217 research outputs found
Climate change literacy and migration potential: micro-level evidence from Africa
No full textAbstract
While a growing literature studies the effects of climate change on international migration, still only relatively little is known about the individual mechanisms linking migration decisions to climate change. We argue that climate change literacy (i.e., knowledge about climate change) is a major determinant of why some individuals consider migrating to other countries in response to climate change effects. In particular, climate change literacy helps individuals translate their perceptions of temperature changes into an understanding of these changes’ irreversible long-term consequences. We test this hypothesis using highly accurate geo-coded data for 37,000 individuals across 30 African countries. We show that climate change indeed leads to stronger migration intentions among climate literates only. Furthermore, we show that climate change only increases migration intentions among climate literates when it is approximated by long-run increases in local temperatures, but not when operationalized as changing heat wave or precipitation patterns. Further analyses show that climate literates are more likely to live in urban areas, have a higher news consumption, are highly educated, and have demanding occupations. Consequently, climate change may further deprive affected countries of valuable talent
7_Supplementary_Figures - Baseline effects of non-flavored e-liquids in the in vitro micronucleus assay
No full text7_Supplementary_Figures for Baseline effects of non-flavored e-liquids in the in vitro micronucleus assay by Daniel J Smart, Fabian R Helbling, Damian McHugh and Patrick Vanscheeuwijck in Toxicology Research and Application</p
International Business Cycle Synchronization in Historical Perspective
No full textIn this paper, we review and attempt to explain the changes in business cycle synchronization among 16 industrial countries and the over the past century and a quarter, demarcated into four exchange rate regimes. We find that there is a secular trend towards increased synchronization for much of the twentieth century and that it occurs across diverse exchange rate regimes. This finding is in marked contrast to much of the recent literature, which has focused primarily on the evidence for the past 20 or 30 years and which has produced mixed results. We then examine the role of global shocks and shock transmission in the trend toward synchronization. Our key finding here is that global (common) shocks generally are the dominant influence.
Direct and indirect acquisition of photoprotective compounds in crab larvae of coastal Patagonia (Argentina)
No full textFirst larval stage (Zoea I) of the crab Cyrtograpsus altimanus can obtain photoprotective compounds (PPCs) from their mother (indirect acquisition) and also via feeding on PPC-producers such as phytoplankton (direct acquisition). The bioaccumulation of PPC resulted in higher survival of larvae exposed to ultraviolet radiation (UVR), when comparing larvae with high and low content of PPC. Thus, both ways of acquiring PPC may contribute to maximize survival of Zoea I when they are exposed to natural UVR.Fil: Hernández Moresino, Rodrigo Daniel. Fundación Playa Unión. Estación de Fotobiología Playa Unión; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gonçalves, Rodrigo Javier. Fundación Playa Unión. Estación de Fotobiología Playa Unión; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Helbling, Eduardo Walter. Fundación Playa Unión. Estación de Fotobiología Playa Unión; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
The Use of Cellulose Membrane to Eliminate Burst Release from Intravaginal Rings
No full textBurst release was observed when ethylene vinyl acetate copolymer (EVA) intravaginal rings were tested for progesterone release in our previous work (Helbling et al. Pharm Res. 31(3):795–808, 2014). Burst release is undesirable in controlled delivery devices because release is uncontrollable and higher levels of active pharmaceutical ingredient could lead to the occurrence of adverse effect. The present contribution is about the use of membranes to coat EVA rings to eliminate burst release. Physicochemical state of progesterone in uncoated rings and the solubility and diffusion coefficient in membrane were studied. Hormone delivery from several rings of different sizes was compared. A mathematical model was used to analyze the effects of membrane properties on delivery rate. No chemical interactions were detected between hormone and polymer. Hormone was mainly forming amorphous aggregates inside rings, and migration to membrane was not observed during storage. Diffusion coefficient was smaller in membrane (~10-8 cm2 s-1) than in matrix (~10-7 cm2 s-1). Zero-order release kinetics were obtained for coated rings, and release rate decreases as the thickness of the coat increases. Cellulose membrane successfully eliminates burst release and controls the delivery from EVA rings. The equations developed can be used to determine the appropriate coat thickness to produce specific release rate.Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Ibarra, Juan Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin
Kundenbindung im Immobilienmanagement
No full textAuf dem Schweizer Immobilienmarkt für Wohnraum ist eine Abschwächung der Nachfrage mit gleichzeitig kontinuierlicher Bautätigkeit festzustellen, was zu einem Anstieg der Leerstände führt. In diesem Marktumfeld wird besonders in den Agglomerationen der grossen Ballungszentren der Schweiz die Bindung der Mieter an die Verwaltung und die daraus resultierende tiefe Leerstandsquote immer wichtiger. Die Branche weist auf Grund des Nachfrageüberschusses der letzten 20 Jahre ein grosses Nachholpotenzial bei der Ausrichtung auf Kundebindung auf
Mathematical Modeling of Drug Delivery from Silicone Devices
No full textBovine estrus synchronization is an important fi eld for the veterinary pharmaceutical industry. A description of the natural bovine cycle and methods to cycle control are presented. In addition, commercially available silicone devices for bovine estrus synchronization are listed. Th e mathematical modeling of progestagens release from such devices is a crucial tool in the development of novel and/ or optimized delivery systems. For this purpose, several in vitro models, approaches to explain the ADME processes and overall models are described. Th is type of mathematical modeling could help in the future to customize drug delivery systems to specifi c animals and/ or situations.Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Ibarra, Juan Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin
Evaluation and optimization of progesterone release from intravaginal rings using response surface methodology
No full textResponse surface methodology was successfully used to study effect of formulation parameters on progesterone release from rings made of ethylene-vinyl acetate copolymers. Significant effects were estimated by an analyses of variance (ANOVA) and statistical model was constructed. Model predictions showed good agreement with experimental data. Results showed that mass of progesterone released can be enhanced by several strategies. In addition, model behavior was compared with previously validated model reported in the literature obtaining satisfactory results. The statistical model was also employed to optimize formulation parameters with the aim to reach release rate of about 3.545 ± 0.020 mg cm-2 days-1/2. Optimized prototype was tested in vitro. Results showed that optimized IVR has similar profiles than the commercial silicone device used as reference. Optimized ring would have several advantages over commercial one like lower initial and residual content of progesterone and the possibility of recycling rings after their usage avoiding incineration of used device (as in the case of silicone commercial device). Pharmacokinetics studies must be done to corroborate in vivo performance of optimized IVRs made of EVA.Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); ArgentinaFil: Ibarra, Juan Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentin
Mathematical Modeling of Drug Delivery from Silicone Devices Used in Bovine Estrus Synchronization
No full textBovine estrus synchronization is an important field for the veterinary pharmaceutical industry. A description of the natural bovine cycle and methods to cycle control are presented. In addition, commercially available silicone devices for bovine estrus synchronization are listed. The mathematical modeling of progestagens release from such devices is a crucial tool in the development of novel and/or optimized delivery systems. For this purpose, several in vitro models, approaches to explain the ADME processes and overall models are described. This type of mathematical modeling could help in the future to customize drug delivery systems to specific animals and/or situations.Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Ibarra, Juan Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin
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