1,720,956 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Design and preparation of imidazole, pyrazole and 5-methylisatin acetylcholinesterase reactivators
No full textU ovom diplomskom radu sintetizirana su tri prekursora Ugijeve reakcije koji sadrže oksimsku
i karboksilnu skupinu: 6-(2-hidroksiiminometilimidazol-1-il)heksanska kiselina, 2-(4-
hidroksiiminometil-pirazol-1-il)heksanska kiselina i 7-(5-metil-3-(hidroksiimino)-2-
oksoindolin-1-il)heksanska kiselina. Dobiveni 5-metilisatinski prekursor poslužio je kao
reaktant za Ugijevu reakciju s benzil-aminom, tert-butil-izocijanidom i formaldehidom pri
čemu se usporedila mogućnost izvođenja sinteze u otopini, mikrovalnom reaktoru te
mehanokemijski. Pripravljeni spojevi pročišćeni su dostupnim kromatografskim tehnikama i
karakterizirani dostupnim analitičkim metodama (UPLC-UV/MS, 1D, 2D NMR). U
računalnom dijelu rada uspoređeno je vezanje produkta Ugijeve reakcije i literaturno opisanih
reaktivatora u aktivnom mjestu sarinom inhibiranoga enzima acetilkolinesteraze pomoću
molekulskog uklapanja.In this diploma thesis new Ugi reaction's precursors containing oxime and carboxyl groups were
synthesized: 6-(2-hydroxyiminomethylimidazol-1-yl)hexanoic acid, 2-(4-
hydroxyiminomethyl-pyrazol-1-yl)hexanoic acid and 7-(5-methyl-3-(hydroxyimino)-2-
oxoindolin-1-yl)hexanoic acid. The 5-methylisatin precursor was used as a reactant for the Ugi
reaction with benzyl-amine, tert-butyl-isocyanide and formaldehyde. Besides the classical
syntheses in solution, the Ugi reaction was performed in a microwave reactor as well as
mechanochemically. The compounds were purified by available chromatographic techniques
and characterized by available analytical methods (UPLC-UV/MS, 1D, 2D NMR). The binding
of the Ugi reaction's products and acetylcholinesterase reactivators in the active site of the sarininhibited enzyme acetylcholinesterase were compared by molecular docking
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Design and preparation of imidazole, pyrazole and 5-methylisatin acetylcholinesterase reactivators
No full textU ovom diplomskom radu sintetizirana su tri prekursora Ugijeve reakcije koji sadrže oksimsku
i karboksilnu skupinu: 6-(2-hidroksiiminometilimidazol-1-il)heksanska kiselina, 2-(4-
hidroksiiminometil-pirazol-1-il)heksanska kiselina i 7-(5-metil-3-(hidroksiimino)-2-
oksoindolin-1-il)heksanska kiselina. Dobiveni 5-metilisatinski prekursor poslužio je kao
reaktant za Ugijevu reakciju s benzil-aminom, tert-butil-izocijanidom i formaldehidom pri
čemu se usporedila mogućnost izvođenja sinteze u otopini, mikrovalnom reaktoru te
mehanokemijski. Pripravljeni spojevi pročišćeni su dostupnim kromatografskim tehnikama i
karakterizirani dostupnim analitičkim metodama (UPLC-UV/MS, 1D, 2D NMR). U
računalnom dijelu rada uspoređeno je vezanje produkta Ugijeve reakcije i literaturno opisanih
reaktivatora u aktivnom mjestu sarinom inhibiranoga enzima acetilkolinesteraze pomoću
molekulskog uklapanja.In this diploma thesis new Ugi reaction's precursors containing oxime and carboxyl groups were
synthesized: 6-(2-hydroxyiminomethylimidazol-1-yl)hexanoic acid, 2-(4-
hydroxyiminomethyl-pyrazol-1-yl)hexanoic acid and 7-(5-methyl-3-(hydroxyimino)-2-
oxoindolin-1-yl)hexanoic acid. The 5-methylisatin precursor was used as a reactant for the Ugi
