazio a questa modalità di relazione tra gli attori che intervengono nei "processi di produzione" della città e del territorio
Lavorare con le persone. Note a margine dell’esperienza: Forlì, Prato, Cagliari
No full textIl saggio indaga la relazione tra planner e contesto socio-territoriale, analizzando tre concrete esperienze di riqualificazione urbana in aree marginali e perifericheThe essay investigates the relationships between planner and social context, analysing three real experiences of urban rehabilitation in marginal area
Whole-slide imaging in cytopathology: state of the art and future directions
No full textWhole slide imaging (WSI) has been increasingly adopted for digital evaluation of surgical pathology specimens. Unlike histological slides, cytological preparations frequently display a heterogeneous distribution of cells throughout slides in different focal planes sometimes admixed with obscuring material, therefore requiring multiple scanning planes which significantly lengthens image acquisition and evaluation times. Although examination of digital images can be more advantageous than conventional glass slides, the challenges of focusing, scanning and screening cytological specimens and the associated increase in scan times and data storage needs have limited the routine application of WSI in cytopathology practice. Emerging digital systems designed to overcome image acquisition obstacles coupled with artificial intelligence algorithms augmenting screening of digital cytology slides offer innovative solutions to address these limitations. The aim of this review is to critically address the potential benefits and pitfalls of employing WSI in cytopathology practice and to introduce promising state-of-the-art solutions on the horizo
Carcinogenesis and Cancer Progression in De Novo Anal Squamous Cell Carcinoma After Organ Transplantation: A Systematic Review
No full textOur aim was to perform a comprehensive literature review on the pathogenesis of squamous anal cancerin patients after solid-organ transplant. Medical databases were consulted until June 1, 2020, for potentially relevant publications.All studies on pathogenesis of de novo anal squamous cell carcinoma in solid-organ transplant recipients were included. Two researchers independently performed study selection, quality assessment, and data extraction and analysis. Twenty-one studies were included.None ofthe selected papers had been solely focused on carcinogenesis. Most ofthe studies identified human papillomavirus infection and immunosuppression to be significantly correlated with the development of de novo anal cancer in adult solid organ transplant recipients. CD4+ T-cell depletion and inactivation oftumor suppressor pathways were mainly implicated. All solid-organ transplant recipients, especially those who were human papillomavirus positive, were shown to be at increased risk for the development of posttransplant anal cancer. Further studies are needed to determine the specific mechanisms of pathogenesis according to different solid-organ transplant populations
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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