771 research outputs found
Markers and indices of infection in critically ill patients
No full textGirbes, A.R.J. [Promotor]Beishuizen, A. [Copromotor]Lange, D.W. de [Copromotor
Epidemiology and risk factors for mortality in critically ill patients with pancreatic infection
No full texthttp://dx.doi.org/10.13039/501100013347 European Society of Intensive Care Medicinehttp://dx.doi.org/10.13039/100004319 Pfize
Correction to Collaborators in Acknowledgments in: Decision-Making on Withholding or Withdrawing Life Support in the ICU: A Worldwide Perspective (Chest (2017) 152(2) (321–329), (S0012369217308206), (10.1016/j.chest.2017.04.176))
No full textThe authors have reported to CHEST that the collaborators from the ICON Investigators were omitted from the Acknowledgments in “Decision-Making on Withholding or Withdrawing Life Support in the ICU: A Worldwide Perspective” (Chest. 2017;152(2):321-329). The corrected Acknowledgments are as follows: ∗ICON Investigators: E. Tomas, E. Amisi Bibonge, B. Charra, M. Faroudy, L. Doedens, Z. Farina, D. Adler, C. Balkema, A. Kok, S. Alaya, H. Gharsallah, D. Muzha, A. Temelkov, G. Georgiev, G. Simeonov, G. Tsaryanski, S. Georgiev, A. Seliman, S. Vrankovic, Z. Vucicevic, I. Gornik, B. Barsic, I. Husedzinovic, P. Pavlik, J. Manak, E. Kieslichova, R. Turek, M. Fischer, R. Valkova, L. Dadak, P. Dostal, J. Malaska, R. Hajek, A. Židková, P. Lavicka, J. Starkopf, Z. Kheladze, M. Chkhaidze, V. Kaloiani, L. Medve, A. Sarkany, I. Kremer, Z. Marjanek, P. Tamasi, I. Krupnova, I. Vanags, V. Liguts, V. Pilvinis, S. Vosylius, G. Kekstas, M. Balciunas, J. Kolbusz, A. Kübler, B. Mielczarek, M. Mikaszewska-Sokolewicz, K. Kotfis, B. Tamowicz, W. Sulkowski, P. Smuszkiewicz, A. Pihowicz, E. Trejnowska, N. Hagau, D. Filipescu, G. Droc, M. Lupu, A. Nica, R. Stoica, D. Tomescu, D. Constantinescu, G. Valcoreanu Zbaganu, S. Adriana, V. Bagin, D. Belsky, S. Palyutin, S. Shlyapnikov, D. Bikkulova, A. Gritsan, G. Natalia, E. Makarenko, V. Kokhno, A. Tolkach, E. Kokarev, B. Belotserkovskiy, K. Zolotukhin, V. Kulabukhov, L. Soskic, I. Palibrk, R. Jankovic, B. Jovanovic, M. Pandurovic, V. Bumbasirevic, B. Uljarevic, M. Surbatovic, N. Ladjevic, G. Slobodianiuk, V. Sobona, A. Cikova, A. Gebhardtova, C. Jun, S. Yunbo, J. Dong, S. Feng, M. Duan, Y. Xu, X. Xue, T. Gao, X. Xing, X. Zhao, C. Li, G. Gengxihua, H. Tan, J. Xu, L. Jiang, Q, Tiehe, Q, Bingyu, Q, Shi, Z. Lv, L. Zhang, L. Jingtao, Z. Zhen, Z. Wang, T. Wang, L. Yuhong, Q, Zhai, Y. Chen, C. Wang, W. Jiang, W. Ruilan, Y. Chen, H. Xiaobo, H. Ge, T. Yan, C. Yuhui, J. Zhang, F. Jian-Hong, H. Zhu, F. Huo, Y. Wang, C. Li, M. Zhuang, Z. Ma, J. Sun, L. Liuqingyue, M. Yang, J. Meng, S. Ma, K. Lee, Y. Kang, L. Yu, Q, Peng, Y. Wei, W. Zhang, R. Sun, A. Yeung, W. Wan, K. Sin, M. Wijanti, U. Widodo, H. Samsirun, T. Sugiman, C. Wisudarti, T. Maskoen, N. Hata, Y. Kobe, Y. Shimomura, D. Miyazaki, S. Nunomiya, S. Uchino, N. Kitamura, K. Yamashita, S. Hashimoto, H. Fukushima, N. Nik Adib, L. Tai, B. Tony, R. Bigornia, R. Bigornia, R. Bigornia, J. Palo, S. Chatterjee, B. Tan, A. Kong, S. Goh, C. Lee, C. Pothirat, B. Khwannimit, P. Theerawit, P. Pornsuriyasak, A. Piriyapatsom, A. Mukhtar, A. Nabil Hamdy, H. Hosny, A. Ashraf, M. Mokhtari, S. Nowruzinia, A. Lotfi, F. Zand, R. Nikandish, O. Moradi