9 research outputs found
Analisi statistica sulla patologia nodulare tiroidea
No full textLa tiroide è una ghiandola endocrina situata nella regione anteriore del collo, specializzata nella produzione e secrezione di ormoni tiroidei. La patologia nodulare tiroidea prevede la presenza di formazioni nodulari nel contesto della tiroide, singole o multiple, che possono alterare la funzionalità e le dimensioni della ghiandola. Tale patologia colpisce il 4-7% circa della popolazione adulta. La tireopatia nodulare può evolversi in patologia maligna: circa 1 nodulo su 20, sottoposto a trattamento chirugico, risulta essere un carcinoma all’esame istologico definitivo. Al fine di individuare il ruolo di alcune variabili nell’evoluzione della malattia, è stato preso in esame un campione di 401 pazienti, di età compresa tra i 17 e gli 84 anni, sottoposti ad intervento chirurgico nel periodo che va dal 2018 al 2021. Obiettivo iniziale è stato quello di stabilire quali variabili influiscono maggiormente sulla diagnosi. Inoltre, sono state individuate le variabili che contribuiscono maggiormente a spiegare la variabilità del fenomeno, e, tramite il modello Logit, quali sono i fattori di rischio, individuabili nel pre-operatorio, che portano a definire una patologia maligna piuttosto che benigna. Per determinare tali fattori di rischio ci si è serviti del software R (un linguaggio di programmazione specifico per la statistica e la grafica computazionale), attraverso cui sono state condotte anche le altre analisi
Editorial : Women in veterinary epidemiology and economics
No full textWhile the number of women graduating from veterinary schools has increased globally over the last few decades, this has not translated into reduced gender bias and inequity in academia and veterinary science research (1). Gender-based discrimination starts at university where women veterinary students are pushed toward “women-majority fields” (e.g., small animal medicine) (2) or where they face discrimination during animal husbandry placements (3). Following graduation, there is clear evidence that gender differences persist in pay and attainment of senior and leadership positions (4). Women's advancement and standing in academic veterinary medicine may in part be influenced by pronounced gender differences in the authorship of veterinary research articles. Women are less likely to be a senior author on a research paper and they are significantly underrepresented in some fields such as surgical and production animal research (5). Gender disparity in professional leadership roles like editorial boards—the median publisher in veterinary sciences had 27.5% editorships belonging to women (6)—can summate by impairing peer recognition and academic advancement.Instituto de VirologíaFil: Capozzo, Alejandra. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología e Innovaciones Tecnológicas; ArgentinaFil: Capozzo, Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vial, Flavie. Animal and Plant Health Agency; Reino Unid
Elevated cerebrospinal fluid neurofilament light levels in patients with amyotrophic lateral sclerosis: A possible marker of disease severity and progression
No full textBackground: To date there are no biomarkers with proven reliability as a measure of disease burden in amyotrophic lateral sclerosis (ALS). The aim of our study is to assess the neurofilament light chain (NFL) in cerebrospinal fluid (CSF) samples as a measure of disease activity and progression in ALS. Methods: Thirty-seven consecutive patients with ALS, 25 with chronic inflammatory demyelinating polyneuropathy and 21 with other neurodegenerative diseases were evaluated. CSF NFL levels were assayed by two-site solid-phase sandwich ELISA. In patients with ALS, neurological status was assessed by the revised ALS Functional Rating Scale (ALSFRS-r) and the Medical Research Council scale, and the progression of the disease was evaluated using the 'diagnostic delay' and the 'progression rate'. Results: Cerebrospinal fluid NFL levels were higher in ALS cases than in controls (P < 0.0001). Using receiver operating curve analysis, an optimal NFL cut-off of 1981 ng/l discriminated between patients with ALS and neurological controls, with a sensitivity of 78.4% and specificity of 72.5%. Multivariate logistic regression confirmed the association between CSF NFL levels and the presence of ALS (age and sex adjusted odds ratio for ALS 8.9; 95% CI 3.1-25.8; P < 0.0001). In ALS, CSF NFL negatively correlated with the diagnostic delay (P < 0.0001) and the ALSFRS-r (P = 0.014) and positively with the progression rate (P < 0.0001). Conclusions: High CSF NFL levels were found in patients with ALS, reflecting the burden of neurodegeneration. The significant relation between CSF NFL levels and disease progression suggests that NFL may be a useful marker of disease activity and progression in ALS. © 2012 The Author(s) European Journal of Neurology © 2012 EFNS
Correction to: A nonsynonymous mutation in <em>PLCG<sub>2</sub></em> reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
