362 research outputs found
Increased Qt Variability In Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy (CADASIL).
No full textBACKGROUND AND PURPOSE:
Although sudden death (SD) accounts for numerous cases of premature mortality in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the risk factors responsible for this dramatic event remain unclear. We sought possible differences in the QT variability index (QTVI) -- a well-known index of temporal dispersion in myocardial repolarization strongly associated with the risk of SD -- between a group of patients with CADASIL and healthy controls.
METHODS:
A total of 13 patients with CADASIL and 13 healthy volunteers underwent a 5-min electrocardiogram recording to calculate the QTVI. All the patients also underwent a clinical assessment, including functional status by Rankin score, and a magnetic resonance imaging (MRI) brain scan for quantitative analysis of T2-weighted (T2-W) and T1-weighted (T1-W) lesion volume (LV).
RESULTS:
Short-term QT-interval analysis showed significantly higher QTVI (P = 0.029) in patients than in controls. In patients, notwithstanding the limitations of the small sample size, QTVI also well correlated with T1-W LV (r = 0.747, P = 0.003) and T2-W LV (r = 0.731, P = 0.005).
CONCLUSION:
Because patients with CADASIL have increased temporal cardiac repolarization variability as assessed by QTVI, this mechanism could underlie these patients' risk of SD. Whether this easily assessed, non-invasive marker could be used to stratify the risk of malignant ventricular arrhythmias in patients with CADASIL and, possibly, to guide their therapeutic management warrants confirmation from larger prospective studies
Scientometric portrait of Nobel laureate Leland H. Hartwell
No full textLeland H. Hartwell was honoured with the Nobel Prize in Physiology or Medicine (2001) at his 62 years age and at 41 years of research publishing career. The first contribution of the author was in 1961 at the age of 22. The number of his contributions in a year peaked in 1997 when it touched 8. He had 108 publications during 1961 – 2001 in domains: Molecular Biology of Cell Cycle Regulation (43), Genetics of Cell Division (48), Genomic Re-arrangement and DNA Repair (9), Molecular Genetics of Yeast Cell Fission (5), and Drug Target Interaction (3) which were analysed for authorship pattern with his 101 collaborators. Most active researchers having number of publications with Leland H. Hartwell were : Weinert, T. A. (10), Garvik, B. M. (8), McLaughlin, C. S. (8), Jenness, D. D. (5). His productivity coefficient was 0.76 which clearly indicates that his productivity increased after 50 percentile age. Highest collaboration coefficient (1) for Leland H. Hartwell was found during 1963-1965, 1968-1969, 1977, 1981-1983, 1985-1990, 1996 and 1998-2001. Journals have been the most preferred channel of communication where, as many as 96 papers out of 108 have been published. The core journals publishing his papers were: Cell (14), Genetics (12), Mol. Cell Biol. (8), J. Bactariol. (7), J. Cell Biol. ( 7), Science (7) J. Mol. Biol.(6), Exp. Cell Res. (5), and Proc. Nat. Acad. Sci.(5). Publication density is 2.63 and Publication concentration is 14.63. Most prolific keywords in titles of publications were: Saccharomyces cerevisiae , Yeast , Cell division cycle , RAD9, DNA Damage , Genes , Cell cycle, Genetic control , Check point (s) , Cell division , Mutant of Yeast
The combined incidence of taxes and public expenditures in the Philippines
No full textIncidence studies of fiscal policy in developing countries typically examine either the distribution of tax burdens or the incidence of public expenditures. But the central issue for policymakers is the combined or net incidence of fiscal activities. One reason that combined incidence studies are so rare is that they require detailed data on both taxation and public spending. The authors show that the net incidence of fiscal policy in a country with average data - the Philippines - can be estimated using a variety of data sources and tools, using simplifying assumptions. For 20 years, the Philippine economy has experienced a series of balance of payments crises triggered by fiscal crises. It has had an unsatisfactory record of poverty alleviation. The authors examine net fiscal incidence to find out how poverty will be affected by the rise in taxes and the cut in spending. They found that: 1) the incidence pattern of taxes is basically neutral. Contrary to expectations, indirect taxes are only slightly regressive; and 2) it is the pattern of expenditures that drives the combined incidence, which is progressive.Public Sector Economics&Finance,Environmental Economics&Policies,Health Systems Development&Reform,Economic Theory&Research,Health Economics&Finance,Environmental Economics&Policies,Public Sector Economics&Finance,Economic Theory&Research,Health Economics&Finance,Banks&Banking Reform
