17 research outputs found
Acute Hypoglycemia Decreases Myocardial Blood Flow Reserve in Patients With Type 1 Diabetes Mellitus and in Healthy Humans
No full textBackground-: Hypoglycemia is associated with increased cardiovascular mortality, but the reason for this association is poorly understood. We tested the hypothesis that the myocardial blood flow reserve (MBFR) is decreased during hypoglycemia using myocardial contrast echocardiography in patients with type 1 diabetes mellitus (DM) and in healthy control subjects. Methods and Results-: Twenty-eight volunteers with DM and 19 control subjects underwent hyperinsulinemic clamps with maintained sequential hyperinsulinemic euglycemia (plasma glucose, 90 mg/dL [5.0 mmol/L]) followed by hyperinsulinemic hypoglycemia (plasma glucose, 50 mg/dL [2.8 mmol/L]) for 60 minutes each. Low-power real-time myocardial contrast echocardiography was performed with flash impulse imaging using low-dose dipyridamole stress at baseline and during hyperinsulinemic euglycemia and hyperinsulinemic hypoglycemia. In control subjects, MBFR increased during hyperinsulinemic euglycemia by 0.57 U (22%) above baseline (B coefficient, 0.57; 95% confidence interval, 0.38 to 0.75; P<0.0001) and decreased during hyperinsulinemic hypoglycemia by 0.36 U (14%) below baseline values (B coefficient,-0.36; 95% confidence interval,-0.50 to-0.23; P<0.0001). Although MBFR was lower in patients with DM at baseline by 0.37 U (14%; B coefficient,-0.37; 95% confidence interval,-0.55 to-0.19; P=0.0002) compared with control subjects at baseline, the subsequent changes in MBFR during hyperinsulinemic euglycemia and hyperinsulinemic hypoglycemia in DM patients were similar to that observed in control subjects. Finally, the presence of microvascular complications in the patients with DM was associated with a reduction in MBFR of 0.52 U (24%; B coefficient,-0.52; 95% confidence interval,-0.70 to-0.34; P<0.0001). Conclusions-: Hypoglycemia decreases MBFR in both healthy humans and patients with DM. This finding may explain the association between hypoglycemia and increased cardiovascular mortality in susceptible individuals. © 2011 American Heart Association. All rights reserved
Inflation induced redistributions via monetary assets in five European countries: 1974-1982. Economic Papers No. 41, September 1985
No full textOptical investigation of action potential and calcium handling maturation of hiPSC-cardiomyocytes on biomimetic substrates
No full textCardiomyocytes from human induced pluripotent stem cells (hiPSC-CMs) are the most promising human source with preserved genetic background of healthy individuals or patients. This study aimed to establish a systematic procedure for exploring development of hiPSC-CM functional output to predict genetic cardiomyopathy outcomes and identify molecular targets for therapy. Biomimetic substrates with microtopography and physiological stiffness can overcome the immaturity of hiPSC-CM function. We have developed a custom-made apparatus for simultaneous optical measurements of hiPSC-CM action potential and calcium transients to correlate these parameters at specific time points (day 60, 75 and 90 post differentiation) and under inotropic interventions. In later-stages, single hiPSC-CMs revealed prolonged action potential duration, increased calcium transient amplitude and shorter duration that closely resembled those of human adult cardiomyocytes from fresh ventricular tissue of patients. Thus, the major contribution of sarcoplasmic reticulum and positive inotropic response to β-adrenergic stimulation are time-dependent events underlying excitation contraction coupling (ECC) maturation of hiPSC-CM; biomimetic substrates can promote calcium-handling regulation towards adult-like kinetics. Simultaneous optical recordings of long-term cultured hiPSC-CMs on biomimetic substrates favor high-throughput electrophysiological analysis aimed at testing (mechanistic hypothesis on) disease progression and pharmacological interventions in patient-derived hiPSC-CMs
