8 research outputs found
The Exploitation of Data from Remote and Human Sensors for Environment Monitoring in the SMAT Project
No full textThe Exploitation of Data from Remote and Human Sensors for Environment Monitoring in the SMAT Projec
Classification of chestnuts with feature selection by noise resilient classifiers
No full textIn this paper we solve the problem of classifying chestnut plants according to their place of origin. We compare the results obtained by state of the art classifiers, among which, MLP, RBF, SVM, C4.5 decision tree and random forest. We determine which features are meaningful for the classification, the achievable classification accuracy of these classifiers families with the available features and how much the classifiers are robust to noise. Among the obtained classifiers, neural networks show the greatest robustness to noise
Effect of microvesicles from Moringa oleifera containing miRNA on proliferation and apoptosis in tumor cell lines
No full texthuman microvesicles are key mediators of cell-cell communication. exosomes function as microRNA transporters, playing a crucial role in physiological and pathological processes. plant microvesicles (MVs) display similar features to mammalian exosomes, and these MVs might enhance plant microRNA delivery in mammals. considering that plant microRNAs have been newly identified as bioactive constituents in medicinal plants, and that their potential role as regulators in mammals has been underlined, in this study, we characterized MVs purified from moringa oleifera seeds aqueous extract (MOES MVs) and used flow cytometry methods to quantify the ability to deliver their content to host cells. the microRNAs present in MOES MVs were characterized, and through a bioinformatic analysis, specific human apoptosis-related target genes of plant miRNAs were identified. In tumor cell lines, MOES MVs treatment reduced viability, increased apoptosis levels associated with a decrease in B-cell lymphoma 2 protein expression and reduced mitochondrial membrane potential. Interestingly, the effects observed with MOES MVs treatment were comparable to those observed with MOES treatment and transfection with the pool of small RNAs isolated from MOES, used as a control. these results highlight the role of microRNAs transported by MOES MVs as natural bioactive plant compounds that counteract tumorigenesis
Políticas del dolor. La subjetividad comprometida : un abordaje interdisciplinario de la problemática del dolor
No full textPunto de venta de la versión impresa: Servicio de Atención Central, Hall de la Facultad de Derecho (Avda. 18 de Julio 1824). Tel.: (+598) 2400 1918, 2408 2566, 2408 9574. Correo electrónico: [email protected] abordaje del dolor, condición que atañe a lo humano, resulta atravesado necesariamente por las condiciones del contexto histórico-social en el que se despliega y por ello requiere del reconocimiento del entramado discursivo que produce sus determinaciones. Se torna así necesario visualizar estructuras y hábitos de pensamiento en los distintos actores sociales que trabajan con este, diseñando políticas y generando prácticas en los que la subjetividad está concernida. Esto no sería posible sin una perspectiva interdisciplinaria que considere las distintas miradas desde la medicina, el psicoanálisis, la antropología, el arte, la economía, la filosofía y otros saberes que lo interpelan. Es así que se promueve un encuentro a fin de producir un espacio de diálogo en el que poner en juego las diversas concepciones acerca del dolor que determinan las estrategias que en el seno de lo social se establecen para su atención.Presentación de la Colección Biblioteca Plural / Roberto Markarian. -- Prólogo / Ana Luisa Hounie y Ana M. Fernández Caraballo. -- Perspectivas sobre el dolor. -- Tratamiento interdisciplinario del paciente con dolor crónico / María José Montes e Irene Retamoso. El dolor: ¿objeto de la Psiquiatría? / Laura Falcón. Dolor-cuerpo-sujeto / María Pilar Bacci. Dolor, escena, acto / Marcelo Novas. El Otro de la Ilustración. Un estudio introductorio a la problemática de «Kant con Sade» / Ivana Deorta y Joaquín Venturini. -- Escenarios del dolor. -- Políticas del dolor: La recursividad de las macro y micropolíticas en el fin de vida / Ana Luz Protesoni. Las desigualdades sociales y sus implicaciones con el sufrimiento contemporáneo / Beatriz Fernández Castrillo. Crónicas desde la implicación en el trabajo con los dolores en la exclusión de la locura / Nelson de León. El significado del dolor para los médicos. Evaluación integral del dolor / María José Montes e Irene Retamoso. Presencia del dolor en padres que consultan por un hijo / Gabriela Bruno. El dolor, ¿una forma de aprendizaje? / Ana Lucía Silva. -- Arte y dolor. -- Duras con Freud: el dolor psíquico / Ginnette Barrantes Sáenz. El dolor tiene muchas caras… La subjetividad comprometida: fragmentos para una estética del dolor /
Ana Hounie. -- El dolor y la risa en la narrativa de Osvaldo Lamborghini / Ofelia Ros. Música en el cine. Una mirada hacia la subjetividad / Olga Picún. Hermenéuticas existenciales: cuerpo y dolor en las performances,
Mariana Picart y Magalí Pastorino. Bashir: El afortunado portador de buenas nuevas / Atilio Escuder. -- Saberes y políticas del dolor. -- Taxonomías del dolor: patologización e indeterminación en los DSM / Andrea Bielli.
