11 research outputs found
Harnessing cheminformatics for catalyst design I. Investigation into a general, asymmetric synthesis of cinchona alkaloid analogs towards asymmetric phase transfer II. Development of an enantioselective brønsted acid catalyzed four-component Ugi reaction
No full textA new paradigm for catalyst design through chemoinformatics utilizing quantitative structure activity relationship was investigated. Under this platform, two ‘core’ catalyst scaffolds were chosen. First, Cinchona alkaloids were studied against an asymmetric phase transfer catalyzed cyclopropanation reaction. Second, (R)-BINOL derived phosphoric acids were studied in regards to the brønsted acid catalyzed Ugi reaction.
In regards to Cinchona alkaloids, the concentration was first on methodology develop to rapidly synthesize diverse Cinchona-like analogs in a highly enantioenriched fashion. Systematic examination of the C(9) aryl substitution on Cinchona-alkaloids would determine the overall steric and electronic roles of the C(9) position on catalyst activity. An asymmetric metalation of quinuclidine N–oxide and trapping of various aldehydes was explored. Quinuclidine was utilized as the bulk starting material. An improved synthesis of quinuclidine was developed through a Henbest modified Wolff-Kishner reduction of 3-quinuclidone. The poor solubility of quinuclidine N-oxide made an asymmetric lithiation was elusive. An alternative method was to resolve the resulting Cinchona-alkaloids from a racemic metalation and trapping. The foremost resolution method was a kinetic acylation of the resultant amino alcohol. However only a modest selectivity factor (6.4) was observed and not synthetically useful.
The second ‘core’ investigated was (R)-BINOL derived phosphoric acids. The formation of the BPA catalysts was a synthetic collaboration, in order to rapidly access the fifty member training set. Several improvements were implemented in the synthesis of the (R)-BINOL backbone derivatives. The partial hydrogenation of (R)-BINOL occurred at a lower: temperature (24 °C), Adam’s catalyst loading (5 mol %), and pressure (150 psi) after only 24 hours. The bromination of dimethylated (R)-BINOL was optimized with Br2 as opposed to a soluble bromine source. A total of 20 catalysts were synthesized.
A classical Ugi reaction was investigated using the isolated imine, to exclude the formation of Passerini byproducts. Since the Ugi reaction is traditionally catalyzed by the carboxylic acid component, the background reaction could serve as a significant problem. Optimization of the Ugi reaction occurred through a temperature and solvent survey. The background reaction was minimized in toluene at – 78 °C. The pKa dependence on brønsted acid catalysis of the Ugi reaction was demonstrated that both phosphoric acids and triflamides catalyzed the Ugi reaction. The low solubility of phosphoric acids in toluene lead to the exclusive use of phosphoramide catalysts. Ten BPA catalysts were screened and resulted in isolated enantioenriched amide, albeit in low selectivity (er 55:45).
To combat a reversible stereodetermining isocyanide imine addition, a tethered Ugi reaction was investigated. By attaching the carboxylic acid to the imine, the capture of the nitrile with the carboxylic acid becomes an intramolecular reaction. An increased rate of nitrile capture would decrease the reversibility of the stereodetermining step. After a solvent survey, a solvent combination of toluene and benzotrifluoride (4:1) at room temperature was found to have a suppressed background reaction, due to minimal imine acid solubility. Twenty BPA catalysts were screened and an enantioenriched lactam was isolated, albeit low selectivity (er 55:54). Reversibility of the stereodetermining step remains a significant challenge.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2019-12-01The student, Rebecca Leising, accepted the attached license on 2017-10-10 at 12:08.The student, Rebecca Leising, submitted this Thesis for approval on 2017-10-10 at 13:45.This Thesis was approved for publication on 2017-10-12 at 15:09.DSpace SAF Submission Ingestion Package generated from Vireo submission #11674 on 2018-03-13 at 09:55:17Made available in DSpace on 2018-03-13T15:21:03Z (GMT). No. of bitstreams: 2
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Previous issue date: 2017-10-12Embargo set by: Seth Robbins for item 105148
Lift date: 2020-03-13T15:21:19Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 105148
Lift date: 2020-03-13T15:25:40Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 105148
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Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 105148 on 2020-03-14T09:15:08Z
The Pruritic Urticarial Papules and Plaques of Pregnancy (PUPPP): Papula Urtikaria Pruritik dan Plak pada Kehamilan (PUPPP)
No full textObjective: To report a rare case of pruritic urticarial papules and plaques of pregnancy (PUPPP) in multiparous woman and its literature review.Methods: A case report with literature review.Discussion: This article reports a multigravida woman, presented with aterm pregnancy with sign and symptoms of pruritic urticarial papules and plaques since the first trimester of pregnancy. This case supports the morphological variation of skin lesions in PUPPP, as the patient had lesions other than the characteristic urticarial papules and plaques, with hyperpigmentation skin changes. The management of this case include oral and topical corticosteroids, oral antihistamines and moisturizer is used to relieve pruritus and skin lesions.Conclusion: PUPPP should be included in the differential diagnosis to differentiate this entity from other dermatoses associated with pregnancy, in order to provide appropriate treatment and reassurance.Keywords: papules, plaques, pregnancy, pruritic, urticarial.
Abstrak
Tujuan: Untuk melaporkan kasus langka mengenai papula urtikaria pruritik dan plak pada kehamilan (PUPPP) perempuan multipara, membahas literatur terkait pada PUPPP.Metode: Laporan kasus dengan telaah literatur.Diskusi : melaporkan kasus perempuan multigravida, datang dalam usia kehamilan cukup bulan dengan tanda dan gejala papula, plak, urtikaria dan pruritus sejak trimester pertama kehamilan. Kasus ini mendukung variasi morfologi lesi kulit pada PUPPP, karena pasien memiliki lesi selain papula dan plak urtikaria yang khas, dengan perubahan kulit hiperpigmentasi. Penatalaksanaan kasus ini meliputi kortikosteroid oral dan topikal, antihistamin oral dan pelembab yang digunakan untuk meredakan pruritus dan lesi kulit.Kesimpulan: PUPPP perlu dimasukkan dalam diagnosis banding untuk membedakan entitas ini dari penyakit kulit lain yang terkait dengan kehamilan, untuk memberikan pengobatan dan pelayanan yang tepat.Kata kunci: kehamilan, , papula, plak, pruritus, urtikaria
 
Consensus on Upper Gastrointestinal Endoscopy Key Performance Indicators to Reduce Post Endoscopy Upper Gastrointestinal Cancer
No full text\ua9 2025 The Author(s). United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.Background: Upper gastrointestinal (UGI) endoscopy lacks established key performance indicators. Up to three-fold variation in post endoscopy upper gastrointestinal cancer rates has been observed among endoscopy providers in England, highlighting the need for standardisation of UGI endoscopy practices. Objective: We aimed to achieve consensus on evidence-based key performance indicators to reduce post endoscopy upper gastrointestinal cancer. Methods: Modified nominal group technique was employed in two consensus workshops, with representation from clinicians, patients and relatives, moderated by James Lind Alliance facilitators. Potential indicators were identified from the umbrella systematic review, English provider post endoscopy upper gastrointestinal cancer rates, and differences in endoscopy practices from the National Endoscopy Database between providers with the highest (worst) and lowest (best) post endoscopy upper gastrointestinal cancer rates. KPIs were categorised as provider or endoscopist/procedure related and ranked as of major or minor importance. Minimum standards were proposed where possible. Results: Participants included 14 clinicians (gastroenterologists and UGI surgeons), 3 nurse endoscopists, 2 UGI cancer nurse specialists, 14 patients, their relatives and representatives from patient support groups and four observers. Endoscopy provider related major key performance indicators and proposed standards included monitoring post endoscopy upper gastrointestinal cancer rates (minimum standard ≤ 7%); less intense endoscopy lists (maximum 10 ‘points’ per list [one point is equivalent to 15 min]); endoscopy provider accreditation (all providers); and premalignant condition surveillance on dedicated lists by endoscopists with adequate training (> 90% surveillance endoscopies). Endoscopist/procedure related major key performance indicators included: examination time ≥ 7 min; training in early UGI neoplasia recognition (all endoscopists); mucosal view quality recorded and cleansing agents used if not excellent (> 90% endoscopies); intravenous sedation offered to all appropriate patients; recommended number of biopsies from cancer associated or premalignant lesions (> 90% endoscopy where such lesions identified); and endoscopists\u27 annual UGI endoscopy volume > 100 (all endoscopists). Conclusion: This study offers a consensus on the key performance indicators and minimum standards that should be used to improve UGI endoscopy quality and reduce post endoscopy upper gastrointestinal cancer
HUBUNGAN MUSLIM DENGAN NON-MUSLIM PERSPEKTIF ULAMA BUGIS
No full textQur’anic exegeses have many variants in terms of sources, methods and languages. Some Qur’anic exegeses using tah}li>li> or mawd}u>’>i method are even written in a local language. This article elucidates the Bugese Muslim scholar thoughts in their work Tafsere Akorang Mabbasa Ugi regarding Muslim and Non-Muslim relations. Using historical approach and content analysis, the author traces the thematic Qur’anic verses on Muslims and non-Muslim relations and the actual practices of interactions between the Prophet Muhammad and non-Muslims. It shows that the verses do not limit interactions and cooperation in the name of religion. Such interactions are limitless to non-Muslims. The acknowledgment on the existence of others and the prominence in ethical attitudes towards them are keywords in maintaining harmonious and tolerant interreligious communication and relations. There are universal and particular values of religion. While the universal values serve as a common denominator for all religions, the particular values are specific to each religious tradition that must be fully tolerated and respected because these are sensitive aspects that may stimulate conflicts.</em
