11 research outputs found
Artificial Intelligence in Wound Care: A Narrative Review of the Currently Available Mobile Apps for Automatic Ulcer Segmentation
No full textIntroduction: Chronic ulcers significantly burden healthcare systems, requiring precise
measurement and assessment for effective treatment. Traditional methods, such as manual segmentation, are time-consuming and error-prone. This review evaluates the potential of artificial intelligence AI-powered mobile apps for automated ulcer segmentation and their application in clinical settings.
Methods: A comprehensive literature search was conducted across PubMed, CINAHL, Cochrane, and Google Scholar databases. The review focused on mobile apps that use fully automatic AI algorithms for wound segmentation. Apps requiring additional hardware or needing more technical documentation were excluded. Vital technological features, clinical validation, and usability were analysed. Results: Ten mobile apps were identified, showing varying levels of segmentation accuracy and clinical validation. However, many apps did not publish sufficient information on the segmentation methods or algorithms used, and most lacked details on the databases employed for
training their AI models. Additionally, several apps were unavailable in public repositories, limiting their accessibility and independent evaluation. These factors challenge their integration into clinical practice despite promising preliminary results. Discussion: AI-powered mobile apps offer significant potential for improving wound care by enhancing diagnostic accuracy and reducing the burden on healthcare professionals. Nonetheless, the lack of transparency regarding segmentation techniques, unpublished databases, and the limited availability of many apps in public repositories remain substantial barriers to widespread clinical adoption. Conclusions: AI-driven mobile apps for ulcer segmentation could revolutionise chronic wound management. However, overcoming limitations related to transparency, data availability, and accessibility is essential for their successful integration into healthcare systems
Brain Connectivity Gradients Alterations in Discordant Cerebrospinal Fluid Profile for Alzheimer's Disease Biomarkers
No full textAlzheimer's disease (AD) is a heterogeneous disorder characterized by brain accumulation of amyloid-beta (Aß, simplified as A for the AD biological model) and tau (T) proteins, with Aß emerging first. However, a significant proportion of individuals exhibit discordant biomarkers' profiles, such as elevated phosphorylated tau181 (p-tau181) with normal Aß42 from cerebrospinal fluid (CSF), posing diagnostic and mechanistic challenges. This study investigated whether functional and structural brain connectivity can distinguish individuals with discordant CSF profiles (A-T+) from those with concordant patterns (A+T+), hypothesizing that distinct connectivity patterns may reflect early divergent pathophysiological processes. Data from cognitively unimpaired or mildly impaired individuals in the ADNI3 repository were analyzed, selecting those with resting-state functional MRI (rsfMRI) and/or diffusion MRI (dMRI) within 18 months of CSF testing for Aß and p-tau181. Participants were grouped into A-T+ or A+T+ groups. Structural and functional connectivity gradients were generated for each participant and summarized using a Euclidean distance measure from reference gradient templates derived from cognitively unimpaired individuals without pathology (A-T-). We applied linear mixed models and analysis of variance to assess connectivity-based gradient differences between A-T+ and A+T+ groups, adjusting for relevant variables. Classification analyzes using logistic regression and support vector machine, along with feature importance via the Boruta algorithm, evaluated the discriminative power of gradient connectivity profiles. Multimodal integration was performed using partial least square canonical analysis (PLSC), and relationships between gradients and cognition were assessed via UMAP-based dimensionality reduction and bootstrapped linear regressions. Results were compared with a classical network analysis examining within- and between-network connectivity differences. Among 424 participants, n = 67 were classified as A-T+, n = 106 as A+T+, and n = 56 as cognitively healthy A-T-. The remaining 195 participants (n = 86 A+T+ and n = 109 cognitively impaired A-T-) were not included. A-T+ individuals (age = 75 ± 8.2) exhibited less cognitive impairment but greater functional connectivity gradients' distance to the reference templates (false discovery rate-corrected p < 0.05) in the temporo-occipital axis compared to A+T+ (age = 76.1 ± 7.7). Structural connectivity differences were not significant. FC-based models classified A-T+ and A+T+ with good accuracy (AUC = 0.77), loading on the same temporo-occipital regions, unlike SC (AUC = 0.52). The posterior brain involvement in A-T+ was confirmed by PLSC analyzes. A+T+ individuals showed a significant relation between cognitive scores and functional connectivity, primarily mapping the default mode network (DMN). A shift was observed in relation to executive functions and functional connectivity in A-T+. Discordant CSF profiles (A-T+) exhibit distinct functional connectivity patterns, particularly in posterior brain regions, compared to concordant CSF patterns (A+T+), which are characterized by a significant cognitive-DMN connectivity association. These results suggest that CSF p-tau181 accumulation in the absence of Aß42 may be associated with specific functional trajectories, suggesting specific pathophysiological patterns.
