177,319 research outputs found
Differential sexual network connectivity offers a parsimonious explanation for population-level variations in the prevalence of bacterial vaginosis: a data-driven, model-supported hypothesis
No full textCITATION: Kenyon, C. R., Delva, W. & Brotman, R. M. 2019. Differential sexual network connectivity
offers a parsimonious explanation for
population-level variations in the
prevalence of bacterial vaginosis : a datadriven,
model-supported hypothesis. BMC Women's Health, 19:8, doi:10.1186/s12905-018-0703-0.The original publication is available at https://bmcwomenshealth.biomedcentral.comBackground: The prevalence of bacterial vaginosis (BV) and vaginal microbiota types varies dramatically between
different populations around the world. Understanding what underpins these differences is important, as highdiversity
microbiotas associated with BV are implicated in adverse pregnancy outcomes and enhanced susceptibility
to and transmission of sexually transmitted infections.
Main text: We hypothesize that these variations in the vaginal microbiota can, in part, be explained by variations in
the connectivity of sexual networks. We argue: 1) Couple-level data suggest that BV-associated bacteria can be
sexually transmitted and hence high sexual network connectivity would be expected to promote the spread of BVassociated
bacteria. Epidemiological studies have found positive associations between indicators of network
connectivity and the prevalence of BV; 2) The relationship between BV prevalence and STI incidence/prevalence can
be parsimoniously explained by differential network connectivity; 3) Studies from other mammals are generally
supportive of the association between network connectivity and high-diversity vaginal microbiota.
Conclusion: To test this hypothesis, we propose a combination of empirical and simulation-based study designs.https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s12905-018-0703-0Publisher's versio
Du purgatoire. La pitoiable voix de Rama. L'Eglise catholique, apostolique et romaine, la belle Rachel : ses prières, ses aumosnes, ses dons, ses sacrifices qu'elle offre incessamment pour les esprits des morts : ensemble la defence de ses larmes contre la pensée profane & impitoiable du Sieur Henry Chroüet Ministre de la Synagogue de Calvin étably au band d'Aulne
No full textEmpreinte : d,r. utur ezce cene (3) 1656 (R)
Porte la mention : "Avec permission des Superieurs"
Signatures : A-Z⁴ 2A-2F⁴ 2G²
Références : Theux, X. de. Bibliographie liégeoise(2e éd.) 210Source d'acquisition : R4236B Legs Baron A. Wittert 1903
Propriété et historique de la conservation : R4236B "Ex libris Joannis de Fraipont"Par Antoine Delva pasteur d'Aulne, au terroir d'Outre-Meus
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Intralymphocyte free magnesium and calcium and insulin tolerance test in a group of essential hypertensive patients.
No full textIn order to assess the links which are claimed to exist between peripheral insulin resistance and intracellular magnesium and calcium concentrations, we measured free intralymphocyte magnesium (Mg(i)) and calcium (Ca(i)) concentrations as well as the rate constant of plasma glucose disappearance (K(itt)) after insulin injection (insulin tolerance test: ITT) in a group of 16 normotensive control subjects (NC) and 34 essential hypertensive subjects (EH). Mg(i) and Ca(i) were measured in triplicate by means of a fluorimetric technique based on the dyes furaptra and fura-2 respectively. K(itt) values proved significantly reduced in EH as compared to NC (M +/- SD, EH: 4.49 +/- 1.31 vs 5.28 +/- 1.19, P <0.05; 95% confidence limits: 0.231.5). Mg(i) and Ca(i) were not statistically different in EH as compared to NC subjects (Mg(i), NC: 266 +/- 20 mumol/l; EH: 245 +/- 50 mumol/l; Ca(i), NC: 47 +/- 9 nmol/l, EH: 46 +/- 13 nmol/l). We found a statistically significant inverse correlation in the whole study group between K(itt) and body mass index (R= -0.363, P<0.01) and a statistically significant positive correlation between K(itt) and Mg(i) (R= 0.347, P=0.013) was found. In a step-up multivariate regression analysis including blood pressure, plasma lipids, BMI, plasma magnesium, fasting insulin, fasting glucose, Mg(i) and Ca(i), the dependent variable K(itt) is statistically significantly correlated with body mass index and Mg(i). In a first attempt to study the relationships between insulin resistance, Mg(i) and Ca(i) in nucleated cells, the chosen index of peripheral resistance seems to be linked to intracellular free magnesium
Measurement by bioluminescence technique of erythrocyte membrane Na+,K+-ATPase activity in hypertensive patients
