383 research outputs found
Mixing the Immiscible: Improvisation within Fixed-Media Composition
No full textThis paper will explore ways in which mastered improvisation practice, with the studio as an instrument, is a proposed avenue to bridge the historical dichotomy between what Ted Gioia describe as ‘the aesthetics of perfection’ and ‘the aesthetics of imperfection’. It is proposed as a way to re-embody fixed music, as experimented by the author through the composition of his last fixed-media work. This will be put in the context of a wider trend observed amongst the current emerging generation of composers interested in the aesthesics of the work, by opposition to the previous generations that placed the value of the work in its poietics. The vital and primal importance of practice outcome as practice-based research’s main document will also be advocated for, as these trends are happening in the laboratory of live music
An Extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at theHLA-DRB1locus
No full textMultiple sclerosis (MS) is a common inflammatory disease of the
central nervous system unsurpassed for variability in disease outcome.
A cohort of sporadic MS cases (n=63), taken from opposite
extremes of the distribution of long-term outcome, was used to
determine the role of theHLA-DRB1locus on MS disease severity.
Genotyping sets of benign and malignant MS patients showed thatHLA-DRB1*01was significantly underrepresented in malignant
compared with benign cases. This allele appears to attenuate the
progressive disability that characterizes MS in the long term. The
observation was doubly replicated in (i) Sardinian benign and
malignant patients and (ii) a cohort of affected sibling pairs
discordant forHLA-DRB1*01. Among the latter, mean disability
progression indices were significantly lower in those carrying theHLA-DRB1*01allele compared with their disease-concordant siblings
who did not. The findings were additionally supported by
similar transmission distortion ofHLA-DRB1*04subtypes closely
related toHLA-DRB1*01. The protective effect ofHLA-DRB1*01in
sibling pairs may result from a specific epistatic interaction with the
susceptibility alleleHLA-DRB1*1501. A high-density (>700) SNP
examination of the MHC region in the benign and malignant
patients could not identify variants differing significantly between
the two groups, suggesting thatHLA-DRB1may itself be the
disease-modifying locus. We conclude thatHLA-DRB1*01, previously
implicated in disease resistance, acts as an independent
modifier of disease progression. These results closely link susceptibility
to long-term outcome in MS, suggesting that shared quantitative
MHC-based mechanisms are common to both, emphasizing
the central role of this region in pathogenesis
Family studies of multiple sclerosis
No full textThe overall objective of the Canadian Collaborative Project on the Genetic
Susceptibility to Multiple Sclerosis (CCPGSMS) is to elucidate the pathogenesis of
Multiple Sclerosis (MS). The aims of this thesis, as part of the CCPGSMS, were to
1) confirm the involvement of genetics in the susceptibility to MS 2) to examine the
effects of the shared familial environment on MS risk and 3) to determine if a maternal
effect can increase the risk to MS. Fourteen thousand nine hundred and ninety active
Multiple Sclerosis (MS) clinic patients were screened as part of the CCPGSMS between
the dates of Sept., 1994 and May,1996. From this group, 203 twin pairs, (80
monozygotic and 123 dizygotic), were identified. The proband-wise monozygotic twin
concordance rate was 28.25% (SE. 5.84%) and the dizygotic twin concordance rate was
5.61% (S.E. 2.45%). The risk to the non-twin sibs of an index case was estimated at
2.49% (S.E. 0.74%) which was not significantly different than the dizygotic twin risk
estimate, 0.05<p<0.10. This confirms the results of previous studies, and supports a
strong genetic contribution to MS susceptibility. Five hundred and forty-five MS patients
were identified with adoptive parents, and/or adopted sibs, and/or adopted children. The
total adoptive first degree relatives of MS patients was 1185. Only one of these
individuals had clinically definite MS. This was significantly different than the 25.2
affected individuals expected if the shared familial environment was important to the
familial aggregation of MS, p=2.98 X 10"10. This supports the hypothesis that familial
aggregation of M S is due primarily to genetics and not to the sharing of the familial
environment. Nine hundred and thirty-six index cases were identified that had at least
one half-sibling. There was no significant difference in the risk estimate between
maternal half-siblings, 1.47% (S.E. 0.42%) and paternal half-siblings, 1.31% (S.E.
0.46%), 0.75<p<0.90. This argues against the contribution of a significant maternal
effect to M S risk.Medicine, Faculty ofMedical Genetics, Department ofGraduat
Linkage and association studies in multiple sclerosis
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
The visceral screen: Between the cinemas of John Cassavetes and David Cronenberg, a Barthesian perspective
No full textThe thesis discusses two directors who are never considered together in academic discourse. Cassavetes’ perceived focus on events led by the dynamics of performance and his looseness of technique opposes the calculated compositions of the Cronenberg film, with its aesthetic of horrific images and its gallery of emotionally detached protagonists. Yet it is between such opposing methods of cinematic expression that the ineffable qualities of film aesthetics can be discovered. Cassavetes’ cinema achieves this by revelling in a surplus of activity that exceeds narrative, while the indescribable characteristics of the Cronenberg oeuvre is achieved through a systematic emptying of the image’s meaning through a simultaneous commitment to paring back emotion and portraying of images that are controversial and inconceivable. Taken together, the thesis identifies these aspects of film as ‘the visceral,’ a facet of the moving image that most certainly exists, but is resolutely, and disturbingly resistant to interpretation.
