58 research outputs found
Her and Me becoming Three
No full textThe Live Art event that happened world-wide and was live streamed, on Saturday 31st of October 2020 between 10-11 am GMT. Artists in different countries communed simultaneously with a local tree or woodland and stream their action to audiences via a shared Zoom conference.
Presenting work by and from:
O. Pen Be (UK), Danielle Imara (UK), Jatun Risba (SLO), Anne Murray (HUN), Surya Tüchler (DE), Phil Barton (UK), Annette Arlander (FIN), Izabela Waszak (SCT), Lucy Stockton-Smith (UK), Agathe Gizard (FR), Lea Jazbec (SLO), Franco G. Livera (ITA), Adam Engler(PT), Myriam Aitelhara (ALG), Emi Bici (DE), Peter Purg (SLO), Dimple B Shah (IND), Deej Fabyc & MJ Forde (IRL), Christine Fentz (FR), Sally Annett (FR)
Efeitos da inulina nas propriedades físicas, químicas, de textura e aceitabilidade no desenvolvimento de muffin destinado a consumidores em idade escolar
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-graduação em Ciência dos alimentos, Florianópolis, 2013A obesidade infantil já é epidemia; o problema é global e se estende por todo o mundo, inclusive no Brasil. A prevalência crescente de excesso de peso deriva de fatores que determinam as escolhas alimentares, dentre eles, palatabilidade e disponibilidade, principalmente para crianças que costumam comer somente aquilo que gostam. O objetivo deste estudo foi investigar as preferências alimentares de escolares com idade de 7 a 10 anos e suas percepções sobre alimentos saudáveis e saborosos para que fosse desenvolvido um lanche saudável e sensorialmente bem aceito por essa população. Foram realizados 26 grupos focais e, após análise de conteúdo, o lanche desejado pela população estudada foi um muffin. A fórmula-base dos muffins foi retirada da literatura e, uma vez definida, foi investigado em que concentrações (2%, 5% e 8%) a inulina influenciou as características físico-químicas, a cor, as propriedades de textura, características de poros da massa e aceitabilidade global do produto. As diferenças entre as amostras foram avaliadas por meio de análise de variância seguida de teste de Tukey. O coeficiente de correlação de Pearson também foi aplicado, com nível de significância de 5% (p < 0,05). Diferenças significativas (p <0,05) foram encontradas entre as amostras para o teor de gordura, fibra alimentar, umidade e valor energético. A adição de inulina reduziu aproximadamente 70% o conteúdo de gordura dos muffins, contribuindo com a diminuição de seu valor calórico. Nas análises de coloração de crosta, a amostra contendo a maior quantidade de inulina (8%) apresentou os maiores valores de L*. Para os valores de a* e b*, não foram significativas as diferenças entre o muffin-controle e as demais amostras. Na avaliação da cor do miolo, a amostra contendo 8% de inulina também obteve maior luminosidade. Em relação a valores de a*, o muffin contendo 8% de inulina foi significativamente diferente de todos os outros, apresentando valores mais elevados que a amostra-padrão. Diferenças significativas foram observadas na dureza, elasticidade, coesividade e mastigabilidade entre todas as amostras. Dentre elas, a amostra com 8% de inulina foi a que apresentou mais semelhança nos parâmetros de perfil de textura, quando comparada à amostra-controle. A imagem do muffin com 2% de inulina foi a mais heterogênea quanto ao número de poros da massa, apresentando pequenos, médios e grandes poros. A amostra com 8% de inulina foi a que apresentou a maior quantidade de poros em tamanhos mais homogêneos. Quanto à aceitabilidade, as amostras contendo inulina não diferiram significativamente (p <0,05) do controle. . A quantidade máxima de inulina testada (8%) foi a que manteve as características físicas, de perfil de textura, cor e aceitabilidade global do muffin mais semelhantes àquelas do controle. Uma das maiores diferenças apresentadas foi a quantidade de gordura; sua diminuição deixou o produto significativamente menos calórico. A modificação na quantidade de fibra também foi bastante expressiva. Além das características apontadas, o tamanho e a quantidade dos poros da massa também foram alterados com as diferentes quantidades de inulina. Os resultados demonstram que a substituição de gordura por 8% de inulina não apresentou diferença significativa na maioria das análises, quando comparada a amostra controle <br
