948 research outputs found
A Bayesian geostatistical Moran Curve model for estimating net changes of tsetse populations in Zambia
No full textFor the first time a Bayesian geostatistical version of the Moran Curve, a logarithmic form of the Ricker stock recruitment curve, is proposed that is able to give an estimate of net change in population demographic rates considering components such as fertility and density dependent and density independent mortalities. The method is applied to spatio-temporally referenced count data of tsetse flies obtained from fly-rounds. The model is a linear regression with three components: population rate of change estimated from the Moran curve, an explicit spatio-temporal covariance, and the observation error optimised within a Bayesian framework. The model was applied to the three main climate seasons of Zambia (rainy – January to April, cold-dry – May to August, and hot-dry – September to December) taking into account land surface temperature and (seasonally changing) cattle distribution. The model shows a maximum positive net change during the hot-dry season and a minimum between the rainy and cold-dry seasons. Density independent losses are correlated positively with day-time land surface temperature and negatively with night-time land surface temperature and cattle distribution. The inclusion of density dependent mortality increases considerably the goodness of fit of the model. Cross validation with an independent dataset taken from the same area resulted in a very accurate estimate of tsetse catches. In general, the overall framework provides an important tool for vector control and eradication by identifying vector population concentrations and local vector demographic rates. It can also be applied to the case of sustainable harvesting of natural population
Recensiones [Revista de Historia Económica Año XI Primavera-Verano 1983 n. 2 pp. 437-463]
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Cytokine concentrations in pus of patients with HS.
No full text<p>(A) Concentrations of tumour necrosis factor-alpha (TNFα), interleukin (IL)-1β, IL-1α, IL-6, IL-10, IL-17 and Il-1ra were measured in the pus of the lesions of 28 patients of Hurley III disease stage. Lines represent medians. Correlations between (Β) the number of patrolling monocytes and pus TNFα; (C) the number of patrolling monocytes and pus IL-1β; and (D) IL-6 and years since disease onset. Classification patterns of patients according to pus cytokines is shown in panel E. Spearman’s coefficients of correlation and p values of significance are provided.</p
Um modelo para avaliação e implantação da mudança de um sistema de produção convencional para manufatura celular empregando simulação discreta
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção.Este trabalho apresenta um modelo para avaliação e implantação da mudança de um sistema de produção convencional para manufatura celular empregando simulação discreta. Usa-se a tecnologia de grupo como forma de criar as famílias de produtos. Analisam-se alternativas de layout celular para servir de base para a execução do modelo. Utiliza-se a simulação computacional como ferramenta de análise capaz de mensurar quantitativamente as mudanças introduzidas no sistema. Apresenta-se um estudo de caso de uma empresa metal-mecânica situada no sul de Santa Catarina. A partir da análise dos resultados e das conclusões efetuadas é possível ter-se uma idéia clara das vantagens obtidas em se migrar para um sistema de produção com células de manufatura, tais como: maior produtividade, menor tamanho do lote, menor lead time, melhor taxa de utilização do espaço físico e operadores mais polivalentes
Express?o imunoistoqu?mica dos receptores Toll-like 5 e 9 e do fator de transcri??o Foxp3 em les?es orais de l?quen plano e l?pus eritematoso
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Previous issue date: 2013-03-22The present study aimed at analyzing the expression of toll-like receptors (TLR) 5 and 9 and forkhead box p3 regulatory T cells transcription factor (Foxp3) in oral lesions of lichen planus and lupus erythematosus. Twenty-one biopsy specimens of lichen planus, 21 of lupus erythematosus and 21 of inflammatory fibrous hyperplasia (control group) were subjected to immunohistochemical staining with anti-TLR5, anti-TLR-9 and anti-Foxp3, whose expressions were quantified using Image Pro Plus 4.5.1 software (Media Cybernetics). Immunostaining for Foxp3 differed significantly between the three groups, where the highest levels were shown by lichen planus and the lowest ones by controls. TLR5 expression did not differ significantly between lupus erythematosus and control group, but it was significantly greater in these two groups than in lichen planus. When we considered the two types of lupus separately, there was no significant difference of TLR5 between lichen planus and systemic lupus