166 research outputs found
Clinical experience with the use of Fluorescence In Situ Hybridization on uncultured cells for prenatal diagnosis.
No full textThe aim of the study was to prospectively evaluate the usefulness and
limitations of Fluorescence In Situ Hybridization (FISH) on uncultured
cells for prenatal diagnosis of numeric aneuploidies of chromosomes 13,
18, 21, X and Y. Hundred prospectively selected pregnant women that
were at high risk of giving birth to an abnormal child were offered
prenatal diagnosis by FISH after appropriate counseling. Fetal tissue
was obtained by chorionic villus sampling (n=26), amniocentesis (n=62)
and or fetal blood sampling (n=12) and processed for FISH using
commercial probes. Six cases were excluded initially owing to maternal
blood contamination or inadequate sample. FISH results were available
in 98% of cases, in 2% of cases there was FISH failure. Of the
remaining 92 cases, chromosome aneuploidy was detected in eleven cases.
FISH was found extremely valuable in cases presenting with fetal
abnormalities detected on ultrasonography and also for rapid screening
of aneuploidies in cases of abnormal triple marker test. But as the
diagnosis is limited to only a small number of chromosomes, appropriate
evaluation of the cases with counseling regarding the limitations of
FISH is mandatory before offering this test for prenatal diagnosis
Correction to: Safety of laparoscopic compared to open right hepatectomy after portal vein occlusion: results from a multicenter study (Surgical Endoscopy, (2025), 39, 3, (1839-1847), 10.1007/s00464-025-11532-8)
No full textThe original online version of this article was revised to correct the presentation of the name of coauthor Nadia Russolillo, and to correct the affiliation information for corresponding author Serena Langella. The original article has been corrected
Psychological treatments in schizophrenia: II. Meta-analyses of randomized controlled trials of social skills training and cognitive remediation
No full textBackground. Social skills training and cognitive remediation are psychological techniques with considerable face validity for the treatment of negative symptoms of schizophrenia and their consequences. This paper provides a meta-analytical review of these treatments. It includes an appreciable number of randomized controlled trials, using comparisons against both standard care and other active interventions. However, the assessment of particular outcomes sometimes had to be based on single studies.Method. A detailed search strategy was used to identify randomized controlled trials of social skills training and cognitive remediation, primarily employing electronic databases. Randomized controlled trials (RCTs) that met predefined criteria were then subjected to meta-analysis on a variety of outcome measures.Results. There was no clear evidence for any benefits of social skills training on relapse rate, global adjustment, social functioning, quality of life or treatment compliance. Cognitive remediation had no benefit on attention, verbal memory, visual memory, planning, cognitive flexibility or mental state.Conclusions. Social skills training and cognitive remediation do not appear to confer reliable benefits for patients with schizophrenia and cannot be recommended for clinical practice
Adjustment of India’s Foreign Policy for Southeast Asia in the Time of Prime Minister Narendra Modi and its Impacts on India - Vietnam Relationships
No full textObjective: The purpose of the article will present and analyze the adjustment of India’s foreign policy towards Southeast Asia under Prime Minister N. Modi and its impacts on Vietnam - India relations.
Theoretical framework: In this study, International Relations theories such as those of Realism, Liberalism and Constructivism have been used to clear the goals, approaches and content of India’s policies for Southeast Asia, the adjustment of Prime Minister N. Modi towards ASEAN and Southeast Asian countries.
Method: The author uses historical methods, interdisciplinary research methods and comparative methods to present and evaluate India’s foreign policy with ASEAN and Southeast Asian countries under Prime Minister Modi compared to before and evaluate the impacts of this adjustment on Vietnam - India relations in the future.
Results and conclusions: Historically, India has reached Southeast Asia by way of peace, trade and religion. Entering the 21st century, Southeast Asia is one of the focal points in India’s strategic adjustment to the Asia-Pacific region because of its extremely important geo-political and geo-economical position. However, India’s foreign policy before 2014 (Look East Policy) was primarily “observation” rather than “action”. Since Prime Minister Narendra Modi came to power in May 2014, the Look East Policy has been adjusted into the Act East Policy to expand the goals, scope and areas of cooperation, and enhance the actions and strategic priorities in relations with its extended neighbor Southeast Asia.
