1,721,036 research outputs found
Antioxidant effect of Iloprost: current knowledge and therapeutic implications for systemic sclerosis
No full textMany lines of independent research have pointed out the role of oxidative stress as a fascinating pathogenic link between the three main hallmarks of systemic sclerosis (SSc), viz. humoral and cellular immunity activation, microvascular damage and widespread tissue fibrosis. Therefore counteracting oxidative stress may have a favourable impact on clinical features and progression of disease. It is becoming clearer that Iloprost, a synthetic stable analogue of prostacycline, currently employed in the treatment of SSc vascular features, also possess anti-oxidative properties beside its prostaglandin-like vasodilatory and antiaggregant effects. This brief review is aimed to discuss available clinical evidences supporting Iloprost antioxidant action and focus on putative molecular pathways underlying it
Repurposing available anti-inflammatory and immunomodulating agents for cardiovascular risk management: A call for submissions to current clinical pharmacology
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GENETIC AND ANTIGENIC CHARACTERIZATION OF CAEV (CAPRINE ARTHRITIS-ENCEPHALITIS VIRUS) RECOMBINANT TRANSMEMBRANE PROTEIN
No full textThe env gene fragment of an Italian strain of Caprine Arthritis Encephalitis virus (CAEV) coding for the hydrophilic region of transmembrane protein was amplified, cloned and expressed in prokaryotic system as fusion protein with glutathione-S-transferase. Sequence analysis revealed 63 to 66% amino acid homology, when compared with three ovine lentiviruses and 83% when compared with one caprine lentivirus. The recombinant transmembrane protein was efficiently expressed, purified under denaturing conditions and used as antigen in western blotting and ELISA. Sera from clinically diseased goats strongly reacted in western blotting and naturally infected animals seroconverted between 20 and 33 weeks of age. An indirect ELISA performed with this antigen showed improved sensitivity in comparison with agar gel immunodiffusion test. Our results confirm that transmembrane protein is an important immunological marker in CAEV infection and its use as antigen may enhance the validity of serological diagnosis of Caprine Arthritis Encephalitis
Genetic and antigenic characterization of CAEV (Caprine Arthritis-Encephalitis Virus) recombinant transmembrane protein
No full textPalladium chemistry of 2-ferrocenyl-1,10-phenanthroline ligand
No full textThe synthesis of the 2-ferrocenyl-1,10-phenanthroline ligand 1 has been improved, and its reactivity toward palladium is described. This study allows evidencing that 1 can coordinate to the metal center in an N-N bidentate fashion or undergo ortho metalation, thus acting as a terdentate N-N-C pincer ligand. Examples of the former coordination mode include complexes [Pd(Cl)(Me)(1)] (2) and [Pd(Me)(NCMe)(1)][PF6] (3), whereas cyclometalation is observed in [Pd(1)(O2CCF3)] (5), [Pd(1)(MeCN)][PF6] (6), and [Pd(1)(PPh3)][O2CCF3] (7). These cyclometalated adducts are chiral, racemic compounds. X-ray crystal structures of compounds 5, 6, and 7 have been determined, confirming the presence of a five-membered palladacycle and evidencing that in the solid state packing occurs through weak pi-pi interactions between the phenanthroline rings of the ligands
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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