Les ressources territoriales du tourisme littéraire - l'exemple des campagnes vietnamiennes
No full textInternational audienceAlso, after having defined in the introduction, the characteristics of literary tourism, our communication will be articulated around four particular stages: first, we will present examples of literary tourism implemented in French rural areas. In the second place, it will be for us to take stock of tourist offers of this same type concerning this time the Vietnamese campaigns. In the third place, we will show that there exists a real literary potential, which is not limited to the only writings of Marguerite Duras. Finally, we will (modestly) mention tourist circuit trails. These can be of two main types; on the one hand, the biographical circuit focuses on the life of the author and its impact on the work produced. And on the other hand, the literary landscape, using literary excerpts, aims to (re)create the atmosphere of places, as conveyed by the text.Además, después de definir en la introducción las características del turismo literario, nuestra comunicación se articulará alrededor de cuatro tiempos particulares: en primer lugar, presentaremos ejemplos de turismo literario implementado en las zonas rurales francesas. En segundo lugar, se tratará para nosotros de hacer el balance de las ofertas turísticas del mismo tipo relativas esta vez a las campañas vietnamitas. En tercer lugar, mostraremos que existe un potencial literario real, que no se limita a los escritos de Margarita Duras. Por último, mencionaremos (modestamente) las pistas de circuitos turísticos. Estos pueden ser de dos grandes órdenes; por un lado, el circuito biográfico se relaciona con la vida del autor y su impacto en la obra producida. Y por otro lado, el paisaje literario, con la ayuda de extractos literarios, pretende (re)crear la atmósfera de los lugares, tal como la transmite el texto.Aussi, après avoir défini en introduction, les caractéristiques du tourisme littéraire, notre communication s’articulera autour de quatre temps particuliers : en premier lieu, nous présenterons des exemples de tourisme littéraire mis en œuvre dans les zones rurales françaises. En second lieu, il s’agira pour nous de faire le bilan des offres touristiques de ce même type concernant cette fois-ci les campagnes vietnamiennes. En troisième lieu, nous montrerons qu’il existe un réel potentiel littéraire, qui ne se limite pas aux seuls écrits de Marguerite Duras. Enfin, nous évoquerons (modestement) des pistes de circuits touristiques. Ceux-ci peuvent être de deux grands ordres ; d’une part, le circuit biographique s’attache à la vie de l’auteur et à son impact sur l’œuvre produite. Et d’autre part, le paysage littéraire, à l’aide d’extraits littéraires, vise à (re)créer l’atmosphère des lieux, telle que véhiculée par le texte
Structural Studies Of Mycobacterial Uracil-DNA Glycosylase (Ung) And Single-Stranded DNA Binding Protein (SSB)
No full textFor survival and successful propagation, every organism has to maintain the genomic integrity of the cell. The information content, in the form of nucleotide bases, is constantly threatened by endogenous agents and environmental pollutants. In particular, pathogenic mycobacteria are constantly exposed to DNA-damaging assaults such as reactive oxygen species (ROS) and reactive nitrogen intermediate (RNI), in their habitat which is inside host macrophage. In addition, the genome of Mycobacterium tuberculosis makes it more susceptible for guanine oxidation and cytosine deamination as it is G-C rich. Therefore DNA repair mechanisms are extremely important for the mycobacterium. An important enzyme involved in DNA repair is uracil-DNA glycosylase (Ung). To access the genomic information, during repair as well as DNA replication and recombination, dsDNA must unwind to form single stranded (ss) intermediates. ssDNA is more prone to chemical and nuclease attacks that can produce breaks or lesions and can also inappropriately self associate. In order to preserve ssDNA intermediates, cells have evolved a specialized class of ssDNA-binding proteins (SSB) that associate with ssDNA with high affinity. As part of a major programme on mycobacterial proteins in this laboratory, structural studies on mycobacterial uracil-DNA glycosylase (Ung) and single-stranded DNA binding protein (SSB) have been carried out.
The structures were solved using the well-established techniques of protein X-ray crystallography. The hanging drop vapour diffusion and microbatch methods were used for crystallization in all cases. X-ray intensity data were collected on a MAR Research imaging plate mounted on a Rigaku RU200 X-ray generator. The data were processed using the HKL program suite. The structures were solved by the molecular replacement method using the program PHASER and AMoRe. Structure refinements were carried out using the programs CNS and REFMAC. Model building was carried out using COOT. PROCHECK, ALIGN, INSIGHT and NACCESS were used for structure validation and analysis of the refined structures. MD simulations were performed using the software package GROMACS v 3.3.1.
Uracil-DNA glycosylase (UNG), a repair enzyme involved in the excision of uracil from DNA, from mycobacteria differs from UNGs from other sources, particularly in the sequence in the catalytically important loops. The structure of the enzyme from Mycobacterium tuberculosis (MtUng) in complex with a proteinaceous inhibitor (Ugi) has been determined by X-ray analysis of a crystal containing seven crystallographically independent copies of the complex. This structure provides the first geometric characterization of a mycobacterial UNG. A comparison of the structure with those of other UNG proteins of known structure shows that a central core region of the molecule is relatively invariant in structure and sequence, while the N- and C-terminal tails exhibit high variability. The tails are probably important in folding and stability. The mycobacterial enzyme exhibits differences in UNG-Ugi interactions compared with those involving UNG from other sources. The MtUng-DNA complex modelled on the basis of the known structure of the complex involving the human enzyme indicates a domain closure in the enzyme when binding to DNA. The binding involves a larger burial of surface area than is observed in binding by human UNG. The DNA-binding site of MtUng is characterized by the presence of a higher proportion of arginyl residues than is found in the binding site of any other UNG of known structure. In addition to the electrostatic effects produced by the arginyl residues, the hydrogen bonds in which they are involved compensate for the loss of some interactions arising from changes in amino-acid residues, particularly in the catalytic loops. The results arising from the present investigation represent unique features of the structure and interaction of mycobacterial Ungs.
To gain further insights, the structure of Mycobacterium tuberculosis Ung (MtUng) in its free form was also determined. Comparison with appropriate structures indicate that the two domain enzyme slightly closes up when binding to DNA while it slightly opens up when binding to its proteinaceous inhibitor Ugi. The structural changes on complexation in the catalytic loops reflect the special features of their structure in the mycobacterial protein. A comparative analysis of available sequences of the enzyme from different sources indicates high conservation of amino acid residues in the catalytic loops. The uracil binding pocket in the structure is occupied by a citrate ion. The interactions of the citrate ion with the protein mimic those of uracil in addition to providing insights into other possible interactions that inhibitors could be involved in.
SSB is an essential accessory protein required during DNA replication, repair and recombination, and various other DNA transactions. Eubacteral single stranded DNA binding (SSB) proteins constitute an extensively studied family of proteins. The variability in the quaternary association in these tetrameric proteins was first demonstrated through the X-ray analysis of the crystal structure of Mycobacterium tuberculosis SSB (MtSSB) and Mycobacterium smegmatis (MsSSB) in this laboratory. Subsequent studies on these proteins elsewhere have further explored this variability, but attention was solely concentrated on the variability in the relative orientation of the two dimers that constitute the tetramer. Furthermore, the effect of this variability on the properties of the tetrameric molecule was not adequately addressed. In order to further explore this variability and strengthen structural information on mycobacterial SSBs in particular, and on SSB proteins in general, the crystal structures of two forms of Mycobacterium leprae single stranded DNA-binding protein (MlSSB) has been determined. Comparison of the structures with other eubacterial SSB structures indicates considerable variation in their quaternary association although the DNA binding domains in all of them exhibit the same OB-fold. This variation has no linear correlation with sequence variation, but it appears to correlate well with variation in protein stability. Molecular dynamics simulations have been carried out on tetrameric molecules derived from the two forms and the prototype E. coli SSB and the individual subunits of both the proteins. The X-ray studies and molecular dynamics simulations together yield information on the relatively rigid and flexible regions of the molecule and the effect of oligomerization on flexibility. The simulations provide insights into the changes in the subunit structure on oligomerization. They also provide insights into the stability and time evolution of the hydrogen bonds/water-bridges that connect two pairs of monomers in the tetramer.