reaction with benzyl-amine, tert-butyl-isocyanide and formaldehyde. Besides the classical
syntheses in solution, the Ugi reaction was performed in a microwave reactor as well as
mechanochemically. The compounds were purified by available chromatographic techniques
and characterized by available analytical methods (UPLC-UV/MS, 1D, 2D NMR). The binding
of the Ugi reaction's products and acetylcholinesterase reactivators in the active site of the sarininhibited enzyme acetylcholinesterase were compared by molecular docking
Ksenonukleinske kiseline
No full textKsenonukleinske kiseline (XNA) su skupina sintetskih genetičkih polimera odnosno kemijski modificiranih analoga nukleinskih kiselina. Izraz „XNA“ prvi put su upotrijebili Herdewijn i Marlière 2009. godine za kemijske modifikacije dušičnih baza, šećernog dijela, fosfodiesterskog mosta ili kombinaciju tih elemenata prirodnih nukleinskih kiselina. Cilj ovog rada je upoznati se s osnovnim vrstama XNA i njihovom strukturom. U drugom dijelu rada je opisano kako se pojedine ksenonukleinske kiseline koriste u kliničke svrhe. U tom području postoji nekoliko pristupa. Antisense oligonukleotidi vežu se na mRNA, čime aktiviraju ribonukleazu H (RNazu H), što uzrokuje degradaciju komplementarnih mRNA. S druge strane vezanjem XNA u blizini mjesta inicijacije translacije sterički se blokira translacija. Osim toga, XNA se mogu uključiti u regulaciju ekspresije gena putem RNA interferencija ili u proces prekrajanja (engl. splicing)
Design and preparation of imidazole, pyrazole and 5-methylisatin acetylcholinesterase reactivators
No full textU ovom diplomskom radu sintetizirana su tri prekursora Ugijeve reakcije koji sadrže oksimsku
i karboksilnu skupinu: 6-(2-hidroksiiminometilimidazol-1-il)heksanska kiselina, 2-(4-
hidroksiiminometil-pirazol-1-il)heksanska kiselina i 7-(5-metil-3-(hidroksiimino)-2-
oksoindolin-1-il)heksanska kiselina. Dobiveni 5-metilisatinski prekursor poslužio je kao
reaktant za Ugijevu reakciju s benzil-aminom, tert-butil-izocijanidom i formaldehidom pri
čemu se usporedila mogućnost izvođenja sinteze u otopini, mikrovalnom reaktoru te
mehanokemijski. Pripravljeni spojevi pročišćeni su dostupnim kromatografskim tehnikama i
karakterizirani dostupnim analitičkim metodama (UPLC-UV/MS, 1D, 2D NMR). U
računalnom dijelu rada uspoređeno je vezanje produkta Ugijeve reakcije i literaturno opisanih
reaktivatora u aktivnom mjestu sarinom inhibiranoga enzima acetilkolinesteraze pomoću
molekulskog uklapanja.In this diploma thesis new Ugi reaction's precursors containing oxime and carboxyl groups were
synthesized: 6-(2-hydroxyiminomethylimidazol-1-yl)hexanoic acid, 2-(4-
hydroxyiminomethyl-pyrazol-1-yl)hexanoic acid and 7-(5-methyl-3-(hydroxyimino)-2-
oxoindolin-1-yl)hexanoic acid. The 5-methylisatin precursor was used as a reactant for the Ugi
reaction with benzyl-amine, tert-butyl-isocyanide and formaldehyde. Besides the classical
syntheses in solution, the Ugi reaction was performed in a microwave reactor as well as
mechanochemically. The compounds were purified by available chromatographic techniques
and characterized by available analytical methods (UPLC-UV/MS, 1D, 2D NMR). The binding
of the Ugi reaction's products and acetylcholinesterase reactivators in the active site of the sarininhibited enzyme acetylcholinesterase were compared by molecular docking
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