Roland Barthes’ writings are integral to a theory of the visceral. His re-evaluation of Saussurean semiology as a method of analyzing and undoing ideologically-imposed meanings informs readings of sequences from Cassavetes and Cronenberg’s films. Following Barthes, the thesis suggests that the existence of the visceral is realized as a resistance to ideological interpretations of the image, and so cannot be described. Ultimately, the inability of semiology to fully grasp certain aspects of the filmed image is put forward as a rejoinder to theories of the fiction film as principally a narrative medium
Hybridization of a RoR HPP with a BESS—The XFLEX HYDRO Vogelgrun Demonstrator
No full textIn the XFLEX HYDRO Vogelgrun demonstrator, a run-of-river hydropower plant, the hybridization of one turbine-generator unit with a battery energy storage system is being investigated. This paper describes the integration methodology of the hybrid control algorithm without replacing the existing speed governor of the unit. Furthermore, the comparison of the performances of a non-hybrid and hybrid unit is discussed, and first experiences gained during the operation and monitoring of the hybrid operating mode are presented.This work has been realized with the participation of INES.2S. David Valentín and Alexandre Presas acknowledge the Serra Húnter program. The corresponding author would like to express his gratitude to Nicolas Ruchonnet for his contributions during the revision.Postprint (published version
O pintor da vida moderna a evolução do corpo e do espaço na cinematografia de David Fincher
No full textA dissertação O Pintor da Vida Moderna - A evolução do corpo e do espaço na
cinematografia de David Fincher tem por objecto a obra cinematográfica do realizador americano
David Fincher, assim como os videoclips e spots publicitários da sua autoria.
Este trabalho pretende identificar temas recorrentes na obra do realizador e "traçar" um
sentido evolutivo da sua obra, sobretudo a partir da análise à evolução do corpo e do espaço nos
filmes do autor. A dissertação atentará também à dimensão referencial patente nos filmes de
Fincher, que se relacionam com outras obras da história do cinema (e de outras áreas) pela citação
de determinadas cenas (através da mise-en-scène). Serão ainda tidos em conta aspectos relacionados
com a "maquinaria" cinematográfica, ou com os processos de captação e edição de imagens,
nomeadamente no respeitante ao impacto da tecnologia digital na sua obra, e à forma como a
narrativa dos seus filmes espelhará essa transição (da tecnologia analógica para a tecnologia
digital).
A análise directa dos filmes será secundada por estudos dedicados por diversos autores a
David Fincher, assim como por pareceres da crítica cinematográfica em relação à sua obra. O corpo
de estudo será ainda alargado às obras literárias de que partiram alguns dos filmes (nomeadamente a
obra de Stieg Larsson que serviu de base ao filme The Girl With a Dragon Tattoo) ou a obras de
referência no que respeita a estudos de cinema (de que é exemplo o livro A Imagem-Tempo, de
Deleuze).Abstract: The dissertation entitled Modern Life Painter – The evolution of body and space in David
Fincher’s cinematography focuses on the American film-maker’s cinematographic work as well as
his videoclips and advertising spots.
This work aims to identify recurring themes and disclose an evolutionary pattern in the filmmaker’s
career, mainly through an analysis of the evolution of body and space in the author’s films.
The dissertation also considers the referential dimension manifest in Fincher’s cinema, that is, we
acknowledge that the author articulates his films with cinematic history (and other areas as well) by
quoting specific scenes through the use of mise-en-scène. Furthermore, we take into account issues
related to the film-making process or the image recording and editing process, namely regarding the
impact of digital technology in his work, and the way in which the films’ narrative mirrors the
transition from analog to digital technology.
Direct film analysis will be reinforced by a literary review of past studies and critiques
focussed on David Fincher’s work. Moreover, the object of study will be extended to include the
literary work that formed the basis to some of the author’s films (namely Stieg Larsson’s book The
Girl With a Dragon Tattoo) and to authoritative work regarding cinema studies (for instance
Deleuze’s The Time-image)
O pintor da vida moderna a evolução do corpo e do espaço na cinematografia de David Fincher
No full textA dissertação O Pintor da Vida Moderna - A evolução do corpo e do espaço na
cinematografia de David Fincher tem por objecto a obra cinematográfica do realizador americano
David Fincher, assim como os videoclips e spots publicitários da sua autoria.
