815 research outputs found
Projet de construction d’un bâtiment d’archives mutualisé à Fribourg/Brisgau (Allemagne) : état des lieux en juillet 2012
No full textEcker Ulrich, Peter Daniel. Projet de construction d’un bâtiment d’archives mutualisé à Fribourg/Brisgau (Allemagne) : état des lieux en juillet 2012. In: La Gazette des archives, n°232, 2013-4. Mutualiser, coopérer, partager : des enjeux pour les archives communales et intercommunales. pp. 231-233
Author Correction: Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis
No full textThe original version of this Article contained an error in the spelling of the author Brett L. Ecker, which was incorrectly given as Brett Ecker. This has now been corrected in both the PDF and HTML versions of the Article.published_or_final_versio
HRABAL und der Mann am Fenster
No full textDer dritte Band der Reihe „Bamberger Texte für Bühne und Film“ (BTBF) präsentiert eine kommentierte und mit Materialien versehene Edition von Bernhard Setzweins Theaterstück HRABAL und der Mann am Fenster (UA 2015, Theater Regensburg). Dieses Projekt dokumentiert das Interesse der hiesigen Germanistik an dramatischer Literatur und der Kooperation mit Theatern sowie ihre Bereitschaft, dramatische Literatur medienübergreifend zu verstehen.
Setzweins Hrabal-Stück geht über eine bloße Hommage an einen der großen Erzähler der tschechischen Literatur weit hinaus. Seine tragikomische Handlung reflektiert das – trotz konkreter historischer Situierung – zeitlose Schicksal eines Menschen, dessen Leben vom Lauf der Weltgeschichte zunächst völlig entwertet, dann aber durch eine ironische Wendung unter umgekehrten Vorzeichen wieder mit Sinn ausgestattet wird: Aus dem Spitzel eines Überwachungsstaats, der mit akribischer Pedanterie und ambivalenten Gefühlen über Jahre hinweg einen Menschen ausgespäht hat, wird nach dem politischen Umsturz von 1989 der ideale Museumsführer für eine Hrabal-Gedenkstätte im Zeichen touristischer Vermarktung; denn er allein weiß noch Zuverlässiges und Interessantes vom Leben und Werk des inzwischen rehabilitierten Schriftstellers zu berichten.
Eine weitere wichtige Dimension des Stückes besteht in seinem poetologischen Diskurs über ästhetische Prinzipien und Techniken der modernen Kunst. Nicht zuletzt deshalb drucken wir im Materialienteil die bislang noch nicht publi-zierte Bamberger Poetikvorlesung des Verfassers ab.The third volume in the series “Bamberger Texte für Bühne und Film” (BTBF) presents a commentated edition with additional materials of Bernhard Setzwein’s play HRABAL und der Mann am Fenster (premiere in 2015 at the Theater Regensburg). This project documents on the one hand the great interest of the local department of German Studies in dramatic literature and cooperation with theatres or drama groups, in addition to its readiness in understanding dramatic literature across media.
Setzwein’s Hrabal play is much more than a mere homage to one of the great storytellers in Czech literature. The tragicomical plot reflects the – despite concrete historical placement – timeless fate of a man whose life is initially made utterly worthless by the course of world history, but then receives meaning through an ironic twist under reversed omens: After years of spying on another man with meticulous pedantry and ambivalent emotions, the informer of a surveillance state becomes the ideal museum guide after the political revolution in 1989 for a Hrabal memorial under the banner of touristic commercialization, because he alone can give reliable and interesting account of the life and work of the author, who was rehabilitated in the meantime.
