1,355,534 research outputs found
Phenomenological implications of an SU(5) × S4 × U(1) SUSY GUT of flavor
No full textWe discuss the characteristic low energy phenomenological implications of an SU (5) supersymmetric (SUSY) grand unified theory whose flavor structure is controlled by the family symmetry S4×U(1), which provides a good description of all quark and lepton masses, mixings as well as charge parity violation. Although the model closely mimics minimal flavor violation (MFV) as shown in M. Dimou, S.?F. King, and C. Luhn, J. High Energy Phys. 02 (2016) 118., here we focus on the differences. We first present numerical estimates of the low energy mass insertion parameters, including canonical normalization and renormalization group running, for well-defined ranges of SUSY parameters and compare the naive model expectations to the numerical scans and the experimental bounds. Our results are then used to estimate the model-specific predictions for electric dipole moments (EDMs), lepton flavor violation (LFV), B and K meson mixing as well as rare B decays. The largest observable deviations from MFV come from the LFV process µ → e γ and the electron EDM
LINE NARROWING IN A H ATOM IN INTENSE LASER FIELDS AT SUBTHRESHOLD AND ABOVE-THRESHOLD FREQUENCIES
No full textDIMOU L, Faisal F. LINE NARROWING IN A H ATOM IN INTENSE LASER FIELDS AT SUBTHRESHOLD AND ABOVE-THRESHOLD FREQUENCIES. PHYSICS LETTERS A. 1992;171(3-4):211-214.Line widths due to ionization decay of a H atom in intense laser fields are investigated by solving the (3 + 1)-D Schrodinger equation numerically exactly. Quantitative results for line narrowing both at sub-threshold and above-threshold frequencies are given and a mechanism for the appearance of minima in the line widths is discussed
Flavour predictions in the Standard Model and beyond
No full textThis thesis reports on two projects concerning flavour physics. In the first project it is shown how approximate Minimal Flavour Violation (MFV) can emerge from an SU(5) Supersymmetric Grand Unified Theory (SUSY GUT) supplemented by an S4 x U(1) family symmetry, which provides a good description of all quark and lepton (including neutrino) masses, mixings and CP violation. Assuming a SUSY breaking mechanism which respects the family symmetry, the low energy mass insertion parameters are calculated in full explicit detail in the super-CKM basis, including the effects of canonical normalisation and renormalisation group running. It is found that the very simple family symmetry S4 x U(1) is sufficient to approximately reproduce the effects of low energy MFV where required but there is also a suggestion of testable new physics. Numerical estimates of the low energy mass insertion parameters are presented for well-defined ranges of SUSY parameters and the naive model expectations are compared to the numerical scans and the experimental bounds. The results are then used to estimate the predictions for Electric Dipole Moments (EDMs), Lepton Flavour Violation (LFV), B and K meson mixing as well as rare B decays. The largest observable deviations from MFV come from the LFV process μ → eγ and the EDMs.In the second project, matrix elements of the chromomagnetic operator, often denoted by O8, between B/D-states and light mesons plus an off-shell photon are calculated, by employing the method of light-cone sum rules (LCSR) at leading twist 2. These matrix elements are relevant for flavour changing transition processes, such as B → K*l+l- and they can be seen as the analogues of the well-known penguin form factors T1;2;3 and fT . A large CP-even phase is found, for which a long-distance (LD) interpretation is given. Results are compared to QCD factorisation (QCDF), for which the spectator photon emission is end-point divergent. The analytic structure of the correlation function used in the LCSR method, admits a complex anomalous threshold on the physical sheet, the meaning and handling of which is discussed
The Role of GSK3β in T Lymphocytes in the Tumor Microenvironment
No full textImmunotherapy options for patients with cancer have emerged following decades of research on immune responses against tumors. Most treatments in this category harness T cells with specificity for tumor associated antigens, neoantigens, and cancer-testis antigens. GSK3β is a serine-threonine kinase with the highest number of substrates and multifaceted roles in cell function including immune cells. Importantly, inhibitors of GSK3β are available for clinical and research use. Here, we review the possible role of GSK3β in the immune tumor microenvironment, with goal to guide future research that tests GSK3β inhibition as an immunotherapy adjunct. © Copyright © 2020 Dimou and Syrigos
Reply to Comment on 'Differential cross sections of low-energy electron-hydrogen scattering in a CO2-laser field'
No full textCionga A, Dimou L, Faisal F. Reply to Comment on 'Differential cross sections of low-energy electron-hydrogen scattering in a CO2-laser field'. JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS. 1998;31(7):1629-1630.The long-range asymptotic behaviour of the interaction potential is of crucial significance for low-energy laser-assisted electron-atom scattering for emission/absorption of one or more photons, especially for the small scattering angles; this is not satisfied by the ansatz of the comment by Rabadan and co-workers, equation (9)
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Consuming Drugs: Soft Drugs, Colonialism and Slavery
No full textWhat is a drug? Is harmfulness the criterion of legality and illegality of substances, or does power construct their legal status regardless of harmfulness?