© 2025 The Author(s). Human Brain Mapping published by Wiley Periodicals LLC
HPV Vaccine Awareness and Uptake Among Sexually Transmitted Infections Clinic Users: A Cross-Sectional Study in Bologna, Italy
No full textHuman Papillomavirus (HPV) infection poses a significant health risk, particularly for high-risk groups such as men who have sex with men (MSM), people living with HIV (PLHIV), and transgender individuals. Despite the availability of effective vaccines, uptake among these groups remains suboptimal due to various social and behavioral barriers (BeSD). A cross-sectional survey was conducted at the Sexually Transmitted Infections (STIs) clinic in Bologna, Italy, from 8 April to 12 April 2024 using a paper questionnaire, investigating HPV vaccine uptake and BeSD factors influencing vaccination decisions. Statistical analyses included descriptive statistics and multivariate logistic regression. Among the 236 respondents, PLHIV and transgender individuals demonstrated lower uptake rates (60.0% and 15.6%) if compared to women under 30 years old (72.7%). Concern about HPV infection varied significantly across groups, with MSM showing the highest worry (48.7%). Perceptions of vaccine safety and access were mixed, influencing vaccination decisions. Multivariate analysis indicated that age inversely correlated with infection worry (OR: 0.94, 95% CI: 0.91–0.98), while being a woman under 30 (OR: 164.0, 95% CI: 17.2–1560.18) or MSM (OR: 3.53, 95% CI: 1.37–9.11) was positively associated with vaccine uptake. The study identifies disparities in HPV vaccine uptake among STI clinic users in Bologna, Italy, emphasizing the need for targeted public health campaigns. These campaigns could engage STI clinics and address awareness, safety perceptions, and access barriers to enhance vaccination coverage among sexual and gender minorities
The road ahead in clinical network neuroscience
No full textClinical network neuroscience, the study of brain network topology in neurological and psychiatric diseases, has become a mainstay field within clinical neuroscience. Being a multidisciplinary group of clinical network neuroscience experts based in The Netherlands, we often discuss the current state of the art and possible avenues for future investigations. These discussions revolve around questions like “How do dynamic processes alter the underlying structural network?” and “Can we use network neuroscience for disease classification?” This opinion paper is an incomplete overview of these discussions and expands on ten questions that may potentially advance the field. By no means intended as a review of the current state of the field, it is instead meant as a conversation starter and source of inspiration to others.Network Architectures and Service
Variational analysis of drifter positions and model outputs for the reconstruction of surface currents in the central Adriatic during fall 2002
No full textAuthor Posting. © American Geophysical Union, 2008. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 113 (2008): C04004, doi:10.1029/2007JC004148.In this paper we present an application of a variational method for the reconstruction of the velocity field in a coastal flow in the central Adriatic Sea, using in situ data from surface drifters and outputs from the ROMS circulation model. The variational approach, previously developed and tested for mesoscale open ocean flows, has been improved and adapted to account for inhomogeneities on boundary current dynamics over complex bathymetry and coastline and for weak Lagrangian persistence in coastal flows. The velocity reconstruction is performed using nine drifter trajectories over 45 d, and a hierarchy of indirect tests is introduced to evaluate the results as the real ocean state is not known. For internal consistency and impact of the analysis, three diagnostics characterizing the particle prediction and transport, in terms of residence times in various zones and export rates from the boundary current toward the interior, show that the reconstruction is quite effective. A qualitative comparison with sea color data from the MODIS satellite images shows that the reconstruction significantly improves the description of the boundary current with respect to the ROMS model first guess, capturing its main features and its exchanges with the interior when sampled by the drifters.Four of the authors are supported by the
Office of Naval Research, V.T. and A.G. under grants N00014-05-1-0094
and N00014-05-1-0095, P.M.P. under grant N00014-03-1-0291, and S.C.
