1,720,954 research outputs found
Prophylactic central neck dissection in clinically node-negative papillary thyroid carcinoma: 10-year impact on surgical and oncologic outcomes
No full textBackground: The role of prophylactic central compartment lymph node dissection in clinically node-negative papillary thyroid carcinoma is debated. This study presents the findings from a 10-year follow-up of a single-institution randomized controlled trial assessing the role of prophylactic central compartment lymph node dissection in clinically node-negative papillary thyroid carcinoma. Methods: Between 2008 and 2010, a total of 196 patients with clinically node-negative papillary thyroid carcinoma were randomly assigned to 2 groups in a 1:1 ratio to undergo total thyroidectomy (group A) or total thyroidectomy with prophylactic central compartment lymph node dissection (group B). Patients received low-dose radioactive iodine treatment (30 mCi) postoperatively, with additional doses as needed. Monitoring included serum thyroglobulin, thyroglobulin antibodies, and neck ultrasound imaging. Results: At the end of the follow-up, 151 patients were analyzed, after 28 from group A and 17 from group B were excluded. The 2 groups were similar in age at diagnosis (P = .643), sex distribution (P = .735), body mass index (P = .134), ultrasound-estimated thyroid volume (P = .650), and histologic tumor features. After >10 years (12.9 ± 2 years), no significant differences were observed in surgical and oncologic outcomes. The mean thyroglobulin levels were 0.1 ± 0.1 ng/mL in group A and 0.3 ± 1.3 ng/mL in group B (P = .146). Both groups showed similar findings in the need for further surgery (P = .917), for additional radioactive iodine (P = .979), and mean radioactive iodine dosage (P = .822). No difference was documented in permanent recurrent laryngeal nerve palsy (P = .640), permanent hypocalcemia (P = .238), and serum calcium level (P = .181). The only observed distinction was more parathyroid removal in prophylactic central compartment lymph node dissection cases based on histologic examination (P = .005). Conclusion: Prophylactic central compartment lymph node dissection does not significantly affect surgical and oncologic outcomes in patients with clinically node-negative small papillary thyroid carcinoma after long-term follow-up
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Linfadenectomia profilattica del comparto centrale in pazienti con diagnosi di carcinoma papillare della tiroide: studio prospettico randomizzato con follow-up a dieci anni
No full textBackground: Il carcinoma papillare è l'istotipo più comune tra i tumori alla tiroide e spesso si presenta con metastasi nei linfonodi del collo. La prevalenza delle metastasi nel compartimento centrale è stata riportata essere fino al 65% nel carcinoma papillare della tiroide. La dissezione profilattica del compartimento centrale in pazienti senza evidenze di linfonodi sospetti in fase preoperatoria è ancora oggetto di dibattito, questo trattamento infatti sembra ridurre i tassi di recidiva e di mortalità del carcinoma papillare tiroideo, ma presenta un rischio maggiore di complicanze chirurgiche. Non sono ancora state definite delle raccomandazioni definitive.
Lo scopo di questo studio prospettico randomizzato è valutare i vantaggi e gli svantaggi clinici della dissezione dei linfonodi del compartimento centrale in modo profilattico (pCCND) dopo dieci anni di follow-up.
Materiali e metodi: Tra il 2008 e il 2010 un totale di 181 pazienti con carcinoma papillare della tiroide senza evidenza di metastasi linfonodali preoperatorie e/o intraoperatorie (cN0) sono stati assegnati in modo casuale al Gruppo A (n = 88), in cui sono stati trattaticon sola tiroidectomia totale (TTx), o al Gruppo B (n = 93), in cui sono stati trattati con la tiroidectomia totale associata alla dissezione linfonodale del comparto centrale (TTx + pCCND).
In questo studio prospettico randomizzato con follow-up a dieci anni sono stati analizzati i dati di un totale di 125 pazienti dei 196 trattati: 56 pazienti sono stati persi al follow-up.
Il Gruppo A includeva 56 pazienti (80,4% donne e 19,16% uomini) trattati TTx, mentre il Gruppo B includeva 69 pazienti (75,4% donne e 24,6% uomini) sottoposti a TTx + pCCND.
Risultati: i due gruppi erano comparabili per età (p: 0,644), BMI (p: 0,327) e volume della tiroide (p: 0,613). Dopo più di 10 anni (follow-up medio: 166 ± 10 mesi), non sono state osservate differenze nell'esito chirurgico e oncologico dei due gruppi. I livelli medi di tireoglobulina sierica (Tg) erano 0,43 ± 2,04 ng/ml nel Gruppo A e 0,24 ± 0,99 nel Gruppo B. Solo un paziente su 125 (0.8%), aveva livelli di anticorpi anti-Tg nel siero superiori a 15 IU/ml e non ha mostrato variazioni significative durante il follow-up.
Non sono state osservate differenze significative tra i due gruppi nemmeno per quanto riguarda il tasso di complicanze (ipoparatiroidismo permanente e paralisi permanente delle corde vocali) (p:0,967). Non sono state riscontrate differenze in termini di dose di radioiodio (p: 0,393) e numero di cicli (p: 0,530).
Conclusioni: i pazienti con carcinoma papillare della tiroide senza evidenze di linfonodi sospetti trattati con la sola tiroidectomia totale o con la tiroidectomia totale associata allo svuotamento profilattico dei linfonodi hanno mostrato risultati analoghi sia per quanto riguarda il tasso di recidiva e persistenza della malattia sia per quanto riguarda i tassi di complicanze
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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