erythematosus, but discoid lupus erythematosus as well as the control group showed significantly greater values than lichen planus. TLR9 immunostaining did not differ significantly between the groups analyzed. A weak negative correlation was observed between Foxp3 and TLR5 (r= -0.279), while there was no other correlation. When this analysis was performed within each group, no correlation was observed between the variables. In conclusion, Foxp3 expression is increased in oral lesions of lichen planus and lupus erythematosus, whereas TLR5 and TLR9 do not show increased expression in these lesions. Foxp3 and TLR5 are inversely correlated. Further investigations analyzing Treg cells and proinflammatory cytokines in these diseases are warranted.O presente estudo teve por objetivo avaliar o padr?o de express?o dos receptores toll-like (TLR) 5 e 9 e do fator de transcri??o forkhead box p3 (Foxp3) de c?lulas T regulat?rias em les?es orais de l?quen plano e l?pus eritematoso. Vinte e um esp?cimes de bi?psias de l?quen plano, 21 de l?pus eritematoso e 21 de hiperplasia fibrosa inflamat?ria (grupo-controle) foram submetidos a processamento imunoistoqu?mico com os marcadores anti-TLR5, anti-TLR9 e anti-Foxp3, e a quantifica??o da express?o desses marcadores foi realizada por meio do software Image Pro Plus 4.5.1 (Media Cybernetics). O padr?o de express?o do Foxp3 diferiu significativamente entre os tr?s grupos, sendo os maiores n?veis observados no grupo l?quen plano, e os menores, no grupo-controle. A express?o do TLR5 n?o diferiu significativamente entre os grupos l?pus eritematoso e controle, mas foi maior nesses grupos quando comparados ao grupo l?quen plano. Ao discriminarem-se os subtipos de l?pus eritematoso sist?mico e discoide, n?o foi verificada diferen?a significativa na express?o do TLR5 entre l?quen plano e l?pus sist?mico, mas foram verificados maiores n?veis desse marcador no l?pus discoide e no grupo-controle quando comparados ao grupo l?quen plano. O padr?o de express?o do TLR9 n?o diferiu significativamente entre os grupos. Foxp3 e TLR5 apresentaram correla??o negativa fraca (r= -0.279). As demais vari?veis n?o apresentaram correla??o, mesmo quando analisadas intragrupo. Os resultados do presente estudo permitem concluir que a express?o de Foxp3 est? aumentada em les?es orais de l?quen plano e l?pus eritematoso, enquanto TLR5 e TLR9 n?o exibem maior express?o nessas les?es; Foxp3 e TLR5 est?o inversamente correlacionados. Novas investiga??es sobre c?lulas T regulat?rias, receptores toll-like e citocinas pr?-inflamat?rias fazem-se necess?rias para o melhor entendimento de doen?as como l?quen plano e l?pus eritematoso
Diagn?stico diferencial de les?es orais de l?quen plano e l?pus eritematoso por meio de imunoistoqu?mica e PAS = Differential diagnosis of lichen planus and lupus erythematosus oral lesions using immunohistochemistry and PAS
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Previous issue date: 2011-08-26As les?es orais do l?quen plano e do l?pus eritematoso exibem apar?ncia cl?nica e histopatol?gica similar, o que dificulta o diagn?stico. A presente pesquisa teve por objetivo investigar crit?rios de diagn?stico diferencial das les?es orais das duas doen?as por meio de PAS e imunoistoqu?mica. Pacientes portadoras de les?es orais de l?quen plano (n=21) e de l?pus eritematoso (n=23) foram submetidas ? bi?psia incisional das les?es, e o diagn?stico cl?nico foi confirmado por HE e imunofluoresc?ncia direta. Ap?s a confirma??o diagn?stica, os esp?cimes foram submetidos ? colora??o por PAS e processamento imunoistoqu?mico. As imagens histol?gicas foram avaliadas no programa Image ProPlus 5.4.1, sendo quantificadas a express?o imunoistoqu?mica de CD1a, CD4, CD8, CD20, caspase-3, triptase e a espessura da membrana basal. A express?o imunoistoqu?mica de CD1a foi significativamente maior no grupo l?quen plano, tanto para epit?lio, quanto para conjuntivo. A express?o de CD4 e CD20 em epit?lio n?o diferiu significativamente entre l?quen plano e l?pus eritematoso; entretanto, no tecido conjuntivo foi significativamente maior para o grupo l?quen plano. A express?o de CD8 foi maior no l?quen, tanto para epit?lio quanto para conjuntivo. A express?o da caspase-3 n?o diferiu significativamente entre os grupos, enquanto a express?o da triptase foi maior no epit?lio das les?es de l?pus eritematoso. A espessura da membrana basal n?o exibiu diferen?a estatisticamente significativa entre os grupos. Os resultados permitem concluir que (1) a express?o imunoistoqu?mica de CD1a, CD4, CD8, CD20, caspase-3 e triptase, bem como a espessura da membrana basal em PAS n?o constituem crit?rios definidores para diagn?stico diferencial entre les?es orais de l?quen plano e de l?pus eritematoso; (2) a express?o imunoistoqu?mica de CD4, CD8 e CD20 ? maior nas les?es orais de l?quen plano do que nas de l?pus, o que sugere que, no l?quen, o infiltrado seja mais rico em linf?citos; (3) a triptase est? mais expressada no epit?lio das les?es orais de l?pus eritematoso, enquanto o CD1a prevalece tanto em epit?lio quanto em conjuntivo das les?es orais de l?quen plano; (4) as les?es orais de l?quen plano e l?pus eritematoso parecem diferir no que se refere ao ant?geno que suscita a resposta inflamat?ria, mas partilham a apoptose de c?lulas epiteliais e inflamat?rias em sua patogeni