under grant N00014-05-1-0730. CNR-ISMAR
activity was partially supported by P.O.R. ‘‘CAINO’’ (Regione Puglia),
VECTOR (Italian MIUR) project, and ECOOP (EU project)
Giosetta Fioroni, Piero Gilardi, Concetto Pozzati, Giorgio Griffa, Claudio Verna, Gianfranco Pardi, Alighiero Boetti, Franco Vaccari, William Xerra, Ugo Carrega, Arrigo Lora Totino, Eugenio Piccini, Luciano Ori, Lamberto Pienotti, Enrico Barbera, Davide Benati, Bruno Benuzzi, Giorgio Zucchini, Paolo Bernardini, Franco Corradini, Roberto Costa, Luigi Mastrangelo, Stefano Teglia
No full textStatistical properties of the surface velocity field in the northern Gulf of Mexico sampled by GLAD drifters
No full textThe Grand LAgrangian Deployment (GLAD) used multiscale sampling and GPS technology to observe time series of drifter positions with initial drifter separation of O(100 m) to O(10 km), and nominal 5 min sampling, during the summer and fall of 2012 in the northern Gulf of Mexico. Histograms of the velocity field and its statistical parameters are non-Gaussian; most are multimodal. The dominant periods for the surface velocity field are 1–2 days due to inertial oscillations, tides, and the sea breeze; 5–6 days due to wind forcing and submesoscale eddies; 9–10 days and two weeks or longer periods due to wind forcing and mesoscale variability, including the period of eddy rotation. The temporal e-folding scales of a fitted drifter velocity autocorrelation function are bimodal with time scales, 0.25–0.50 days and 0.9–1.4 days, and are the same order as the temporal e-folding scales of observed winds from nearby moored National Data Buoy Center stations. The Lagrangian integral time scales increase from coastal values of 8 h to offshore values of approximately 2 days with peak values of 3–4 days. The velocity variance is large, O(1)m2/s2, the surface velocity statistics are more anisotropic, and increased dispersion is observed at flow bifurcations. Horizontal diffusivity estimates are O(103)m2/s in coastal regions with weaker flow to O(105)m2/s in flow bifurcations, a strong jet, and during the passage of Hurricane Isaac. The Gulf of Mexico surface velocity statistics sampled by the GLAD drifters are a strong function of the feature sampled, topography, and wind forcin
(schede ragionate delle opere di Umberto Boccioni; Jannis Kounellis; Gastone Novelli; Achille Perilli; Salvatore Scarpitta; Toti Scialoja; Francesco Somaini; Tancredi; Giulio Turcato; Giuseppe Uncini; Emilio Vedova; Dadamaino; Getulio Alviani; Giovanni Anceschi; Davide Boriani; Gianni Colombo; Gabriele De Vecchi; Enzo Mari; Bruno Munari; Grazia Varisco; Rodolfo Aricò; Marco Gastini; Giorgio Griffa; Vittorio Matino; Claudio Olivieri; Pino Pinelli; Claudio Verna; Franco Angeli; Mimmo Rotella; Mario Schifano; Emilio Tadini; Giovanni Anselmo; Alighiero Boetti; Pier Paolo Calzolari; Mario Merz; Giulio Paolini; Giuseppe Penone; Michelangelo Pistoletto; Gilberto Zorio)
No full textOperina by Ludovico Vicentino for the study of writing in cursive chancery hand
No full textJest to pierwsze polskie wydanie – reprint, przekład oraz opracowanie naukowe – Operiny Ludovica degli Arrighi, zwanego Vicentino, które ukazuje się 500 lat po wydaniu tego pierwszego podręcznika kursywy kancelaryjnej, zwanej (littera) cancellaresca, cancelleresca italica bądź kursywą renesansową. Choć jego autor – kopista w kancelarii papieskiej, pisarz brewe apostolskich (scriptor!), jak sam przedstawia nam się w traktaciku, dumny przedstawiciel i uczestnik kultury wysokiej, wydawca i kodyfikator kursywy XVI-wiecznej – pierwsze słowa swego traktaciku kreślił "do wielce łaskawego Czytelnika" jeszcze w 1522 roku, to editio princeps podręcznika wydanego w technice drzeworytniczej, nie opuściła prasy drukarskiej wcześniej niż w 1524 roku.