In continuation of our effort to understand structure-function relationships of mycobacterial SSBs, the structure of MsSSB complexed with a 31-mer polydeoxy-cytidine single stranded DNA (ssDNA) was determined. The mode of ssDNA binding in the MsSSB is different from the modes in the known structures of similar complexes of the proteins from E. coli (EcSSB) and Helicobacter pylori (HpSSB). The modes in the EcSSB and HpSSB also exhibit considerable differences between them. A comparison of the three structures reveals the promiscuity of DNA-binding to SSBs from different species in terms of symmetry and the path followed by the bound DNA chain. It also reveals commonalities within the diversity. The regions of the protein molecule involved in DNA-binding and the nature of the residues which interact with the DNA, exhibit substantial similarities. The regions which exhibit similarities are on the central core of the subunit which is unaffected by tetramerisation. The variable features of DNA binding are associated with the periphery of the subunit, which is involved in oligomerization. Thus, there is some correlation between variability in DNA-binding and the known variability in tetrameric association in SSBs.
In addition to the work on Ung and SSB, the author was involved in X-ray studies on crystals of horse methemoglobin at different levels of hydration, which is described in the Appendix of the thesis. The crystal structure of high-salt horse methaemoglobin has been determined at environmental relative humidities (r.h.) of 88, 79, 75 and 66%. The molecule is in the R state in the native and the r.h. 88% crystals. At r.h.79% the molecule appears to move towards the R2 state. The crystal structure at r.h.66% is similar, but not identical, to that at r.h.75%. Thus variation in hydration leads to variation in the quaternary structure. Furthermore, partial dehydration appears to shift the structure from the R state to the R2 state. This observation is in agreement with the earlier conclusion that the changes in protein structure that accompany partial dehydration are similar to those that occur during protein action.
A part of the work presented in the thesis has been reported in the following publications.
1. Singh, P., Talawar, R.K., Krishna, P.D., Varshney, U. & Vijayan, M. (2006). Overexpression, purification, crystallization and preliminary X-ray analysis of uracil N-glycosylase from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor. Acta Crystallogr. F62, 1231-1234.
2. Kaushal, P.S., Talawar, R.K., Krishna, P.D., Varshney, U. & Vijayan, M. (2008). Unique features of the structure and interactions of mycobacterial uracil-DNA glycosylase: structure of a complex of the Mycobacterium tuberculosis enzyme in comparison with those from other sources. Acta Crystallogr. D64, 551-560.
3. Kaushal, P.S., Sankaranarayanan, R. & Vijayan, M. (2008). Water-mediated variability in the structure of relaxed-state haemoglobin. Acta Crystallogr. F64, 463-469
The Log Vol. 9 No. 12
No full textBetween 1914 and the late 1960s, the Champion Fibre Company published an internal newsletter, called The Log, to share news about the Canton mill, the community, and its employees. After 1940, news from the entire “Champion Family,” which included mills in Hamilton, Ohio; Houston, Texas and Sandersville, Georgia, was featured in each issue.•
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YOL. J_- ANTO , N. C' •• FEBRUARY, 1927
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Out· Motto:
uSa e/JI---Cleanliness---E
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¥ . MEMBERSHIP CAMPAIGN
L -\ N~ hn e been perfe ""ted fot-~ OlH~ of the big~rc s t drivcs fnt· member hip, ih:! ( 'hnmpion Y. '1\f. r. A.
hu .... c r)r atten1pted . The membrhip Comm_ittet? headed by Let<;h Worl ey~ have 1 ·ft nE"JthinJZ t.
h anc~. The1~ ·will be up,,·ards of 160 men wc"'men, boys and gil'l:o;, take part in going oot to
roundup the tn-e mbe1~s in this annutt l ~l riv() .
!h ·re will be t~am ~ to rept"e "llt e~·e:r~r J eparhnent in th Club, P. T.
A. 1'eachel" , Bo~l's and girl ~ of the ntembership. Much competition is expected between the.' ~ ditf~rcnt learns
fol" the honor of b~ving high score in tb2 dt·ive. ·
An elaborate program will b~ arra ng~d for t he opening banquet to be held ('In Monday night, F eb, 1-lth
~t lhe "· ~· · {'-)r the worke1·~. at ' hich t ime in truction s wi.U be given all those who participate. 1t1r .. T. \\~ il
On roith.., State e cret:u·. of the Y. 1\I. C. l~ .. ~-ill be 'the p rincipal ~peaker, and will de light his hear er s a.s
he did last ~~eaT. ...
V\. e a r l" publi -hing tlle natue of. wor kers, that have been carefully selec l~rl by the member hip cha irman
a nd the ee.rctat·y. There are mauy m.ore good .fello\ s in th e. mill wh<' would be wiltingt we are sutc
to help out , in the dri~) but a s ot'le of the men put it: By Golly we 'va got tc1 have s on1ebody to call nn fo1·
m en'tbe~hi p;' and that is a fact. One thing that can be ot intere t is, there will be a large c.Jock placed in
front of the Y, telling the peopJ~ just hov.- ihe drive is coining f ront day to day, alsp a scol"'e board in t.he
building giYing t he dail~" total. .
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Plca_e note the departments and the men 1'ep1·cs0n ting lheJn.
BOOK ~liLL
Geo. Rh·?leY
J . M. Ca,~a imugh
J . J . .Martin
K. E. Inman
.J. I. Curtev· • Ray Byer-.,
~J. _L Alexander
H. C. Clark
1\fr s . Gevrgie Brown
Mi'~F Tommie Burch
~ fi~~ Bon11ie Rhodarmer
E TRACT
T'. E. Wll on
S. E. Htpp.
C. X . Wri q-ht
\Vash St ile:;
H. \\·. Stiles
\\ . V. Hay·nes ~ A. J. \Yil liaru ...
F. L. Mann
J. l ~. Rnberts
E LE 1 RIC
C. B. ~\- ilt
J. R. :\11lne
Portet· Honderson
,Y, M. Bryson - -
OOD YARD
\\"ade UiU
Frank :By<:ts
T. \ . 1\ ing
0 . G. Clark
}f. J.J. Fntd . r'
C .. L HPn-- on
\!\'. A:.. • Hvr. r
G. M ... ,.i; ley
1h A. C tJnlEil-l
P • "" • • KL•~ l n ,
\"r:. F . \\'-Hson
T() JTl 1 ar.kit1s
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LPRITE & " 700D Rl\-1.
\V. V. I-vester ·
C. E. McGowan
D. R. EYerhar t
S. C. Wood
F. L. ~'ebster
~t. l\1. Wai"Ten
~1. L. Trantham
T. P. Owen
C. L. Brookshlre
l\"'. T. Blalck
\\. J. Trull
. lA HI1-E
Frank Collins
U. K. Hyatt
B. b. S1nather
A. 1\". Devlin
.J. C. Elli.:
0. :!\1. . crogg
G.. R. . hope
Horace Coffev • Roy ~{a tt.irwn
F. W. Keener
SOD.\
C. A. :Moonev • Wm. Robertson
J. r. Bo\~lin
Jim Gt~s~ett
L. G. Cudv • L. Dw Boyclt:tlon
Dallas Row"-'
Bob Varner
Gao. Man~~s .
0. M. \Vhitak el·
.J a&. Ca rtwrjght
A. C. Rowe
STiE ~1
J . e. Spr-adlin
G~n H.o\\Cil
Ed. BQrnett
.J. K. D ll\V1l!':l
Andy .. fcClure
~1 ~<:k SltUllC:\"'
.J Qt :Milne
A leJ.; Juck, 011
Cl yde Blythe
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R ~\~D A
Frank S1nathers
G. E. Rolland
P. D. De,Veese
Chas. tinnet.t
B. 1\{. Stam3y
D. L. Brown
Bill Nash
Charlie Towe
Sebe Plott
1\II. A. St~nney
,V. P. Childers
Tom Rhinehart
C. R. Rouinson
A. L. F ord
E, BLEACH
''f. L. Jamis~nl
0. F . Gillis
\'". L. Reno
E. S. Brank
\V. M. Cogdifl
Thomas Mw-ray
J es-s F~>r.d
BOYS
Fort S math e.r~
Ben Blalock
lloward Srnathers
Doyle Ro bert~
.Jack Htunpto11
Hunt Bailie
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d eo. Howard 'frostel
TE .~. lJERS
Rut.h l•'ag ;.\n
• ::l.lJy r.1 ~kOll
Rddyi.h~ H Fnvkins
P~ctuline Rainwntc·r
'rlaomas ine Und ~rwuot.l
}fr~. :M ul'ic 1 J o .• 1in
\V. P. Ba1•he
H . F . Whitr•uf\ad
R. J . Ht>v ;o(ev ~ . r. N . l•'l~t!C"- JY\an
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. CONSTRUCTION
T. 0 . Thom son
I. D. Wens·
G. T. Worley:
Gerge Vaincourt
E. G. Batitle
Thomas Collins
GlRLS
Alke Wild
Elizabeth B.at tison
Ruth Boydston
Sarah Kir kpa (..rick
Ernestine Smith
Nevil Grut~
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TOWN AND CIVIT. K
If. A. Osborn<'
J. T. Bailey
S. R. Felmet
,J. Bat Srnatbors
Luther Snyder
\V. ~. M cElr~nh
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O}" FlC~ ETC.
\\". B. Wi ll i;:H~\son , J r: .
