442 research outputs found
IKKalpha negatively regulates ASC-dependent inflammasome activation
No full textFull author list omitted for brevity. For the full list of authors, see article.The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines. Here we report that IkappaB kinase alpha (IKKalpha) is a critical negative regulator of apoptosis-associated specklike protein containing a C-terminal caspase-activation-andrecruitment (CARD) domain (ASC)-dependent inflammasomes. IKKalpha controls the inflammasome at the level of the adaptor ASC, which interacts with IKKalpha in the nucleus of resting macrophages in an IKKalpha kinase-dependent manner. Loss of IKKalpha kinase activity results in inflammasome hyperactivation. Mechanistically, the downstream nuclear effector IKK-related kinase (IKKi) facilitates translocation of ASC from the nucleus to the perinuclear area during inflammasome activation. ASC remains under the control of IKKalpha in the perinuclear area following translocation of the ASC/IKKalpha complex. Signal 2 of NLRP3 activation leads to inhibition of IKKalpha kinase activity through the recruitment of PP2A, allowing ASC to participate in NLRP3 inflammasome assembly. Taken together, these findings reveal a IKKi-IKKalpha-ASC axis that serves as a common regulatory mechanism for ASC-dependent inflammasomes
CHEMICAL-BOND APPROACH TO THE DIELECTRIC-CONSTANT OF SEMICONDUCTORS
No full textThe extension of the Nucho, Ramos, and Wolff method for the non-tetrahedral semiconductors was made by Brum and Ramos. This extended NRW method is applied to the elemental, group III-V, and group II-VI semiconductors and better accuracy is claimed. The ionicity for the II-VI semiconductors (zinc-blende structure) is also calculated and confirms the ionicity scale established by Phillips. Again, Coulson's definition is reconciled with that of Phillips.171241742
Conditions of Selection for a Community health worker (ASC) in the rural areas in Senegal : From a case study of a Japan Overseas Cooperation Volunteer who supported ASC activities
No full textセネガルでは、国の方針として基礎保健員(以下ASCと略す)と呼ばれるコミュニティーヘルスワーカーの活動を期待している。しかし、その育成方法は各州・県に委ねられている。筆者は青年海外協力隊・保健師隊員として、セネガルでの活動の際にASC育成に関わった。その育成時に直面した「人選」の問題を通してASCの適切な選出条件を検討する。研究対象者は、1998年9月から2000年1月までにセネガルの農村部であるA村のASC候補者となった5人で、この5人が候補者として選出された経緯や性別、年齢、職業、現住所、出身村、村での役職、配偶者の職業、候補者以外の家族員の村での役職について比較検討を行った。その結果、候補者の性別は男性1名女性4名であり、年齢は20歳代から30歳代であった。現住所は保健小屋(ASCの活動拠点となる施設)のある村に在住している者が4名、そうでない者が1名であった。5人の候補者(A氏～E氏)の内ASCに選出された者はE氏であった。それ以外の4名の落選理由は、A氏の場合、有職(農業)者であることと保健委員長としてA村で活動していることであり、C氏の場合は義父が村長で義母が産婆であるため、D氏はA村外在住であるためだった。また、B氏については候補者となったが、夫の病気、自身の妊娠・出産、また産後の健康状態がふるわず、ASCを辞退していた。A村での選出過程を通してセネガルの農村部におけるASCの重要な選出条件は、1.ASCが保健小屋のある村の出身か、そうでない場合はASCの出身村が保健小屋のある村と関係性が良好であること。2.ASCとして活動に専念できることを期待されているため、20～40歳代の無職の者で、かつ女性は近い将来出産の予定がないこと。3.ASCの一家族内に、村での重要な役職に就いている者がいないこと。4.ASCの配偶者が現金収入を得ているといった、ASCの家族の経済状態が安定していることであった。The author was involved in training and educating ASCs (Senegal's equivalent of community health workers) as a Japan Overseas Cooperation Volunteer in Senegal. This paper considers the appropriate selection condition for ASCs, based on the problems concerning "personnel selection" experienced by the author during activities. The subjects of this study were five persons who became ASCs in Village A in a rural area of Senegal from September 1998 to January 2000. A comparative analysis was conducted on these five persons. As a result of analyzing the processes of selecting ASCs in Village A, the following important selection conditions were identified : 1) It is good for a ASC to be from a village where a health center is located, or if not, for his/her hometown to have a good relation with the village where a health center is located ; 2) An ASC should be a person who has no work in from his/her 20s to 40s, and yet in the case of a woman is not planning to become pregnant in the near future ; 3) An ASC's family should not hold an important position in the village ; and 4) The economic condition of the ASC's family should be stable, for example the ASC's spouse has cash earnings.10KJ00004723711研究報告Repor
"Put your own house in order first": local perceptions of EU influence on Romani integration policies in the Czech Republic
No full textThis article examines the influence of the European Union (EU) on the development and implementation of Romani integration policy in the Czech Republic from the perspective of those responsible for policy delivery. Based on analysis of key policy documents and research conducted in the Czech Republic, this article first examines how Romani integration became a more important issue during membership negotiations and then discusses how the criticism of the European Commission's Regular Reports was received by those responsible for implementing pro-Romani policies. Finally, the paper assesses how the status of full EU membership has impacted on integration policy. The article concludes that while funding for Romani integration projects has benefitted some groups, the overall impression of the EU is of a remote institution, quick to criticise and unwilling to practise what it preaches
