1,721,264 research outputs found

    Data Archiving and Distribution of the Virgo Antenna for Gravitational Wave Detection

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    We describe the architecture of the data archiving and distribution of the Virgo antenna for gravitational wave detection. The main characteristic of this system is the modularity of the architecture. This solution allows system upgrades without dramatic changes of the hardware and software components. The main performances are: 1. Maximum sustained data flow of 10 Mbyte/s on DLT tapes (35/70 Gbyte) for the raw data archiving; 2. Up to 1 Tbyte data archiving capacity on disk at a maximum sustained data flow of 25 Mbyte/s for the online data distribution; 3. Up to 10 Mbyte/s data retrieval flow for the on-line data distribution. The basic architecture of the system consists of two sections: an acquisition and storage section and a data management section. The former is a LynxOS based system with the disks directly connected to the CPU slave boards, the latter is a DEC-Unix Alpha Server (Data Server), NFS mounting the LynxOS disks through a Fast Ethernet networ

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Rapid reverse phase-HPLC assay of HMG-CoA reductase activity

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    Radioisotope-based and mass spectrometry coupled to chromatographic techniques are the conventional methods for monitoring HMG-CoA reductase (HMGR) activity. Irrespective of offering adequate sensitivity, these methods are often cumbersome and time-consuming, requiring the handling of radiolabeled chemicals or elaborate ad-hoc derivatizing procedures. We propose a rapid and versatile reverse phase-HPLC method for assaying HMGR activity capable of monitoring the levels of both substrates (HMG-CoA and NADPH) and products (CoA, mevalonate, and NADP+) in a single 20 min run with no pretreatment required. jlr The linear dynamic range was 10-26 pmol for HMG-CoA, 7-27 nmol for NADPH, 0.5-40 pmol for CoA and mevalonate, and 2-27 nmol for NADP +, and limit of detection values were 2.67 pmol, 2.77 nmol, 0.27 pmol, and 1.3 nmol, respectively. Copyright © 2010 by the American Society for Biochemistry and Molecular Biology, Inc
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