Frequency selective analog to digital converter design : optimality, fundamental limitations, and performance bounds
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2013.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (p. 131-137).In this thesis, the problem of analysis and design of Analog to Digital Converters (ADCs) is studied within an optimal feedback control framework. A general ADC is modeled as a causal, discrete-time dynamical system with outputs taking values in a finite set. The performance measure is defined as the worst-case average intensity of the filtered input-matching error, i.e., the frequency weighted difference between the input and output of the ADC. An exact analytic solution with conditions for optimality of a class of ADCs is presented in terms of the quantizer step size and range, resulting in a class of optimal ADCs that can be viewed as generalized Delta-Sigma Modulators (DSMs). An analytic expression for the performance of generalized DSMs is given. Furthermore, separation of quantization and control for this class of ADCs is proven under some technical conditions. When the technical conditions needed for establishing separation of quantization and control and subsequently optimality of the analytical solution to ADC design problem are not satisfied, suboptimal ADC designs are characterized in terms of solutions of a Bellman-type inequality. A computational framework is presented for designing suboptimal ADCs, providing certified upper and lower bounds on the performance.by Mitra M. Osqui.Ph.D
Correction: Need for ICU and outcome of critically ill patients with COVID-19 and haematological malignancies: results from the EPICOVIDEHA survey (Infection, (2024), 52, 3, (1125-1141), 10.1007/s15010-023-02169-7)
No full textAcknowledgements Members of the EPICOVIDEHA registry: Joseph Meletiadis, Florian Reizine, Jan Novák, Summiya Nizamuddin, Roberta Di Blasi, Alexandra Serris, Pavel Jindra, Sylvain Lamure, François Danion, Maria Chiara Tisi, Mario Virgilio Papa, Nurettin Erben, ľuboš DrgoňA, Nathan C. Bahr, Murtadha Al-Khabori, Ayten Shirinova, Jörg Schubert, Lisset Lorenzo De La Peña, José-Ángel Hernández-Rivas, Elena Busch, Josip Batinić, Giuseppe Sapienza, Mohammad Reza Salehi, Reham Abdelaziz Khedr, Nina Khanna, Baerbel Hoell-Neugebauer, Ana Groh, Eleni Gavriilaki, Rita Fazzi, Rémy Duléry, Roberta Della Pepa, Mario Delia, Nicola Coppola, Maria Calbacho, Darko Antić, Hossein Zarrinfer, Ayel Yahia, Vivien Wai-Man, Ana Torres-TIenza, Alina Daniela Tanasa, Andrés Soto-Silva, Laura Serrano, Enrico Schalk, Ikhwan Rinaldi, Gaëtan Plantefeve, Monica Piedimonte, Maria Enza Mitra, Carolina Miranda-Castillo, Jorge Loureiro-Amigo, Ira Lacej, Martin Kolditz, María-Josefa Jiménez-Lorenzo, Guillemette Fouquet, Omar-Francisco Coronel-Ayala, Mathias Brehon, Panagiotis Tsirigotis, Anastasia Antoniadou, Gina Varricchio, Maria Vehreschild, Agostino Tafuri, José-María Ribera-Santa Susana, Joyce Marques De Almeida, María Fernández-Galán, Avinash Aujayeb, Athanasios Tragiannidis, Malgorzata Mikulska, Sein Win, Elizabeth De Kort, Hans-Beier Ommen, Donald C. Vinh, Hans Martin Orth, Sandra Malak, Przemyslaw Zdziarski, Modar Saleh, Chi Shan Kho, Fabio Guolo, M. Mansour Ceesay, Christopher H. Heath, Sergey Gerasymchuk, Monica Fung, Maximilian Desole, Erik De Cabo, Tania Cushion, Fazle Rabbi Chowdhury, Louis Yi Ann Chai, Fevzi Altuntaş, Charlotte Flasshove. The original article has been updated
Management of Venous ThromboEmbolism in patients with acute leukemia at high bleeding risk: a multicenter study
No full textIn the last decades, evaluation of clinically relevant thrombotic complications in patients with acute leukemia (AL) has been poorly investigated. We performed a multicenter study to evaluate the management of symptomatic venous thromboembolism (VTE) in adult patients with AL. We intended as clinically relevant the following: symptomatic Venous Thrombosis (VT) occurred in typical (lower limbs) and atypical (cerebral, upper limbs, abdominal, etc) sites with or without pulmonary embolism (PE). Over a population of 1461 patients with AL, 22 cases of symptomatic VTE were recorded in hospitalized patients with a mean age of 54.6 years. The absolute incidence of VTE was 1.5%. VTE occurred during chemotherapy in 17/22 (77.2%) cases, mainly (14/17, 82.3%) during the induction phase. Treatment of acute VTE was based on Low Molecular Weight Heparin (LMWH) at full dosage for the first month from diagnosis and reduced dosage (75%) for the following months
