1,720,957 research outputs found
Prognostic Factors for Hearing Preservation Surgery in Small Vestibular Schwannoma
Full text linkObjective: to evaluate recent contributions to the literature on prognostic factors of hearing preservation in small vestibular schwannoma microsurgery. Methods: review of the most recent studies. Results: factors such as tumor size, preoperative hearing status, tumor growth rate, tumor origin, surgical approach, radiological characteristics, results of preoperative neurophysiological tests, preoperative symptoms and demographic features have been investigated and some of them reported to be significant in the prediction of hearing preservation. Conclusions: tumor size and preoperative hearing status are the most impactful factors and play a key role in patient selection for hearing preservation surgery. Other features such as fundal extension, tumor origin and impaired ABR could have prognostic value on hearing preservation. Tumor growth rate, preoperative impedance, cVEMPs and age have also recently been found to be significant, but more studies are needed. The role of preoperative tinnitus, vertigo and gender is lacking and controversial, whereas the differences between available surgical approaches have been smoothed out in recent years
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Outcomes of different treatment patterns for adenoid cystic carcinoma of the anterior craniofacial area: a multi-institutional study on 578 patients
No full textreservedBackground
L’adenocarcinoma adenoido cistico (ACC) è un tumore raro delle ghiandole salivari, caratterizzato da crescita infiltrativa, invasione perineurale e alti tassi di recidiva. L’area craniofacciale anteriore (ACF) rappresenta la sede più frequentemente coinvolta. Nonostante lo standard attuale preveda chirurgia seguita da radioterapia adiuvante, la resezione completa è spesso difficile, sollevando interrogativi sul ruolo della terapia definitiva non chirurgica (NST).
Obiettivi
Analizzare una coorte multi-istituzionale di pazienti con ACF-ACC per descrivere caratteristiche clinico-patologiche, esiti di sopravvivenza, fattori prognostici e valutare l’efficacia comparativa delle strategie di trattamento locoregionali.
Metodi
Analisi retrospettiva su 578 pazienti trattati in otto centri internazionali (1984–2023). Sono stati inclusi casi con diagnosi istopatologica di ACC a epicentro nasosinusale, rinofaringeo o palatino, in qualsiasi stadio e presentazione clinica, trattati sia ad intento curativo che non. Sono stati esclusi casi trattati con IMPT a ioni carbonio e partecipazioni a studi clinici con terapie sistemiche non citotossiche somministrate in ambito curativo. I dati raccolti includevano presentazione clinica, estensione tumorale, modalità terapeutiche e malattia residua. Gli esiti di sopravvivenza (OS, DSS, LRFS, LRCI) sono stati analizzati mediante Kaplan-Meier, incidenza cumulativa, propensity score matching (PSM) e modelli di Cox multivariati.
Risultati
Il 75,8% dei tumori originava dal tratto nasosinusale; il 68,6% era di grado basso-intermedio. L’intento curativo era nel 89,9%. Tra i 392 pazienti operati, le resezioni erano R0 nel 37,2%, R1 nel 40,3%, R2 nel 16,8%.GTR + IMPT ha mostrato il miglior controllo locale (LRFS e LRCI). Nei pazienti trattati con NST (n=110), la risposta completa era più frequente con IMPT (74,5%) che con fotoni (52,1%, p=0,023). La LRFS e la LRCI non differivano significativamente né per modalità di RT (fotoni vs IMPT) né per presentazione (biopsia vs R2). A lungo termine, OS e DSS declinavano progressivamente: oltre metà dei pazienti decedeva entro 20 anni; solo l’11,9% era vivo e libero da recidiva. L’incidenza cumulativa di eventi avversi ≥G3 a 10 anni era 36,0%, senza variazioni significative in base al tipo di RT o alla presentazione clinica.
Conclusioni
La combinazione di GTR seguita da RT adiuvante con IMPT rappresenta la strategia più efficace nel controllo locale per l’ACF-ACC. La chirurgia R2 non offre vantaggi prognostici e dovrebbe essere evitata, poiché ritarda l’avvio del NST definitivo. Nei pazienti responder al NST, il controllo locale è paragonabile a quello della GTR + RT, suggerendo futuri cambiamenti degli attuali paradigmi terapeutici qualora diventino disponibili strumenti predittivi affidabili di risposta.Background
Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor characterized by infiltrative growth, perineural invasion, and high recurrence rates. The anterior craniofacial (ACF) region represents the most frequently involved site. Although the current standard of care includes surgery followed by adjuvant radiotherapy (RT), complete resection is often challenging, raising questions about the role of definitive non-surgical therapy (NST).
Objectives
To analyze a multi-institutional cohort of patients with ACF-ACC in order to describe clinicopathologic features, survival outcomes, prognostic factors, and to assess the comparative efficacy of locoregional treatment strategies.
Methods
A retrospective analysis was conducted on 578 patients treated across eight international centers (1984–2023). Eligible cases included histopathologically confirmed ACC with epicenter in the sinonasal tract, nasopharynx, or palate, at any stage or clinical presentation, treated with either curative or non-curative intent. Exclusion criteria were carbon ion therapy and participation in clinical trials involving non-cytotoxic systemic agents administered in the curative setting. Collected data included clinical presentation, tumor extension, treatment modalities, and residual disease status. Survival outcomes (OS, DSS, LRFS, LRCI) were analyzed using Kaplan–Meier estimates, cumulative incidence functions, propensity score matching (PSM), and multivariable Cox regression models.
Results
A total of 75.8% of tumors originated from the sinonasal tract, and 68.6% were low-to-intermediate grade. Curative intent was reported in 89.9% of cases. Among the 392 surgically treated patients, resections were R0 in 37.2%, R1 in 40.3%, and R2 in 16.8%. The combination of GTR + IMPT showed the best local control (LRFS and LRCI). In patients treated with definitive NST (n=110), complete response was more frequent with IMPT (74.5%) than with photon-based RT (52.1%, p=0.023). LRFS and LRCI did not significantly differ according to RT modality (photon vs IMPT) or presentation (biopsy vs R2). Over the long term, OS and DSS progressively declined: more than half of patients died within 20 years, and only 11.9% were alive and disease-free. The 10-year cumulative incidence of ≥G3 adverse events was 36.0%, with no significant differences according to RT type or clinical presentation.
Conclusions
The combination of GTR followed by adjuvant IMPT represents the most effective strategy for achieving local control in ACF-ACC. R2 surgery provides no prognostic advantage and should be avoided, as it delays the initiation of definitive NST. In NST responders, local control is comparable to that achieved with GTR plus adjuvant RT, suggesting potential future shifts in treatment paradigms once reliable predictors of response become available
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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