256 research outputs found
A Realistic View on “The Essential Medicinal Chemistry of Curcumin”
No full textACS MEDICINAL CHEMISTRY LETTER
HBSAG, ANTI-HCV, ANTI-HIV 1/2, AND SYPHILIS SEROPREVALENCE IN BLOOD DONORS IN EASTERN MARMARA REGION, TURKEY AND AN OVERVIEW OF TRANSFUSION TRANSMITTED INFECTIONS IN TURKEY
No full textConclusion: The risk of transfusion-transmitted infections can be decreased by effectively using questionnaires and screening tests in blood donation centers, HBV vaccination programs, and awareness-raising activities. It is necessary to use improved screening methods for detection of transfusion-transmitted infection agents
Energetska varnost v času krize: študiji primera Bolgarije in Srbije
No full textThis thesis aims to assess the EU’s external energy policy and to what degree it has been embraced by small states during the energy crisis by posing the question, “How does European Union membership influence the external energy policy decisions of small states within the foreign policy dimension during energy security crises?”. To answer this, the research is taking Bulgaria and Serbia as case studies due to their similar population sizes, GDP, and energy consumptions. This research conceptualizes energy security and energy diplomacy to understand how diplomacy and energy dependencies are interrelated and how this relationship can be utilised as a tool in international relations. Through supporting the qualitative work on foreign policy analysis with the quantitative analysis of the energy industry structures and energy dependencies of Serbia and Bulgaria in a comparative manner, this research is conducting mixed research on the issue. The comparison of Bulgaria and Serbia enables the author to analyse and understand the role of EU membership
Management of extravasation of oxaliplatin by mimicking its biotransformation
No full textAlthough oxaliplatin (Oxali) plays a key role in the treatment of many types of cancer and has been reported to be an irritant, there is no specific and effective method for its extravasation and failure in Oxali extravasation management results in the need for plastic surgery. In the body, Oxali bio-transforms upon dilution in chloride-containing buffer salts to its di-chloro derivative and loses an oxalate molecule. Consequently, the chloride ions exchange with water molecules in the intracellular environment to produce the di-aqua derivative, which is the most active biotransformation product of Oxali in terms of forming the DNA adducts. Thus, inhibiting transformation of di-chloro to di-aqua derivatives by accumulating chloride ions at the site of extravasation and saturating the Oxali molecule with these ions is a strategy that could help manage extravasation. Injecting normal saline at this site is a simple yet effective way to achieve this goal. © 2018, Federación de Sociedades Españolas de Oncología (FESEO)
A Realistic View on
No full textThe review paper entitled “The Essential Medicinal Chemistry of Curcumin”, published in the Journal of Medicinal Chemistry, by Nelson et al. (1) is a well-designed paper, presenting a new (and negative) approach to the well-known biologically active compound; curcumin. Although some arguments throughout this paper are completely true, the approach of the authors is unfortunately far from impartial, and many of the conclusions the authors draw from some of their referred papers are especially hard to accept
Erratum: A case with synchronous quadruple cancer (THOD-Turk Hematoloji-Onkologi Dergisi (2002 12:3 158))
No full textKişilerarası iletişim sürecinde romantik eşlerde iletişimötesi iletişim aktörlerinin kullanımı : Anadolu Üniversitesi İletişim Bilimleri Fakültesi öğrenci örneği
No full textTez (doktora) - Anadolu ÜniversitesiAnadolu Üniversitesi, Sosyal Bilimler Enstitüsü, Basın ve Yayın Anabilim DalıKayıt no: 102816Bu araştırmanın amacı, kişilerarası iletişim sürecinde romantik eşlerarası iletişimötesi iletişim aktörlerini araştırmak olmakla birlikte, bu aktörlerin işlevsellik boyutunu incelemek ve analiz etmektir. Kişilerarası iletişim sürecinde romantik eşlerde iletişimötesi iletişim aktörlerinin kullanımının değerlendirilmesine dayanan bu çalışma, kişilerarası iletişimde yeni yaklaşımların aile sosyolojisi ve psikoloji alanlarıyla hem kuramsal hem de uygulamalı olarak bütünleştirilmesinde disiplinler arası bir niteliktedir. Mutlu ve uyumlu bir birliktelik her şeyden önce sağlıklı ve yeterli bir iletişim ve eşlerin bundan sağladıkları doyumla gerçekleşir. Evliliğin kalitesi ve uyumun artırılması konusundaki önemli noktalardan biri eşlerden her ikisini de hoşnut eden iletişim türleri ve düzeyi üzerinde eşlerin anlaşmaları fikir birliğine varmaları ve memnuniyet duymalarıdır (Şener ve Terzioğlu, 2008). İletişim düzeyinin önemli belirleyici faktörlerden biri olan iletişimötesi iletişimin bir amacı da; eşlere kendi ilişkilerinden sorumlu olmaya izin vererek ilişki kalitesini artırmak olacaktır. Mutlu birliktelik yaşamak isteyen insanları iletişimin bu özel tip süreçleri destekleyen bir bilgi alanı diğer tüm alanlarda da önemli olabilir. Bulgular ışığında, eşlerin iletişim kurarken iletişimötesi iletişim aktörlerini kullanmalarının romantik doyumları ile pozitif yönde bir ilişkisi olduğu söylenebilir
Temperature measurements in a capacitive system of deep loco-regional hyperthermia.
