101 research outputs found
Reflections and Comments: A Reading of the book Il Medioevo Degli Alberi. Piante e Paesaggi d'Italia (secoli XI-XV) by Alfio Cortonesi
No full textThis critical commentary revolves around the recent book by Alfio Cortonesi entitled Il Medioevo degli alberi. Piante e paesaggi d'Italia (secoli XI-XV). Taking into account the basic research carried out in recent years, the author proposes an interpretative synthesis of particular relevance that can be considered a model to be followed in the coming years.Este comentario crítico gira en torno al reciente libro de Alfio Cortonesi titulado Il Medioevo degli alberi. Piante e paesaggi d'Italia (secoli XI-XV). Tomando en consideración las investigaciones de base realizadas en los últimos años, el autor propone una síntesis interpretativa de especial relevancia que puede ser considerada un modelo a seguir en los próximos años
Reflexiones y comentarios: una lectura del libro Il Medioevo degli Alberi. Piante e Paesaggi d’Italia (Secoli XI-XV) de Alfio Cortonesi
No full textEste comentario crítico gira en torno al reciente libro de Alfio Cortonesi titulado Il Medioevo degli alberi. Piante e paesaggi d’Italia (secoli XI-XV). Tomando en consideración las investigaciones de base realizadas en los últimos años, el autor propone una síntesis interpretativa de especial relevancia que puede ser considerada un modelo a seguir en los próximos años.
This critical commentary revolves around the recent book by Alfio Cortonesi entitled Il Medioevo degli alberi. Piante e paesaggi d’Italia (secoli xi-xv). Taking into account the basic research carried out in recent years, the author proposes an interpretative synthesis of particular relevance that can be considered a model to be followed in the coming years
On the senior authorship of Musca oleae (Diptera: Tephritidae)
No full textPietro Rossi (1738–1804), Professor at the University of Pisa, in 1790 described the olive fruit
fly Musca oleae in his opus Fauna Etrusca and for the next 121 years, Rossi was considered its
author. During all the 900 century, Gmelin was considered the senior author. In this paper we report that the date of Rossi's Fauna Etrusca has
been found to pre-date Gmelin's 13th Edition for the part that includes Musca oleae. Thus, we conclude that the senior author has to be considered definitively
Rossi and not Gmelin
UTILIZZAZIONE INDIRETTA E TUTELA DEI LAVORATORI NEGLI APPALTI
No full textLa tesi si prefigge di ricostruire il quadro normativo e concettuale che si è venuto ad enucleare a seguito dell’abrogazione della legge n.1369/1960 in tema di interposizione di manodopera, nonché della contemporanea dilatazione della responsabilità solidale del committente di un appalto di opera o servizi in forza del disposto dell’art. 29, d.lgs. n. 276/2003.
Nella prospettiva di attribuire al regime di solidarietà particolare attenzione l’Autore descrive, nel primo capitolo, tutte le ipotesi di responsabilità solidale presenti nel Codice civile con l’intento di individuare una base comune a tutte le fattispecie prese in esame.
Nel capitolo secondo si analizzano le evoluzioni dell’art. 29, d.lgs. n. 276/2003 e le numerose modifiche che tale norma ha dovuto sopportare, estendendo l’analisi al regime contributivo e fiscale, nonché alla disciplina relativa alla salute e sicurezza dei lavoratori.
Il terzo capitolo, infine, analizza gli aspetti critici della solidarietà negli appalti, dal tema della successione nel contratto di appalto da parte di un nuovo appaltatore a quello della compatibilità delle clausole sociali con il diritto europeo passando per la derogabilità al suddetto regime da parte della contrattazione collettiva, alle ipotesi di simulazione di contratti di appalto, senza tralasciare di analizzare l’ambito di applicazione della responsabilità solidale di cui all’art. 29, d.lgs. n. 276/2003 anche ad altre fattispecie negoziali attigue all’appalto.
L’analisi si conclude, poi, con la confutazione dell’opinione dottrinale secondo la quale le esternalizzazioni d’impresa realizzate attraverso contratti di appalto porterebbero all’insorgenza di ipotesi di codatorialità.The thesis aims to reconstruct the conceptual framework and that it has come to devise following the repeal of the law n.1369/1960 concerning the interposition of labor, as well as the contemporary expansion of joint liability of the buyer of a tender contract for work or services under the provisions of art. 29, Legislative Decree n. 276/2003.
In the perspective of giving special attention to the system of joint and several liability in tender contracts the author describes, in the first chapter, all cases of joint and several liability in the Italian Civil Code with the intent to establish a common base in all cases examined.
In the second chapter we analyze the evolution of the art. 29, Legislative Decree n. 276/2003 and the many changes that this standard has had to endure, extending the analysis to social insurance contribution and tax, as well as the rules on the health and safety of workers.