E. l\1. ~ier
Mr .. 1. D. 'VelL
:VJ rs . Lee )I(·Elralh
fi s~ .Julin Nevet"('O]
l\Jiss Gea·trude \ri l ~t)n
I•"' red Dc,u tt
'J'. s. ~~1\b lt?\"
T. R. !Adfo1·cl
W.OME. ".: ('L('B
M 1'. C h· d ~ Hi lch!brtul,l
l\It·s. N: n. \ il·l
~r.::. H. A. Uc· lcl~r
1\lln•. l·'rmtk Bell
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Mi." M tq.;Rrt·t Hul~~but· t,Jn
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Mrs.
Mr ..
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P. 1'. .\ .
G. L. Hau'l~tl,m
\V .E. Shc .. ffh ltl
, . Y. Halyhunc)l.
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HE . PER FOR THlS MAGAZINE IS MADE IN OTJR PLANT OUT OF WOOD FROM THE FOREST OF
Ol{TH ('AROLI. -~~- \VE MANUFACTURE MANY GRAUES OF BLEACHED SULPHITE PAPERS,
MACHI E FINISH:~ AND SUPER-CALENDERED .
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"UPERINTENDENTS AND FOREMEN PLEASE NOTE.
N the operation of a large jndustrial plant, the cost of alterations is a big iten1. Ofttinl~ "
hu·ge sums of money are spent in malting unprofitable changes, due to the fact that \Ve do
not always keep before us the chief consideration, which is that every dollar "pent in
alt -I·ai.ion ~hould yield proper returns on the e>-.LJen e inctu·l'ed.
\\ (! bPJ'cve thaL the cost of alte1·ations in our plant can be n1ateria1ly reduced by a c-areful considera
ti progran1 a Jl ·(A LT I~. r.. A'flO NS'' in equipn1ent must b covcrt?d b~· JOn 0 Rn EHS
an'l the· following r~rocodur will t P! Jl~.
'J hP J()B OI DE I~ nla.v be origh1rtLed by auy S upcdntcndeni or fo l'l' llHtn b~ direct verbal, tel \pllvnt
· ''}' 'A- rjttt~n advice to the Cler k iJ1 tltQ 8nginertng D ~p<-)rtnl ent. But. to J -ssen the chan('~' r
eJ·, Qr aud to IJe ~ ure thai the r·he:Hll:f0 i.· app• o c-~tl l>.\ the Depad rnenL SupcriuLend0.nt l> )for" i~su ing
jc ,b nurnhe-r, it j ~ ) ilt fl S Ul}~l'iJ1tl·ndc:nl ~UHl u~
ltlll,!h jnf cJt·nultion a.:) posr-;iblr; hl1 J.d vt n on tl1e .JOh ord0l'.
: 'o JO l ~ Ollf >Ell cau lJe C)P,u,..,d f 1·< rn lhl_) l~ n gin<'<' rt n g· Depa.l'tnw nt t'or aetllal Ct n::-qtnwti n unti l:
(:-t) Jt lla-.: hP(H >tJJprnV'(·d by lhe dotH\ H .~
lo th~ tit 1e;:;· 'Jr t.h · d4 ·~ ign .
(IJ) 1"'h aJ'prl~ va l of tiH ... Plt•nt J·;n!! in<r.· t· :ts lo the : onnd {·ugi nl''-·t·iHg JJ1 tilt' dP~ ig-rL
( ) ·rhf\ :tJ!.t l'~"vv ... l of tht· :t TwJ~d 1\ lauag"1 or ~nn1 · unP to wlwrn lhi t· du t \' h:l~ hPt.'t1 o l'l'("t tll.\
r~ i::r, ed by l1 in1.
'Jot,~ v.llt.A heCjt•f t!d c·<•opt•t atiou jp tid:-:; Jlt ; t-t
1 ~JlJ bt gt• ·~t'l~· a.pp ·r..,r•i(l\ ~ll.
Y ,.ut·: 1ntl.\, '
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(~RE T Al\1ERIC;\ ~-
!\1 ROE.
IE.S nl "'rOE. lhc fiflh pe~sid(.'nt. of Ch<·
t •nited St :.tt ~ . and author of the ·· Totu·ol:
Doctrine," 'as uorn priJ :..8, 175 . iu the..•
C u n t~· f WestJnorla,nd \a.
!lis father ' "·as a \V ~\ lth ~- tlanter, '"ho~ e .feJ· tilfl land~
joined th :1 (:)sta · of Aug·u stine 'Va "'hingto11l th ~ father
of G ~ol'g;) \Yash ingto.n. JanleS nlonro lliOYed all • •
th advan tages \Yhich the ouutry couJd affOL'd. lt~e:n·J y
'in lift: he "·as ~ent to a V~l'y nne "Chool, and at th~
age of ~ixteen ente1·ed \Villiam and 1\lary Coli ge. T\\~
years a1 er he entered college, tb~ Dclaration of Independence
,vas adopted, a nd he at once left hi~ "'tudies
to j oi.n the Continental ...~ .Jn1\r . •
It '"a~ one of the gloon1iest hour in our hi tor,-.
The enen1)· "~as Yictorious in n1ost e v er~- battle, but
the cotn·ageous yocng l\lonroe never falter ed. He en rolled
a~ a cadet but 'va soon advanced to lieutenan t
an~ a little l'aterf because of his braver y, he ,·vas pronloted
to a Captaincy.
He ~tood br the side of Lafayette, the brave
.roung French noblernan1 ~·hen he \\·as shot in the
leg at Braudy\Yine at the Battle of Trenton, he
foug~1 t so gallently that he \\"On the eon1men dation of
his superiol· oriicer. During this uattle he wa.:· \\'OUnded
jn the shoulder. Tl1e next year he ,,·as pr omoted
a nd ~er\red on the staff of G-en era] ~'illian1 Ale. ·ander
(··Lord ._ terling~ · ) as Lieu tenant-Colonel.
In 1780 he began the stud~~ of law under the direction
of Tho1nas Jefferson, the governor of ' irginin.
I{is a~~ociation '"ith Jefferson probably had a marked
inrluenc.e upon his ~ub::scl]uent political career. A;l
through his iife he continued to enjoy t he fl'iend..;htp
of both Jefferson and ~Iar ison.
~lonroe developed a ve1·y noble charaet eT ~t~ od \Von
the luve of an ,\·ho kne'\"\' him. He en te~"ed }JUblic lift
at an earlv age. In 1782, he became a men1ber of
t.he \ Til·ginia a _embl~ and ·~·as sent the next. _yeal~ to
congress. Here hjs services \\:ere in ftu e:n tia 1 in bringing
about the conventions at Annavolis and< Philadelphia
where the Cont>titu1ion of t he "CnH.ed State~
,\.·as fr<:tn1ed . -- -
ln 1790 he was elected u nitetl S.ta tes Senator and
becan1e rrri.nister to Ft~nce jn J 7·94 to 1796. " 'hen he
\Vas recalled becaus~ of his too O!Jen exp ressions of
v1npath. ;vith the It evolution .
1n 1799, he became goven 1.o1-· of '\Tjrginja and \Vas
eon 1n1i~~ion eo to act ~· ith Li;vingsi 011, 1·e:-ildent n1inister
at Paris, to n ... gotjati ng the purcha~ of New Odeau.
and t h"' ter:rito1·.v e1nbtacing the n1outh of th .. :i\li !->sissippi,
\Vhich fotmed a Jlc rt ,,f th province of Lou isiana
, recently· ceded by Spain to Franc· e. But, in absenc
.. of in st:vuctions, they as umed the r ~ pOt1 s iiJiJi y
of n(:>gotiatjng t he purcha. (~ not onl.\· of N ~ ... ,v 0.-Jcjan;-;
but of t he ent ire terl·itoJ'Y of Louisiana an V(·n t tha t
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i~ horcll.'' Xt'Cnnd in inlpn•tnnc~t· 1 v any in tit .. Justf,ry
ll[ this countrr. l\'lon•>op v ut-< n xt • l•ll'JOli. ~ioned a
tnini ~tv1,· to l:~n~lnnd to SIHlcttt·d J~ uru :; King who ht.trl
resign rl.
Jn 180 J he ''" nt tn Madl'irl, \\ ith th' ol}j t uf
u got iating the purrhn~c nf Florida~ hut in this he ~a.
uu. uc<.·e~ fuJ. and rt\Lut·nprf to I~ondon in 1800.
ln 1~10 he \V:l:-t asraill cl Cted to tht.· }t-"gishJ.1 Ul" • Of
Virginia, and during- the next year he \\·as elflc~ted governor,
but, dudng 1911 h<.) \VO.s called to the National
Council to supersede Robe rt Smiuh as sect·(·ta r.v o(
state in iVIadison's cabinet, and he took an acUve pait
in precipitating' '"~u· against England in 1812~
In 1816 h e \va eJected president of the United
States, and 'vas re-elected in 1820. The n1ost popular
n1eas ures of his adn1inistration ":ere the obtaining of
Florida fron1 pain in 1819, the recognition of the in ...
dependence of the Spanish American republic and the
announcer1ant of \Vhat is l\no\Vn as the 1\Ionroe Doctrine.
The period of his administration, 1-817-1825 has been
called ''the eta of good feeling," for the reason that
t he party issues of the past were J1e10Stly dead, and ne~·
issues had not yet a.rien .
