1,177 research outputs found
Charm cross section and fragmentation fractions in pp collisions with ALICE (12'+3')
No full textIn this contribution, the latest , and the first , and baryon measurements performed with the ALICE detector at midrapidity in proton--proton collisions at TeV and TeV at the LHC are presented. Recent measurements of baryon-to-meson cross-section ratios at midrapidity show significantly higher results than in and ep collisions, suggesting that the fragmentation of charm is not universal across different collision systems. Thus, measurements of charm-baryon production are crucial to study the charm-quark hadronisation in pp collisions and the possible difference with respect to and ep collisions.
In addition, the baryon-production measurements were essential for the measurement of the c production cross section performed by ALICE at midrapidity in pp collisions and also presented in this contribution.
Furthermore, the new preliminary measurement of the / ratio in in p--Pb collisions will be discussed. The measurement of charm baryons in proton--nucleus collisions provides important information about Cold Nuclear Matter (CNM) effects. It also helps to understand how the possible presence of collective effects could modify the production of heavy-flavour hadrons and to interpret the similarities observed among pp, proton--nucleus and nucleus--nucleus systems
A Strategy Oriented Framework for Food and Beverage E-Supply Chain Management
No full textSeveral authors have emphasized the importance of analysing the impact of e-business, e-commerce and online-shopping on supply chain and operations management; however, it seems that to date no one has suggested a comprehensive framework that could help identify and support supply chain design decisions for companies about to enter the online-business in the consumer goods retail trade, encompassing the business drivers at a strategic level. This paper aims to bridge the gap between theoretical taxonomies or abstract models and the concrete supply chain design problems encountered by logistics managers who need to take their Food & Beverage retail company into the internet business while also preserving a consistent alignment with their current company strategy. Some insights on this area are presented along with a field study approach and a proposal of a 6-phase framework to jointly manage all the relevant strategic and functional aspects of supply networks
Supply chain network design for the diffusion of a new product
No full textSupply Chain Network Design (SCND) deals with the determination of the physical configuration and infrastructures of the supply chain. Specifically, facility location is one of the most critical decisions: transportation, inventory and information sharing decisions can be readily re-optimized in response to changes in the context, while facility location is often fixed and
difficult to change even in the medium term. On top of this, when designing a supply network to support a new product diffusion (NPD), the problem becomes both dynamic and stochastic. While literature concentrated on approaching SCND for NPD separately coping with dynamic and stochastic issues, we propose an integrated optimisation model, which allows warehouse positioning decisions in concert with the demand dynamics during the diffusion stage of an innovative product/service. A
stochastic dynamic model, which integrates a Stochastic Bass Model (SBM) in order to better describe and capture demand dynamics, is presented. A myopic policy is elaborated in order to solve and validate on the data of a real case of SCND with 1,400 potential market points and 28 alternatives for logistics platforms
A business process modeling approach to support production systems analysis and simulation
No full textIn this paper we propose a reference model conceived to simplify the development of production simulation paradigms as well as to support software houses in formalizing the main functions and properties of manufacturing systems simulation software. The proposed model results from a research project aiming to the design of a new manufacturing systems simulation tool, embedding the main production and logistics processes archetypes. Indeed, the designed tool natively entrenches several well-known production and inventory control policies on top of the greatest part of the typical processes and work methods in a manufacturing plant; the model is formally represented in Business Process Modelling Notation, which increase its clearness and the related benefits for industrial users.
The proposed reference model architecture and working logic has been validated on a manufacturing company case study
Issues in integrating MRP in production systems simulation tools
No full textLiterature review suggests concentrating on the development of new reference model for manufacturing system simulation, which may implement an operation logic much closer to real industrial contexts. A production system modelling tool should be designed with the aim of standardizing and simplifying the simulation of manufacturing processes and to widespread this approach in {SMEs.} Pursuing this aim, the authors got committed in designing a reference model for providing a structural framework to support shop-floor simulation and optimization. This paper presents the basic framework logic and structure of the simulation tool, showing how it is possible to represent it in Business Process Modelling Notation {(BPMN).} The efforts of implementing an {MRP} module on top of a simulation tool, which was originally conceived to embed look-back material handling policies, are described together with the operative solutions chosen to reach the integration
Manufacturing Systems Modelling and Simulation Software Design: a Reference Model
No full textNowadays production environments request standard efficient frameworks in order to map and simulate manufacturing processes which literature or market can barely provide. A generalized reference model is necessary to highlight the differences and affinities among manufacturing systems resources, so as to examine the possibilities of modelling of such concepts and their respective roles. {OPUS} project formalizes a new modelling and simulation language for productive manufacturing systems through the support of an optimization tool development. On a practical level a {BPMN} approach has been useful to conceive a model strictly related to business processes, in addition to the simplification of the implementation/coding of the simulation tool
A stochastic dynamic programming approach for integrating supply chain network design and new product diffusion
No full textWe focus on the problem of designing a supply chain for a new product. We propose a stochastic dynamic program based on a Stochastic Bass Model of the product demand dynamics. We heuristically solve our model using Monte Carlo simulation and math programming techniques. We apply our approach to the case of a new distribution service for Made-in-Italy wine and food products, benchmarking the performance of our heuristic policy against the performance of an easier to compute heuristic policy and a lower bound
BRCA2 deletion induces alternative lengthening of telomeres in telomerase positive colon cancer cells
No full textBRCA1/2 are tumor suppressor genes controlling genomic stability also at telomeric and subtelomeric loci. Their mutation confers a predisposition to different human cancers but also sensitivity to antitumor drugs including poly(ADP-ribose) polymerase (PARP) inhibitors and G-quadruplex stabilizers. Here we demonstrate that BRCA2 deletion triggers TERRA hyperexpression and alternative lengthening mechanisms (ALT) in colon cancer cells in presence of telomerase activity. This finding opens the question if cancer patients bearing BRCA2 germline or sporadic mutation are suitable for anti-telomerase therapies, or how ALT activation could influence the short or long-term response to anti-PARP inhibitors or anti-G-quadruplex therapies
Does Smartphone Use Affect a Subsequent Swimming Training Session? Preliminary Results in Amateur Triathletes
No full textTo date, the literature has failed to individuate a clear motivation for the performance decrement after a mental fatigue-inducing task. This study aimed to evaluate biomechanical and perceptual variables during a swimming training session in different mental fatigue states. Seven amateur triathletes watched a documentary, utilized a smartphone, or performed an AX-CPT for 45 min randomly on three different days. After, they performed a 15-min warm-up followed by 6 x 200 m at constant pre-set speed plus one 200 m at maximal effort. The mental fatigue status was assessed by the visual analog scale (VAS) and short-Stroop task results before, post-mental task, and post-swimming session. The biomechanical and motor coordination variables during swimming were assessed using five IMU sensors and video analysis. The heart rate and rate of perceived exertion were monitored during the task. No differences in biomechanical and perceptual variables were found between and within conditions. Higher mental fatigue was found only in the AX-CPT condition at post task by VAS. In this preliminary study, no changes in swimming biomechanics were highlighted by mental fatigue, but the warm-up performed may have counteracted its negative effects. Further studies are recommended
Charm-quark fragmentation fractions and productioncross section at midrapidity in pp collisions at the LHC
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