Exchange rate policy for Eastern Europe and a peg to the ECU. Economic Papers No. 90, March 1992
No full textBudget deficit and interest rates: Is there a link? International evidence. Economic Papers No 105, November 1993
No full textThe economics of policies to stabilize or reduce greenhouse gas emissions: the case of CO2. Economic Papers No. 87, October 1991
No full textCopernicus Marine Service Ocean State Report, Issue 4
No full textThe 4th edition of the Copernicus Marine Service Ocean State Report (OSR 4) published in 2020 provides information on changes and variations in the ocean over the past decades, with a focus on changes in the marine environment during the year 2018. It is written by 140 scientific experts from more than 30 institutions and draws from the marine monitoring capabilities of the Copernicus Marine Service.The authors would like to thank the Institut Cartogràfic i Geològic de Catalunya (ICGC) for providing data. Thanks are due to FCT/MCTES for the financial support to CESAM (UID/AMB/50017/2019), through national funds.Article signat per 142 autors/es: Karina von Schuckmann (Editor), Pierre-Yves Le Traon (Editor), Neville Smith (Chair) (Review Editor), Ananda Pascual (Review Editor), Samuel Djavidnia (Review Editor), Jean-Pierre Gattuso (Review Editor), Marilaure Grégoire (Review Editor), Glenn Nolan (Review Editor), Signe Aaboe , Enrique Álvarez Fanjul , Lotfi Aouf , Roland Aznar , T. H. Badewien , Arno Behrens , Maristella Berta , Laurent Bertino , Jeremy Blackford , Giorgio Bolzon , Federica Borile , Marine Bretagnon , Robert J.W. Brewin , Donata Canu , Paola Cessi , Stefano Ciavatta , Bertrand Chapron , Thi Tuyet Trang Chau , Frédéric Chevallier , Boriana Chtirkova , Stefania Ciliberti , James R. Clark , Emanuela Clementi , Clément Combot , Eric Comerma , Anna Conchon , Giovanni Coppini , Lorenzo Corgnati , Gianpiero Cossarini , Sophie Cravatte , Marta de Alfonso , Clément de Boyer Montégut , Christian De Lera Fernández , Francisco Javier de los Santos , Anna Denvil-Sommer , Álvaro de Pascual Collar , Paulo Alonso Lourenco Dias Nunes , Valeria Di Biagio , Massimiliano Drudi , Owen Embury , Pierpaolo Falco , Odile Fanton d’Andon , Luis Ferrer , David Ford , H. Freund , Manuel García León , Marcos García Sotillo , José María García-Valdecasas , Philippe Garnesson , Gilles Garric , Florent Gasparin , Marion Gehlen , Ana Genua-Olmedo , Gerhard Geyer , Andrea Ghermandi , Simon A. Good , Jérôme Gourrion , Eric Greiner , Annalisa Griffa , Manuel González , Annalisa Griffa , Ismael Hernández-Carrasco , Stéphane Isoard , John J. Kennedy , Susan Kay , Anton Korosov , Kaari Laanemäe , Peter E. Land , Thomas Lavergne , Paolo Lazzari , Jean-François Legeais , Benedicte Lemieux , Bruno Levier , William Llovel , Vladyslav Lyubartsev , Pierre-Yves Le Traon , Vidar S. Lien , Leonardo Lima , Pablo Lorente , Julien Mader , Marcello G. Magaldi , Ilja Maljutenko , Antoine Mangin , Carlo Mantovani , Veselka Marinova , Simona Masina , Elena Mauri , J. Meyerjürgens , Alexandre Mignot , Robert McEwan , Carlos Mejia , Angélique Melet , Milena Menna , Benoît Meyssignac , Alexis Mouche , Baptiste Mourre , Malte Müller , Giulio Notarstefano , Alejandro Orfila , Silvia Pardo , Elisaveta Peneva , Begoña Pérez-Gómez , Coralie Perruche , Monika Peterlin , Pierre-Marie Poulain , Nadia Pinardi , Yves Quilfen , Urmas Raudsepp , Richard Renshaw , Adèle Révelard , Emma Reyes-Reyes , M. Ricker , Pablo Rodríguez-Rubio , Paz Rotllán , Eva Royo Gelabert , Anna Rubio , Inmaculada Ruiz-Parrado , Shubha Sathyendranath , Jun She , Karina von Schuckmann , Cosimo Solidoro , Emil V. Stanev , Joanna Staneva , Andrea Storto , Jian Su , Tayebeh Tajalli Bakhsh , Gavin H. Tilstone , Joaquín Tintoré , Cristina Toledano , Jean Tournadre , Benoit Tranchant , Rivo Uiboupin , Arnaud Valcarcel , Nadezhda Valcheva , Nathalie Verbrugge , Mathieu Vrac , J.-O. Wolff , Enrico Zambianchi , O. Zielinski , Ann-Sofie Zinck & Serena ZuninoPostprint (published version