In the form;a.tion of h~is cabinet :Nlonroe sh o\ved good
judgnH:)nt in selecting spch men as J. Q. Aclan1s. J. G.
Calhoun , W. II. Cro"vford and William ''rerL \\~ith
th-ese advisers he devoted h.in1s-elf io the econon1ic d ·: •
ve1otlment of t he country whic·~h ¥lad been so loug y·e-tarded
by foreign co1nplications.
On the expiJ·ation of his pl'·esidential teTn1 l\Ionr0t·
r et ir ed to Oak Hill, his r esidence in Loudou11 Count.y '
' ' a. He rlied July 4, 1831.
James l\1.on1·oe the fifth president of the United
States is best kno~·n to the people of this gen~1ntion
as the a uthor of the ":b•Ionroe Doctrjne," ?1 flee lara tion
inserted in his seven th ·annual n1essage, l)ecen'lber 2,
1823. 1 t \vas the foriHulation of the sentiment Lhcr1
beginning to prevail, that An1 ~ric~1 "as .for th • mer ...
icGtn s . That is, that Anlerica \vould not inter1ert\ in
J~ u1·opean politics ; t-tnd t hat Europe Rhouhl not int :\rf~
re in An1ericaH politics, " ,hetlte1· h1 No1·th . nH~ l'i c a
or Sou tl1 Anu~rica. rrhe occas ion vf pt·oclainl ill~): t h~~
doctr ine \! ·a s t he run1 on.Hl intt.'l'Y nt iou of the; I It I~ ...- tliance
to nid Sp-ain in t h ..) l'l'Conquc:-;i of hl r ~-\ nt er i c1 l
Colonios . This derJCl t·alionJ tog0ther " ·ith tlH~ kno\VtJ
host ility of r :ng-IHnd to :such a proj Pe t " ·~ sutJ'kh. nt
to pr·eYen1 fuythct· acii not inb 1·fcnJd
and !'ha11 not int ~tff~rt', but ith th ;& go t!l'llment.~ who
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J1 .JO'\N
Tbt> JjttJe J)au}.!ht.er of Mr. and Mr~->. ChtUde \ViU.
}·· a~ · dc;!(:irn·ed t here Jn.riepend'=·nc(:: Hild maintai ned it,
a t(j ·w}JO i 1d oopt:ndence Wt' h:.l ve on gn.:et t COll::>irlcl'atl
m atJ(I ·u~t nrincipl, <; ackn(J\,\'l cd.f{t~\1 , we could not
v c4
, . an~ int ·~J0~it j, n fur the plll'JIO~!: o{' ' an JU t t , .. a~J pn\ver jn ;.1ny o lJH 1· lipht iltt-.tll as
th.e rl1anif . ati .:~n of at unfr~( ndly dt s~,o )Hivu townnl
t h·" l"n1 d "taies.7
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1~·. \V. H. Crutt·, Jilal1l l·~ nglnct 1'.
< ~c up I H~J <: l ~~-xc u · f01· gt!ttlJtg , IC!ep v, it i f.li !'\ jlJIJ1l .V u
;: r, ni · J•.Ht h :d:.>it , attd frtntl } l"l a 1 ti(·lt 1~.· MJ'. l). V.
WJk ox, j find U ;jt \ • >Irrou p
of four \Vnrnen ancl five rnen l';.tngi ng in ctg(!S fYon1 J 7
tu ~.a .\ c<.n·s -,,·h o wen L for 72 hours wi thoul sleep, and
\Y(" I'C aJ,lr to do their work ju ~l as wel l or heLter than
if thc.. . y ll<td s1epi thejr usnal nun1ber s of houn;. On<!
of then1 a .voung lady f ell ::;o .reJieved heca u ~-;e shP fou nd
that she did not have lo was te tjrne s leeping that she
celebrated by swimming across the Poton1ac niver on~
night. Two of the group, just because the} liked it,
stayed avvake for 18 hour~ longer or a Lotal of fnur
days and lh.ree nig-hts and al the end n1ade a better
showing in the Army alpha test, than they had made
before starting in on their prolonged period of ·wakf:fulness.
The e results spoiled a whole lot of phrases as to
the eiTect of Jost sleep, and proved that Thos. A. Ed!son
and our old friend Socrates '"-ere not so far wrong
when they advanced the idea that s leep is n1o ·tlr a ·
habjt that can be brol<en or at least shortened . \Viii1
the inforn1ation furnish ed by these te8ts available,
there is no reason for f urther losses in n1anufacturing •
establish1nents due to waste and inefficient operation
on account of n1en being as leep on the job. for it should
no'v be a simple n1atter to pick a crew that can stay
awake for at least 10 hours. There is reason to beli ev~
that these tests \vill be of g r ea t value. .. on1e conce1
·ns are now considering· having their E1nployn1ent
1\tlanagers ca::;t a \vary eye over all applicants for employnlent
and put them thru the 72 hour test or have
them bring affidavit::; signed by their \Vives or landlady
stating j ust how much sleep they l'equire.
Anothel' str a ng-e thing that has been den1on. trated
in these studies r~vg-ard ing sleep, is that there are n1any
n1en who go around Lheir jobs with their eyes open
.vet are n~le<.;\ p, in so fat, as attention to their \Vork i
conce.rned.
Before cJo~ing t his article of praise to thOtablish records for '~akefuln~ss in ueh~' lf
of sci('nce, we feel called up()n lo n1ake ~t)n1e nH' ntion
of tho::; · who nn.' al)parcntl)' trying to establish rt>t:\)l~d~
for sl ~epi n es~.
It is stated c.m good etulhorjty th~t th ') art' n1cn tn
lllis .:-; tale who hav) h~Pn a leep on theil· job~ r~.~r M.'Vei
·~tJ f(-ltl. r s, whi t(• W<' acknowl )dge t hat lhig i ~ .. S(ltUL'
sl ·cpi ng'' wt~ do not bt' 1 icvc it i ~ n rceord, a ~ Wt' ha vv
hell tl i nfo • ·, , ~,d LhaL IVIl·. I~ip 'Vctn \:Vinl,le lH\: ::nt aut-ht•lltic'
1·ccnrd, t'~ labli l'1 ht'd snn1' Yt':-ll s t\g·o, <)f h tving ::;lvpt
nn his .i i> I o t' ~0 y L'U t s.
f f these tt·.'t !-'; so c;.nvfulh ·onduc1t..\d l;v !Jr. ~·l oss . • •
a i'P in ~Lt llln e nta1 in convincing an \ t'f lh n'an\ wht)
;U'l• sJ, •f·J>iog on t iH•i1· JObs (~ · ith r \viLh l') ··s upen or
elo~ed) th ~ t nitlt1 hflll• s <t dn.) i;:; ~ufl'ici ·nl sh.· 'p f,,r atn·
one, ;tnd I hat th{' ht•e-\t Hnd ~' f~:-;l plcu·t l(\ do thi ~ ~ lt~l'Piug
· is >If hnrt tl'. t h . Jns~ and lti~ cu-work(~r~ .,;ht,nld
fN·l rully l'c• [ttid r. I' I hcil· trouul<·, aTHl tlu· iudu ~t rj,,s )r
th( COUHtl·y :-.hf11thl ('Xh' lld th ~nt tl - t)ll' of tlwnk .. '.
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. JR •. HE~-BE ~ B. ROBERTS01'
· DO ·1 t n year: ag0, the PaYent 'reacher A -
~oci a b on 'a~ nrganiz -rl in Canton, IJy nll·s.
lL ·uben 1...~. J~olJ rt:=on of A ~h .. v ill ·. For a
nun J.~ 1· ,f ·rea i-s _ i .-~. Roi..~Prtson \\a::, very active in • •
Parent Te, ch , .. r \\·ork and th r<,ug-h ht~r effort. Pa1·c·nt
Teache1~ A.·. ociatic,n ~ were (Jl·gani~c d in a numbe1· of
to" n " in \~· t e1·n . -o1·th ar(>lina; including A. he ville~
IIenc1 'JI'. on' Hl<:. Canton and a nun1ber of other plac ·s .
• 'Ill ~ ~soe i;. .. ti•,n in Ce: nton, Jjke all nev. organizations,
had a J1ard :-tcugg-1<-· tt survive during the fir~t _rt:al'.
nut, "ith tJ e lr ·ltJ ano incoun.tgen1ent of ~\<Irs. rto bc:J·t,(
ll \' ll<J r.ttt nd( d t] - n1eetinu~ J·egu larl ~·, and undt•r
th · 'i. 1 .. ( der. ~tip of It<::. H. D. ~ .. c1· ·~t. its fi1·st
pJ·(-:sjd ~nt t-H rd n1c ·t e 11Htll ia ... lie '" JJ ker, th 0 people of
th~~ "Ul11mU1lit)' O":a ]uall,\· J' 3))/'( d the Va)U Of ')U(;h ~l11
organ1za itJT1 a1Jd l,t ca1 1 ", n<J~ vul;v inte t·P~t(.:r} bot, (~ nt1lu
... ia. tic ~ur'P >rters ,,f tJ, ar-nt T ~ a<;IH··r As~ ocicttion.
