276 research outputs found
Henry Watterson and the New South: The Politics of Empire, Free Trade, and Globalization
No full textHenry Watterson (1840–1921), editor of the Louisville Courier-Journal from the 1860s through World War I, was one of the most important and widely read newspaper editors in American history. An influential New South supporter of sectional reconciliation and economic development, Watterson was also the nation\u27s premier advocate of free trade and globalization. Watterson\u27s vision of a prosperous and independent South within an expanding American empire was unique among prominent Southerners and Democrats. He helped articulate the bipartisan embrace of globalization that accompanied America\u27s rise to unmatched prosperity and world power. This book restores Watterson to his place at the heart of late nineteenth-century southern and American history by combining biographical narrative with an evaluation of Watterson\u27s unique involvement in the politics of free trade and globalization.https://uknowledge.uky.edu/upk_united_states_history/1186/thumbnail.jp
21st Century Neighborhood:
No full textGladys Haddad continues to explore the Greater University Circle Initiative and how it hopes to bring community wealth and economic inclusion to these neighborhoods of Cleveland. This conversation focuses on the 21st Century Urban Neighborhood with a combination of new and old residents, sustainable businesses, and collaborative environments. The session was held at the Shorebank Enterprise Center in Glenville, this session brings together Andrew Watterson (Program Director, Office of Sustainability, City of Cleveland), Holly Harlan (President and Founder, Entrepreneurs for Sustainability) and Chris Bongorno (Associate Planner, University Circle Inc) to discuss the Greater University Initiative. Part two was held at the Shorebank Enterprise Center in Glenville, this session brings together Steven Kiel (Managing Director, Hudson Consulting Group), Genna Petrolla (Greater Circle Living Manager Dorothy Adams (Glenville Resident) and Donald Hunt (Hough Resident, Deputy Registrar, Case Western Reserve University) to discuss the Greater University Initiative and to discuss how to create a 21st century neighborhood with traditional and new residents
Involvement of p38 MAPK in Synaptic Function and Dysfunction
Get PDFMany studies have revealed a central role of p38 MAPK in neuronal plasticity and the regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) and long-term depression (LTD). However, p38 MAPK is classically known as a responsive element to stress stimuli, including neuroinflammation. Specific to the pathophysiology of Alzheimer’s disease (AD), several studies have shown that the p38 MAPK cascade is activated either in response to the Aβ peptide or in the presence of tauopathies. Here, we describe the role of p38 MAPK in the regulation of synaptic plasticity and its implication in an animal model of neurodegeneration. In particular, recent evidence suggests the p38 MAPK α isoform as a potential neurotherapeutic target, and specific inhibitors have been developed and have proven to be effective in ameliorating synaptic and memory deficits in AD mouse models
Modelling subrogation as an “equitable remedy”
Get PDFFollowing the landmark decision of the House of Lords in Banque Financière de la Cité v Parc (Battersea) Ltd, the English courts have come to say that subrogation to extinguished rights is an “equitable remedy” designed to reverse “unjust enrichment”. This creative re-rationalisation requires a fresh look at the nature and operation of this phenomenon, and in particular, at the key components of the “new” orthodoxy — that such subrogation is a “remedy”, which is “equitable” in origin, and is “restitutionary” in aim and effect. A clear understanding of these components is not of merely academic interest. It is vital for a proper understanding of the nature and timing of the entitlements that are afforded to subrogation claimants, and of a court’s role in their recognition and effectuation. On closer examination, the cases reveal an unacknowledged and unresolved tension between two different conceptions of the remedy’s operation: (i) a “strong institutional model”; and (ii) a weaker institutional model, which is labelled the “liability model”. Adopting either model, subrogation is not a drastically “remedial” phenomenon which yields entitlements for claimants only by virtue of some judicial order. Subrogation-justifying facts will immediately trigger some form of entitlement for a subrogation claimant, which arises prior to, and independently of, any subsequent court order. Nevertheless, the nature and quality of this pre-court entitlement, and the court’s role in its recognition and effectuation, will differ depending on the model preferred. On balance, the liability model is the more defensible in principle. It should ultimately prevail.Peer reviewe
The influences of crustal extension, salt tectonics and gravity-driven deformation on the structural evolution of the Halten Terrace, offshore mid-Norway: new sights from 3D seismic data and fault analysis
Get PDFNormal fault zones play a fundamental role in the development of sedimentary basins and in the migration and trapping of hydrocarbons. The idealised geometry of an isolated post-sedimentary normal fault (Barnett, 1987, Walsh & Watterson, 1989) existing conceptual models that describe the process of fault growth and linkage in brittle systems (Childs et al, 1995; Cartwright et al, 1996; Childs et al, 1995, 1996b; Huggins et al, 1995), where fault planes composed of many overstepping segments are linked by areas of complex deformation called relay ramps, are generally accepted. Relay zones can trap significant volumes of hydrocarbon or act as leakage points, thus understanding the style of fault linkage, which strongly influences the location of hydrocarbon tops and reservoir compartmentalisation, is vital for any petroleum system.EThOS - Electronic Theses Online ServiceGBUnited Kingdo
Nicotine-induced place conditioning and locomotor activity in an adolescent animal model of attention deficit/hyperactivity disorder (ADHD)
Get PDFabstract: Attention deficit/hyperactivity disorder (ADHD) is a risk factor for tobacco use and dependence. This study examines the responsiveness to nicotine of an adolescent model of ADHD, the spontaneously hypertensive rat (SHR). The conditioned place preference (CPP) procedure was used to assess nicotine-induced locomotion and conditioned reward in SHR and the Wistar Kyoto (WKY) control strain over a range of nicotine doses (0.0, 0.1, 0.3 and 0.6 mg/kg). Prior to conditioning, SHRs were more active and less biased toward one side of the CPP chamber than WKY rats. Following conditioning, SHRs developed CPP to the highest dose of nicotine (0.6 mg/kg), whereas WKYs did not develop CPP to any nicotine dose tested. During conditioning, SHRs displayed greater locomotor activity in the nicotine-paired compartment than in the saline-paired compartment across conditioning trials. SHRs that received nicotine (0.1, 0.3, 0.6 mg/kg) in the nicotine-paired compartment showed an increase in locomotor activity between conditioning trials. Nicotine did not significantly affect WKY locomotor activity. These findings suggest that the SHR strain is a suitable model for studying ADHD-related nicotine use and dependence, but highlights potential limitations of the WKY control strain and the CPP procedure for modeling ADHD-related nicotine reward.This is the final peer-reviewed accepted manuscript. The final article as published is available at http://dx.doi.org/10.1016/j.bbr.2015.05.031
Book Reviews
Get PDFKaren Watterson is a consultant on database design and the author of several books on database programming, including bestselling Visual Basic Database Programming (Addison-Wesley). She is also the editor of the Visual basic Developer newsletter and Contributing Editor to Windows Sources magazine
Literary Allusions in Selected Newspaper Editorials
No full text A study of collections of editorials by William Allen White and Henry Watterson and of recent editorials in the Arkansas Gazette and Atlanta Constitution discloses differences in the use of literary references—across papers and through time. The author suggests that editorial writing may benefit from such allusions. </jats:p
Examining the dual role of dengue virus E domain III in receptor binding and membrane fusion
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