An investigation of computer based tools for mathematical programming modelling
No full textThis thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel University.Science and Engineering Research Counci
Response-Time Analysis of Limited-Preemptive Parallel DAG Tasks Under Global Scheduling
No full textMost recurrent real-time applications can be modeled as a set of sequential code segments (or blocks) that must be (repeatedly) executed in a specific order. This paper provides a schedulability analysis for such systems modeled as a set of parallel DAG tasks executed under any limited-preemptive global job-level fixed priority scheduling policy. More precisely, we derive response-time bounds for a set of jobs subject to precedence constraints, release jitter, and execution-time uncertainty, which enables support for a wide variety of parallel, limited-preemptive execution models (e.g., periodic DAG tasks, transactional tasks, generalized multi-frame tasks, etc.). Our analysis explores the space of all possible schedules using a powerful new state abstraction and state-pruning technique. An empirical evaluation shows the analysis to identify between 10 to 90 percentage points more schedulable task sets than the state-of-the-art schedulability test for limited-preemptive sporadic DAG tasks. It scales to systems of up to 64 cores with 20 DAG tasks. Moreover, while our analysis is almost as accurate as the state-of-the-art exact schedulability test based on model checking (for sequential non-preemptive tasks), it is three orders of magnitude faster and hence capable of analyzing task sets with more than 60 tasks on 8 cores in a few seconds
PENGARUH PENGELOLAAN LAPORAN KEUANGAN TERHADAP EFEKTIVITAS ARUS KAS PADA PT. MABAR MITRA BERSAMA
No full textCash flow is the basis for financial calculations and the management of financialstatements carried out by the company and its routine activities. Improper financialstatement management and unstable income and expenditure streams will result in acrisis for the company in the future. The effectiveness of cash flow is a measure of theextent to which the success of cash flow has an impact on the achievement andconsideration of the consequences that will be received by the company. The purpose ofthis study was to determine whether the management of financial statements owned byPT. Mabar Mitra Bersama affects the effectiveness of cash flow. The population of thisstudy are 42 employees of PT. Mabar Mitra Bersama where 30 employees of the financedepartment are the sample in this study. Simple linear regression test is a data analysistechnique used by the author in this study with the type of data used in the form ofquantitative data collected from respondents who filled out questionnaires. Based on theresults of the research that has been done, the value of the financial statementmanagement variable has a significance smaller than the probability value of 0.05, or thevalue of 0.000 <0.05, then Ha is accepted, H0 is rejected. Variable X has a t arithmeticvalue (21.935) greater than t table (2.048) so it can be concluded that the managementof financial statements has a significant influence on the effectiveness of cash flows andit can be seen that the contribution of financial management in influencing theeffectiveness of cash flows is 94 .5% while other variables only affect 5.5%
Skills, Informality, and Development
No full textThis paper makes an attempt to estimate the index of informal sector employment which can be attributed to the supply-push phenomenon. Factors which explain the inter-state variations include the industrial-informal sector wage gap, revenue expenditure, and development expenditure incurred by the government. Increased development expenditure brings in a decline in distress-led informalization. With improved education, health, and infrastructure facilities the employability of an individual goes up, which, in turn, reduces the compulsion to get absorbed residually. However, expansion in government activities measured through increased revenue expenditure raises in-migration, which in turn raises the supply-push phenomenon. We also observed that with an increase in distress-led informalization inequality tends to rise. Adoption of labour intensive technology in the organized industrial sector is indeed crucial for pro-poor growth. The other policy implication is in terms of enhanced investment in the areas of education, health and other infrastructural facilities.Informal sector, supply-push, development expenditure, stochastic frontier
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