Wraz z Operiną Arrighi dokonuje kodyfikacji renesansowej kursywy kancelaryjnej: jego cancelleresca, którą przełożył na znaki typograficzne równie eleganckie, co ich wersja kaligrafowana, w krótkim czasie miała zastąpić kursywę zaprojektowaną przez słynnego rytownika Francesca Griffa dla Manucjusza w 1499 roku i stać się czcionką stosowaną powszechnie w druku zbiorów sentencji i edycjach autorów klasycznych w XVI wieku, nie tylko we Włoszech. Świadomość nowości (Arrighi zaznacza w Operinie, że traktat powstał "per inventione di Ludovico Vicentino", z pomysłu Ludovica Vicentina), a zarazem dydaktyczny charakter i chęć dotarcia do szerokiego odbiorcy przekładają się na wybór języka włoskiego w warstwie objaśnieniowej, ale sam traktat zachowuje hybrydową formę językową: zwłaszcza w części, zatytułowanej "Exempli per firmar la mano", „Przykłady do ćwiczenia pewności ręki”, łacina przenika przytaczane przykłady, które nie mają jedynie wartości dydaktycznej, ale stanowią także świadectwo połączenia tradycji literackiej starożytnej i humanistycznej w jedno intelektualne podłoże kulturowe, współdzielone bardziej przez czytelników przynależnych do kultury wysokiej aniżeli przez szerokie grono odbiorców, do którego chciał dotrzeć Arrighi. Nie przeszkodziło mu to jednak w osiągnięciu sukcesu wydawniczego, o którym świadczą liczne edycje jego traktatu w XVI wieku. Tę hybrydowość językową postarano się ocalić w niniejszej edycji, zachowując w treści przekładu łacińskie cytaty, których znaczenie i pochodzenie objaśniono w przypisach.This is the first Polish edition - a reprint, translation and scholarly study - of Operina by Ludovico degli Arrighi, called Vicentino, which comes 500 years after the publication of that first manual of chancellery italics, known as (littera) cancellaresca, cancelleresca italica or Renaissance italics. Although its author - copyist at the papal chancellery, scribe of the apostolic breve (scriptor!), as he introduces himself in the treatise, proud representative and participant of high culture, publisher and codifier of 16th century cursive - wrote the first words of his treatise ‘to the most gracious reader’ as early as 1522, the editio princeps of the manual, published in woodcut, did not leave the printing press before 1524.
With Operina, Arrighi is codifying Renaissance chancellery italics: his cancelleresca, which he translated into typographic characters as elegant as their calligraphic version, was soon to replace the italic designed by the famous engraver Francesco Griffo for Manucius in 1499 and become the font commonly used in the printing of collections of sentences and editions of classical authors in the 16th century, not only in Italy. The awareness of novelty (Arrighi notes in the Operina that the treatise was written ‘per inventione di Ludovico Vicentino’, from the idea of Ludovico Vicentino) and at the same time the didactic nature and the desire to reach a wide audience translate into the choice of Italian in the explanatory layer, but the treatise itself retains a hybrid linguistic form: especially in the section entitled ‘Exempli per firmar la mano’, ‘Examples for exercising the confidence of the hand’, Latin permeates the examples cited, which are not only of didactic value, but also bear witness to the fusion of ancient and humanist literary traditions into a single intellectual cultural substrate, shared more by readers belonging to high culture than by the wide audience Arrighi wanted to reach. However, this did not prevent him from achieving publishing success, as evidenced by the numerous editions of his treatise in the 16th century. This linguistic hybridity has been attempted to be preserved in the present edition by retaining the Latin quotations in the body of the translation, the meaning and origin of which are explained in the footnotes
Deep-water hydrodynamic observations around a cold-water coral habitat in a submarine canyon in the eastern Ligurian Sea (Mediterranean Sea)
No full textA 2-year dataset of a stand-alone mooring, deployed in November 2020 down the Levante Canyon in the eastern Ligurian Sea, is presented. The Levante Canyon Mooring (LCM) is a deep submarine multidisciplinary observatory positioned at 608 m depth in a key ecosystem area. The Levante Canyon hosts a valuable and vulnerable ecosystem of deep-living cold-water corals (CWCs), studied and monitored since 2013 through integrated mapping of the seabed and water column. The 2-year dataset, acquired on the mooring and presented here (data from November 2020 to October 2022), includes measurements conducted with both current meters and conductivity–temperature–depth (CTD) probes and provides information about the hydrodynamics and thermohaline properties across almost the entire water column. The observatory is still ongoing, and the dataset is regularly updated. All the described data are publicly available from https://doi.org/10.17882/92236 (Borghini et al., 2022). They must therefore be preserved and are of considerable scientific interest.This research has been supported by the Distretto Ligure delle Tecnologie Marine (DLTM) through funding obtained from Regione Liguria (PAR-FSC 2007–2013 funds) and by institutional funds from Consiglio Nazionale delle Ricerche – Istituto di Scienze Marine (CNR-ISMAR), Agenzia nazionale per le nuove tecnologie, l’energia e lo sviluppo economico sostenibile (ENEA), Istituto Idrografico della Marina (IIM) and Istituto Nazionale di Geofisica e Vulcanologia (INGV).Published1933–1946OSA4: Ambiente marino, fascia costiera ed Oceanografia operativaJCR Journa
