8,107 research outputs found
Demir toksisitesinde alfa tokoferolün etkisi
No full textBu tez, Pamukkale Üniversitesi Biilimsel Araştırma Projesi Birimi tarafından desteklenen, 2006-SBE-005 nolu proje kapsamında gerçekleştirilmiştir. Bu tezin yapılmasına Pamukkale Üniversitesi Tıbbi Etik Kurulu tarafından onay verilmiştir (2006/41).Biyolojik sistemlerdeki serbest radikallerin oluşum ve metabolizmasında demir önemli bileşendir. Demir yüklemesi metale bağlı en yaygın toksisitelerden biridir. Karaciğerde demir birikimi lipit peroksidasyonuna yol açar. Membran fosfolipitleri peroksidatif bozunmaya uğradıklarında malondialdehit meydana gelir. E vitamini demire bağlı hasarın çoğunu önleyebilir. Bu çalışmada demir yüklemesinin karaciğerde yaratığı oksidatif stres ve E vitamininin oksidatif strese etkisi araştırılmıştır. Elli adet Wistar rat rasgele beş gruba ayrılmıştır. Gruplardan ikisi haftada 3 doz olacak şekilde, 6 doz 100 mg /kg demir dekstran (i.p.) almıştır. Bu iki gruptan biri altı hafta süreyle her gün 200 mg/kg alfa tokoferol asetat (i.p.) almıştır. Diğer iki grup 6 hafta süreyle karbonil demir (%2,5 w/w) ilaveli diyet ile beslenmiştir. Bu iki gruptan biri altı hafta süreyle her gün 200 mg/kg alfa tokoferol asetat (i.p.) almıştır. Kontrol gurubu 6 hafta süreyle normal diyet almıştır. Her iki yolla demir yüklemesi kontrole göre karaciğer MDA düzeylerinde artışa (p0.05), GSH düzeylerinde azalmaya (p0.05) neden oldu. Demir dekstran alan ratlarda karbonil demir alan ratlara kıyasla daha yüksek MDA düzeyleri gözlendi (p0.05). Sonuç olarak, demir yüklemesinin lipit peroksidasyonunu arttırdığına ve vitamin E'nin demirin neden olduğu oksidatif streste koruyucu olabileceğine karar verilmiştir.Iron is a major component in the production and metabolism of free radicals in biological systems. Iron overload is one of the most common metal related toxicity. Iron deposition in liver leads to peroxidation of lipits. Malondialdehyde is formed when membrane phospholipits undergo peroxidative decomposition. Vitamin E can prevent the majority of iron related damage. In this study oxidative stress which is caused by iron overload in liver and the effect of alpha tocopherol on oxidative stress have been evaluated in rats. 50 Wistar rats were distributed in five groups randomly. Two groups received 6 doses (three doses per week) 100 mg/kg each iron-dextran (i.p.). One of these groups received daily 200 mg/kg each alpha tocopherol acetate (i.p.) for six weeks. The other two groups were fed diets supplemented carbonyl iron (2,5% w/w) for six weeks. One of these groups received daily 200 mg/kg each alpha tocopherol acetate (i.p.) for six weeks. Control group was fed normal diet for six weeks. In the both way, iron overload led to increase MDA levels (p0.05) and decrease GSH levels (p0.05) in liver compared with control rats. Higher MDA level was observed in iron-dextran-treated rats compared to carbonyl iron treated rats (p0.05). In conclusion, it was decided that iron overload leads to increase in lipid peroxidation and vitamin E can give protection against oxidative stress caused by iron
Strategy for tourism development in the Municipality of Demir Kapija 2020-2024
No full textThe territory of the municipality of Demir Kapija is spread in the southern part of Macedonia, i.e. in the southeastern part of the Tikves valley, at an extremely important geographical-strategic position. Its excellent location, railway line and proximity to the E-75 motorway make it easily accessible to all travelers and tourists. The great climate, clean environment and fertile soil create ideal conditions for producing quality grapes, brandy and wine that smells exhilaratingly and will conquer you forever with a sip. Demir Kapija has a land with varieties of grapevines, which has contributed to the construction of more wineries in the area.
