1,720,979 research outputs found
EFEK PEMBERIAN ALPHA LIPOIC ACID PADA ENDOTEL TIKUS PUTIH YANG DIINDUKSI LIPOPOLISAKARIDA
Full text linkABSTRACT Endothelial dysfunction play a major role in the pathogenesis of vascular diseases, especially atherosclerosis. Endothelial dysfunction causes endothelial cells are activated and resulting homeostasis changes in endothelial cell. Rats were induced by LPS 0.5 mg/kg and treated with ALA at doses of 30 mg/kg, 60 mg/kg and 120 mg/kg BW for 2 weeks which given 1 hour before the LPS administration. This study show that LPS causes morphological changes in rat aorta based on histochemical staining show that endothelial cell are irregular, not homogeneous and increase permeability but in group that received show that ALA can improve the morphological of endothelial cell by reduces ROS, regenerates of exogenous and endogenous antioxidants. Administration of ALA and LPS reduce the rats body weight but not significant compared to the control group. Therefore can be concluded that administration of ALA can prevent endothelial dysfunction. Keywords: Endothel dysfunction, alpha lipoic acid, lipopolysaccharide  ABSTRAK Disfungsi endotel berperan penting pada pathogenesis penyakit vascular, khususnya aterosklerosis.  Disfungsi endotel menyebabkan sel endotel teraktivasi dan terjadi perubahan homeostatis pada sel endotel. Tikus diinduksi dengan LPS 0.5 mg/Kg BB dan selanjutnya di terapi dengan ALA pada dosis 30mg/Kg BB, 60mg/Kg BB, dan 120mg/Kg BB selama 2 minggu 1 jam sebelum pemerian LPS. Penelitian ini menujukan bahwa LPS dapat menyebabkan perubahan morfologi pada sel nedotel berdasakan pada hasil pewarnaan jaringan yang menunjukan sel endotel yang tersusun tidak beraturan, tidak homogeny dan terjadi peningkatan permeabilitas tapi pada kelompok perlakuan yang mendapatkan terapi ALA menunjukan ALA dapat memperbaiki morfologi sel endotel dengan mengurangi ROS, meningkatkan antioksidan eksogen dan endogen. Pemberian ALA dan LPS tidak menyebabkan perubahan berat badan tikus yang signifikan di bandingkan dengan kelompok control. Sehingga dapat disimpulkan pemberian ALA dapat mencegah disfungsi endotel. Kata Kunci: disfungsi endotel, histokimia, alpha lipoic acid, lipopolisakarid
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
UJI AKTIVITAS FAGOSITOSIS MAKROFAG EKSTRAK TANAMAN GEDI Abelmoschus Manihot (L) SEBAGAI IMUNOMODULATOR
Full text linkGedi plant (Abelmoschus manihot L.) is one of the plants that contain flavonoids which have not been made into preparations for medicinal purposes. The purpose of this study was to determine the effectiveness of gedi plant extract as an immunomodulator. By looking at the activity and capacity of mouse macrophages (Rattus norvegicus) with Staphylococcus auereus bacteria in vitro. The results showed that gedi leaf extract had a significant effect on the activity and capacity of macrophages P(<0.05) which stated that gedi leaf extract had effectiveness as an immunostimulant. At a concentration of gedi plant extract of 1000 ppm, the activity and phagocytosis capacity showed the highest values, namely 87.66% and 4.23.
PHYTOCHEMICAL SCREENING AND TOXICITY TEST OF MANGROVE LEAF ETHANOL EXTRACT (Bruguiera gymnorrhiza) WITH BRINE SHRIMP LETHALITY TEST (BSLT) METHOD
Full text linkCancer is one of the biggest causes of death in the world. Therefore, efforts to manufacture drugs for cancer treatment continue to be developed. One of the efforts to develop cancer drugs is by using medicinal plants which are empirically used by local communities in various regions. This study aims to analyze the content of secondary metabolites contained in the leaf extract of the Mangrove Bruguiera gymnorrhiza and to determine the potential as an anticancer by determining the LC50 value. The extract was obtained by maceration using 96% ethanol solvent, identification of secondary metabolites by phytochemical screening and to determine the anticancer potential using the BSLT method with data analysis using Microsoft Excel. The phytochemical test results showed that the leaf extract contained alkaloids, flavonoids, saponins, tannins, and did not contain steroid/triterpenoid compounds. The results of the analysis showed that the ethanol extract of mangrove leaf (Bruguiera gymnorrhiza) was highly toxic with an LC50 value of 24.1 µg/ml.Â
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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