110,008 research outputs found
Effect of the “thank you-t” gratitude education program (Tygep-T) on gratitude levels of Turkish elementary school teachers
No full textThe purpose of this study is to develop and examine the effectiveness of the “Thank You-T” Gratitude Education Program (TYGEP-T) for Turkish elementary school teachers. TYGEP-T aims to contribute elementary school teachers to develop their skills to recognize and express gratitude and review the school-based activities they can do to make gratitude a part of their “school culture”. A pre-test, posttest, and follow-up experimental design with one treatment and one none-treatment control group were used to examine the effectiveness of the program, with a sample of 23 elementary school teachers. Results revealed that after the TYGEP-T a significant difference appeared between the total gratitude scores of the experimental group and the control group. This difference disappeared in the follow-up test. Moreover, in this study in a more different way than the former studies, the effects of the program on the sub-dimensions of gratitude, Lack of Sense of Deprivation (LOSD), Simple Appreciation (SA) and Appreciation of Others (AO), were examined. In terms of subscale scores, while the program is considered effective in increasing LOSD and AO scores, permanency was only observed in AO scores
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Mr. Lupe M. Garcia, Joe T. Martinez, Arthur Tafoya, Ann Dominguez, Mr. Jacob Duran. (photograph)
No full text(L. to R.) Mr. Lupe M. Garcia, Joe T. Martinez, Arthur Tafoya, Ann Dominguez, Mr. Jacob Duran
The construction of Karen Karnak: The multi-author-function
No full textThis thesis is situated within the comparatively recent developments of Web 2.0 and the emergence of interactive WikiMedia, and explores the mode of authorship within a Read/Write culture compared to that of a Read/Only tradition. The hypothesis of this study is that the role of the audience has become merged with the author, and as such, represents new functions and attributes, distinct from a more conventional concept of authorship, in which the roles of audience and author are more separate. Read/Write and participatory culture, as defined by this study, is focused on collaboration, and includes the influences of D.I.Y. culture, Open-Source practices and the production of text by multiple authors. Multi-authorship presents a re-thinking of several concepts which support the notion of the individual author, since the focus of multi-authorship is not on attribution and ownership of a finished text, but on the continued malleability of a text. Modes of multi-authorship, demonstrated in the use of the pseudonyms Alan Smithee and Karen Eliot, represent declarative authors whose names signify multiple origins, whilst concurrently indicating a distinct body of work. The function of these names form an important context to this study, since primary research involves the construction of an experimental mode of multi-authorship utilising WikiMedia technology and the interaction of thirty nine participants, who are invited to create a body of work under the collective pseudonym Karen Karnak. The data generated by this experiment is analysed using aspects of Michel Foucault's author-function to identify and determine power structures inherent in the WikiMedia context. The interplay of power structures, including concepts such as identity, ownership and the body of work, affect the resulting mode of authorship and contribute to the construction of Karen Karnak, suggesting further areas of research into the emerging multi-author
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
From barrier breach to brain invasion: Modulators of T cell migration in Multiple Sclerosis
No full textMultiple Sclerosis (MS) is the most common neurological disorder in young adults, and every 5 minutes someone in the world is diagnosed with MS. The symptoms of MS present in unpredictable episodes impairing visual, sensory, physical, emotional and cognitive functions, which severely impact the lives of patients in the prime of their lives. The disease is caused by immune cells infiltrating into the brain and spinal cord attacking the insulating layer, called myelin, around the nerves. This causes disturbed signalling between neurons, leading to the array of symptoms. The immune system consists of many different cell types, of which the CD4+ T cell is believed to play a critical role in MS development, by opening and migrating through brain barriers. In healthy brains, T cells are not able to cross these barriers, but in people with MS these barriers are permeable, allowing T cells to enter and cause inflammation. In the first part of this thesis, I focussed on intercellular communication via small messengers called extracellular vesicles (EV). I investigated whether EV derived from blood brain barrier endothelial cells (BBB-EC) impacted BBB integrity, and if the size of these vesicles mattered. When the BBB was inflamed, much like in a brain of an MS patient, BBB-EC released more EV and their content mimicked the inflamed BBB. Large EV showed the most overlap with inflamed BBB cells. Thereby, EV