16 research outputs found
Augmentation Rhinoplasty and Centrofacial Lipofilling: Our Experience (ARCL)
No full textIntroduction: Augmentation rhinoplasty traditionally represents a serious challenge for plastic surgeons. The association with centrofacial lipofilling is a great approach to achieve harmonious, aesthetic results. The aim of this article is to describe our personal association between Augmentation Rhinoplasty and Centrofacial Lipofilling (ARCL) in non-Caucasian patients. Materials and Methods: In this study, we retrospectively reviewed patients treated with ARCL at our institution between January 2019 and December 2023. We described our personal approach and technique. At a minimum follow-up time of one year, post-operative pictures were taken, and patients were reassessed, evaluating aspects such as global symmetry, shape and contour of the nose, and facial harmony and rejuvenation; finally, patients’ satisfaction was investigated according to the ROE questionnaire and the modified S-GAIS. Results: A total of 307 patients were included in the study. They reported a significant satisfactory aesthetic result in nasal image and facial harmony, as the mean postoperative ROE and S-GAIS score show. None of the grafts extruded or collapsed. Wounds healed without reported major infection. Conclusions: This study has demonstrated that ARCL is a safe approach that contributes to improve functional and aesthetic outcomes, has a high patient satisfaction rate, and limited post-operative complications
Off-label application of the breast expander magnet: An alternative approach to enable localisation and removal of ferromagnetic subcutaneous foreign bodies
No full textObjective: Included foreign bodies of a metallic nature are commonly found. They are often small, asymptomatic, with few or non-visible scars or even clinically invisible. Sometimes the patient does not remember their existence. The condition is benign and does not require special attention, unless a magnetic resonance imaging scan is necessary. Indeed, magnetic field interactions could pose significant risks, and the procedure is typically contraindicated unless the ferromagnetic foreign body (FFB) has been previously removed. For such purposes, the magnet that is commonly used in breast and plastic surgery units for breast expanders port injection site identification could represent a time-saving and cost-effective solution. Methodology: This paper presents an alternative technique based on off-label application of the breast expander magnet to localize FFBs. Results: Between April 2023 and June 2023, the breast expander magnet allowed successful pre-operative localisation and intra-operative guidance for removal of FFBs in four clinical cases. The post-operative ultrasound confirmed the absence of metal residues after the procedure in all cases. Conclusion: Off-label application of the breast expander magnet allows for FFB pre-operative localisation and safe intra-operative surgical guidance, thus representing a promising off-label application of the device. After surgical removal of FFBs, the magnetic resonance imaging is allowed without any risk
La versione siriaca di Barhebraeus del K. al-isharat wa 'l-tanbihat di Avicenna nel ms. Firenze, Biblioteca Medicea Laurenziana, Orientale 86
No full textLa presente tesi di laurea magistrale consiste in uno studio preliminare del ms. BML Or. 86, contenente la versione siriaca composta da Barhebraeus dell’ultima opera di Avicenna, conosciuta in arabo come K. al-išārāt wa ʼl-tanbīhāt (Libro delle indicazioni e messe in allerta) e in siriaco con il titolo di Ktābā d-remzē wa-m‘irānwātā.
Il testo bilingue, arabo in grafia araba e siriaco in grafia serto, ha determinato la direzione del lavoro verso una generale panoramica che include un’analisi del contesto di produzione della traduzione in lingua siriaca, un’indagine sullo sviluppo della relativa tradizione manoscritta, un esame critico limitato ad alcuni brani problematici, emersi dal confronto con il ms. Tehran, Melli-ye Malek 713 e l’edizione araba di Forget (1892) e utili a comprendere il modus traducendi del Mafriano. Si è ritenuto opportuno fornire un riepilogo del lessico siriaco specialistico relativo alla logica adattato da Barhebraeus e, infine, una trascrizione dei primi cinque capitoli contenuti nella parte introduttiva del ms. BML Or. 86.
Il Ktābā d-remzē wa-m‘irānwātā di Barhebraeus non è ancora disponibile in un’edizione critica o in una traduzione completa in una lingua europea. La realizzazione di un’edizione, corredata da una traduzione e un commento, potrebbe essere determinante per lo studio della tradizione logica di scuola siriaca – avviata nei primi secoli dell’era cristiana e che sembra avere in Barhebraeus il suo culmine – e l’individuazione delle fonti ancora disponibili in epoca medievale, per l’analisi concettuale e terminologica interna alle opere filosofiche del Nostro Autore e, infine, per la comprensione dell’adattamento lessicale che il Mafriano attua alla luce delle nuove dottrine formulate dai logici arabi dal X al XII secolo. Inoltre, la presenza nel ms. BML Or. 86 del testo in lingua e grafia arabe costituisce a tutti gli effetti un testimone attualmente sconosciuto e relativamente antico dell’ultima summa filosofica di Avicenna
Are Interferon (IFN)-related and IFN-unrelated Graves’ Diseases in patients with chronic C hepatitis the same disease ?
