6 research outputs found
Land use and social rights
No full textThis thesis studies the themes of land use and social rights with special reference to the urban village, which is a special phenomenon in city-expansion in contemporary China. By conducting an extensive review of literatures on urban villages and boundary studies, the author studies land use and social rights from the perspective of boundary. The author also emphasizes boundary-making as a social construction process, which involves different stakeholders in this “game”. Further, the author reviews many historical documents and archives pertinent to land use and social rights in China and carries out a fieldwork in Nanjiao Village as a case study. Through qualitative analysis, this study answers the following research questions: 1) how are the diverse land uses arranged by boundary-making in the urban village; 2) how do the stakeholders maintain the order of the status quo for land use and the attained social rights in the urban village. The research found that different stakeholders are involved in the boundary-making of land use, which arranges the inclusion in and exclusion from the access to land use and the attainment of social rights in the urban village. The research concludes that through boundary-making of stakeholders, land use and social rights are inter-related and accessible for residents in the urban village. This research hopes to turn the spotlight on individuals’ social rights, when planners and interested parties make a plan of land use
The rhetorical detour of criticism in Walter Banjamin
No full textEl presente trabajo se propone analizar el desvío retórico que hace Walter Benjamin en su lectura de la crítica kantiana a la metafísica. En función de ello, mediante una vía de interpretación expositiva, abordaremos cómo se sitúa lo retórico en el marco de una tarea crítica que busca ampliar los dominios transcriptos de la experiencia posible hacia un trasfondo incondicionado, no reducible bajo el ideal sistemático de la Wissenschaft y sus primados de tipo metafísico-gnoseológico. A partir de la exposición de los vínculos entre crítica retórica, Sprache y el uso retórico de figuras teológicas en algunos contextos discursivos de las disquisiciones benjaminianas, arribaremos a las consideraciones finales, en las que planteamos que el desvío retórico de la crítica efectuado por el autor resulta inseparable de una crítica radical al estatuto del discurso filosófico sistemático y a su fundamento de determinación idealista, concebida mediante una reinvención de categorías y problemas estéticos.El presente trabajo se propone analizar el giro retórico que hace Walter Benjamin en su lectura de la crítica kantiana a la metafísica. En función de ello, mediante una vía de interpretación expositiva, abordaremos cómo se sitúa lo retórico en el marco de una tarea crítica que busca ampliar los dominios transcriptos de la experiencia posible hacia un trasfondo incondicionado, no reducible bajo el ideal sistemático de la Wissenschaft y sus primados de tipo metafísico-gnoseológico. A partir de la exposición de los vínculos entre crítica retórica, Sprache y el uso retórico de figuras teológicas en algunos contextos discursivos de las disquisiciones benjaminianas, arribaremos a las consideraciones finales, en las que planteamos que el giro retórico de la crítica efectuado por el autor resulta inseparable de una crítica radical al estatuto del discurso filosófico sistemático y a su fundamento de determinación idealista, concebida mediante una reinvención de categorías y problemas estéticos.The present work proposes to analyze the rhetorical detour that Walter Benjamin makes in his reading of Kant\u27s critique of metaphysics. Based on this, through a way of expository interpretation, we will address how rhetoric has to deal with a critical task so as to broaden the transcribed domain of possible experience towards an unconditioned background, not reducible under the predominance of the Wissenschaft and its metaphysical-gnoseological assumptions. From the exposition of the articulation among rhetorical critique, Sprache and the rhetorical use of theological figures in some discursive contexts of Benjamin\u27s disquisitions, we will arrive at the final considerations. We state that the rhetorical detour made by the author around criticism is inseparable from a radical critique of the status of systematic philosophical discourse and its idealist underpinning, conceived as a reinvention of categories and aesthetic problems
Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease
No full textAlzheimer’s disease (AD), the leading cause of dementia, has an estimatedheritability of approximately 70%1. The genetic component of AD has been mainly assessed using genome-wide association studies, which do not capture the risk contributed by rare variants2. Here, we compared the gene-based burden of rare damaging variants in exome sequencing data from 32,558 individuals—16,036 AD cases and 16,522 controls. Next to variants in TREM2, SORL1 and ABCA7, we observed a significant association of rare, predicted damaging variants in ATP8B4 and ABCA1 with AD risk, and a suggestive signal in ADAM10. Additionally, the rare-variant burden in RIN3, CLU, ZCWPW1 and ACE highlighted these genes as potential drivers of respective AD-genome-wide association study loci. Variants associated with the strongest effect on AD risk, in particular loss-of-function variants, are enriched in early-onset AD cases. Our results provide additional evidence for a major role for amyloid-β precursor protein processing, amyloid-β aggregation, lipid metabolism and microglial function in AD.Intelligent SystemsInformation managementPattern Recognition and Bioinformatic
The Relative Biological Effect of Spread-Out Bragg Peak Protons in Sensitive and Resistant Tumor Cells
No full textPurpose: Variations in the radiosensitivity of tumor cells within and between tumors impact tumor response to radiation, including the dose required to achieve permanent local tumor control. The increased expression of DNA-PKcs, a key component of a major DNA damage repair pathway in tumors treated by radiation, suggests that DNA-PKcs– dependent repair is likely a cause of tumor cell radioresistance. This study evaluates the relative biological effect of spread-out Bragg-peak protons in DNA-PKcs–deficient cells and the same cells transfected with a functional DNA-PKcs gene. Materials and Methods: A cloned radiation-sensitive DNA-PKcs–deficient tumor line and its DNA-PKcs–transfected resistant counterpart were used in this study. Thepresence of functional DNA-PKcs was evaluated by DNA-PKcs autophosphorylation.Cells to be proton irradiated or x-irradiated were obtained from the same single cell suspension and dilution series to maximize precision. Cells were concurrently exposed to 6-MV x-rays or mid 137-MeV spread-out Bragg peak protons and cultured for colony formation. Results: The surviving fraction data were well fit by the linear-quadratic model for each of 8 survival curves. The results suggest that the relative biological effectiveness of mid spread-out Bragg peak protons is approximately 6% higher in DNA-PKcs–mediated resistant tumor cells than in their DNA-PKcs–deficient and radiation-sensitive counterpart.Conclusion: DNA-PKcs–dependent repair of radiation damage is less capable ofrepairing mid spread-out Bragg peak proton lesions than photon-induced lesions, suggesting protons may be more efficient at sterilizing DNA-PKcs–expressing cells that are enriched in tumors treated by conventional fractionated dose x-irradiation
Galectin-3 and Soluble CD146 Identify Cardiorenal Injuries in Severe Burn Patients: A Biomarker-Based Approach
No full textThis study was supported by a grant from the “Association des Gueules cassées” to Matthieu Legrand and by a grant from “agence nationale de la recherche.
The body in question : some perceptions, problems and perspectives of the body in relation to character, c. 1750-1850
No full textThis work is a critical and historical exploration of some of the issues raised once it is posited that the appearance of the human body is a reliable and accurate indicator of
psychological life beneath the skin. Its object is not to provide a continuous narrative [say, about the rise of scientific psychology] but to assemble and juxtapose a wide array of disparate materials and thereby resolve a number of issues. What made the appearance of the body an important subject of inquiry, what forms that inquiry took, and what made possible the development of a variety of discourses and practices centered on the body as a sign-system- such questions are at the centre of this study.
The thesis is divided into 3 parts. The first takes as its
focus the work of a number of leading intellectual figures of the mid- and late-eighteenth century, and explores their
treatment of the body. The second deals with the rise of
scientific culture in Britain and with the shift in discursive structures from the realms of 'artistic' and 'literary' culture to that of the scientific. The third seeks through scientific culture to deal with a set of popular characterologies- physiognomy, phrenology, and organology- tracing the relations of each to a number of different discourses.
In what is a long and complex series of arguments and
expositions, the thesis is equipped with numerous general
and particular summaries and introductions to facilitate
reading