Luis Campa, grabador y fotógrafo. Historias. Revista de la Dirección de Estudios Históricos. Num. 26 (1991) abril-septiembre
No full text1 Archivo de la Antigua Academia de San Carlos. [En adelante ASC] Documento 4401.2 ASC, documento 4760. Y Eduardo Báez Macías, Guía de la antigua Academia de San Carlos. 1844-1867 (Tercera parte), México, Instituto de Investigaciones Estéticas, UNAM, Col. Estudios y Fuentes del Arte en México, XXXV, 1976.3 ASC, doc. 5580.4 ASC, doc. 5686. Confróntese también en Báez Macías, op. cit.5 ASC, doc. 6246.6 ASC, doc. 5829. Confróntese también Báez.7 El Siglo XIX, México, 19 de febrero de 1962. Tomado de Ida Rodríguez Prampolini, La critica de arte en México en el siglo XIX, tomo 2, México, Imprenta Universitaria, 1964.8 El Artista, México, enero de 1874. Tomado de I. Rodríguez Prampolini, op. cit.9 Cfr. Báez Macías, op. cit., Documento 5932.10 José María Pérez Hernández, Estadísticas de la República Mexicana, Guadalajara, Jalisco, 1862. Tomado de María Gayón Córdova, Condiciones de vida y de trabajo en la ciudad de México en el siglo XIX, México, Dirección de Estudios Históricos del INAH, 1988 (Cuadernos de Trabajo 53), p. 40.11 ASC, doc. 6419. Confróntese también Báez, op. cit.12 Cfr. Cuentas del Tesoro Federal, año fiscal 1899-1900
FASB ASC Topic 606: Revenue from Contracts with Customers Analysis and Impact on the Real Estate Industry
No full textabstract: In 2014, IASB and FASB published a new revenue recognition standard that will upend the way revenue is recognized on financial statements filed with the SEC. The new standard, ASC 606 \u2014 Revenue from Contracts with Customers, is effective as of December 16, 2017 for all public US GAAP entities and effective for all IFRS entities as of January 1, 2018. All non-public US GAAP entities are required to implement the reporting standards for financial periods following December 16, 2018. The purpose of this new guidance is to shift from industry and transaction specific revenue recognition methods to a framework that enables financial statement users to understand how and when revenue is recognized. As an incoming associate within the audit industry, I decided to analyze the key differences between the new revenue recognition standard with the existing GAAP and IFRS standards. The following research explores the impact on various industries, particularly the real estate industry. ASC 606's impact will vary depending on the industry. In terms of real estate, the industry will experience a moderate impact. The new guidance will likely enable the earlier recognition of revenue in most instances, based on the five-step revenue recognition process laid out by the IASB and FASB. This publication also analyzes the 10-K's of three companies in the real estate industry; Kennedy Wilson Holdings Inc., CBRE Group Inc., and Digital Realty Trust, Inc. Through excerpts from the 10-K's of these companies, readers will gain insights into how real estate companies are preparing for the implementation of ASC 606. With this new revenue recognition standard, financial statement users will be able to better grasp the nature, timing, amount, and uncertainty of revenue recognition, thereby increasing transparency within the public accounting profession
Evaluación de la Certificación ASC Salmón en la región de los Lagos, Chile, con enfoque en criterios para sedimentos
No full textUniversidad Nacional Agraria La Molina. Facultad de Pesquería. Departamento Académico de Manejo Pesquero y Medio AmbienteEl presente trabajo tuvo como objetivo describir la aplicación de la certificación Aquaculture Stewardship Council (ASC) salmón aplicada en dos centros comerciales de engorde de salmónidos en la Región de los Lagos en Chile. Para lo cual primero se describió el proceso de auditoría de la certificación ASC salmón, llevado a cabo por el autor del presente trabajo cumpliendo el rol de auditor para ambas auditorías, considerando los principios que aplican y los criterios evaluados durante el proceso de auditoría. Este programa de certificación se llevó a cabo el año 2022, durante los meses de mayo y julio, donde se recabo información para evaluar el cumplimiento de los requisitos de la Certificación ASC, en CE1 que produce Salmón del Atlántico (Salmo salar) y el CE2 que produce Salmón Coho (Oncorrhynchus kisutch) ubicados en el Seno de Reloncaví, Puerto Montt. En ambos procesos de certificación se evaluaron los 8 principios de ASC salmón, sin embargo, para fines del presente trabajo, se valoraron 2 principios y, particularmente, 4 criterios relacionados con el muestreo y análisis de sedimentos para determinar el cumplimiento o no con el estándar ASC salmón. El análisis de sedimentos se presenta al auditor, mediante un informe preliminar realizado por consultoras y laboratorios externos debidamente acreditados, contratados por la empresa que opta por la certificación. La información utilizada para la caracterización y valoración de los impactos se realizó en función al muestreo de sedimentos en el polígono definido como la Zona de Efectos Permitidos (Z.E.P.) y