The third chapter analyzes the critical aspects of joint and several liability in tender contracts, the issue of succession in the contract by a new contractor to that of the compatibility of social clauses with European law through the derogation to that scheme by the collective bargaining, the simulation assumptions of tender contracts, without neglecting to analyze the scope of joint liability in art. 29 , Legislative Decree n. 276/2003 also to other cases adjacent negotiating. The analysis concludes, then, with the refutation doctrinal opinion according to which the outsourcing business achieved through procurement contracts would lead to the onset of hypotheses of joint employment doctrine
Ethanol-mediated stress promotes autophagic survival and aggressiveness of colon cancer cells via activation of Nrf2/HO-1 pathway
No full textEpidemiological studies suggest that chronic alcohol consumption is a lifestyle risk factor strongly associated with colorectal cancer development and progression. The aim of the present study was to examine the effect of ethanol (EtOH) on survival and progression of three different
colon cancer cell lines (HCT116, HT29, and Caco-2). Our data showed that EtOH induces oxidative and endoplasmic reticulum (ER) stress, as demonstrated by reactive oxygen species (ROS) and ER stress markers Grp78, ATF6, PERK and, CHOP increase. Moreover, EtOH triggers an autophagic response which is accompanied by the upregulation of beclin, LC3-II, ATG7, and p62 proteins.
The addition of the antioxidant N-acetylcysteine significantly prevents autophagy, suggesting that autophagy is triggered by oxidative stress as a prosurvival response. EtOH treatment also upregulates the antioxidant enzymes SOD, catalase, and heme oxygenase (HO-1) and promotes
the nuclear translocation of both Nrf2 and HO-1. Interestingly, EtOH also upregulates the levels of matrix metalloproteases (MMP2 and MMP9) and VEGF. Nrf2 silencing or preventing HO-1 nuclear translocation by the protease inhibitor E64d abrogates the EtOH-induced increase in the antioxidant enzyme levels as well as the migration markers. Taken together, our results suggest that EtOH mediates both the activation of Nrf2 and HO-1 to sustain colon cancer cell survival, thus leading to the acquisition of a more aggressive phenotype
Aerobic Exercise and Metabolic Syndrome: The Role of Sympathetic Activity and the Redox System
No full textBackground: Aerobic exercise can greatly assist in reducing collateral effects of metabolic syndrome (MetS). Moreover, aerobic exercise is associated with sympathetic activation and adaptive responses to sustain muscle engagement, changes in the release of Orexin A, a pleiotropic neuropeptide.Aim: The aim of this study was to analyze the beneficial effects of aerobic exercise without dietary changes, in a cohort of MetS subjects, focusing on the role of sympathetic and orexinergic activity. Several blood parameters linked to MetS ROS production, heart rate, galvanic skin response, d-ROM test, and Orexin A serum levels were evaluated in ten males with MetS (BMI 30-34.9) before and after a period of 6 months of aerobic exercise compared to ten healthy subjects.Methods: Ten male subjects (aged 54 +/- 4.16) with MetS (MetS group) and ten healthy males (aged 49.7 +/- 2.79, Healthy group) were told about the study protocol and possible risks, signed the informed consent, and voluntarily participated in the study. Several blood parameters were evaluated in the two tested groups and were re-evaluated in the MetS group after 6 months of training (MetS6M group). The training protocol consisted of more than 30 min/day of walking (average speed of 4.5 km/h) and 3 days/week of aerobic activities (jogging under heart rate control - 120-140 bpm for 45 min).Results: The results showed that exercise induced a significant increase in GSR and plasma Orexin A but no significant increase in d-ROM values. Significant decreases in the serum ALT enzyme, triglycerides, and total cholesterol were found, while the HDL levels were significantly higher. Finally, a significant reduction of BMI and resting HR were reported.Conclusion: The results of this study confirm that physical activity is associated with sympathetic activation, having a pivotal role against adverse effects linked to MetS. Moreover, this study demonstrates that, in patients with MetS, Orexin A is involved in hormonal adaptations to exercise
A sustainable porous composite material based on loofah-halloysite for gas adsorption and drug delivery
No full textThe development of new advanced polymers has led researchers to look at nature to find new, high-performance, low-cost materials. This work aims to easily functionalize fibers, made up of polysaccharides, of loofah with halloysite through crosslinkers. Bio-composites have been extensively characterized using different techniques. The synthesized loofah-halloysite composites have improved CO2 adsorption properties superior to those of both individual components and materials currently used in industry. In particular, compared to BEA and the MOR zeolites, an improvement in CO2 capture of about 50% and 23%, respectively, was observed. Moreover, the composite investigated in this work showed superior CO2 capture compared to other cellulose-based and sustainable materials. Furthermore, the presence of halloysite also increased the mechanical properties of the cellulosic polymer. The new cellulose composites have proved to be excellent candidates for the delivery of resveratrol, maintaining its anticancer activity. The results underline the synergistic effect of functionalization on increasing the adsorption properties compared to the starting materials and the possibility of using this eco-sustainable and low-cost porous system in various fields such as gas adsorption and drug administration
Building the future. Zero energy school : Cairate
No full textLAUREA MAGISTRALENel contesto di un piccolo comune di provincia, Cairate, abitato da
meno di 8.000 cittadini si inserisce la progettazione di un Nuovo Polo
Scolastico da 600 studenti, che permetterà la dismissione di obsolete
e tecnologicamente inadeguate strutture presenti nella zona.