Epididymitis rates in Australian hospitals 2009-2018: Ecological analysis
No full textObjectives To investigate rates of acute epididymitis diagnosed in Australian hospital settings. Methods Yearly hospital admission and emergency department (ED) rates of epididymitis as primary diagnoses were calculated for 15-44-year-old men for three states (Victoria, New South Wales, Queensland) from 2009 to 2014 using population denominators. Zero inflated Poisson regression models were used to analyse variation in rates by year, age, and residential area. Additionally, we investigated national epididymitis admission trends from 2009 to 2018 using generalised linear models. Results Between 2009 and 2014, there was a total of 7375 admissions and 17 281 ED presentations for which epididymitis was the main reason for care. Most epididymitis diagnoses (94.0% in admissions, 99.7% in EDs) were without abscess, and 2.5% of admissions were for chlamydial epididymitis. Almost a quarter (23.3%) of epididymitis diagnosed in EDs resulted in hospital admission. In 2014, the epididymitis rate per 100 000 men was 38.7 in admissions and 91.9 in EDs. Comparing 2014 with 2009, the overall epididymitis diagnosis rate increased in admissions by 32% (adjusted incident rate ratio (aIRR) 1.32, 95% CI 1.20 to 1.44) and in ED attendances by 40% (aIRR 1.40, 95% CI 1.31 to 1.49). By age, the highest rates were among men 35-44 years in admissions and men 15-24 years in EDs. National admission rates of epididymitis during 2009-2018 showed a similar pattern. Conclusion Rates of epididymitis diagnosis in hospital admission and ED presentations increased. Different age-related rates in these settings suggest a different aetiology or differential severity by age group
Multiple imputation methods for handling missing values in longitudinal studies with sampling weights: Comparison of methods implemented in Stata
No full textMany analyses of longitudinal cohorts require incorporating sampling weights to account for unequal sampling probabilities of participants, as well as the use of multiple imputation (MI) for dealing with missing data. However, there is no guidance on how MI and sampling weights should be implemented together. We simulated a target population based on the Australian Bureau of Statistics Estimated Resident Population and drew 1000 random samples dependent on three design variables to mimic the Longitudinal Study of Australian Children. The target analysis was the weighted prevalence of overweight/obesity over childhood. We evaluated the performance of several MI approaches available in Stata, based on multivariate normal imputation (MVNI), fully conditional specification (FCS) and twofold FCS: a weighted imputation model, imputing missing data separately for each quintile sampling weight grouping, including the design stratum indicator in the imputation model, and using sampling weights as a covariate in the imputation model. Approaches based on available cases and inverse probability weighting (IPW), with time-varying weights, were also compared. We observed severe issues of convergence with FCS and twofold FCS. All MVNI-based approaches performed similarly, producing minimal bias and nominal coverage, except for when imputation was conducted separately for each quintile sampling weight group. IPW performed equally as well as MVNI-based approaches in terms of bias, however, was less precise. In similar longitudinal studies, we recommend using MVNI with the design stratum as a covariate in the imputation model. If this is unknown, including the sampling weight as a covariate is an appropriate alternative
Determinación de hemoglobinopatías y anemia ferropénica en población estudiantil Afrodescendiente de la Universidad Colegio Mayor de Cundinamarca
