113 research outputs found
Supplemental Material, DS1_VET_10.1177_0300985818823781 - Response to Letter to the Editor on “<i>Coxiella burnetii</i> in Infertile Dairy Cattle With Chronic Endometritis”
No full textSupplemental Material, DS1_VET_10.1177_0300985818823781 for Response to Letter to the Editor on “Coxiella burnetii in Infertile Dairy Cattle With Chronic Endometritis” by Davide De Biase, and Orlando Paciello in Veterinary Pathology</p
Essential and current methods for a practical approach to comparative neuropathology
No full textThe understanding of mechanisms that provoke neurological diseases in humans and in animals has progressed rapidly in recent years, mainly due to the advent of new research instruments and our increasing liability to assemble large, complex data sets acquired across several approaches into an integrated representation of neural function at the molecular, cellular, and systemic levels. Nevertheless, morphology always represents the essential approaches that are crucial for any kind of interpretation of the lesions or to explain new molecular pathways in the diseases. This mini-review has been designed to illustrate the newest and also well-established principal methods for the nervous tissue collection and processing as well as to describe the histochemical and immunohistochemical staining tools that are currently most suitable for a neuropathological assessment of the central nervous system. We also present the results of our neuropathological studies covering material from 170 cases belonging to 10 different species of mammals. Specific topics briefly addressed in this paper provide a technical and practical guide not only for researchers that daily focus their effort on neuropathology studies, but also to pathologists who occasionally have to approach to nervous tissue evaluation to answer questions about neuropathology issues
Supplemental material for Characterization of inflammatory infiltrate of ulcerative dermatitis in C57BL/6NCrl-Tg(HMGA1P6)1Pg mice
No full textSupplemental Material for Characterization of inflammatory infiltrate of ulcerative dermatitis in C57BL/6NCrl-Tg(HMGA1P6)1Pg mice by Davide De Biase, Francesco Esposito, Marco De Martino, Claudio Pirozzi, Antonio Luciano, Giuseppe Palma, Giuseppina Mattace Raso, Valentina Iovane, Stefania Marzocco, Alfredo Fusco and Orlando Paciello in Laboratory Animals</p
Supplemental Material, Combined_supplemental_materials-Pagano_et_al - Muscular Sarcocystosis in Sheep Associated With Lymphoplasmacytic Myositis and Expression of Major Histocompatibility Complex Class I and II
No full textSupplemental Material, Combined_supplemental_materials-Pagano_et_al for Muscular Sarcocystosis in Sheep Associated With Lymphoplasmacytic Myositis and Expression of Major Histocompatibility Complex Class I and II by Teresa Bruna Pagano, Francesco Prisco, Davide De Biase, Giuseppe Piegari, Maria Paola Maurelli, Laura Rinaldi, Giuseppe Cringoli, Serenella Papparella and Orlando Paciello in Veterinary Pathology</p
sj-pdf-1-lan-10.1177_00236772221138942 - Supplemental material for Identification of vacuolar autophagic aggregates in the skeletal muscles of inbred C57BL/6NCrl mice
No full textSupplemental material, sj-pdf-1-lan-10.1177_00236772221138942 for Identification of vacuolar autophagic aggregates in the skeletal muscles of inbred C57BL/6NCrl mice by Davide De Biase, Teresa Bruna Pagano, Donatella Malanga, Valeria Russo, Giuseppe Piegari, Ilaria d’Aquino, Valentina Iovane, Marzia Scarfò, Serenella Papparella, Slawomir Wojcik, Orlando Paciello in Laboratory Animals</p
sj-pdf-2-lan-10.1177_00236772221138942 - Supplemental material for Identification of vacuolar autophagic aggregates in the skeletal muscles of inbred C57BL/6NCrl mice
No full textSupplemental material, sj-pdf-2-lan-10.1177_00236772221138942 for Identification of vacuolar autophagic aggregates in the skeletal muscles of inbred C57BL/6NCrl mice by Davide De Biase, Teresa Bruna Pagano, Donatella Malanga, Valeria Russo, Giuseppe Piegari, Ilaria d’Aquino, Valentina Iovane, Marzia Scarfò, Serenella Papparella, Slawomir Wojcik, Orlando Paciello in Laboratory Animals</p
Supplemental Material, DS1_VET_10.1177_0300985818760376 - <i>Coxiella burnetii</i> in Infertile Dairy Cattle With Chronic Endometritis
No full textSupplemental Material, DS1_VET_10.1177_0300985818760376 for Coxiella burnetii in Infertile Dairy Cattle With Chronic Endometritis by Davide De Biase, Alessandro Costagliola, Fabio Del Piero, Rossella Di Palo, Domenico Coronati, Giorgio Galiero, Barbara Degli Uberti, Maria Gabriella Lucibelli, Annalisa Fabbiano, Bernard Davoust, Didier Raoult, and Orlando Paciello in Veterinary Pathology</p