Moghaddam, J. Cohen, O. Sold, T. Sfeir, A. Hasan, D. Abugaber, H. Ahmad, T. Tantawy, S. Baharoom, H. Algethamy, A. Amr, G. Almekhlafi, R. Coskun, M. Sungur, A. Cosar, B. Güçyetmez, O. Demirkiran, E. Senturk, H. Ulusoy, H. Atalan, S. Serin, I. Kati, Z. Alnassrawi, A. Almemari, K. Krishnareddy, S. Kashef, A. Alsabbah, G. Poirier, J. Marshall, M. Herridge, M. Herridge, R. Fernandez, G. Fulda, S. Banschbach, J. Quintero, E. Schroeder, C. Sicoutris, R. Gueret, R. Kashyap, P. Bauer, R. Nanchal, R. Wunderink, E. Jimenez, A. Ryan, A. Ryan, A. Ryan, A. Ryan, A. Ryan, A. Ryan, A. Ryan, D. Prince, J. Edington, F. Van Haren, A. Bersten, B. Richards, M. Kilminster, D. Sturgess, M. Ziegenfuss, S. O'Connor, J. Lipman, L. Campbell, R. Mcallister, B. Roberts, P. Williams, R. Parke, P. Seigne, R. Freebairn, D. Nistor, C. Oxley, P. Young, R. Valentini, N. Wainsztein, P. Comignani, M. Casaretto, G. Sutton, P. Villegas, C. Galletti, J. Neira, D. Rovira, J. Hidalgo, F. Sandi, E. Caser, M. Thompson, M. D'agostino Dias, L. Fontes, M. Lunardi, N. Youssef, S. Lobo, R. Silva, J. Sales Jr, L. Madeira Campos Melo, M. Oliveira, M. Fonte, C. Grion, C. Feijo, V. Rezende, M. Assuncao, A. Neves, P. Gusman, D. Dalcomune, C. Teixeira, K. Kaefer, I. Maia, V. Souza Dantas, R. Costa Filho, F. Amorim, M. Assef, P. Schiavetto, J. Houly, J. Houly, F. Bianchi, F. Dias, C. Avila, J. Gomez, L. Rego, P. Castro, J. Passos, C. Mendes, C. Grion, G. Colozza Mecatti, M. Ferrreira, V. Irineu, M. Guerreiro, S. Ugarte, V. Tomicic, C. Godoy, W. Samaniego, I. Escamilla, I. Escamilla, L. Castro Castro, G. Libreros Duque, D. Diaz-Guio, F. Benítez, A. Guerra Urrego, R. Buitrago, G. Ortiz, M. Villalba Gaviria, D. Salas, J. Ramirez-Arce, E. Salgado, D. Morocho, J. Vergara, M. Chung Sang, C. Orellana-Jimenez, L. Garrido, O. Diaz, D. Resiere, C. Osorio, A. De La Vega, R. Carrillo, V. Sanchez, A. Villagomez, R. Martinez Zubieta, M. Sandia, M. Zalatiel, M. Poblano, D. Rodriguez Gonzalez, F. Arrazola, L. Juan Francisco, S. A. Ñamendys-Silva, M. Hernandez, D. Rodriguez Cadena, I. Lopez Islas, C. Ballesteros Zarzavilla, A. Matos, I. Oyanguren, J. Cerna, R. Quispe Sierra, R. Jimenez, L. Castillo, R. Ocal, A. Sencan, S. Mareque Gianoni, A. Deicas, J. Hurtado, G. Burghi, A. Martinelli, I. Von Der Osten, C. Du Maine, M. Bhattacharyya, S. Bandyopadhyay, S. Yanamala, P. Gopal, S. Sahu, M. Ibrahim, D. Rathod, N. Mukundan, A. Dewan, P. Amin, S. Samavedam, B. Shah, D. Gurupal, B. Lahkar, A. Mandal, M. Sircar, S. Ghosh, V. Balasubramani, F. Kapadia, S. Vadi, K. Nair, S. Tripathy, S. Nandakumar, J. Sharma, A. Kar, S. Jha, K. Zirpe Gurav, M. Patel, A. Bhavsar, D. Samaddar, A. Kulkarni, M. Hashmi, W. Ali, S. Nadeem, K. Indraratna, A. Margarit, P. Urbanek, J. Schlieber, J. Reisinger, J. Auer, A. Hartjes, A. Lerche, T. Janous, E. Kink, W. Krahulec, K. Smolle, M. Van Der Schueren, P. Thibo, M. Vanhoof, I. Ahmet, G. Philippe, P. Dufaye, O. Jacobs, V. Fraipont, P. Biston, A. Dive, Y. Bouckaert, E. Gilbert, B. Gressens, E. Pinck, V. Collin, J. L. Vincent, J. De Waele, R. Rimachi, D. Gusu, K. De