No full textStructure and metal-binding properties of PA4063, a novel player in periplasmic zinc trafficking by Pseudomonas aeruginosa
No full textThe capability to obtain essential nutrients in hostile environments is a critical skill for pathogens. Under zinc-deficient conditions, Pseudomonas aeruginosa expresses a pool of metal homeostasis control systems that is complex compared with other Gram-negative bacteria and has only been partially characterized. Here, the structure and zinc-binding properties of the protein PA4063, the first component of the PA4063-PA4066 operon, are described. PA4063 has no homologs in other organisms and is characterized by the presence of two histidine-rich sequences. ITC titration detected two zinc-binding sites with micromolar affinity. Crystallographic characterization, performed both with and without zinc, revealed an α/β-sandwich structure that can be classified as a noncanonical ferredoxin-like fold since it differs in size and topology. The histidine-rich stretches located at the N-terminus and between β3 and β4 are disordered in the apo structure, but a few residues become structured in the presence of zinc, contributing to coordination in one of the two sites. The ability to bind two zinc ions at relatively low affinity, the absence of catalytic cavities and the presence of two histidine-rich loops are properties and structural features which suggest that PA4063 might play a role as a periplasmic zinc chaperone or as a concentration sensor useful for optimizing the response of the pathogen to zinc deficiency
SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF PSEUDOPALINE AND ITS MOLECULAR SIMPLIFICATION DERIVATIVES AS CANDIDATES FOR ZINCOPHORE-ANTIBIOTICS CONJUGATES DEVELOPMENT
No full textPolyphenol Bioavailability and Plasma Antiradical Capacity in Healthy Subjects after Acute Intake of Pigmented Rice: A Crossover Randomized Controlled Clinical Trial
No full textHealth-promoting eects of plant foods have been emphasized in the last few decades and ascribed to the bioactive phytochemicals present therein—in particular, phenylpropanoids. The latter have been investigated for a number of preclinical biological activities, including their antioxidant power. Due to the paucity of human studies, in this randomized intervention trial, we investigated whether the acute intake of pigmented rice could increase the plasma bioactive levels and antiradical power in twenty healthy subjects. A crossover randomized controlled clinical trial was conducted on 19 volunteers. Artemide and Venere black rice cultivars were tested, while brown rice Carnaroli was used as a control. Each patient received randomly one serving (100 g) of rice on three dierent experimental days, separated by a 7-day washout period. After baseline blood withdrawal, time-course changes of plasma polyphenols, flavonoids and radical-scavenging capacity were determined at 30, 60, 120 and 180 min post rice intake. Compared to Carnaroli rice, the two black rice cultivars significantly increased the plasma levels of polyphenols and flavonoids at 60 and 120 min and, correspondingly, the plasma antiradical power at 60 min after consumption. Pigmented rice consumption can contribute to diet-related health benefits in humans
Structured professional judgment in the new italian forensic treatment model: the validation of the italian version of the DUNDRUM TOOLKIT|Il giudizio professionale strutturato nel nuovo modello trattamentale forense italiano: la validazione della versione italiana del DUNDRUM TOOLKIT
No full textObjective: The purpose was to demonstrate the effectiveness of the DUNDRUM Toolkit in Italy. The research focused on evaluating the disposition of forensic patients in REMS and CRAPs, hypothesizing that the correspondence between standardized assessments and juridical decisions was not that satisfying. Methods: The DUNDRUM Toolkit was translated, after adapting it to national standards and tested in different regions. A total of 192 forensic patients from 9 REMS and several CRAPs in Italy were evaluated, comparing current levels of therapeutic safety with those ones considered as most appropriate. The evaluation used DUNDRUM1 to determine pretreatment safety needs. The progress in the treatment and recovery was examined through DUNDRUM3 and DUNDRUM4. Interrater reliability was assessed by two independent evaluators on a sample of 50 patients. All health professionals involved in the research had been previously trained in the use of the DUNDRUM Toolkit. Results: Results revealed that 3.7% of patients in REMS needed more security, while 38.2% could be placed in less restrictive environments. In CRAPs, 56% of patients required a higher level of security. Conclusions: The study demonstrated the validity and reliability of the Italian version of the DUNDRUM Toolkit and highlighted significant discrepancies between current forensic patient placements and needed levels of safety, suggesting the importance of using professional tools in the forensic practice that allow more accurate assessment of safety needs for each patient
Investigation of Zur-regulated metal transport systems reveals an unexpected role of pyochelin in zinc homeostasis
No full textLimiting the availability of transition metals at infection sites serves as a critical defense mechanism employed by the innate immune system to combat microbial infections. Pseudomonas aeruginosa exhibits a remarkable ability to thrive in zinc-deficient environments, which is facilitated by intricate cellular responses governed by numerous genes regulated by the zinc-responsive transcription factor Zur. Many of these genes have unknown functions, including those within the predicted PA2911-PA2914 and PA4063-PA4066 operons. A bioinformatic analysis revealed that PA2911-PA2914 comprises a TonB-dependent outer membrane receptor and an inner membrane ABC-permease responsible for importing metal-chelating molecules, whereas PA4063-PA4066 contains genes encoding a MacB transporter, likely involved in the export of large molecules. Molecular genetics and biochemical experiments, feeding assays, and intracellular metal content measurements demonstrated that PA2911-PA2914 and PA4063-PA4066 are engaged in the import and export of the pyochelin-cobalt complex, respectively. Notably, cobalt can reduce zinc demand and promote the growth of P. aeruginosa strains unable to import zinc, highlighting pyochelin-mediated cobalt import as a novel bacterial strategy to counteract zinc deficiency. These results unveil an unexpected role for pyochelin in zinc homeostasis and challenge the traditional view of this metallophore exclusively as an iron transporter
