2,428 research outputs found
Recommended from our members
The IAAF’s hyperandrogenism regulations suspended
On 27 July, the Court of Arbitration for Sport (‘CAS’) delivered a landmark ruling on the regulation of gender in sport. The decision explores how the categorisation of sport on the basis of sex can be best reconciled with the “biological reality” that human sex cannot necessarily be divided so clearly. Dr. Seema Patel, Senior Lecturer at Nottingham Trent University, Deputy Director of the Centre for Sports Law and author of ‘Inclusion and Exclusion in Competitive Sport: Socio-Legal and Regulatory Perspectives,’ reviews the case and suggests that sport regulation must be cautious of traditional criteria to determine eligibility in sports
Author interview: Q and A with Dr Ian Sanjay Patel on we’re here because you were there: immigration and the end of empire
In this author interview, we speak to Dr Ian Sanjay Patel about his new book, We’re Here Because You Were There: Immigration and the End of Empire, which explores post-war immigration laws, the afterlives of British imperial citizenship and related attempts to reimagine and rejuvenate British imperialism after 1945. Contributing to transnational histories of decolonisation, the book also explores the interconnections between human rights, post-war migration and international diplomacy. Author Interview with Dr Ian Sanjay Patel, author of We’re Here Because You Were There: Immigration and the End of Empire. Verso. 2021
Embedded in the Body: the Poetry, History and Politics of Migritude with Shailja Patel (2021-02-25)
Online discussion, reading and Q&A; Thursday, February 25 at 4:00PM CST; Shailja Patel is the bestselling author of Migritude, taught in over 100 colleges and universities worldwide. Patel's poems have been translated into 17 languages, and been featured in the Smithsonian. The Nobel Women's Initiative honored her with a Global Feminist Spotlight. She is currently a Research Associate at Five College Women's Studies Research Center.Women, Gender & Sexuality Studies program; Alworth Institute for International Studies; Department of Anthropology, Sociology & Criminology; English program; Writing Studies programPatel, Shailja. (2021). Embedded in the Body: the Poetry, History and Politics of Migritude with Shailja Patel (2021-02-25). Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/220654
Abstract 1341: Talin plays an important role in cell-cell interactions
Abstract
Appropriate cell adhesion is necessary for numerous physiological processes and can be deranged in many diseases, including cancer. It has long been recognized that the cadherins mediated cell-cell adhesion receptor is an important determinant of tumor progression, serving as a suppressor of invasion and metastasis. Recently a role for the C-terminal region of talin (the VAD fragment) in cadherin mediated cell-cell attachment has been suggested, but its molecular mechanism remained unclear. Here, we identified a small region of the VAD fragment required for its localization to cadherin-mediated cell-cell junctions and also found that its localization to cell-cell junctions is independent of its actin binding properties. To identify the binding partner of the VAD fragment at cell-cell junctions we utilized immune-pulldown and found that it interacts with catenins, an important component of cadherin-mediated cell-cell junction. Based on our data, we proposed that the VAD-fragment of talin stabilized and/or stimulated the cell-cell junction by interacting with catenins.
Citation Format: Devang M. Patel, Akhilesh Kumar, William Morgan, Michael D. Birnbaum, Chaunhua Jiang, Fangliang Zhang. Talin plays an important role in cell-cell interactions [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1341. doi:10.1158/1538-7445.AM2017-1341</jats:p
Development, Characterization of Hydroxyl Terminated Dendritic Macromolecules as Prospective Drug Carriers
Competing Interests: The authors have declared that no competing interests exist. Copyright: 2015 Patel PM et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original auth or and source are credited
The Patel trials: further evidence of the need to reform the Griffith Codes
This article argues that the two trials of Dr Jayant Patel for criminal medical negligence under s 288 of the Criminal Code 1899 Act (Qld) highlight the inadequacies of the duty provisions in the Griffith Codes of Queensland and Western Australia. The difficulties with these duty provisions extend beyond causation and go to the heart of the construction of the Griffith Codes. The fundamental problem lies in the wording of s 23 of both the Queensland and
the Western Australia Codes, the principal section dealing with criminal responsibility, which allows a prosecution for criminal negligence under two alternative routes with different standards of proof, and the importation of
common law criminal negligence into the duty provisions in the absence of a specified fault element in the relevant Code sections. It is further contended that other criminal law jurisdictions in Australia, such as the Criminal Code
1995 (Cth), offer a better model for the prosecution of criminal negligence cases that flow from breach of a specified duty. The article has greatly benefited from comments provided to the author by Justice HG Fryberg, who
conducted the second Patel trial
- …
