1,720,961 research outputs found
The biochemical and cardiovascular consequences of LCAT deficiency
Full text linkWe have recently identified 14 Italian families with LCAT deficiency,
carrying 19 different mutations in the LCAT gene. All carriers of two
mutant LCAT alleles (n=17) had remarkably low plasma HDL-C, apoA-I,
and apoA-II levels, associated with multiple alterations in HDL structure
and particle distribution, with a selective depletion of LpAI:A-II particles,
a predominance of small, pre-beta-migrating HDL and a complete lack
of HDL2. Unesterified cholesterol, the unesterified/total cholesterol ratio,
VLDL-cholesterol, and triglycerides were significantly elevated, whereas
apoB was significantly lower compared to controls. Twenty-three out of 44
carriers of one mutant LCAT allele (53%) had a low plasma HDL-C; the
average plasma HDL-C and apoA-I levels were significantly lower than
in controls. Plasma LCAT activity was also significantly lower than in
controls. Despite the atherogenic profile, only one of the 17 carriers of two
mutant LCAT alleles, a 71 y.o. man with elevated LDL-C, hypertension, and
diabetes, presented with premature coronary artery disease. The evaluation
of carotid intima-media thickness (IMT) showed that carriers of two mutant
LCAT alleles have IMT values comparable to age-sex matched controls,
despite the severe hypoalphalipoproteinemia. Carriers of one mutant LCAT
allele have widely distributed IMT values, showing on average IMT values
comparable to controls. In a large series of subjects carrying mutations
in the LCAT gene, the inheritance of a mutated LCAT genotype causes
a gene-dose-dependent alteration in the plasma lipid/lipoprotein profile.
No premature cardiovascular disease and no increase in carotid IMT
was observed, despite the hypoalphalipoproteinemia, in the Italian LCAT
deficient subjects
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The LXR agonist T0901317 increases the efflux potential of sera and promotes the reverse cholesterol transport in mice
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Increased ability of sera from LCAT-deficient subjects to promote ABCA1-mediated cholesterol efflux
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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