fuera de la misma. El resultado de la auditoría y posterior certificación, indican que ambos centros de engorde logran un nivel cumplimiento adecuado, por ende, se otorga la certificación ASC salmón.The objective of this paper was to describe the application of the Aquaculture Stewardship Council (ASC) salmon certification applied in two commercial salmon farming centers in the Los Lagos Region in Chile. For which the audit process of the ASC salmon certification was first described, carried out by the author of this work fulfilling the role of auditor for both audits, considering the principles that apply and the criteria evaluated during the audit process. This certification program was carried out in May and July, 2022, where information was collected to evaluate compliance with the requirements of the ASC Certification, in CE1 that produces Atlantic Salmon (Salmo salar) and CE2 that produces Coho Salmon (Oncorrhynchus kisutch) located in the Seno de Reloncaví, Puerto Montt. In both certification processes, the 8 principles of ASCsalmon were evaluated; however, for the purposes of the paper, 2 principles were evaluated and, particularly, on 4 criteria that are related to sediment sampling and análisis to determine compliance or not with the standard ASC salmon. The sediment analysis is presented to the auditor, through a preliminary report carried out by duly accredited consultants and external laboratories, contracted by the company that opts for the certification. The information used for the characterization and assessment of the impacts was carried out based on the sampling of sediments in the polygon defined as the Allowable Zone of Effect (AZE) and outside of it. The result of the audit and subsequent certification indicate that both fattening centers achieve an adequate level of compliance, therefore, the ASC salmon certification is granted
Chenopodium capatatum (Strawberry Blite) : Strawberry Blite
No full textClass: Dicotyledoneae
Family: Chenopodiaceae
Genus: Chenopodium
Species: capatatu
SCR+ASC systems control by backward induction with adaptive grid and different disturbance scenarios
No full text[EN] The purpose of this study is to enhance control strategies for selective catalytic reduction (SCR) and ammonia slip catalyst (ASC) systems, aiming to effectively reduce NOx emissions from automotive engines during realistic driving cycles. Despite the effectiveness of these after-treatment systems (ATS), their dynamic and non-linear characteristics present significant challenges in achieving precise control. Therefore, this research proposes a hybrid approach that combines backward induction (BI) as the primary optimization technique with model predictive control (MPC) framework for real-time application. The article introduces a reduced-state control-oriented model of the SCR + ASC system, which is embedded into the BI algorithm to calculate optimal control actions within a finite horizon. Additionally, it is proposed an alternative approach for adapting the grid of model states within the BI algorithm, effectively reducing the computational cost. This adjustment enables the algorithm to operate in real-time with near-optimal results, as confirmed by experimental validation. Lastly, the study explores how different degrees of knowledge regarding system disturbances impact the strategy¿s performance, examining three distinct scenarios: constant prediction horizon, probabilistic description, and full knowledge of the prediction horizon.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research has been supported by Grant PID2020-114289RB-I00 funded by the Spanish Ministerio de Ciencia eInnovacion, Agencia Estatal de Investigacion (MCIN/AEI/10.13039/501100011033).Pla Moreno, B.;Piqueras, P.;Bares-Moreno, P.;Nakaema-Aronis, A. (2024). SCR+ASC systems control by backward induction with adaptive grid and different disturbance scenarios. International Journal of Engine Research. 25(11):2058-2072. https://doi.org/10.1177/14680874241261101S20582072251
Effect of acclimation and nutrient supply on 5-tolyltriazole biodegradation with activated sludge communities.
No full textThe corrosion inhibitor 5-tolyltriazole (5-TTri) can have a detrimental impact on aquatic systems thus implying an acute need to reduce the effluent concentrations of 5-TTri. In this study, 5-TTri biodegradation was enhanced through acclimation and nutrient supply. Activated sludge communities (ASC) were setup in nine subsequent ASC generations. While generation two showed a lag phase of five days without biodegradation, generations four to nine utilized 5-TTri right after inoculation, with biodegradation rates from 3.3 to 5.2mgL(-1)d(-1). Additionally, centrifuged AS supernatant was used to simulate the nutrient conditions in wastewater. This sludge supernatant (SS) significantly enhanced biodegradation, resulting in removal rates ranging from 3.2 to 5.0mgL(-1)d(-1) without acclimation while the control groups without SS observed lower rates of ⩽2.2mgL(-1)d(-1).journal article2014 Jul2014 05 05importe
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