Decker, K. Mandianga, L. Heytens, X. Wittebole, S. Herbert, V. Olivier, W. Vandenheede, P. Rogiers, P. Kolodzeike, M. Kruse, T. Andersen, V. Harjola, K. Saarinen, M. Leone, A. Durocher, S. Moulront, A. Lepape, M. Losser, P. Cabaret, E. Kalaitzis, E. Zogheib, P. Charve, B. Francois, J. Lefrant, B. Beilouny, X. Forceville, B. Misset, F. Jacobs, F. Bernard, D. Payen, A. Wynckel, V. Castelain, A. Faure, P. Lavagne, L. Thierry, M. Moussa, A. Vieillard-Baron, M. Durand, M. Gainnier, C. Ichai, S. Arens, C. Hoffmann, M. Kaffarnik, C. Scharnofske, I. Voigt, C. Peckelsen, M. Weber, J. Gille, A. Lange, G. Schoser, A. Sablotzki, U. Jaschinski, A. Bluethgen, F. Vogel, A. Tscheu, T. Fuchs, M. Wattenberg, T. Helmes, S. Scieszka, M. Heintz, S. Sakka, J. Kohler, F. Fiedler, M. Danz, Y. Sakr, R. Riessen, T. Kerz, A. Kersten, F. Tacke, G. Marx, T. Volkert, A. Schmutz, A. Nierhaus, S. Kluge, P. Abel, R. Janosi, S. Utzolino, H. Bracht, S. Toussaint, M. Giannakou Peftoulidou, P. Myrianthefs, A. Armaganidis, C. Routsi, A. Xini, E. Mouloudi, I. Kokoris, G. Kyriazopoulos, S. Vlachos, A. Lavrentieva, P. Partala, G. Nakos, A. Moller, S. Stefansson, J. Barry, R. O'Leary, C. Motherway, M. Faheem, E. Dunne, M. Donnelly, T. Konrad, E. Bonora, C. Achilli, S. Rossi, G. Castiglione, A. Peris, D. Albanese, N. Stocchetti, G. Citerio, L. Mozzoni, E. Sisillo, P. De Negri, M. Savioli, P. Vecchiarelli, F. Puflea, V. Stankovic, G. Minoja, S. Montibeller, P. Calligaro, R. Sorrentino, M. Feri, M. Zambon, E. Colombaroli, A. Giarratano, T. Pellis, C. Capra, M. Antonelli, A. Gullo, C. Chelazzi, A. De Capraris, N. Patroniti, M. Girardis, F. Franchi, G. Berlot, M. Buttigieg, H. Ponssen, J. Ten Cate, L. Bormans, S. Husada, M. Buise, B. Van Der Hoven, A. Reidinga, M. Kuiper, P. Pickkers, G. Kluge, S. Den Boer, J. Kesecioglu, H. Van Leeuwen, H. Flaatten, S. Mo, V. Branco, F. Rua, E. Lafuente, M. Sousa, N. Catorze, M. Barros, L. Pereira, A. Vintém De Oliveira, J. Gomes, I. Gaspar, M. Pereira, M. Cymbron, A. Dias, E. Almeida, S. Beirao, I. Serra, R. Ribeiro, P. Povoa, F. Faria, Z. Costa-E-Silva, J. Nóbrega, F. Fernandes, J. Gabriel, G. Voga, E. Rupnik, L. Kosec, M. Kerin Povšic, I. Osojnik, V. Tomic, A. Sinkovic, J. González, E. Zavala, J. Pérez Valenzuela, L. Marina, P. Vidal-Cortés, P. Posada, A. Ignacio Martin-Loeches, N. Muñoz Guillén, M. Palomar, J. Sole-Violan, A. Torres, M. Gonzalez Gallego, G. Aguilar, R. Montoiro Allué, M. Argüeso, M. Parejo, M. Palomo Navarro, A. Jose, N. Nin, F. Alvarez Lerma, O. Martinez, E. Tenza Lozano, S. Arenal López, M. Perez Granda, S. Moreno, C. Llubia, C. De La Fuente Martos, P. Gonzalez-Arenas, N. Llamas Fernández, B. Gil Rueda, I. Estruch Pons, N. Cruza, F. Maroto, A. Estella, A. Ferrer, L. Iglesias Fraile, Q, Brigida, A. Quintano, M. Tebar, F. Frutos-Vivar, A. Reyes, A. Rodríguez, A. Abella, S. García Del Valle, S. Yus, E. Maseda, J. Berezo, A. Tejero Pedregosa, C. Laplaza, R. Ferrer, J. Rico-Feijoo, M. Rodríguez, P. Monedero, K. Eriksson, D. Lind, D. Chabanel, H. Zender, K. Heer, B. Frankenberger, S. Jakob, A. Haller, S. Mathew, R. Downes, C. Barrera Groba, A. Johnston, R. Meacher, R. Keays, P. Haji-Michael, C. Tyler, A. Ferguson, S. Jones, D. Tyl, A. Ball, J. Vogel, M. Booth, P. Downie, M. Watters, S. Brett, M. Garfield, L. Everett, S. Heenen, S. Dhir, Z. Beardow, M. Mostert, S. Brosnan, N. Pinto, S. Harris, A. Summors, N. Andrew, A. Rose, R. Appelboam, O. Davies, E. Vickers, B. Agarwal, T. Szakmany, S. Wimbush, K. Williams, R. Pearse, R. Hollands, J. Kirk-Bayley, N. Fletcher, B. Bray, D. Brealey. The online version of the article has been corrected
Management of intoxicated patients – a descriptive outcome analysis of 4,267 ICU patients