\ ~ fln ev i(~c .. nce {If tl ',) f; ~t, Wf· J1a e t o-d<t ,. in
'a11ton th •;) .\. :-u ·iatinn · in ...· l(·a I r11 ou ...< \ II of whieh
Cllt- V 1'~' at·ti 7 <.iJd a:rr• h1lllr1 "' pl(ndjd ~.'Or' ) '" .
ThP- ptJr]1C, · of t in.•. Pr.u ent 'T' ·4the1· . Rc ci~ ti, ,n i~ ,
\\'ith t J r~ t ad .. J" • of 1 (~ J 'nl1ii(' .·c·hu<,l
an 'f) i 11.-o at· a p(, ·si bit . A ltiu. do
JJ ci£t1 \1. )rk uc11 a~ . IJ .A utjf.; ing Ll e ch >nl gt otntds,
J>Urcha.Jng IH,{J t. f r the libr: 1·. , pta.\ -'•ruul•d llliJl-llll'llt
;utd \<Jt' Jnll ~ )(IH•t• fhiu,·
tlll• ~ ·hnPl.
' r lltt l 't·f·ul:n nJntdltl. 111 '"t.tu r ,,. lh £· c ci1Lfi,l.
:lll'Pnl .. p'l' tldid .. p ,,nrlllltiti · j'., 1 • pf J'cln1 t , , ·t
ncqun inl · d \\'if It l.h( lt•:tr'" lt(IJ' ~ arHI l.h t"ir ~·}tc,(,J n ohh.•
Ht~. ' l'h u:, \\·itlt a <:lt.:•r r 1· unci 'l sb~tttlinsr nf f lH" n u l·
tillldt..' pf proh1 · rn ~ ,,},idt ntnst be aohf..:d by tla. t a·ft<..'
1'". il hL'i ( Pt" ~ pirit or ('(\·fiJH•ntliOU h •( \ o\'(•(!l] pat•~'nt and
h·aclH'l", \vhiell i ~ PS:"l nti:tl tc tit< ueces. of hr schc•ul,
is Cl' <:\L<·d.
l·"or a nurnb(' l' of ' ear~ th<:fl'f' wa.-.; onl v t)fle a .. :ociPt- •
tion jn Canton, but. c.1 s the lHlnli>t?r of. chools incr ... a c·'l
the \rork of the aR~ociation a l ~o incr as 'd <Jnd the
1 e ;ult \Yas, t '' o other A ·:-;ocia l
0000
No full textiatlg fain Alto Hitms
TWENTY-THIRD YEAR.
EIGHT PAGES.
PALO ALTO. CAI_ WEDNESDAY, PEC. 15, 1915 EIGHT PAGES.
NO. joo.
WILLYS KNIGHT
FIYIMVVKSKM'Ki: Till IUMi CAR embrac-r*-. eTer-,thlm« in
STYLE, CO.HH1KT. SAITTT. . I-OWER, SPd'I- and sATisl-ACTIO*.
Forty h—999*Wm Kaiitt tyye motor
Elertrfr ttgtttia*; and slarUai;
*U-.*i-ia< h tirca. *ao-a*ki<J rear
I*-emoun[«t>le rim (rase extra)
PKKTK Sl.'2-iA *mWmtrrtn*e*i ■,, i*,j„ Alio
Term* If dr-ir,-,! i-ri Us -lio-a -nu ttwlr man*- supe-riar qaaJlUe*
at ttM*
Palo Alio Hardware Co.
DO YOU OWN A
CLEAR LOT
If so I will liotld you a b-mve on tuonthjy payme-oU. Or for |0
per rent caah pay mem t 1 Will fun-lab house and lot; balance like
renl. fte-vcrml lnnni-r. now ready If tbey don't -itlt I have nnmer-
otgs plan*. fte«
John Dudfield
PI'I.KIM.II U'striKP COMPANY—Pl^-.MN<; HUM, AXI. LOI-
111:11 VAHlsH. I-HONE* 121 ana- tot*..
Santa Claus will
be at the Regent
next Friday and
Saturday. Bring
the children, he
will have presents
(or them all.
The Regent
i-hornls. llolrproot aad K-rcsi-su-
IttsM- fnr n-ssa. women aad ,1,11,1m..
..uar.nt.-rd Hoar csrhaae—1 al storr.
i-iiiim: ft 1 111 r HKUVI UIK-v
I'scful presents are sensible and please the
recipient.
Little folks arc especially pleated with shoes
and slippers.
»Ve show a great variety.
JAXI?
PHONE
15
AM.lUa TAXI HKHVKT
Opposite I>ej-.t.
Autos For Mire
Seven and Fire pM»ien-*cr
To-arinc Oars and Taxla.
25c
Statistics prove tliat thr uvrr;i-.*c
aRT ai death ib ten yrara older than
ii was forti vcir* ago Ptxeplr live
out-ol-d(air» more, the automobile
ha* a W to do with that. and then
thev have -Mirer food to eat-
WILSON'S CO-ED
Chocolates
arr niami farm ml of (he purest,
nehcM materia ii, under the inoit
unitary cnn.|itioni for the pur-
'•OM* >•{ v. inning thc ruM-ntm of
Imople *.*..>-. Know (jtAUTY
THK ER*Nl-*M1 WIIaWlN Co., Inc.
HOSTEL TO OPEN BROOKS SECURES INAUGURATION OF
UP FOR WINTER NEW LOCATION WILBUR JAN. 2?
Chief of Police Noble Seta Next Palo Alto Baker Buys Model Stanford's New President to Be
Monday aa Probable Equipment at Exposition— Solemnly Installed in
Reopening Sanitary Conditions Memorial Church
City Engineer Byxbee Plans to New Plant in Plannelty Building! One Admiasion Ticket Allotted
Double the Potato Crop Reault of Fire Which J to Each Memhtr of University
Thia Year Destroyed Factory Community
t'hief of police Cheater 1J Noble
announce* the rfsopentnj; of the
Palo Alto munarlpal hotel for lhe
i- * ■ -■ :■:■-' ■ ■! to take plac- about
tifit Monday or in ample time i«i
Insure ihnt no traveler thr-ouKh
Palo Alio ahall ro humeri al Chrlsl-
Riaa time
The cii) haa made a litmlied a|>-
proprlatlon tor the maintenance of
the hotel tilon*- tba tines followed
!n*( year hot the aeasoD has been
nillil ami (her have been fewer
tramp* (han last year hence (he re-
opr-iln-* has heen intentlonallv do-
tared It 1" ihe aim of the author I
tie- lo keep the hole! open later In
Iln- -.print* tn OaH** lh«- bad wea(her
ah.-n 1.1 .'■>n tin-ie late
\ a*t u-kMiD a ri[srr1enre ..bowed
that rnO*l of the tramp* who ft topped
here u..-,- tacer to WOf. for the
food abetlet ami buttling fn. i!(( lea
offered bi the pit? Professional
bums man bed atesdllr by avoiding
the Palo Alio bath and work method a* (hei would A pestilence The
offer of mnnlel-afll assistance did
tan with the neee*al(\ for (rampn
tn b-g at h.*,ck doors In fact be**
(HOI a *• forbidden The .hole
Ides was t. ••r.f! a human welcome
to unfortunate men Instead of
either dnvlnit them a*n> or allow-
i (ondntled on pn((e H *
MOTOR TRUCKS
I-TUMTIIIK MOVING
1-oiik and Short Hani*.
Prompt and apart.-.' attention
given (o hacsaa* orders.
PHONE 00
Palo Alto Tranafer and
Storage Company
lit C-1ROLN
Immediate Delivery on
1916 Buicks
For the first time this season we are able
to make immediate deliveries on our 1916 cars.
Take advantage of this opportunity and enjoy
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Metabolic consequences of neuronal mitochondrial fission ablation
No full textDynamin-related protein 1 (Drp1), the main mammalian mediator of mitochondrial fission, has an especially important role in neuronal development, such that its deletion gives rise to pre- or perinatal lethality. However, less is known about the need for Drp1 in adult neurons; this is relevant because inhibition of Drp1 could prevent pre-apoptotic mitochondrial fragmentation, and therefore be neuroprotective.
In our mouse model, inducible Drp1 ablation in the forebrain of adult mice leads to swollen, perinuclearly aggregated mitochondria and to impaired synaptic transmission. Of note, ablated mice also develop a complex and ultimately lethal catabolic phenotype, marked by weight loss, increased lipolysis and elevated corticosterone. We traced this back to the activation of the integrated stress response in Drp1-ablated brain regions, culminating in the ectopic induction of metabolic cytokine Fgf21. Fgf21 is normally produced in liver, fat and muscle tissue in response to fasting or exercise, and no reports exist of it being produced in the brain. This “mitokine” increases insulin sensitivity and stimulates corticosterone production via receptors in the hypothalamus, thus explaining essential aspects of the catabolic phenotype.