No full text\ua9 2020, The Author(s). The IPDGC (The International Parkinson Disease Genomics Consortium) and EADB (Alzheimer Disease European DNA biobank) are listed correctly as an author to the article, however, they were incorrectly listed more than once
Trauma and amyotrophic lateral sclerosis: A case-control study from a population-based registry
No full textBackground and purpose: Published reports on the association between amyotrophic lateral sclerosis (ALS) and trauma are controversial suggesting the need for a new case-control study done in a large population. Methods: A case-control study was undertaken in Italy to assess this association. Cases were patients with newly diagnosed ALS from four population-based registries. For each case, two hospital controls were selected, matched for age, sex, and province of residence, one with a neurological (non-degenerative) disease and one with a non-neurological disease (other than orthopedic or surgical). Traumatic events (defined as accidental events causing injuries requiring medical care) were recorded with details on type, site, timing, severity, and complications. The risks were assessed as odds ratios (ORs) with 95% confidence intervals (CI), crude and adjusted for age, sex, education, interviewee (patient or surrogate), physical activity, smoking, alcohol, and coffee. Results: The study population comprised 377 patients in each of the three groups. One or more traumatic events were reported by 225 cases (59.7%), 191 neurological controls (50.7%), and 179 non-neurological controls (47.5%) (P < 0.01) (OR 1.63; 95% CI 1.25-2.14) (P < 0.01). The ORs were 3.07 (95% CI 1.86-5.05) for patients reporting 3+ traumatic events and 2.44 (95% CI 1.36-4.40) for severe traumatic events. The ORs remained significant when the analysis was limited to events that occurred 5+ and 10+ years before ALS onset, to incident ALS, and direct informant. Conclusion: Antecedent trauma, repeated trauma, and severe trauma may be risk factors for ALS. © 2012 The Author(s) European Journal of Neurology © 2012 EFNS
Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity (Acta Neuropathologica, (2019), 138, 2, (237-250), 10.1007/s00401-019-02026-8)
No full textThe IPDGC (The International Parkinson Disease Genomics Consortium) and EADB (Alzheimer Disease European DNA biobank) are listed correctly as an author to the article, however, they were incorrectly listed more than once
Coffee and amyotrophic lateral sclerosis: A possible preventive role
No full textThe relation between coffee intake and risk of amyotrophic lateral sclerosis (ALS) was investigated in 377 newly diagnosed ALS patients from 4 Italian population-based registries in the European ALS Consortium (EURALS Group) (2007-2010). For each patient, 2 age-and sex-matched hospital controls were selected, one from a neurology department and one from a nonneurologic department. Two additional healthy control groups were identified from local general practitioners' (GPs') lists (n = 99) and residents of the same area as a cancer cohort (n = 7,057). Coffee intake was defined in terms of status (ever consuming coffee daily for ≥6 months vs. never), duration, and history (never, former, or current). Ever coffee drinkers comprised 74.7% of ALS patients, 80.4% of neurologic controls, 85.6% of nonneurologic controls (P = 0.0004), 88.9% of GP controls (P = 0.0038), and 86.0% of cancer cohort controls (P < 0.0001). Current coffee drinkers comprised 60.2% of ALS patients, 70.2% of neurologic controls (P = 0.0294), 76.4% of nonneurologic controls (P < 0.0001), and 82.3% of GP controls (P = 0.0002); duration of intake was ≥30 years for 62.3%, 67.7%, 74.7%, and 72.6%. ALS patients had lower lifetime coffee exposure: Odds ratios were 0.7 (95% confidence interval (CI): 0.5, 1.1), 0.6 (95% CI: 0.4, 0.8), and 0.4 (95% CI: 0.2, 0.9) in comparison with neurologic, nonneurologic, and GP controls, respectively. In current (vs. never) coffee drinkers, odds ratios were 0.7 (95% CI: 0.5, 1.0), 0.5 (95% CI: 0.3, 0.7), and 0.4 (95% CI: 0.2, 0.8), respectively. These findings provide epidemiologic evidence of an inverse correlation between coffee intake and ALS risk. © 2011 The Author
Author Correction: Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS
No full textA correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.</jats:p
Application of the Nagoya Protocol to veterinary pathogens: concerns for the control of foot-and-mouth disease
No full textInternational audienceNetwork and were explored at a recent multistakeholder meeting hosted by the European Commission for the Control of FMD. The aim of this paper is to promote wider awareness of the Nagoya Protocol, and to highlight its impacts on the regular exchange and utilisation of biological materials collected from clinical cases which underpin FMD research activities, and work to develop new epidemiologically relevant vaccines and other diagnostic tools to control the disease