No full textIntroduction: Intoxications are common in intensive care units (ICUs). The number of causative substances is large, mortality usually low. This retrospective cohort study aims to characterize differences of intoxicated compared to general ICU patients, point out variations according to causative agents, as well as to highlight differences between survivors and non-survivors among intoxicated individuals in a large-scale multi-center analysis.
Methods: A total of 105,998 general ICU patients and 4,267 individuals with the admission diagnoses “overdose” and “drug toxicity” from the years 2014 and 2015 where included from the eICU Collaborative Research Database. In addition to comparing these groups with respect to baseline characteristics, intensive care measures and outcome parameters, differences between survivors and non-survivors from the intoxication group, as well as the individual groups of causative substances were investigated.
Results: Intoxicated patients were younger (median 41 vs. 66 years; p<0.001), more often female (55 vs. 45%; p<0.001), and normal weighted (36% vs. 30%; p<0.001), whereas more obese individuals where observed in the other group (37 vs. 31%; p<0.001). Intoxicated individuals had a significantly lower mortality compared to general ICU patients (1% vs. 10%; aOR 0.07 95%CI 0.05-0.11; p<0.001), a finding which persisted after multivariable adjustment (aOR 0.17 95%CI 0.12-0.24; p<0.001) and persisted in all subgroups. Markers of disease severity (SOFA-score: 3 (1-5) vs. 4 (2-6) pts.; p<0.001) and frequency of vasopressor use (5 vs. 15%; p<0.001) where lower, whereas rates of mechanical ventilation where higher (24 vs. 26%; p<0.001) in intoxicated individuals. There were no differences with regard to renal replacement therapy in the first three days (3 vs. 4%; p=0.26). In sensitivity analysis (interactions for age, sex, ethnicity, hospital category, maximum initial lactate, mechanical ventilation, and vasopressor use), a trend towards lower mortality in intoxicated patients persisted in all subgroups.
Conclusion: This large-scale retrospective analysis indicates a significantly lower mortality of intoxicated individuals compared to general ICU patients
Does platelet hyperfunction explain grim survival rates after out-of-hospital cardiac arrest?
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COVID-19 machine learning model predicts outcomes in older patients from various European countries, between pandemic waves, and in a cohort of Asian, African, and American patients
No full textBackground
COVID-19 remains a complex disease in terms of its trajectory and the diversity of outcomes
rendering disease management and clinical resource allocation challenging. Varying symptomatology in older patients as well as limitation of clinical scoring systems have created the
need for more objective and consistent methods to aid clinical decision making. In this
regard, machine learning methods have been shown to enhance prognostication, while
improving consistency. However, current machine learning approaches have been limited
by lack of generalisation to diverse patient populations, between patients admitted at different waves and small sample sizes
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