were able to negatively regulate the integrity of the BBB. Next, EV were administered to mice induced with a MS-like disease, and we expected worsening of the disease. However, the group that received small EV actually got less sick and had less leakage of the BBB, indicating a protective effect. More research with EV derived from other origins is necessary. Nevertheless, this study indicates that BBBEV have a disease modifying effect in the context of MS. In the second part of this thesis, I investigated inflammasome activation within T cells, and determined whether it is crucial for BBB-transmigration, or if it is the result of migration. I first analysed inflammasome components in immune cells of MS patients and HD, and found no differences in directly isolated cells. However, I found that stimulation of CD46 induced inflammasome activation in both donor populations, and I established that in CD4+ T cells, the amount of inflammasome activation was higher in MS patients compared to HD. In the MS-like disease in mice, I found that inflammasome activation in CD4+ T cells increased in the central nervous system over time but not in peripheral lymphoid organs. I therefore looked further into the effect of inflammasome activation on the migratory capacities of T cells. Herein, I found indications that inflammasome activation is the result of BBBtransmigration rather than just contact with endothelial cells, and that this only happens in CD4+ T cells and not in other immune cells present in the blood. Finally, I looked into a specific molecule found on the endothelial cell layer that could be the trigger for inflammasome activation. In future research, I aim to validate this and show that blocking this interaction limits the pathogenicity of infiltrating T cells
From barrier breach to brain invasion: Modulators of T cell migration in Multiple Sclerosis
No full textMultiple Sclerosis (MS) is the most common neurological disorder in young adults, and every 5 minutes someone in the world is diagnosed with MS. The symptoms of MS present in unpredictable episodes impairing visual, sensory, physical, emotional and cognitive functions, which severely impact the lives of patients in the prime of their lives. The disease is caused by immune cells infiltrating into the brain and spinal cord attacking the insulating layer, called myelin, around the nerves. This causes disturbed signalling between neurons, leading to the array of symptoms. The immune system consists of many different cell types, of which the CD4+ T cell is believed to play a critical role in MS development, by opening and migrating through brain barriers. In healthy brains, T cells are not able to cross these barriers, but in people with MS these barriers are permeable, allowing T cells to enter and cause inflammation. In the first part of this thesis, I focussed on intercellular communication via small messengers called extracellular vesicles (EV). I investigated whether EV derived from blood brain barrier endothelial cells (BBB-EC) impacted BBB integrity, and if the size of these vesicles mattered. When the BBB was inflamed, much like in a brain of an MS patient, BBB-EC released more EV and their content mimicked the inflamed BBB. Large EV showed the most overlap with inflamed BBB cells. Thereby, EV were able to negatively regulate the integrity of the BBB. Next, EV were administered to mice induced with a MS-like disease, and we expected worsening of the disease. However, the group that received small EV actually got less sick and had less leakage of the BBB, indicating a protective effect. More research with EV derived from other origins is necessary. Nevertheless, this study indicates that BBBEV have a disease modifying effect in the context of MS. In the second part of this thesis, I investigated inflammasome activation within T cells, and determined whether it is crucial for BBB-transmigration, or if it is the result of migration. I first analysed inflammasome components in immune cells of MS patients and HD, and found no differences in directly isolated cells. However, I found that stimulation of CD46 induced inflammasome activation in both donor populations, and I established that in CD4+ T cells, the amount of inflammasome activation was higher in MS patients compared to HD. In the MS-like disease in mice, I found that inflammasome activation in CD4+ T cells increased in the central nervous system over time but not in peripheral lymphoid organs. I therefore looked further into the effect of inflammasome activation on the migratory capacities of T cells. Herein, I found indications that inflammasome activation is the result of BBBtransmigration rather than just contact with endothelial cells, and that this only happens in CD4+ T cells and not in other immune cells present in the blood. Finally, I looked into a specific molecule found on the endothelial cell layer that could be the trigger for inflammasome activation. In future research, I aim to validate this and show that blocking this interaction limits the pathogenicity of infiltrating T cells
Kamu ?ktisadi Te?ebbüslerinin Aktiflerinde Yer Alan Maddi Duran Varl?klar?n Envanter ve De?erleme Ara?t?rmas?