No full textLa población afrodescendiente en Colombia va en constante crecimiento cada año según cifras del DANE y como consecuencia las enfermedades genéticas asociadas a dicha etnia, lo que representa un grave problema de salud pública en el mundo, según la organización mundial de la salud las hemoglobinopatías se encuentran en un 71% de los países y cada año nacen en el mundo 330.000 niños afectados con este tipo de alteraciones en su molécula de hemoglobina, afectando principalmente a los ya denominados afrodescendientes, los cuales se encuentran en su mayoría en países del sur del continente americano como: Brasil, Cuba, Ecuador, Costa rica, Colombia, entre otros. En Colombia el porcentaje de población afrodescendientes corresponde al 10,4% según el censo realizado en 2005 por el DANE lo que corresponde a un total de 4’311.757 habitantes, esto acompañado por desplazamiento (6.3 %) y migración por violencia (6.8%) realizado por estas comunidades , ha contribuido al aumento de intercambio genético y con ello la aparición de hemoglobinopatías en el país, en cuanto a la anemia por deficiencia de hierro, tiene una prevalencia en el país de entre el 20 - 39,9% en la población afrocolombiana, en el mismo censo realizado por el DANE en el año 2005 el 14,32% (612.194 personas) de la población negra y afrocolombiana declararon haber pasado días de ayuno en la semana previa al Censo 6,49,50. Este trabajo tiene como objetivo determinar hemoglobinopatías y anemia ferropénica en población Afrodescendiente de la Universidad Colegio Mayor de Cundinamarca mediante el examen de frotis de sangre periférico, cuadro hemático, ferritina, electroforesis de hemoglobina ácida y alcalina, en esta forma se identificaron portadores sanos de beta-talasemia, hemoglobina C y deficiencias subclínicas de hierro. Además, se concientizo a la población en estudio sobre la necesidad de una consejería genética.1. Antecedentes 13
2. Marco teórico 25
2.1 Eritrocito 25
2.2 Molécula de hemoglobina 25
2.3 Anemia 26
2.4 Anemia ferropénica 27
2.5 Ferritina 28
2.6 Transferrina 29
2.7 Receptores solubles de transferrina 29
2.8 Hierro sérico 30
2.9 Estados de deficiencia del hierro 31
2.10 Metabolismo del hierro 33
2.11 Hemoglobinopatías 34
2.12 Electroforesis de hemoglobina 39
3. Diseño metodológico 40
3.1 Diseño muestral y tipo de investigación 40
3.2 Universo 40
3.3 Muestra 41
3.4 Variables 41
3.5 Técnicas y parámetros para recolección de la información 41
3.6 Procedimiento 43
4. Reporte y análisis de resultados 45
5. Discusión 59
6. Conclusiones 64
7. Referencias 66PregradoBacteriólogo(a) y Laboratorista ClínicoTrabajo de grad
Lifestyle, medication and socio-demographic determinants of mental and physical health-related quality of life in people with multiple sclerosis
No full textBACKGROUND: Health-related quality of life (QOL) is a key outcome for people with multiple sclerosis (MS). While modifiable lifestyle factors, like smoking, physical activity and vitamin D, have strong associations with development and progression of MS, few studies have examined such associations with QOL. METHODS: Using patient-reported data from 2312 people with MS from 54 countries, regression models explored associations of socio-demographic, therapeutic and lifestyle factors with QOL, using the Multiple Sclerosis Quality of Life-54 (MSQOL-54). RESULTS: Participants were on average 45.6 years old, 82.4% women, mostly partnered (74.1%), with a university degree (59.5%). Controlling for socio-demographic factors and disability, factors associated with better physical health composite (PHC) (on a 100 point scale) were: moderate and high physical activity compared to low (5.9 [95% confidence interval: 4.2, 7.6] and 9.9 [CI: 8.1, 11.6] points higher score respectively); non-smoking compared to current smoking (4.6 points [CI: 2.4, 6.7]); better diet (per 10 points on the 100 point Diet Habits Questionnaire scale (DHQ) 1.6 points [CI: 1.0, 2.2] points); normal body mass index (BMI) versus overweight or obese (2.1 points [CI: 0.4, 3.7] and 2.4 points [CI: 0.5, 4.3]); fewer comorbidities (4.4 points [CI: 3.9, 4.9]); and not taking a disease-modifying drug (DMD) (2.1 points [CI: 0.7, 3.4]). Better mental health composite (MHC) determinants were: moderate and high physical activity compared to low (4.0 points [CI: 2.0, 6.0] and 5.7 points [CI: 3.5, 8.0]); non-smoking compared to current (6.7 points [CI: 4.1, 9.3]); better diet (2.8 points [CI: 1.9, 3.5]); normal BMI versus overweight or obese (3.1 points [CI: 1.1, 5.1] and 3.5 points [CI: 1.3, 5.7]); meditating regularly (2.2 points [CI: 0.2, 4.2]); and no DMD use (2.9 points [CI: 1.3, 4.6]). CONCLUSIONS: While causality cannot be concluded from cross-sectional data, the associations between modifiable lifestyle factors and QOL suggest significant potential for secondary prevention of the known deterioration of QOL for people with MS through lifestyle risk factor modification