Implication of the research: This adjustment has greatly impacted on India, Southeast Asian countries and the Vietnam - India Comprehensive Strategic Partnership. The article provides some policy implications for Vietnam to promote the Vietnam - India Comprehensive Strategic Partnership in the coming time.
Originality/ Value: This study is an elaborate, comprehensive and systematic work of the authors through an international approach.
 
Author response image 1. Author response
No full textAnimals can learn causal relationships between pairs of stimuli separated in time and this ability depends on the hippocampus. Such learning is believed to emerge from alterations in network connectivity, but large-scale connectivity is difficult to measure directly, especially during learning. Here, we show that area CA1 cells converge to time-locked firing sequences that bridge the two stimuli paired during training, and this phenomenon is coupled to a reorganization of network correlations. Using two-photon calcium imaging of mouse hippocampal neurons we find that co-time-tuned neurons exhibit enhanced spontaneous activity correlations that increase just prior to learning. While time-tuned cells are not spatially organized, spontaneously correlated cells do fall into distinct spatial clusters that change as a result of learning. We propose that the spatial re-organization of correlation clusters reflects global network connectivity changes that are responsible for the emergence of the sequentially-timed activity of cell-groups underlying the learned behavior. DOI: http://dx.doi.org/10.7554/eLife.01982.001
Acute and chronic effects of aspirin on hematological parameters and hepatic ferritin expression in mice
No full textOBJECTIVE: To examine the acute and chronic effects of aspirin on peripheral blood and bone marrow counts and hepatic ferritin expression in mice. MATERIAL AND METHODS: Adult male albino mice were orally administered aspirin at a dose of 600 mg/kg thrice daily for 7 days or 150 mg/kg once daily for 6/7 days up to 25 weeks. At the end of the experiment the red and white blood cell counts, hemoglobin, and packed cell volume were estimated. Bone marrow films were studied to estimate the rate of erythropoiesis and leucopoiesis. Expression of liver ferritin was tested by immunohistochemistry. RESULTS: Acute or chronic doses of aspirin reduced the RBC count, hemoglobin and other red cell indices as compared to controls. The WBC counts were higher in the treated animals as compared to the untreated animals. Both the treatment regimens appeared to suppress the rate of erythropoiesis in the marrow, while the rate of leucopoiesis appeared to increase in the marrow of the treated animals. Aspirin treatment did not significantly affect the expression of ferritin in the liver. CONCLUSION: Aspirin in either acute or chronic doses induces anemia associated with leucocytosis in mice; the anemia does not seem to be induced due to alterations in iron metabolism. The drug appears to use multiple targets which affect red cell production and maturation processes
Building resilient societies after COVID-19: the case for investing in maternal, neonatal, and child health
No full textResilient societies respond rapidly and effectively to health challenges and the associated economic consequences, and adapt to be more responsive to future challenges. Although it is only possible to recognise resilience retrospectively, the COVID-19 pandemic has occurred at a point in human history when, uniquely, sufficient knowledge is available on the early-life determinants of health to indicate clearly that a focus on maternal, neonatal, and child health (MNCH) will promote later resilience. This knowledge offers an unprecedented opportunity to disrupt entrenched strategies and to reinvest in MNCH in the post-COVID-19 so-called new normal. Furthermore, analysis of the short-term, medium-term, and longer-term consequences of previous socioeconomic shocks provides important insights into those domains of MNCH, such as neurocognitive development and nutrition, for which investment will generate the greatest benefit. Such considerations apply to high-income countries (HICs) and low-income and middle-income countries (LMICs). However, implementing appropriate policies in the post-COVID-19 recovery period will be challenging and requires political commitment and public engagement. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licens
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