No full textErythrocyte membrane Na+,K+-ATPase activity was measured using a bioluminescence technique in 28 hypertensive patients (24 with essential hypertension, 2 with renovascular hypertension and 2 with hypertension secondary to primary hyperaldosteronism) and in 28 normotensive control subjects matched for age and sex. Erythrocyte Na+,K+-ATPase activity was significantly reduced in the patients with essential hypertension (130.9 +/- 11.4 vs. 186.6 +/- 19.5 nmol ATP/mg prot per h; mean values +/- SEM; p less than 0.05) and in the patients with secondary hypertension. A significant negative correlation was found between erythrocyte Na+,K+-ATPase and systolic blood pressure (r = -0.603; p less than 0.01), but not between Na+,K+-ATPase and plasma renin activity or plasma aldosterone levels. These data confirm the findings of a number of previous studies reporting reduced activity of erythrocyte Na+,K+-ATPase possibly related to the presence of a circulatory inhibitor of sodium pump. The method, based on ATP assay by bioluminescence, presents a high degree of specificity as well as simple, rapid execution
Letter from R. R. Zellick, Assistant Trust Officer, Anglo California National Bank of San Francisco, to Joseph R. Goodman, October 2, 1942
No full textLetter from R. R. Zellick, Assistant Trust Officer at The Anglo California National Bank of San Francisco, to Joseph R. Goodman, regarding property owned by Dave Tatsuno. Zellick mentions a dispute between current tenants and Tatsuno, and that Tatsuno has asked Goodman to help locate trustworthy tenants.Personal correspondence, organizational records, government documents, publications, and other papers created or collected by Joseph R. Goodman documenting the forced removal and incarceration of Japanese Americans during World War II, as well as organized resistance to incarceration. Included in the collection are records of the Japanese Young Men's Christian Association and the Japanese American Citizens' League in San Francisco, including papers of the Japanese YMCA's executive secretary Lincoln Kanai; Sakai family papers; Goodman's correspondence to and from Japanese American incarcerees, organizations opposing forced removal and incarceration of Japanese Americans, the War Relocation Authority, and others; publications, photographs, and ephemera from the Topaz Relocation Center, where Goodman taught high school; War Relocation Authority records and publications; and newspaper clippings, pamphlets, and reports about forced removal and incarceration created by various government, religious, and civic organizations, in California and nationwide
Endothelial progenitor cells and aptoptosis in patients with heart failure
No full textObjective: One the main features of heart failure is endothelial disfunction and some authors claimed this is caused by endothelial cell apoptosis. Scope of the study is to evaluate in a group of patients with heart failure the number of EPC (endothelial progenitor cells) both ex vivo and in culture in parallel with the assessment of EPC apoptosis and the echocardiographic evaluation of systolic and diastolic left ventricular function.
Design and Method: We studied 30 patients with congestive heart failure (CHF) and 16 healthy control subjects CS) by measuring the number of EPC both ex vivo and after 4 days in culture. We measured also EPC apoptosis together with echocardiographic parameters of systolic and diastolic left ventricular function.
Results and Conclusion: The EPC count measured both ex vivo (CD34+/KDR+; M ± ES, CHF, 9.5 ± 1.1%, CS, 5.1 ± 0.8%, p < 0.02) and after culture (KDR+/CD34+; M ± ES, CHF, 51.2 ± 6.6%; CS, 23.5 ± 8.8%, p < 0.0001) was significantly increased in CHF patients as compared to CS. In CHF patients EPC number measured in culture is directly correlated with hs-CRP (p = 0.035, r = 0.497). The EPC apoptosis does not show any statistically difference between CHF patients and CS. In CHF patients the number of apoptotic EPC was inversely correlated with total (r = −0.418, p = 0.02) and LDL cholesterol (r = −0.399, p = 0.03). We hypnotize that the increased oxidative stress characterizing heart failure may explain the increased EPC number which may have a compensatory significance for endothelial dysfunction as EPC number is directly linked to a crucial flogistic parameter as CRP. EPC apoptosis is not altered in CHF patients and does not seem to be related with the increased EPC number. The inverse correlation between EPC apoptosis and LDL cholesterol may represent the clinical equivalent of the in vitro ability of oxidized LDL to inhibit the macrophage binding to apoptotic endothelial cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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