An Exploratory Bioinformatic Investigation of Cats' Susceptibility to Coronavirus-Deriving Epitopes
No full textCoronaviruses are highly transmissible and pathogenic viruses for humans and animals. The vast quantity of information collected about SARS-CoV-2 during the pandemic helped to unveil details of the mechanisms behind the infection, which are still largely elusive. Recent research demonstrated that different class I/II human leukocyte antigen (HLA) alleles might define an individual susceptibility to SARS-CoV-2 spreading, contributing to the differences in the distribution of the infection through different populations; additional studies suggested that the homolog of the HLA in cats, the feline leukocyte antigen (FLA), plays a pivotal role in the transmission of viruses. With these premises, this study aimed to exploit a bioinformatic approach for the prediction of the transmissibility potential of two distinct feline coronaviruses (FCoVs) in domestic cats (feline enteric coronavirus (FeCV) and feline infectious peritonitis virus (FIPV)) using SARS-CoV-2 as the reference model. We performed an epitope mapping of nonapeptides deriving from SARS-CoV-2, FeCV, and FIPV glycoproteins and predicted their affinities for different alleles included in the three main loci in class I FLAs (E, H, and K). The predicted complexes with the most promising affinities were then subjected to molecular docking and molecular dynamics simulations to provide insights into the stability and binding energies in the cleft. Results showed the FLA proteins encoded by alleles in the FLA-I H (H*00501 and H*00401) and E (E*01001 and E*00701) loci are largely responsive to several epitopes deriving from replicase and spike proteins of the analyzed coronaviruses. The analysis of the most affine epitope sequences resulting from the prediction can stimulate the development of anti-FCoV immunomodulatory strategies based on peptide drugs
Delta-front associations of ancient flood-dominated fluvio-deltaic systems
No full textAncient flood-dominated fan-delta and river-delta systems of tectonically-active basins can be viewed as essentially small and immature fluvial systems (in the sense of Schumm, 1977) with relatively high-elevation catchment basins, short and high-gradient transfer zones, and marine depositional zones where transport and deposition are dominated by hyperpycnal flows. The delta-front deposits of these ancient systems are represented by facies and facies associations whose stratigraphic and sedimentological importance has been largely overlooked in previous literature. Both fan-delta and river-delta systems contain a common and very distinctive terminal depositional element consisting of sharp-based and parallel-sided, graded sandstone beds commonly containing HCS. These sediments, herein termed "flood-generated delta-front sandstone lobes", form impressive sedimentary accumulations in many basins worldwide. Commonly mistaken for storm-dominated nearshore and shelfal deposits, these sandstone lobes probably represent the most genuine expression of fluvial-dominated delta-front sedimentation.
In ancient river-delta systems, river-mouth deposits show a great variability in terms of geometry and facies types, essentially recording the locally prevailing conditions ranging from extensive erosion and sediment bypass to deposition of the entire sediment load carried by sediment-laden stream flows entering seawaters.
Flood-related processes are intrinsically catastrophic and, as such, under-represented in modern settings. It thus appears that ancient flood-dominated fluvio-deltaic systems cannot be described and interpreted following current sedimentological models for fluvial and deltaic sedimentation. Actually, these models are largely derived from modern depositional environments dominated by "normal" fluvial and marine processes. There are, on the other hand, impressive similarities between ancient flood-dominated fluvio-deltaic systems and turbidites - another category of catastrophic deposits which is under-represented in modern basins. Comparing facies and processes of these two groups of sediments deposited by density currents can provide significant insight into both types of sedimentation
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