El cuerpo en la política de las cosas: un saber silenciado / Raumar Rodríguez Giménez. Política, teología y espiritualidad en Schreber / Ana M. Fernández Caraballo. Algunas puntuaciones sobre el dolor en Nietzsche /
Alba Fernández Roglia. Reflexiones en torno a la transmisión intergeneracional. Articulaciones entre el dolor y la violencia doméstica / Gonzalo Corbo
MusA: Using Indoor Positioning and Navigation to Enhance Cultural Experiences in a museum
No full textIn recent years there has been a growing interest into the use of multimedia mobile guides in museum environments. Mobile devices have the capabilities to detect the user context and to provide pieces of information suitable to help visitors discovering and following the logical and emotional connections that develop during the visit. In this scenario, location based services (LBS) currently represent an asset, and the choice of the technology to determine users' position, combined with the definition of methods that can effectively convey information, become key issues in the design process. In this work, we present MusA (Museum Assistant), a general framework for the development of multimedia interactive guides for mobile devices. Its main feature is a vision-based indoor positioning system that allows the provision of several LBS, from way-finding to the contextualized communication of cultural contents, aimed at providing a meaningful exploration of exhibits according to visitors' personal interest and curiosity. Starting from the thorough description of the system architecture, the article presents the implementation of two mobile guides, developed to respectively address adults and children, and discusses the evaluation of the user experience and the visitors' appreciation of these application
Genomic Epidemiology of 2015-2016 Zika Virus Outbreak in Cape Verde
No full textDuring 2015-2016, Cape Verde, an island nation off the coast of West Africa, experienced a Zika virus (ZIKV) outbreak involving 7,580 suspected Zika cases and 18 microcephaly cases. Analysis of the complete genomes of 3 ZIKV isolates from the outbreak indicated the strain was of the Asian (not African) lineage. The Cape Verde ZIKV sequences formed a distinct monophylogenetic group and possessed 1-2 (T659A, I756V) unique amino acid changes in the envelope protein. Phylogeographic and serologic evidence support earlier introduction of this lineage into Cape Verde, possibly from northeast Brazil, between June 2014 and August 2015, suggesting cryptic circulation of the virus before the initial wave of cases were detected in October 2015. These findings underscore the utility of genomic-scale epidemiology for outbreak investigations.sponsorship: This work was supported by Institut Pasteur de Dakar. P.L. received funding by the European Research Council under the European Union's Horizon 2020 Research and Innovation Programme (grant agreement no. 725422-ReservoirDOCS) and by the Wellcome Trust through project 206298/Z/17/Z S.L. and B.V. are supported by the Fonds Wetenschappelijk Onderzoek (Belgium). E.S.-E. received funding from the INCEPTION program (Investissements d'Avenir grant ANR46-CONY-0005) and Institut Pasteur. F.G.-R. is part of the Pasteur-Paris University International doctoral program, BioSPC doctoral school. E.C.H. is funded by an Australian Research Council Australian Laureate Fellowship (FL170100022). (Institut Pasteur de Dakar, European Research Council under the European Union's Horizon 2020 Research and Innovation Programme|725422-ReservoirDOCS, Wellcome Trust|206298/Z/17/Z, Fonds Wetenschappelijk Onderzoek (Belgium), INCEPTION program (Investissements d'Avenir grant)|ANR46-CONY-0005, Institut Pasteur, Australian Research Council Australian Laureate Fellowship|FL170100022, Wellcome Trust|206298/Z/17/Z)status: Publishe
A new national survey of centers for cognitive disorders and dementias in Italy
No full textIntroduction: A new national survey has been carried out by the Italian Centers for Cognitive Disorders and Dementias (CCDDs). The aim of this new national survey is to provide a comprehensive description of the characteristics, organizational aspects of the CCDDs, and experiences during the COVID-19 pandemic. Methods: A list of all national CCDDs was requested from the delegates of each Italian region. The online questionnaire is divided in two main sections: a profile section, containing information on location and accessibility, and a data collection form covering organization, services, treatments, activities, and any service interruptions caused by the COVID-19 outbreak. Results: In total, 511 out of 534 (96%) facilities completed the profile section, while 450 out of 534 (84%) CCDDs also completed the data collection form. Almost half of the CCDDs (55.1%) operated for 3 or fewer days a week. About one-third of the facilities had at least two professional figures among neurologists, geriatricians and psychiatrists. In 2020, only a third of facilities were open all the time, but in 2021, two-thirds of the facilities were open. Conclusion: This paper provides an update on the current status of CCDDs in Italy, which still shows considerable heterogeneity. The survey revealed a modest improvement in the functioning of CCDDs, although substantial efforts are still required to ensure the diagnosis and care of patients with dementia
A new national survey of centers for cognitive disorders and dementias in Italy
No full textIntroduction: A new national survey has been carried out by the Italian Centers for Cognitive Disorders and Dementias (CCDDs). The aim of this new national survey is to provide a comprehensive description of the characteristics, organizational aspects of the CCDDs, and experiences during the COVID-19 pandemic. Methods: A list of all national CCDDs was requested from the delegates of each Italian region. The online questionnaire is divided in two main sections: a profile section, containing information on location and accessibility, and a data collection form covering organization, services, treatments, activities, and any service interruptions caused by the COVID-19 outbreak. Results: In total, 511 out of 534 (96%) facilities completed the profile section, while 450 out of 534 (84%) CCDDs also completed the data collection form. Almost half of the CCDDs (55.1%) operated for 3 or fewer days a week. About one-third of the facilities had at least two professional figures among neurologists, geriatricians and psychiatrists. In 2020, only a third of facilities were open all the time, but in 2021, two-thirds of the facilities were open. Conclusion: This paper provides an update on the current status of CCDDs in Italy, which still shows considerable heterogeneity. The survey revealed a modest improvement in the functioning of CCDDs, although substantial efforts are still required to ensure the diagnosis and care of patients with dementia