The beauties of the unique Demir Kapija gorge represent a special attraction for tourists and passers-by who admire this magnificent creation of nature. Three rivers flow in the area of Demir Kapija: Vardar, Doshnica and Boshava. Authentic Demir Kapija nature provides ideal conditions for developing and practicing outdoor sports such as mountaineering, rock climbing, mountain biking and canoeing. This place is also a challenge for the speleologists who come here to explore the two local caves - Bela Voda and Zmejovec. Demir Kapija also houses a wine museum, the only one of its kind in our country, and has an archeological and wine gallery.
Tourism is an important economic branch that contributes to greater economic growth and development of a municipality. Taking into account the natural potentials of Demir Kapija municipality, the local self-government continuously strives and works to promote and develop wine and adventure tourism. For this purpose, every year traditionally organized by the municipality of Demir Kapija, cultural and sports events (Tradition Week - St. Trifun, International Outdoor Festival) are held which are attractive for both domestic and foreign tourists.
The local self-government of Demir Kapija recognizes these potentials for tourism development, which as an important economic branch will greatly contribute to the improvement of local economic development and therefore adopts this Tourism Development Strategy in the municipality of Demir Kapija. Strategic planning will enable all stakeholders to properly target and utilize Demir Kapija's branding potential in a recognizable wine and adventure destination
Demir eksikliği ile demir-çinko eksikliğinde hücresel bağışıklık
No full textAnkara üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Has talıkları Kliniğinde saf demir eksikliği ile demir ve çinko eksikliği tanısı alan, 10' u erkek, 20' si kız, yaşları 7 ay-20 yaş arasında değişen 30 hastada bir bölüm hücresel bağışıklık parametresi incelendi. Hastaların 17' sinde saf demir eksikliği, 13' ünde demir ve çinko eksikliği vardı. Sağlıklı 10 çocuk da kontrol grubu olarak incelendi. Bu amaçla hastalarda ve kont rol grubunda total lenfosit sayıları, E-rozet yüzdeleri ve geç aşırı duyarlık deri testlerine (PPD,DNCB) yanıtları incelendi. Total lenfosit sayılarının, hasta gruplarında kritik sınır olan 1200* ün altına düşmediği görüldü. Saf demir eksik liği grubunda kontrollere oranla hafif bir düşüklük saptanma sına karşın bunun hastaların yaş dağılımından ileri geldiği düşünüldü. E-rozet yüzdeleri saf demir eksikliği grubunda % 34.05*2.93, demir ve çinko eksikliği grubunda % 25.44+1.52, kontrol grubunda ise % 44.25 t- 1.61 olarak, belirlendi. Demir-çinko eksikliği grubunun E-rozet oranları hem saf demir eksikliği hem de kont- -68- -69- rol grubundan p<0.01 düzeyinde düşük bulunurken, saf demir eksikliği grubunun oranı, kontrol grubuna göre p<0.05 düze yinde düşük olarak saptandı. Geç aşırı duyarlık testlerinde ise demir eksikliği grubu ile demir ve çinko eksikliği grubunun PPD ve DNCB'ye deri ya nıtlarında istatistik olarak anlamlı bir fark saptanamazken, her iki hasta grubunun yanıtlarının da kontrollere oranla önemli ölçüde düşüklük gösterdiği belirlendi (p<0.01). DNCB'ye ya nıtlar tek başına değerlendirildiğinde ise demir-çinko eksik liği olan hastaların demir eksikliği grubuna oranla anlamlı olarak (p<0.01) düşüklük gösterdiği görüldü. Sonuç olarak, inceleyebildiğimiz parametrelerde, hem demir, hem de demir-çinko eksikliğinin hücresel bağışıklığı olumsuz yönde etkiledikleri, demir-çinko eksikliği durumunda bu olumsuz etkinin daha büyük oranda olduğu belirlendi
SAP SOLUTIONS FOR SPORTS
No full textTema diplomskega projekta so rešitve podjetja SAP v športni panogi. Na začetku diplomskega projekta so predstavljene rešitve ERP in njihov razvoj, kot osnove poslovnih rešitev. V nadaljevanju je predstavljeno podjetje SAP skozi zgodovinski razvoj in trendi na področju njihovih rešitev. Sledi podrobna analiza rešitev podjetja SAP za šport. Rešitve so razdeljene v tri kategorije in sicer trženje in sodelovanje, prodaja in poslovanje ter učinek ekipe. V treh kategorijah je predstavljeno 16 različnih rešitev. Analizira je tudi rešitev SAP Sports One, ki je najboljša in najsodobnejše rešitev podjetja SAP za športno panogo. Za konec sta prikazana dva primera iz prakse. Liga NBA in Nemška nogometna zveza sta se odločila za rešitve podjetja in SAP in dosegla odlične rezultate.The topic of the diploma project is SAP solutions for sports. ERP solutions are base of business solutions and their development is presented at the beginning of the diploma project. Afterwards company SAP is presented together with theirs historical development and solution spotlights. Solutions for sports are next part of the diploma project. They are divided into three groups: Marketing and Engagement, Sales and Commerce and Team Performance. 16 different solutions are presented in these three categories. SAP Sports One is the best and the latest solution for sports and it is also analyzed. At the end you can find two case studies. NBA and German Football Association chose SAP solutions and achieved great results
