3,603 research outputs found
Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression
No full textAbstract not availableCraig T. Wallington-Beddoe, Jason A. Powell, Daochen Tong, Stuart M. Pitson, Kenneth F. Bradstock and Linda J. Bendal
Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice
No full textSphingosine kinase (SphK) 2 has been implicated in the development of a range of cancers and inhibitors of this enzyme are currently in clinical trial. We have previously demonstrated a role for SphK2 in the development of acute lymphoblastic leukemia (ALL).In this and our previous study we use mouse models: in the previous study the disease was driven by the proto-oncogene BCR/ABL1, while in this study cancer risk was elevated by deletion of the tumor suppressor ARF.Mice lacking ARF and SphK2 had a significantly reduced incidence of ALL compared mice with wild type SphK2.These results show that the role of SphK2 in ALL development is not limited to BCR/ABL1 driven disease extending the potential use of inhibitors of this enzyme to ALL patients whose disease have driver mutations other than BCR/ABL1.Vicki Xie, Daochen Tong, Craig T. Wallington-Beddoe, Ken F. Bradstock and Linda J. Bendal
Identification of sphingosine kinase 1 as a therapeutic target in B-lineage acute lymphoblastic leukaemia
No full textLink to a related website: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15097, Open Access via UnpaywallAbstract not availableCraig T. Wallington‐Beddoe, Vicki Xie, Daochen Tong, Jason A. Powell, Alexander C. Lewis, Lorena Davies, Stuart M. Pitson, Kenneth F. Bradstock
Linda J. Bendal
John Tong
No full textabstract: John was ten years old when he left his home. He traveled to Ethiopia with his friends and elders without food or water.
“Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.Age: 25Region: BarakazarThis picture and bio was donated to the "Lost Boys Found" oral history project from The Arizona Lost Boys Cente
Waste is "wicked" when we try to solve it. Author's response to Joshua Goldstein's comments
No full textThis is the author's response to Dr. Goldstein's response to our recent article The rise and fall of a Waste cityin the construction of an urban circular economic systenif The changing landscape of waste in Beijingin the February 2016 issue of this publication. (C) 2016 Elsevier B.V. All rights reserved.SCI(E)REVIEW175-17611
Developing Chimeric Antigen Receptor T cells for the Treatment of Acute Myeloid Leukaemia
No full textAML is the most common acute leukaemia in adults with a high incidence of relapse following allogeneic HSCT. CAR T cells have shown remarkable outcomes in R/R B-cell leukaemia/lymphoma and MM. However, replicating this success in AML has been challenging chiefly due to heterogeneity of AML and lineage specific antigen expression in AML within and between patients, leading to immune escape and treatment failure.
CD123 is a leading target as it is frequently overexpressed in bulk and LSCs, with relatively lower expression on myeloid cells. Others in our lab have shown that PiggyBac CAR T cells targeting CD123 with natural ligand IL-3 recognition domain are effective in vitro. However, the discovery of CAR T derived lymphomas in treated patients prompted us to seek alternative gene modification systems. In this thesis, I explored 2 main themes, namely (i) to improve the genetic safety of CARIL3 therapy; and (ii) to increase the efficacy of anti-AML CAR T therapy.
Chapter 3 describes the pre-clinical development of CARIL3 using alternative lentiviral and PiggyBat systems with a focus on maintaining efficacy while exploring differences in gene integration patterns.
Chapter 4 looks at TIM-3 as another potential target with the aim of combining with CARIL3 to reduce the risk of antigen escape. The issue of fratricide due to expression of TIM-3 on T cells was overcome by CRISPR/Cas9 KO.
Chapter 5 explores whether the TIM-3 knockout could also improve efficacy of CARIL3, since TIM-3 is studied as a T cell exhaustion marker. The theme of genetic safety is again explored, by using CRISPR-Cas9 directed knock-in into the TIM-3 locus to minimise the risk of random integration.
While further work is required to enable safe and efficacious CAR T cells against AML in the clinic, the work in this thesis presents several proof-of-concept strategies taking significant steps towards realising this goal
The Socio-Cultural Context of Mo Xiang Tong Xiu's Novel “The Founder of the Demon Path” Mo Xiang Tong Xiu
No full textАвтор розкриває стиль, структуру та наратив роману Мосян Тунсю «Засновник демонічного шляху», що сформувалися під впливом літературних тенденцій Китаю 2010-х років.
The author reveals the style, structure, and narrative of Mosiang Tongxiu's Mo Xiang Tong Xiu's novel The Founder of the Demon Path, which were shaped by the literary trends in China in the 2010s
Whose story is it anyway? The ethics of narration and the narration of ethics in Summertime and Die Sneeuslaper
No full textIncludes bibliographical references.This dissertation analyses and compares the narrative strategies in J.M. Coetzee’s Summertime and Marlene van Niekerk’s Die sneeuslaper and considers the implications of these strategies for the authors’ exploration of the ethics of writing. Much has been written about the literary oeuvres of both Coetzee and Van Niekerk, including studies of the translations of Van Niekerk’s Afrikaans novels into English. There are few “interlingual” comparative studies of contemporary works in Afrikaans and English, however, and certainly none to my knowledge which compares the work of Coetzee and Van Niekerk. My contribution to the conversation about Coetzee’s and Van Niekerk’s work, but also to an increasingly multilingual and interconnected South African literary criticism, will be a comparison of one recent work by each of these two authors, written in English and Afrikaans respectively. I draw on the theories of Bakhtin, Barthes and Levinas to consider the ethical dimension of texts in which “double-voicedness”, a questioning not only of existence, but of the self is fore grounded in the content and narrative structure; where there is a shift in focus from the author to the reader (“the birth of the reader”) and “utterances” are made with the response of “the other” in mind
基于概率的地图实体匹配方法
No full textAuthor name used in this publication: 童小华, Tong, Xiao-huaAuthor name used in this publication: 邓愫愫Author name used in this publication: SHI Wen-zhong2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishedVoR allowe
Dian xing BMP Smad xin hao dui xiao shu pei tai fa yu he chu sheng hou de xiao shu fa yu zhi yan jiu
No full textTong, Ka Kui.Thesis Ph.D. Chinese University of Hong Kong 2014.Includes bibliographical references (leaves 174-189).Abstracts also in Chinese.Title from PDF title page (viewed on 12, December, 2016).Tong, Ka Kui
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