No full textBu ara?t?rmada, kamu iktisadi te?ekkülü olarak faaliyet gösteren Elektrik Üretim Anonim ?irketi (EÜA?) Genel Müdürlü?ü Hirfanl? Hidroelektrik Santrali (HES) ??letmesi’nin aktifinde kay?tl? maddi duran varl?klar?n?n gerçe?e uygun de?erleri ile envanter kay?tlar?nda yer alan tarihi (net) de?erleri kar??la?t?r?lm??t?r. Ara?t?rmada varl?k de?erleme çal??mas?nda; bilimsel esaslar, uluslararas? standartlar ve mevzuat?n amir hükümlerine göre gerçekle?tirilmi? ve i?letmenin varl?klar?n de?erlenmesinde piyasa de?eri (emsal de?er, ikame de?eri), maliyet yönetimi ve di?er de?erleme ölçütlerinden faydalan?lm??t?r. ??letmenin mevcut mali kay?tlar?na göre maddi duran varl?klar?n?n 2016 y?l?n?n fiyatlar? üzerinden toplam de?erinin (8.872.054,07 TL), söz konusu varl?klar?n güncel de?erinden (54.342.356,11 TL) yakla??k 6 kat daha dü?ük oldu?u ve do?al olarak i?letmenin varl?k de?erinin oldu?undan çok daha dü?ük olarak kay?tlara yans?t?ld??? dikkati çekmektedir. Ara?t?rma sonuçlar?na göre i?letmenin maddi duran varl?klar?n envanter ve de?erleme çal??malar?n?n, gerçek varl?k de?erlerinin analiz edilmesi ve ç?kan sonuçlar?n finansal yönden yorumlamas? bak?m?ndan anlaml? oldu?u ortaya konulmu?tur.</jats:p
Capillary reserve in isometrically contracting dog hearts
No full text Page H276: W. N. Duran, T. H. Marsicano, and R. W. Anderson. “Capillary reserve in isometrically contracting dog hearts.” In the citation of the Journal in the third line of the abstract, the volume number should read 233. </jats:p
Enzyme Applications In The Textile Industry
No full textDevelopments and advances in the processing of cotton fabrics to minimize the environmental effects of processing effluents are reviewed. The focus is on biological methods such as the replacement of stone-washing of denim garments with cellulases, and other enzymatic related processes using xylanases, lipases, laccase, proteases and catalases.304144Vigo, T.L., (1995) Trends in Polymer Sci., 3, p. 407Cegarra, J., (1996) J.S.D.C., 112, p. 326Etters, J.N., Annis, P.A., (1998) Amer. Dyestuff Rep., 87, p. 18Akin, D.E., Henriksson, G., Morrison, W.H., Eriksson, K.E.L., (1998) ACS Symp. Ser., (687), p. 269Cavaco-Paulo, A., (1998) ACS Symp. Ser., (687), p. 180Vandevivere, P.C., Bianchi, R., Verstraete, W., (1998) J. Chem. Technol. Biotechnol., 72, p. 289Beguin, P., Aubert, J.P., (1994) FEMS Microbiol. Rev., 13, p. 25Chikkodi, S.V., Khan, S., Mehta, R.D., (1995) Text. Res. J., 65, p. 564Cavaco-Paulo, A., Almeida, L., (1996) Text. Res. J., 87, p. 227Tyndall, R.M., (1992) Text. 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Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
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