Construction and validation of science culture index : Results from comparative analysis of engagement knowledge and attitudes to science: India and Europe
No full textCountries world-wide routinely collate statistics on STS performance indicators such as R&D expenditure, science publications, citations and impact, high-tech employment, and penetration of high-tech goods. In parallel there have been several, but often isolated, attempts to define complementary ‘public understanding of science (PUS)’ indicators including concepts such as scientific literacy, public sentiment, interest, and attitudes. This has been somewhat successful, but also controversial. Thus, little progress has been achieved to explicitly combine STS performance indicators and PUS indicators in a composite index of ‘science culture’. This exercise draws conceptual and methodological material used in the construction of such a composite index based on a combined data base of EU (32 countries) and India (23 States). On the basis of these 55 ‘state units’ the theoretical basis, feasibility and validity of a globally portable index of science culture is demonstrated. Details of the analytical options considered and decisions made, particularly in regard to integration of two data sets, identifying and defining indicators, constructing composite indices and finally its validation has been discussed. The discussion inevitably involves a degree of EU-India specific analyses, however, the methodological issues and suggested solutions are of broader interest to researchers on the topic in other contexts.Science culture index
Construção do mapa base para sistemas de informações geográficas :: uma proposta baseada no levantamento das necessidades de usuários de informações cartográficas sediados em Florianópolis, SC /
No full textDissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.Este trabalho apresenta uma proposta de um modelo do mapa base para construção de sistema de informações geográficas, elaborada a partir de dados do levantamento das necessidades de usuários de informações cartográficas sediados em Florianópolis, SC, do resultado da avaliação de uma amostra de produtos cartográficos digitais e, do estudo de alguns recursos computacionais atualmente disponíveis para as atividades cartográficas
Construction and Validation of ‘Science Culture Index’
No full textCountries world-wide routinely collate statistics on STS performance indicators such as R&D expenditure, science publications, citations and impact, high-tech employment, and penetration of hightech goods. In parallel there have been several, but often isolated, attempts to define complementary public understanding of science (PUS) indicators including concepts such as scientific literacy, public sentiment, interest, and attitudes. This has been somewhat successful, but also controversial. Thus, little progress has been achieved to explicitly combine STS performance indicators and PUS indicators in a composite index of science culture. This exercise draws conceptual and methodological material used in the construction of such a composite index based on a combined data base of EU (32 countries) and India (23 States). On the basis of these 55 state units the theoretical basis, feasibility and validity of a globally portable index of science culture is demonstrated. Details of the analytical options considered and decisions made, particularly in regard to integration of two data sets, identifying and defining indicators, constructing composite indices and finally its validation has been discussed. The discussion inevitably involves a degree of EU-India specific analyses, however, the methodological issues and suggested solutions are of broader interest to researchers on the topic in other contexts.science culture, EU, India, public understanding of science, STS, indicators
Usage de la coudée dans l'architecture palatiale de Chypre au premier millénaire
No full textInternational audiencePendant la campagne de 1997 au palais d'Amathonte, une base de colonne a été découverte dans le sol du premier état du palais (ca. 800 av. J.-C.). Son diamètre, comparable à celui d'autres colonnes du palais et du péristyle du palais de Vouni (nord de l'île), correspond à la coudée, unité métrologique utilisée au Proche-Orient. A Chypre, elle diffère de la coudée égyptienne, palestinienne ou mésopotamienne mais est identique à la coudée syro-anatolienne
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