1,721,132 research outputs found
Facciate architettate
No full textComporre la facciata di una architettura significa darle un disegno, un volto, una immagine da mostrare al mondo. L’operazione non consiste nel disporre o meno delle aperture in maniera casuale su un piano verticale, ma corrisponde a una accurata e attenta analisi della superficie idealmente intatta come un foglio di carta bianca che può essere scomposta e ripartita da aperture definite e circoscritte, oggetti indizio di un modo di abitare e luogo di contaminazione tra esterno e interno. Ipotizzare che i progetti dei due edifici in Mostra siano stati pensati dai suoi architetti a partire dalle loro facciate, così come Mario Ridolfi concepiva le sue architetture, può indurre a un gioco di modulazione a posteriori che si pone l’obiettivo di ricercare la forma nascosta della progettazione dei prospetti
Letter by Galderisi and Esposito Regarding Articl', "tissue Doppler Imaging in the Estimation of Intracardiac Filling Pressure in Decompensated Patients with Advanced Systolic Heart Failure"
No full textFulminant myocarditis in the time of coronavirus
No full textWe congratulate Hongde Hu et al. for their timely work concerning a case of healed fulminant myocarditis. The authors suggest that the diagnosis is coronavirus myocarditis because nucleic acid tests for 11 other viruses were negative. Although very likely, the diagnosis is not certain. Not all the diagnostic tests necessary for a differential diagnosis have been carried out. Global type stress-induced cardiomyopathy has not been ruled out with certainty. The authors state that glucocorticoid and immunoglobulin therapy are of important value in this type of patient and conclude that this case report is helpful in treating other similar patients. We disagree with these conclusions. Early glucocorticoid therapy has not been proven with certainty to be effective in acute myocarditis. In a systematic review including 719 patients, corticosteroids did not reduce mortality. Glucocorticoids exacerbate acute murine viral myocarditis. The current position statement of the European Society of Cardiology recommends that immunosuppression should be started only after ruling out active infection. The patient presented in the case report had an acute infection. Moreover, limited data are available on the use of immunoglobulins in acute myocarditis. A systematic review of intravenous immunoglobulins for therapy of acute myocarditis concluded that there are insufficient data to recommend their routine use. In the absence of multicentre randomized studies, the European Society of Cardiology does not give recommendations for the use of immunoglobulins in acute myocarditis.
It is possible that further studies may identify a subset of patients with acute coronavirus myocarditis responsive to such a regimen of glucocorticoid and human immunoglobulin. Until then, current literature data do not seem to justify the extensive use of these therapies
The use of transthoracic echocardiography for the assessment of left ventricular systolic and diastolic function in patients with suspected or ascertained chronic heart failure
No full textCan Carvedilol Prevent Chemotherapy-Related Cardiotoxicity?: A Dream to Be Balanced With Tolerability
No full text
The "next-generation" knowledge of papillary thyroid carcinoma
No full textThe application of Next-Generation Sequencing for studying the genetics of papillary thyroid carcinomas (PTC) has recently revealed new somatic mutations and gene fusions as potential new tumor-initiating events in patients without any known driver lesion. Gene and miRNA expression analyses defined clinically relevant subclasses correlated to tumor progression. In addition, it has been shown that tumor driver mutations in BRAF, and RET rearrangements - altogether termed "BRAF-like" carcinomas - have a very similar expression pattern and constitute a distinct category. Conversely, "RAS-like" carcinomas have a different genomic, epigenomic, and proteomic profile. These findings justify the need to reconsider PTC classification schemes
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
- …