The chapter examines these questions by focusing on the social construction of drugs. That is, the cultural, contextual and political processes that determine the legal or illegal status of substances alongside how these definitional dynamics are linked to state and corporate imperial power and harms. Drawing on cultural criminology, it explores how meanings of drugs and drug control are constantly being shaped by power, discourse, and resistance, particularly within the context of contemporary media-saturated, consumerist societies. The chapter challenges dominant discourses on drugs by focusing on sugar (a legal psychoactive substance), whose production and consumption are not constructed as deviant or criminal. The case study of sugar reveals how legal substances can cause far-reaching harm. Through a contrapuntal, decolonial lens, it traces sugar’s entanglement with European colonial expansion, slavery, extractivism and global capitalism, revealing the historical and ongoing violence obscured by its legal status. The chapter illuminates the exploitative and harmful foundations of the international legal trade of soft drugs, highlighting silenced histories and contemporary injustices perpetuated by the Global North
The peroxisomal SspA protein is redundant for purine utilization but essential for peroxisome localization in septal pores in Aspergillus nidulans
No full textIn an in silico search for correlated gene loss with fungal peroxisomal uric acid oxidase (UOX), we identified PMP22-like proteins, some of which function as promiscuous channels in organellar membranes. To investigate whether PMP22 channels have a role in peroxisomal uric acid transport and catabolism, we functionally analyzed the closest homologue in Aspergillus nidulans, named SspA. We confirmed that SspA is a peroxisomal membrane protein that co-localizes significantly with PTS1-tagged mRFP, UOX or HexA, the latter considered a protein of Woronin bodies (WB), organelles originating from peroxisomes that dynamically plug septal pores in ascomycetes. Our results suggest that in A. nidulans, unlike some other ascomycetes, there is no strict protein segregation of peroxisomal and WB-specific proteins. Importantly, genetic deletion of sspA, but not of hexA, led to lack of peroxisomal localization at septal pores, suggesting that SspA is a key factor for septal pore functioning. Additionally, ΔsspA resulted in increased sensitivity to oxidative stress, apparently as a consequence of not only the inability to plug septal pores, but also a recorded reduction in peroxisome biogenesis. However, deleting sspA had no effect on uric acid or purine utilization, as we hypothesized, a result also in line with the observation that expression of SspA was not affected by regulatory mutants and conditions known to control purine catabolic enzymes. Our results are discussed within the framework of previous studies of SspA homologues in other fungi, as well as, the observed gene losses of PMP22 and peroxisomal uric acid oxidase
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Entangled Paths Towards Modernity : Contextualizing socialism and nationalism in the Balkans
No full textSuggesting that the introduction of socialism was a correlative of political modernity in the Balkans, Dimou (Institute of Slavic Studies, U. of Leipzig, Germany) examines how it developed as an ideology in Serbia, Bulgaria, and Greece. Her analytical approach, which focuses principally on socialist discourses and socialist intellectuals, is three-fold: to examine the correlation between context and ideology; to discuss the process of transfer and adaptation of socialist paradigms; and to explore the potential dynamic that socialism generated as a political option within these societies, particularly in relation to other ideologies of mass representation such as liberalism, nationalism, and agrarianism.--ACKNOWLEDGMENTS XIII
--LIST OF ABBREVIATIONS XV
--I. INTRODUCTION 1
--II. INTELLECTUALS 17
--III. THE AMBIGUITIES OF MODERNITY 59
--IV. CAUGHT UP IN THE CONTRADICTIONS OF MODERNITY 157
--V. MODERNITY WITHOUT SOCIALISM 301
--VI. EPILOGUE 407
--INDEX 427Published version of EUI PhD thesis, 200
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