This work has implications not only for mitochondrial biology but also for the understanding of the central regulation of systemic metabolism
A vital sustainable means for community empowerment
No full textDynamic changes in the present day quality of life and quality of environment are greatly influenced by the space sciences and technology. Notwithstanding the dual use of space technology the irreversible impacts on health, resources and ecology for each abuse of finite resources are alarming. Over two decades of development reviewed by UN Systems during 1970-90s reveal that Participation is the key to Sustainability at Community Levels. Space vision of a stewardship for the present generation to sustain a healthy and safe Space ship are challenging (UNCED.1992). The next two decades after Rio'92 have also provided ample break through Space Education Out Reach activities all over the globe. Few such are Bharath Jana Vigyaan Jatha Indian People Science March ( 1987), Earth Day Network(1972) and Clean Up the World(2000) Campaigns to name a few and thousands of Community Empowerment Models which have started providing the Tunnel Effect as a societal catalyst. Thus, these living through role eco literacy models enrich and add value to the Space Education and Outreach initiatives.. Space Eco Literacy Model (Jagannatha, COSPAR 2012) provides one such simple Space Education Tool for empowering community for sustainable Development. UNESCO/UNEP/IEEP 1977 Tbilisi conference provided historical mandates for nations to embark on formal and informal environmental education. Objectives of Environmental Education for individuals and community as awareness, attitude, knowledge, skills and participation have lived through the Rio Earth Summit-1992.Pro- Active role of nations are vital to address and show case compliance to United Nations mandates. Public outreach activities need to be networked with various diversified activities aimed at space eco-literacy both at Individual and Community Levels. An EESS Ecological Environmental Studies by Students model developed in 1987 is one such Eco education Model which was cited as one of the 20 Best Eco Education Models.(Earth Day Network, 2000).In this presentation, genesis and process of development of EESS, 1987 and Space Eco-literacy, 2011 models in the backdrop of People Science Movement in India with over 35 years is captured from the Space Situational Awareness (SSA) point of view. A community eco literacy drive during 2000-2010 on the banks of Kukkarahally lake, Mysore, India for over 320 Sundays with 4500 man-hours 300 volunteers including all the authors provided the backdrop for Space Eco Literacy Campaign.. Later the effort culminated in to a Sunday Space Eco Literacy model which was developed during April-June 2011 and are discussed.. Copyright ©2013 by the International Astronautical Federation., keywords=Ecology; Education; Education computing; Spacecraft; Sustainable development, Community empowerments; Dynamic changes; Environmental education; Environmental studies; Public outreaches; Quality of life; Space situational awareness; Space technologies, Earth (planet), references=(2000) Earth Day Network, , www.earthday.org, EESS Model; (1977) UNEP/UNESCO/IEEP; (1987) National Council for Science & Technology, , www.ncstc-network.org, DST, Gol; Dhawan, S., (1989) Star Wars ISRO Bangalore; Williamson, R., (2011) Space Security Foundation, , www.spacesecurity.org, UniSA, ISU; (1966) First Photo of Earth from Moon, , www.nasa.gov/multimedia/imagegallery; (1987) National Council for Science & Technology, , www.ncstc-network.org, DST, Gol; (2004) Year of Scientific Awareness, , www.oocities.org/ysa2004/, DST, Gol; (2011) Path Ways to Progress, , www.unisa.edu.au/itee/spaceprogram/2011-whitepaper.asp; (2011) Space Eco Literacy Campaign, , http://spaceecoliteracymysore.blogspot.com, correspondenceaddress1=Venkataramaiah, J.; Civil Engineering Department, ISTRAC Indian Space Research Organization, Bangalore University, Panya Sadana 173, 3rd A Main D Block, 3rd Stage Vijaya Nagar, Mysore 570 023, India; email: [email protected], sponsors=, publisher=International Astronautical Federation, IAF, address=Beijing, issn=00741795, isbn=9781629939094, language=English, abbrevsourcetitle=Proc. Int. Astronaut. Congr., IAC, documenttype=Conference Paper, source=Scopus, @CONFERENCEChowdappa2013135, author=Chowdappa, N.a and Usha Devi, L.b and Ramasesh, C.P.c , title=Use pattern of archives on the history of mysore, journal=GL-Conference Series: Conference Proceedings, year=2013, pages=135-138, note=cited By 0; Conference of 14th International Conference on Grey Literature: Tracking Innovation Through Grey Literature, GL 2012 ; Conference Date: 29 November 2012 Through 30 November 2012; Conference Code:111200, url=http://www.scopus.com/inward/record.url?eid=2-s2.0-84924185057&partnerID=40&md5=a04d8e561af552ea04f0fbc17ac822bc, affiliation=BMS College of Engineering, Bangalore, India; Bangalore University, Bangalore, India; University of Mysore, Mysore, India, abstract=Records on the Administration of the Princely State of Mysore and Mysore History form rare collections for historians who venture to study the history of Mysore State under the rule of the Wadiyars, the rulers of Mysore State. These rare materials and archives have been carefully preserved at the Archival Section of the University of Mysore and also at other libraries in Mysore city. The present study furnishes the type of archival materials available at the University Library, Oriental Research Institute and the Karnataka State Archives, Mysore Division. Further, the study depicts the purposes of accessing archives and the use pattern of these rare archival sources on Mysore history by the research scholars, students and teachers in the discipline of Karnataka/Mysore History and allied fields. The present study also projects the extent of dependency of scholars from various professional fields, for information sources on Mysore History. The study also projects the rare collections of manuscripts and books of Tipu's Library., authorkeywords=Administrative records; Archives; Mysore history; Mysore history; Mysore state; Tipu's library collection; Wadiyars, keywords=Libraries; Teaching, Administrative records; Archives; Library collections; Mysore state; Wadiyars, History, references=Rukminamma, P., (2012) Mysore University Library: Evaluation of Facilities and Services, , Tamil Nadu, Alagappa University (M. Phil., dissertation); Seifi, L., Ramasesh, C.P., (2012) Digital and Preservation of Cultural Heritage Collection Among Libraries of India and Iran, , Germany, Lambert Academic Publishing; Ramasesh, C.P., (1995) Record of 75 Years of Mysore University Library, pp. 2-5. , March of Karnataka. Feb. 1995; Stuvert, G., (1809) Tipu's Library, , London, Cambridge University Press; Ramasesh, C.P., (2009) Mysore: A Brief Note on its Culture, pp. 26-28. , Silver Unifest, University of Mysore; Ramasesh, C.P., Saga of library resource sharing in mysore city (2002) National Conference on Consortia Approach for Content Sharing, pp. 185-206. , Mangalore University, sponsors=EBSCO Publishing; et al.; Library of Congress, Federal Library Information Network (FEDLINK); National Research Council (CNR), Central Library "Guglielmo Marconi"; National Research Council (CNR), Institute of Information Science and Technologies (ISTI); National Research Council (CNR), Institute of Research on Population and Social Policies (IRPPS), publisher=TextRelease, issn=13862316, isbn=9789077484203, language=English, abbrevsourcetitle=GL-Conf. Series: Conf. Proc., documenttype=Conference Paper, source=Scopus, @ARTICLEDatta2013303, author=Datta, B. and Pasha, M.A., title=Silica chloride catalyzed efficient route to novel 1-amidoalkyl-2- naphthylamines under sonic condition in water, journal=Ultrasonics Sonochemistry, year=2013, volume=20, number=1, pages=303-307, doi=10.1016/j.ultsonch.2012.06.008, note=cited By 8, url=http://www.scopus.com/inward/record.url?eid=2-s2.0-84867742556&partnerID=40&md5=b7269a8b6cab8f0d007b12461f14e035, affiliation=Department of Studies in Chemistry, Bangalore University, Central College Campus, Bengaluru, India, abstract=A one-pot three-component condensation of an aldehyde, 2-naphthylamine, and acetamide has been achieved by sonication at 35 kHz. The reaction is catalysed by silica chloride in aqueous medium. This protocol afforded corresponding 1-amidoalkyl-2-naphthylamines in shorter reaction durations, and in high yields. The method involves simple work-up procedure, and avoids use of hazardous reagents. © 2012 Elsevier B.V. All rights reserved., authorkeywords=2-Naphthylamine; Acetamide; Aldehydes; Silica chloride; Ultrasound; Water, keywords=2-Naphthylamine; Acetamide; Aqueous medium; Hazardous reagents; High yield; One pot; Silica chlorides; Sonic