Este trabalho pretende identificar temas recorrentes na obra do realizador e "traçar" um
sentido evolutivo da sua obra, sobretudo a partir da análise à evolução do corpo e do espaço nos
filmes do autor. A dissertação atentará também à dimensão referencial patente nos filmes de
Fincher, que se relacionam com outras obras da história do cinema (e de outras áreas) pela citação
de determinadas cenas (através da mise-en-scène). Serão ainda tidos em conta aspectos relacionados
com a "maquinaria" cinematográfica, ou com os processos de captação e edição de imagens,
nomeadamente no respeitante ao impacto da tecnologia digital na sua obra, e à forma como a
narrativa dos seus filmes espelhará essa transição (da tecnologia analógica para a tecnologia
digital).
A análise directa dos filmes será secundada por estudos dedicados por diversos autores a
David Fincher, assim como por pareceres da crítica cinematográfica em relação à sua obra. O corpo
de estudo será ainda alargado às obras literárias de que partiram alguns dos filmes (nomeadamente a
obra de Stieg Larsson que serviu de base ao filme The Girl With a Dragon Tattoo) ou a obras de
referência no que respeita a estudos de cinema (de que é exemplo o livro A Imagem-Tempo, de
Deleuze).Abstract: The dissertation entitled Modern Life Painter – The evolution of body and space in David
Fincher’s cinematography focuses on the American film-maker’s cinematographic work as well as
his videoclips and advertising spots.
This work aims to identify recurring themes and disclose an evolutionary pattern in the filmmaker’s
career, mainly through an analysis of the evolution of body and space in the author’s films.
The dissertation also considers the referential dimension manifest in Fincher’s cinema, that is, we
acknowledge that the author articulates his films with cinematic history (and other areas as well) by
quoting specific scenes through the use of mise-en-scène. Furthermore, we take into account issues
related to the film-making process or the image recording and editing process, namely regarding the
impact of digital technology in his work, and the way in which the films’ narrative mirrors the
transition from analog to digital technology.
Direct film analysis will be reinforced by a literary review of past studies and critiques
focussed on David Fincher’s work. Moreover, the object of study will be extended to include the
literary work that formed the basis to some of the author’s films (namely Stieg Larsson’s book The
Girl With a Dragon Tattoo) and to authoritative work regarding cinema studies (for instance
Deleuze’s The Time-image)
O pintor da vida moderna a evolução do corpo e do espaço na cinematografia de David Fincher
No full textA dissertação O Pintor da Vida Moderna - A evolução do corpo e do espaço na
cinematografia de David Fincher tem por objecto a obra cinematográfica do realizador americano
David Fincher, assim como os videoclips e spots publicitários da sua autoria.
Este trabalho pretende identificar temas recorrentes na obra do realizador e "traçar" um
sentido evolutivo da sua obra, sobretudo a partir da análise à evolução do corpo e do espaço nos
filmes do autor. A dissertação atentará também à dimensão referencial patente nos filmes de
Fincher, que se relacionam com outras obras da história do cinema (e de outras áreas) pela citação
de determinadas cenas (através da mise-en-scène). Serão ainda tidos em conta aspectos relacionados
com a "maquinaria" cinematográfica, ou com os processos de captação e edição de imagens,
nomeadamente no respeitante ao impacto da tecnologia digital na sua obra, e à forma como a
narrativa dos seus filmes espelhará essa transição (da tecnologia analógica para a tecnologia
digital).
A análise directa dos filmes será secundada por estudos dedicados por diversos autores a
David Fincher, assim como por pareceres da crítica cinematográfica em relação à sua obra. O corpo
de estudo será ainda alargado às obras literárias de que partiram alguns dos filmes (nomeadamente a
obra de Stieg Larsson que serviu de base ao filme The Girl With a Dragon Tattoo) ou a obras de
referência no que respeita a estudos de cinema (de que é exemplo o livro A Imagem-Tempo, de
Deleuze).Abstract: The dissertation entitled Modern Life Painter – The evolution of body and space in David
Fincher’s cinematography focuses on the American film-maker’s cinematographic work as well as
his videoclips and advertising spots.
This work aims to identify recurring themes and disclose an evolutionary pattern in the filmmaker’s
career, mainly through an analysis of the evolution of body and space in the author’s films.
The dissertation also considers the referential dimension manifest in Fincher’s cinema, that is, we
acknowledge that the author articulates his films with cinematic history (and other areas as well) by
quoting specific scenes through the use of mise-en-scène. Furthermore, we take into account issues
related to the film-making process or the image recording and editing process, namely regarding the
impact of digital technology in his work, and the way in which the films’ narrative mirrors the
transition from analog to digital technology.
Direct film analysis will be reinforced by a literary review of past studies and critiques
focussed on David Fincher’s work. Moreover, the object of study will be extended to include the
literary work that formed the basis to some of the author’s films (namely Stieg Larsson’s book The
Girl With a Dragon Tattoo) and to authoritative work regarding cinema studies (for instance
Deleuze’s The Time-image)
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