Abbiamo portato avanti il lavoro in due macro-fasi, la prima di approfondimento
sulla situazione del sistema scolastico Italiano e dell’edilizia
scolastica Italiana, messi a paragone con quanto è accaduto in
Europa e nel Mondo nel corso degli ultimi cent’anni, e la seconda di
progettazione, tramite l’utilizzo di software BIM e di analisi veicolare,
che ci ha permesso di controllare tutto il processo progettuale, non
solo dal punto di vista compositivo, ma anche energetico, funzionaleorganizzativo
e riguardante i flussi veicolari che il progetto avrebbe
causato nella viabilità di quartiere.
Il risultato mostra un manufatto scolastico energicamente autosufficiente,
caratterizzato da elevati standard tecnologici, dotato di ambienti
flessibili che rispondono alle esigenze attuali senza inficiare future
e mutate richieste; l’analisi avente oggetto i flussi veicolari inoltre
ci ha mostrato come l’impatto del progetto sulla viabilità di quartiere
potesse essere critico, abbiamo quindi proposto una nuova viabilità
che possa sfruttare appieno le infrastrutture presenti senza caricare la
zona di nuove.In the context of a small town of Varese district, Cairate, in which live
less than 8,000 citizens, there is the project of a new School for 600
students, which will allow the disposal of obsolete and technologically
inadequate artifacts in the area.
We keep on the work into two main phases, the first deepening the
situation of the Italian school system and school buildings, put in
comparison with what happened in Europe and in the World over the
last hundred years, and the second on the design, through the use of
BIM software and vehicular analysis, which allowed us to control the
entire design process, not only from the point of view of composition,
but also energetic, functional and organizational concerning traffic
flow that the project would have caused to the viability of the district.
The result shows an artifact school energetically self-sufficient, characterized
by high technological standards, with flexible room that
meet the needs of the present without compromising future and
changing demands; vehicular and flows analysis also showed us how
the project’s impact on the viability of the district could be critical, we
have proposed a new way that can take full advantage of the existing
facilities without loading new road
Italie : quand la politique invente la société civile
No full textItaly : when politics invents civil society
At the end of the second millennium, between 1992 and 1994, Italy was hit by a crisis, not really a very dramatic one, but obviously an upheaval that radically transformed the physiognomy of its political system. The basic cause of this crisis is usually considered to lie in the corruption of public life in the previous decades and the financial collapse caused by omnipresent cliente-lism. This article asks if these two phenomena can sufficiently account for a crisis that seems unique in the history of democratic regimes. The author puts forward a different hypothesis : that one of the main causes of the crisis which Italian democracy had to confront is to be found in the discourses which the major political actors constructed about it and the flowering of other discourses presented by new, unconventional actors : « antipolitical » discourses, based on a ruthless, instrumental and unfair denunciation of the state of Italian democracy. By so doing these actors, whether official or unofficial, sought to relegitimize or to legitimize themselves. By presenting Italian democracy under these colors, and by proposing as the only valid prescription a mythical change from the « First » to the « Second » Republic, they managed only to poison common sense and to push democracy into a legitimacy crisis which is not yetÀ la fin du deuxième millénaire, entre 1992 et 1994, l'Italie a été frappée par une crise, en vérité, peu dramatique, mais sans doute bouleversante et qui a radicalement transformé la physionomie de son système politique. Normalement, on considère que la cause fondamentale de cette crise a été la corruption de la vie publique dans les décennies précédentes et la faillite des finances publiques provoquée par un clientélisme omniprésent. Cet article se demande si ces deux phénomènes constituaient des raisons suffisantes pour provoquer une crise assez unique dans l'histoire des régimes démocratiques. L'auteur avance une autre hypothèse : l'une des causes principales de la crise à laquelle la démocratie italienne a dû faire face provient des discours que les principaux acteurs politiques officiels ont construit à son égard et de la floraison d'autres discours formulés par de nouveaux acteurs non conventionnels : des discours « antipolitiques », fondés sur une dénonciation impitoyable, instrumentale et injuste, de l'état de cette démocratie. Ce faisant, ces mêmes acteurs, officiels ou non, ont tenté de se relégitimer ou de se légitimer. En présentant sous ces couleurs la démocratie italienne, et en proposant comme unique recette valable un mythique passage de la « Première » à la « Deuxième » République, on a obtenu uniquement l'effet d'intoxiquer le sens commun et de pousser la démocratie vers une crise — de légitimité — dont on ne voit pas encore la conclusion.Mastropaolo Alfio. Italie : quand la politique invente la société civile. In: Revue française de science politique, 51ᵉ année, n°4, 2001. pp. 621-636
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