No full textHyperthermia has been shown to be a medically useful procedure applicable for different indications. For the connection between clinical effects and heat, it is important to understand the actual temperatures achieved in the tissue. There are limited temperature data available when using capacitive hyperthermia devices even though this is worldwide the most widespread method for loco-regional heating. Hence, this study examines temperature measurements using capacitive heating. Bioequivalent phantoms were used for the measurements, which, however, do not consider perfusion in live tissue. In general, the required temperature impact for an effective cancer therapy should need an increase of 0.2°C/min, which has been achieved. In the described tests on the non-perfused dummy, on average, the temperature increases by approximately 2°C in the first 12 min. The temperature difference relative to the starting temperature was 10-12°C within a therapy time of 60 min (rising from the initial room temperature between 20-24°C and 32-34°C). The average deviation with three individual measurements each on different days in a specified localization was 2°C. The minimum temperature difference was 4.2°C, and the maximum value was reached in the liver with 10.5°C. These values were achieved with a moderate energy input of 60-150 watts, with much higher performance outputs still available. These results show that the tested capacitive device is capable of achieving quick temperature increase with a sufficient impact into the depth of a body
Combinatorial therapy of high dose vitamin C and PARP inhibitors in DNA repair deficiency: A series of 8 patients
No full textAbstract Background: Tumor-specific DNA repair defects are ubiquitous in cancerous tissue, which offers a potential for clinical gain to build on these perturbations. Intravenous high-dose vitamin C (IVC) triggers the formation of hydrogen peroxide (H2O2), which contributes to Fenton chemistry producing hydroxyl radicals (-OH), causing selective damage to DNA. Herein, we evaluated the therapeutic response to IVC and PARP inhibitors (PARPi) in combination in 8 patients with a deficiency of homologous recombination repair system (dHRR) in a 3-year period. Material and Methods: Eight patients with progressive stage IV malignancy, who were pre-treated with conventional methods, were admitted to our clinic. Subsequent therapy has included IVC at a dose that was set to be in the range of 1 to 1.5g/kg, although 1.25g/kg was dominantly administered. Furthermore, following genomic evaluation, PARPi (niraparib or olaparib or talazoparib) was chosen to be used in combination with IVC which was administered 2 to 4 times a week. Results: In the present study, we achieved partial response in 5 patients and complete response in 3 patients. Grade 2 anemia and fatigue toxicities were observed in some cases, while grade 3 toxicity was not found in any of the patients. Conclusion: Our 8 patient case study shows that IVC could be a plausible additional therapy for HRR deficiency. Although the single agent PARPi therapy is effective for metastatic disease, an overall survival (OS) advantage has not been demonstrated. Our results suggest that adding IVC can improve PARPi therapy outcomes. To fully endorse the results stated above, combinatorial therapy of intravenous high dose vitamin C and PARP inhibitors needs to be reviewed in broader cohorts of patients
5-Fluorouracil, epirubicin and cisplatin in the treatment of metastatic gastric carcinoma: A retrospective analysis of 68 patients
No full textBACKGROUND: Gastric cancer is one of the most common types of cancer
and one of the most frequent causes of cancer-related death. The
majority of gastric cancers show distant metastasis at the time of
diagnosis. At present, there is no general agreement over one standard
chemotherapy regimen for metastatic gastric cancer. AIMS: We evaluated
the activity and toxicity of the combination of 5-Fluorouracil (5-FU),
epirubicin and cisplatin (FEP) in previously untreated patients with
metastatic gastric cancer. SETTING AND DESIGN: Medical Oncology
Department of Uludag University Faculty of Medicine, Bursa;
retrospective study. MATERIAL AND METHODS: Sixty-eight patients
received 5-FU 300 mg/m2 on Days 1-5, epirubicin 50 mg/m2 on Day 1 and
cisplatin 60 mg/m2 on Day 1, every 4 weeks. A median of 3.5 cycles was
administered. The response rate, time to disease progression, survival
and toxic effects were analyzed. STATISTICAL ANALYSIS USED: Overall
survival and time to progression were estimated using Kaplan-Meier
method. RESULTS: There were 4 partial responses and 1 complete
response (overall response rate 7.3%); 16 patients had stable disease.
Median progression-free and overall survival rates were 3.1 months (95%
CI 1.9-4) and 6 months (95% CI 4.2-7), respectively. The principal
toxicity was myelosupression. Grade 3-4 neutropenia occurred in 27.9%,
anemia in 17.6%, and thrombocytopenia in 11.7% of patients.
Non-hematological toxicity was mild and manageable. CONCLUSIONS: We
concluded that FEP combination as used at the doses and schedules in
this study has inferior activity against metastatic gastric cancer
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