conditions; Three-component, Aldehydes; Amines; Catalysis; Silica; Ultrasonics; Water, Chlorine compounds, 1 amidoalkyl 2 naphthylamine; 2 naphthylamine; silicon dioxide; unclassified drug; water, article; catalysis; chemical reaction; one pot synthesis; priority journal; ultrasound, chemicalscas=2 naphthylamine, 91-59-8; silicon dioxide, 10279-57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9; water, 7732-18-5, references=Dömling, A., (2006) Chem. Rev., 106, p. 17; Weber, L., (2002) Curr. Med. Chem., 9, p. 2085; Hulme, C., Gore, V., (2003) Curr. Med. Chem., 10, p. 51; Lorimer, J.P., Mason, T.J., (1987) Chem. Soc. Rev., 16, p. 239; Mehrabi, H., (2012) Ultrason. Sonochem., 19, p. 125; Glomb, M.A., Pfahler, C., (2001) J. Biol. Chem., 9, p. 41638; Mishra, A., Kumar, M., Mishra, A., Kumar, A., Kant, R., Thakur, R.S., International (2010) J. Chem. Res., 1, p. 28; Kagechika, H.T., Himi, E., Kawachi Shudo, K.J., (1989) Med. Chem., 32, p. 2292; Madl, A., Spange, S., (2000) Macromolecules, 33, p. 5325; Ugi, I., Meyr, R., Fetzer, U., Steinbrückner, C., (1959) Angew. Chem., 71, p. 386; Passerini, M., Simone, L., (1921) Gazz. Chim. Ital., 51, p. 126; Zhang, C., Price, L.M., Daly, W.H., (2006) Biomacromolecules, 7, p. 139; Burguete, M.I., Collado, M., Escorihuela, J., Galindo, F., GarcÃa-Verdugo, E., Luis, S.V., Vicent, M.J., (2003) Tetrahedron Lett., 44, p. 6891; Renck, H., Hassan, H.G., (1992) Acta Anaesthesiol. Scand., 36, p. 387; Detsi, A., Bouloumbasi, D., Prousis, K.C., Koufaki, M., Athanasellis, G., Melagraki, G., Afantitis, A., Hadjipavlou-Litina, D.J., (2007) J. Med. Chem., 50, p. 2450; Li, Y., Chen, H., Shi, C., Shi, D., Ji, S., (2010) J. Comb. Chem., 12, p. 231; Breslow, R., Bovy, P., Hersh, C.L., (1980) J. Am. Chem. Soc., 102, p. 2115; Li, C., (1993) J. Chem. Rev., 93, p. 2023; Ballini, R., Bosica, G., (1996) Tetrahedron Lett., 37, p. 8027; Ballini, R., Bosica, G., Mecozzi, T., (1997) Tetrahedron, 53, p. 7341; Bigi, F., Chesini, L., Maggi, R., Sartori, G., (1999) J. Org. Chem., 64, p. 1033; Bigi, F., Carloni, S., Ferrari, L., Maggi, R., Mazzacani, A., Sartori, G., (2001) Tetrahedron Lett., 42, p. 5203; Shi, D.Q., Chen, J., Zhuang, Q.Y., Hu, W.W., (2003) J. Chem. Res., p. 674; Shi, D.Q., Mou, J., Zhuang, Q.Y., Niu, L.H., Wu, N., Wang, X.S., (2004) Synth. Commun., 34, p. 4557; Reddy, M.B.M., Jayashankara, V.P., Pasha, M.A., (2010) Synth. Commun., 40, p. 2930; Datta, B., Pasha, M.A., (2011) Ultrason. Sonochem., 18, p. 624; Pasha, M.A., Jayashankara, V.P., (2006) Bioorg. Med. Chem. Lett., 17, p. 621; Karade, H.N., Sathe, M., Kaushik, M.P., (2007) Chem. Commun., 8, p. 741; Mason, T.J., Lorimer, J.P., (1988) Sonochemistry: Theory, Application and Uses of Ultrasound in Chemistry, , John Wiley and Son New York, correspondenceaddress1=Pasha, M.A.; Department of Studies in Chemistry, Bangalore University, Central College Campus, Bengaluru, India; email: [email protected], issn=13504177, coden=ULSOE, language=English, abbrevsourcetitle=Ultrason. Sonochem., documenttype=Article, source=Scopus, @ARTICLESiddheshwar201384, author=Siddheshwar, P.G.a and Bhadauria, B.S.b and Suthar, O.P.a , title=Synchronous and asynchronous boundary temperature modulations of Bénard-Darcy convection, journal=International Journal of Non-Linear Mechanics, year=2013, volume=49, pages=84-89, doi=10.1016/j.ijnonlinmec.2012.09.006, note=cited By 7, url=http://www.scopus.com/inward/record.url?eid=2-s2.0-84868250517&partnerID=40&md5=e54737ede2ff0a4eb17351d59d77732d, affiliation=Department of Mathematics, Bangalore University, Central College Campus, Bangalore 560 001, India; Department of Applied Mathematics, Babasaheb Bhimrao Ambedkar University, Lucknow 226 025, India, abstract=A theoretical analysis of thermo-convective instability in a densely packed porous medium is carried out when the boundary temperatures vary with time in a sinusoidal manner. By performing a weakly non-linear stability analysis, the Nusselt number is obtained as a function of amplitude of convection which is governed by a non-autonomous Ginzburg-Landau equation derived for the stationary mode of convection. The paper succeeds in unifying the modulated Bénard-Darcy, Bénard-Rayleigh, Bénard-Brinkman and Bénard-Chandrasekhar convection problems and hence precludes the study of these individual problems in isolation. A new result that shows that asynchronous temperature modulation may be effectively used to either enhance or reduce heat transport by suitably adjusting the frequency and phase-difference of the modulated temperature is presented. © 2012 Elsevier Ltd., authorkeywords=Bénard-Darcy convection; Ginzburg-Landau amplitude equation; Nusselt number; Temperature modulation; Weakly non-linear stability analysis, keywords=Amplitude equation; Boundary temperature; Convection problem; Ginzburg-Landau equations; Modulated temperature; Phase difference; Temperature modulation; Weakly non-linear stabilities, Nonlinear equations; Nusselt number; Porous materials, Modulation, fundingdetails=University Grants Commission, references=Ahlers, G., Hohenberg, P.C., Lucke, M., Thermal convection under external modulation of the driving force, I. The Lorenz model (1985) Physical Review A, 32 (6), pp. 3493-3518; Bhadauria, B.S., Thermal modulation of Raleigh-Benard convection in a sparsely packed porous medium (2007) Journal of Porous Media, 10 (2), pp. 175-188. , DOI 10.1615/JPorMedia.v10.i2.50; Bhadauria, B.S., Suthar, O.P., Effect of thermal modulation on the onset of centrifugally driven convection in a vertical rotating porous layer placed far away from the axis of rotation (2009) Journal of Porous Media, 12 (3), pp. 239-252; Bhadauria, B.S., Bhatia, P.K., Debnath, L., Weakly non-linear analysis of Rayleigh-Benard convection with time periodic heating (2009) International Journal of Non-Linear Mechanics, 44, pp. 58-65; Bhadauria, B.S., Bhatia, P.K., Time-periodic heating of Rayleigh-Benard convection (2002) Physica Scripta, 66 (1), pp. 59-65. , DOI 10.1238/Physica.Regular.066a00059; Bhadauria, B.S., Siddheshwar, P.G., Suthar, O.P., Non-linear thermal instability in a rotating viscous fluid layer under temperature/gravity modulation, ASME (2012) Journal of Heat Transfer, 134, pp. 1-9; Chandrasekhar, S., (1961) Hydrodynamic and Hydromagnetic Stability, , Oxford University Press, London; Chhuon, B., Caltagirone, J.P., Stability of a horizontal porous layer with timewise periodic boundary conditions (1979) Journal of Heat Transfer, 101 (2), pp. 244-248; Davis, S.H., The stability of time periodic flows (1976) Annual Review of Fluid Mechanics, 8, pp. 57-74; Epherre, J.F., Critére d'apparition de la convection naturalle dans une couche poreuse anisotrope (1975) Revue Générale de Thermique, 168, pp. 949-950; Getling, A.V., (2001) Rayleigh-Benard Convection: Structures and Dynamics, , World Scientific Press, Singapore; Govender, S., Stability of convection in a gravity modulated porous layer heated from below (2004) Transport in Porous Media, 57 (1), pp. 113-123. , DOI 10.1023/B:TIPM.0000032739.39927.af; Homsy, G.M., Global stability of time-dependent flows. Part 2. 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This paper introduces a prototype web search results clustering engine that use the random sampling technique with medoids instead of centroids to improve clustering quality, Cluster labeling is achieved by combining intra-cluster and inter-cluster term extraction based on a variant of the information gain measure by using Modified Furthest Point First algorithm. M-FPF is compared against two other established web document clustering algorithms: Suffix Tree Clustering (STC) and Lingo, which are provided by the free open source Carrot2 Document Clustering Workbench. We measure cluster quality by considering precision , recall and relevance. Results from testing on different datasets show a considerable clustering quality. © 2013 Springer., keywords=Information retrieval; Websites, Cluster labeling; Clustering quality; Clustering system; Data sets; Document Clustering; Information gain; Intra-cluster; Medoids; Open sources; Random sampling; Suffix-trees; Term extraction; Web document clustering; Web searches, Clustering algorithms, references=Zamir, O., Etzioni, O., Web document clustering: A feasibility demonstration Proceedings of the 21st Annual International SIGIR Conference on Research and Development in Information Retrieval (1998); Hanumanthappa, M., Prakash, B.R., Mamatha, M., Improving the efficiency of document clustering and labeling using Modified FPF algorithm Proceeding of International Conference on Problem Solving and Soft Computing (2011); Geraci, F., Leoncini, M., Montangero, M., Pellegrini, M., Renda, M.E., FPF-SB: A Scalable Algorithm for Microarray Gene Expression Data Clustering (2007) LNCS, 4561, pp. 606-615. , Duffy, V.G. (ed.) HCII 2007 and DHM 2007. Springer, Hei
