1,720,995 research outputs found
Impiego del bromuro di potassio in cani epilettici. Studio retrospettivo su 30 casi
No full textRIASSUNTO In alcuni casi l’uso del fenobarbital può risultare insufficiente per controllare in modo adeguato le crisi epilettiche nel cane. Il bromuro di potassio (KBr), come noto, per la sua capacità di indurre una iperpolarizzazione delle membrane nervose, svolge un’azione anticonvulsivante. Grazie alla peculiare modalità di eliminazione ed alla sua emivita, KBr è considerato un farmaco antiepilettico di seconda scelta, ma può risultare di primaria importanza nel trattamento delle crisi epilettiche “refrattarie”. Il nostro studio, svolto su 30 cani affetti da epilessia idiopatica in stadio di refrattarietà, ha voluto saggiare l’efficacia del farmaco, stabilendone le dosi terapeutiche ed il relativo range delle concentrazioni plasmatiche. A tutti i cani presi in considerazione è stata diagnosticata epilessia primaria (PES) sulla scorta di una normale valutazione diagnostica metabolica e neurologica. Tutti i cani considerati erano stati già trattati con diversi farmaci antiepilettici (AEDs). I soggetti presi in esame sono stati divisi in due gruppi: uno (gruppo A) è stato trattato con solo KBr, l’altro (gruppo B) impiegando invece l’associazione fenobarbital- KBr. Durante il periodo di studio, la somministrazione di KBr non è stata mai sospesa. Il valore della fenobarbitalemia è stata mantenuta in tutti i cani al di sotto di 34,6 mg/ml. Col trattamento singolo di KBr, si è avuto controllo delle crisi epilettiche nei soggetti che presentavano un range delle concentrazioni plasmatiche di KBr di 960- 3000 mg/ml. I soggetti trattati con KBr e fenobarbital hanno presentato un miglioramento della sintomatologia con un range del KBr compreso tra 830-2600 mg/ml. SUMMARY 10 to 50% of epileptic dogs having seazures are refractory to phenobarbital sodium alone. Bromide is a halide anticonvulsivant that offers an effective alternative to phenobarbital and other barbiturates for treatment of epilepsy in dogs. Materials and methods. In this study, 30 dogs affected by idiopathic epilepsy has been investigated. All dogs were diagnosed as having idiopathic epilepsy based on normal metabolic and neurologic diagnostic evaluations. All the dogs investigated received multiple antiepileptic drugs (AEDs) before bromide therapy. Dogs have been divided in two groups: • Group A: 20 dogs, different for breed, sex, age, were considered refractory to treatment with barbiturates alone becouse of relapsing seizures and serum phenobarbital concentration higher than 36 mg/ml. Those dogs have been treated only with bromide (30 mg/Kg, PO, sid) after progressive dismissing therapy with phenobarbital. • Group B: 10 dogs, different for breed, sex, age, with weekly seizures despite of an optimal serum phenobarbital concentration (9-36 mg/ml). Those dogs have been treated with bromide-phenobarbital association (bromide: 20 mg/Kg, PO, sid; phenobarbital 2-4 mg/Kg, PO, bid; serum phenobarbital concentration always 960 mg/ml and bromide-phenobarbital therapy was considered effective when serum bromide concentration was > 810 mg/ml and serum phenobarbital concentration was 9.6-34.6 mg/ml
Exploring the impact of big data analytics capabilities on business model innovation: The mediating role of entrepreneurial orientation
Full text linkBig Data Analytics Capabilities (BDAC) represent critical tools for business competitiveness in highly dynamic markets. In this connection, by leveraging on the Dynamic Capabilities View (DCV) this study analyses the relationship between BDAC and Business Model Innovation (BMI). It argues that the impact of BDAC (a lower-order dynamic capability) on BMI is mediated by Entrepreneurial Orientation (EO; a higher-order dynamic capability). The proposed model is assessed by PLS-SEM (symmetric) and fuzzy-set Qualitative Comparative Analysis (asymmetric) methods using survey data from 253 UK firms. Our findings demonstrate that BDAC have both direct and indirect positive effects on BMI, with the latter being mediated by EO. These results enrich the innovation management literature on Big Data (BD) by showing that BDAC influence company strategic logics and objectives, rather than depending on them, thus playing a significant role in creating value for companies and their stakeholders
Rilievi istopatologici epatici in vitelli "a carni bianche" e confronto con il profilo organo-metabolico
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The big data-business strategy interconnection: a grand challenge for knowledge management. A review and future perspectives
Full text linkPurpose: Designing knowledge management (KM) systems capable of transforming big data into information characterised by strategic value is a major challenge faced nowadays by firms in almost all industries. However, in the managerial field, big data is now mainly used to support operational activities while its strategic potential is still largely unexploited. Based on these considerations, this study proposes an overview of the literature regarding the relationship between big data and business strategy. Design/methodology/approach: A bibliographic coupling method is applied over a dataset of 128 peer-reviewed articles, published from 2013 (first year when articles regarding the big data-business strategy relationship were published) to 2019. Thereafter, a systematic literature review is presented on 116 papers, which were found to be interconnected based on the VOSviewer algorithm. Findings: This study discovers the existence of four thematic clusters. Three of the clusters relate to the following topics: big data and supply chain strategy; big data, personalisation and co-creation strategies and big data, strategic planning and strategic value creation. The fourth cluster concerns the relationship between big data and KM and represents a ‘bridge’ between the other three clusters. Research limitations/implications: Based on the bibliometric analysis and the systematic literature review, this study identifies relevant understudied topics and research gaps, which are suggested as future research directions. Originality/value: This is the first study to systematise and discuss the literature concerning the relationship between big data and firm strategy
- Dati preliminari sulla determinazione dell'Aptoglobinemia in cani sani ed affetti da patologie in fase acuta e cronica.
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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