Evaluating the efficacy and safety of GKT137831 in adults with type 1 diabetes and persistently elevated urinary albumin excretion: A statistical analysis plan
No full textBACKGROUND: The investigational medicinal product GKT137831 is a selective inhibitor of NOX 1 and 4 isoforms of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase family of enzymes, which has the potential to ameliorate diabetic kidney disease. An investigator-initiated, double-blind, randomised, placebo-controlled, multicentre phase 2 clinical trial started recruitment in December 2017, with the aim of evaluating the efficacy and safety of GKT13783, in adults with type 1 diabetes mellitus and persistently elevated urinary albumin excretion over a period of 48 weeks. METHODS/DESIGN: The trial is currently recruiting in Australia and New Zealand, with recruitment expected to end on 30 June 2020. The primary outcome measure of the trial is the urinary albumin excretion level measured at 48 weeks of treatment. This statistical analysis plan presents an update to the published trial protocol and provides a comprehensive description of the statistical methods that will be used for the analysis of the data from this trial. In doing so, we follow the "Guidelines for the content of statistical analysis plans in clinical trials" to support transparency and reproducibility of the trial findings. DISCUSSION: With the use of this prior statistical analysis plan, we aim to minimise bias in the reporting of the findings of this trial, which evaluates the investigational medicinal product GKT137831. The results of the trial are expected to be published in 2022. TRIAL REGISTRATION: ANZCTR registry: ACTRN12617001187336. Registered on 14 July 2017. Universal Trial Number: U1111-1187-2609; Protocol number: T1DGKT137831; Genkyotex trial number: GSN000241
Psychological shift in partners of people with multiple sclerosis who undertake lifestyle modification: An interpretive phenomenological study
No full textUNLABELLED: Introduction: Being in an intimate relationship with a person with multiple sclerosis (MS) may have a substantial impact on the partner's quality of life. Existing research has largely focused on negative impacts of MS for both people with MS (PwMS) and their partners and has sampled the population of partners of PwMS who have primarily adopted standard medical management only. Modifiable lifestyle factors have become increasingly recognized in the management of MS symptoms and disease progression. For partners of PwMS who have undertaken lifestyle modification as an additional strategy to minimize disease progression, the impacts, both positive and negative remain unexplored. This research is unique as it focuses on partners of PwMS who have attempted to adopt major lifestyle interventions outside of the prevailing paradigm of MS management. Aim: To explore and interpret the lived experiences of partners of PwMS who have adopted lifestyle modification, to understand partners' attitudes to and experiences of the effect of MS and lifestyle modification on their life, relationship and view of the future. Method: Design: a qualitative, interpretive, phenomenological study using semi-structured interviews. PARTICIPANTS: English-speaking; aged 18 years or more; in a spousal relationship for 12 months or more with a person with MS who had attended a residential lifestyle educational intervention and undertaken lifestyle modification. ANALYSIS: Interviews were recorded, transcribed verbatim and thematically analyzed using NVivo™ software. Results: Twenty-one partners were interviewed. This paper reports one of the study's themes, the psychological shift experienced by partners of PwMS. Sub-themes included adaptation; loss and grief; difficult emotions; reframing, re-evaluating and re-prioritizing; hope and optimism; empowerment and taking control; and self-awareness, greater understanding and personal growth. Conclusion: Partners of PwMS who have undertaken lifestyle modification experienced a broad range of psychological adjustments. Whilst reflecting the potential difficulties that partners of PwMS may experience, this group experienced a range of positive psychological changes that add to the literature regarding partners' potential experiences and may provide hope for those in partnerships with people with MS. This study provides themes to potentially inform a quantitative study of a larger population of partners of PwMS
