3,155 research outputs found
Heart rate variability and target organ damage in hypertensive patients
No full textBackground:
We evaluated the association between linear standard Heart Rate Variability (HRV) measures and vascular, renal and cardiac target organ damage (TOD).
Methods:
A retrospective analysis was performed including 200 patients registered in the Regione Campania network (aged 62.4 ± 12, male 64%). HRV analysis was performed by 24-h holter ECG. Renal damage was assessed by estimated glomerular filtration rate (eGFR), vascular damage by carotid intima-media thickness (IMT), and cardiac damage by left ventricular mass index.
Results:
Significantly lower values of the ratio of low to high frequency power (LF/HF) were found in the patients with moderate or severe eGFR (p-value < 0.001). Similarly, depressed values of indexes of the overall autonomic modulation on heart were found in patients with plaque compared to those with a normal IMT (p-value <0.05). These associations remained significant after adjustment for other factors known to contribute to the development of target organ damage, such as age. Moreover, depressed LF/HF was found also in patients with left ventricular hypertrophy but this association was not significant after adjustment for other factors.
Conclusions:
Depressed HRV appeared to be associated with vascular and renal TOD, suggesting the involvement of autonomic imbalance in the TOD. However, as the mechanisms by which abnormal autonomic balance may lead to TOD, and, particularly, to renal organ damage are not clearly known, further prospective studies with longitudinal design are needed to determine the association between HRV and the development of TOD
I am style : Tilda Swinton as Emma in Luca Guadagnino's I Am Love
No full textThis article examines the relationship between costume and character, self and appearance in Luca Guadagnino’s film, Io Sono l’Amore/I Am Love (Guadagnino, 2009). As played by Tilda Swinton, Emma Recchi is a woman whose dress reveals a meticulous record of her emotional journey, providing an almost textbook case of costume performing emotional exteriority. Complicating any straightforward analysis of costume design in I Am Love, however, is a deep fashion consciousness that pervades the film and goes beyond the widely publicized association with fashion houses, Jil Sander, Fendi and Hermès, to a recognition of fashion as a complex discourse able to canvas multiple, even contradictory, interpretations. Just as Guadagnino draws on other narratives and other films to tell his story, Swinton’s off-screen life and on-screen personae shadow her portrayal of Emma, constructing a character who is both the unique individual of I Am Love and the hollow image of fashion that is the Emma of ‘I Am Style’
Implementing non-invasive positive pressure ventilation approach to respiratory failure after cardiac surgery: devil is in the detail.
No full textNeuro-Immune Hemostasis: Homeostasis and Diseases in the Central Nervous System.
No full textCoagulation and the immune system interact in several physiological and pathological conditions, including tissue repair, host defense, and homeostatic maintenance. This network plays a key role in diseases of the central nervous system (CNS) by involving several cells (CNS resident cells, platelets, endothelium, and leukocytes) and molecular pathways (protease activity, complement factors, platelet granule content). Endothelial damage prompts platelet activation and the coagulation cascade as the first physiological step to support the rescue of damaged tissues, a flawed rescuing system ultimately producing neuroinflammation. Leukocytes, platelets, and endothelial cells are sensitive to the damage and indeed can release or respond to chemokines and cytokines (platelet factor 4, CXCL4, TNF, interleukins), and growth factors (including platelet-derived growth factor, vascular endothelial growth factor, and brain-derived neurotrophic factor) with platelet activation, change in capillary permeability, migration or differentiation of leukocytes. Thrombin, plasmin, activated complement factors and matrix metalloproteinase-1 (MMP-1), furthermore, activate intracellular transduction through complement or protease-activated receptors. Impairment of the neuro-immune hemostasis network induces acute or chronic CNS pathologies related to the neurovascular unit, either directly or by the systemic activation of its main steps. Neurons, glial cells (astrocytes and microglia) and the extracellular matrix play a crucial function in a "tetrapartite" synaptic model. Taking into account the neurovascular unit, in this review we thoroughly analyzed the influence of neuro-immune hemostasis on these five elements acting as a functional unit ("pentapartite" synapse) in the adaptive and maladaptive plasticity and discuss the relevance of these events in inflammatory, cerebrovascular, Alzheimer, neoplastic and psychiatric diseases. Finally, based on the solid reviewed data, we hypothesize a model of neuro-immune hemostatic network based on protein-protein interactions. In addition, we propose that, to better understand and favor the maintenance of adaptive plasticity, it would be useful to construct predictive molecular models, able to enlighten the regulating logic of the complex molecular network, which belongs to different cellular domains. A modeling approach would help to define how nodes of the network interact with basic cellular functions, such as mitochondrial metabolism, autophagy or apoptosis. It is expected that dynamic systems biology models might help to elucidate the fine structure of molecular events generated by blood coagulation and neuro-immune responses in several CNS diseases, thereby opening the way to more effective treatments
Caractérisation de relations de proximité temporelle, spatiale et sémantique pour l'exploration d'un corpus d'images photographiques
No full textContributors: Laura Willot (LW), D Vodislav (DV), Livio De Luca (LDL), Valérie Gouet-Brunet (VGB), Adeline Manuel (AM).CRediT (https://credit.niso.org/): Conceptualization : LW, DV, LDL, VGB, AM; Data curation : LW; Funding acquisition : DV, LDL, VGB; Methodology : LW, DV, LDL, VGB, AM; Project administration : DV, LDL, VGB; Software : LW, AM; Supervision : DV, LDL, VGB, AM; Visualization : LW; Writing – original draft : LW; Writing – review & editing : LW, DV, LDL, VGB, AM.International audienceLes images prennent une place importante au sein des travaux des différents chercheurs du Chantier Scientifique mais la quantité massive et la diversité des regards portés sur ces images rend leur exploration "manuelle" difficile. Cette présentation s'inscrit dans le cadre d'une thèse portant sur la structuration, l'exploration et l'exploration d'un corpus de plusieurs dizaines de milliers d'images par la mise en place de méthodes (semi-)automatiques. La notion de similarité, fondamentale dans notre apporche exploratoire du corpus d'images, est définie dans un premier temps. Une description détaillée des images et de leurs métadonnées est ensuite présentée, suivie d'une introduction du modèle de données utilisé pour l'implémentation d'une base de données orientée graphe. La notion de graph embedding est ensuite définie et employée comme outil exploratoire du corpus d'images via des mesures de distance/similarité
Implementing non-invasive positive pressure ventilation approach to respiratory failure after cardiac surgery: devil is in the detail
No full textPerfil epidemiológico das complicações infecciosas adquiridas na UTI do HU-UFSC
No full textTrabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina. Departamento de Clínica Médica
Influence of chronic Naltrexone treatment on growth hormone and insulin secretion in obese subjects.
No full text
Uno ex operariis et manualibus. Il contributo di Nicola Zabaglia (1664-1750) all'arte di formar macchine e ponti tra XVII e XIX secolo
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