Demir Baba : saint et héros des musulmans hétérodoxes en Bulgarie
No full textL’auteur présente les kızılbaş en soulignant leur non-conformisme politique et leur messianisme. Situé dans ce contexte à partir de son vilayetname, Demir Baba fait alors l’objet d’une analyse historique et culturelle.The author sets out the kızılbaş by emphasizing their non-conformism and messanism. In this context, thanks to his vilayetname, Demir Baba is analyzed in an historical and cultural perspective
Demir Baba : saint et héros des musulmans hétérodoxes en Bulgarie
No full textL’auteur présente les kızılbaş en soulignant leur non-conformisme politique et leur messianisme. Situé dans ce contexte à partir de son vilayetname, Demir Baba fait alors l’objet d’une analyse historique et culturelle.The author sets out the kızılbaş by emphasizing their non-conformism and messanism. In this context, thanks to his vilayetname, Demir Baba is analyzed in an historical and cultural perspective
Approach for siting a support facility for transporting supplies in emergency cases in the Republic of Bulgaria
No full textIn this paper, the author determines the most suitable transportation location for intervention in a large scale disaster in the Republic of Bulgaria, by means of the Weber Problem and the Weiszfeld method. The objective is to minimise the cost of transporting emergency supplies across the country by locating a support facility, and thus reaching the area of event at the lowest possible cost. A brief description of the Weiszfeld method is provided in the paper. Further, using recent population data of both provinces and municipalities, the method is applied respectively to obtain the results. They were compared in terms of spatial correspondence and the final facility location was fixed. Erecting the supply site is recommended to help decrease the losses
Exploiting Array Geometry for Reduced-Subspace Channel Estimation in RIS-Aided Communications
No full textA reconfigurable intelligent surface (RIS) can be used to improve the channel
gain between a base station (BS) and user equipment (UE), but only if its
reflecting elements are configured properly. This requires accurate estimation
of the cascaded channel from the UE to the BS through each RIS element. If the
channel structure is not exploited, pilot sequences of length must be used,
which is a major practical challenge since is typically at the order of
hundreds. To address this problem without requiring user-specific channel
statistics, we propose a novel estimator, called reduced-subspace least squares
(RS-LS) estimator, that only uses knowledge of the array geometry. The RIS
phase-shift pattern is optimized to minimize the mean-square error of the
channel estimates. The RS-LS estimator largely outperforms the conventional
least-squares estimator, and can be utilized with a much shorter pilot length
since it exploits the fact that the array geometry confines the possible
channel realizations to a reduced-rank subspace.Comment: Accepted for presentation in IEEE SAM 2022, 5 pages, 2 figure
You Lose, I Feel Better: Rivalry Between Soccer Teams and the Impact of Schadenfreude on Stock Market
No full textThis study considers the game-related performance of two listed soccer clubs in Italy which share the same stadium: Roma and Lazio. We introduce the performance of the archrival in the analysis. The high level of rivalry in sports should lead to a feeling of pleasure at the suffering of another group (known in German as Schadenfreude) and we assume to see the satisfaction of investor fans with the defeat of the archrival. Likewise, the win of the archrival can have a negativeimpact on the mood of investors. This study shows that, when club supporters experience the negative performance of their team, the results of their archrival can affect their investment decisions. It is therefore proven that, at least in this respect, the investors (also widely represented by club supporters) are driven by the sentiments conveyed by rivalry which, considered to be a source of emotion, may be relevant to the market
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