On the path together: Experiences of partners of people with multiple sclerosis of the impact of lifestyle modification on their relationship
No full textMultiple sclerosis (MS) has a major impact on the relationship of couples living with the illness. Although some positives of dealing with MS as a couple have been identified, MS has been associated with higher rates of relationship breakdown and worse Quality of Life (QOL) for both people in the relationship, especially if the person with MS experiences a decline in mental or physical health or develops disability. Modification of lifestyle-related risk factors has been associated with improved outcomes for people with MS, including physical and mental health-related QOL, and these improved outcomes may lead to improved experiences for their partners. We aimed to explore the perspectives and experiences of the partners of people with MS, when the people with MS had undertaken an intensive residential workshop regarding healthy lifestyle, to understand the impact of MS and lifestyle modification on these partners' experiences of their relationship. Within the framework of Heidegger's interpretive phenomenology, semi-structured interviews were thematically analysed. Participants were in a spousal relationship with people with MS who had attended an intensive residential workshop regarding modification of lifestyle-related risk factors between 2002 and 2016. Participants lived in Australia, New Zealand, the United Kingdom and Europe. Three major themes were identified relating to the couple's relationships: providing support, remaining connected and togetherness. Aspects of these themes, not commonly previously reported, included the personal and relationship benefits experienced from providing support with lifestyle modification, improved communication, and the resultant greater sense of closeness. These experiences of partners of people with MS improve our understanding of both the complexities of living with MS and adopting lifestyle modification, and suggest some potential benefits to relationships
Associations of lifestyle, medication, and socio-demographic factors with disability in people with multiple sclerosis: An international cross-sectional study
No full textOBJECTIVE: Emerging evidence links modifiable lifestyle risk factors to disease progression in multiple sclerosis (MS). We sought further evidence around this hypothesis through detailed analysis of the association with disability of lifestyle behaviours of a large international sample of people with MS. MATERIALS AND METHODS: A total of 2469 people with MS from 57 countries provided self-reported data via cross-sectional online survey on lifestyle (mostly with validated tools) and the primary outcome measure, disability (Patient Determined Disease Steps), categorised from 8 steps into 3 categories, mild, moderate and major disability. Multinomial logistic regression modelling derived relative risk ratios (RRRs) for disability categories. RESULTS: RRRs of having moderate vs mild disability were: diet (per 30 points on 100 point scale) 0.72 (95%CI 0.52-0.98), ever smoking 1.32 (1.06-1.65), exercise (moderate/high vs low) 0.35 (0.28-0.44), latitude (per degree from the equator) 1.02 (1.01-1.04), and number of comorbidities (2 vs none) 1.43 (1.04-1.95), (3 vs none) 1.56 (1.13-2.16). RRRs of having major vs mild disability were: exercise (moderate/high vs low) 0.07 (0.04-0.11), alcohol consumption (moderate vs low) 0.45 (0.30-0.68), plant-based omega 3 supplementation 0.39 (0.18-0.86), and disease-modifying medication use 0.45 (0.29-0.70). CONCLUSIONS: Healthier lifestyle has strong associations with disability in our large international sample of people with MS, supporting further investigation into the role of lifestyle risk factors in MS disease progression
- …