Another important aspect of the play is in its poetological discourse about aesthetic principles and techniques of modern art. Not least because of this, we present the hitherto not published Bamberg poetological lecture of the author in the additional materials
Particles, fields, quanta: from quantum mechanics to the standard model of particle physics
No full textThis book provides an introduction to the current state of our knowledge about the structure of matter. Gerhard Ecker describes the development of modern physics from the beginning of the quantum age to the standard model of particle physics, the fundamental theory of interactions of the microcosm. The focus lies on the most important discoveries and developments, e.g. of quantum field theory, gauge theories and the future of particle physics. The author also emphasizes the interplay between theory and experiment, which helps us to explore the deepest mysteries of nature. "Particles, Fields, Quanta" is written for everyone who enjoys physics. It offers high school graduates and students of physics in the first semesters an encouragement to understand physics more deeply. Teachers and others interested in physics will find useful insights into the world of particle physics. For advanced students, the book can serve as a comprehensive preparation for lectures on particle physics and quantum field theory. A brief outline of the mathematical structures, an index of persons with research focuses and a glossary for quick reference of important terms such as gauge theory, spin and symmetry complete the book. From the foreword by Michael Springer: “The great successes and the many open questions this book describes illustrate how immensely complicated nature is and nevertheless how much we already understand of it.” The author Gerhard Ecker studied theoretical physics with Walter Thirring at the University of Vienna. His research focus has been on theoretical particle physics, in particular during several long-term visits at CERN, the European Organisation for Nuclear Research in Geneva. In 1986 he was promoted to Professor of Theoretical Physics at the University of Vienna. Since 1977 he has given both basic lectures in theoretical physics and advanced courses on different topics in particle physics, e.g., quantum field theory, symmetry groups in particle physics and renormalisation in quantum field theory
Aberrant connectivity of lateral prefrontal networks in presymptomatic Huntington's disease
No full textIn clinically presymptomatic individuals with the Huntington's disease (HD) gene mutation, functional neuroimaging data have suggested a dysfunction of multiple cortical and subcortical regions including the prefrontal and parietal cortex, as well as the striatum. Although it has been hypothesized that these activation differences most likely reflect aberrant corticostriatal circuits, the functional coupling of neural networks associated with cognitive performance has not been investigated so far. In this study, we used functional magnetic resonance imaging (fMRI) and multivariate analytic techniques to investigate memory-related patterns of functional connectivity in healthy controls (n = 16) and pre-HD individuals (n = 16). Independent component analyses (ICA) revealed distinct bilateral frontostriatal and frontoparietal networks that were activated during a verbal working memory paradigm in both healthy controls and pre-HD subjects. Compared with healthy controls, pre-HD individuals exhibited lower functional connectivity in left lateral prefrontal and parietal regions as well as in the bilateral putamen. Functional connectivity indices in the left putamen were negatively correlated with the CAG repeat size and the UHDRS behavioral score, and positively correlated with the predicted years to manifest symptom onset. The connectivity of the right putamen was negatively correlated with the UHDRS motor score. In pre-HD individuals, these results suggest an early frontostriatal and frontoparietal deficit of dissociable functional networks associated with executive processin
Optimization of carbon ion and proton treatment plans using the raster-scanning technique for patients with unresectable pancreatic cancer
No full textBackground: The aim of the thesis is to improve radiation plans of patients with locally advanced, unresectable pancreatic cancer by using carbon ion and proton beams. Patients and methods: Using the treatment planning system Syngo RT Planning (Siemens, Erlangen, Germany) a total of 50 treatment plans have been created for five patients with the dose schedule 15 × 3 Gy(RBE). With reference to the anatomy, five field configurations were considered to be relevant. The plans were analyzed with respect to dose distribution and individual anatomy, and compared using a customized index. Results: Within the index the three-field configurations yielded the best results, though with a high variety of score points (field setup 5, carbon ion: median 74 (range 48–101)). The maximum dose in the myelon is low (e.g. case 3, carbon ion: 21.5 Gy(RBE)). A single posterior field generally spares the organs at risk, but the maximum dose in the myelon is high (e.g. case 3, carbon ion: 32.9 Gy(RBE)). Two oblique posterior fields resulted in acceptable maximum doses in the myelon (e.g. case 3, carbon ion: 26.9 Gy(RBE)). The single-field configuration and the two oblique posterior fields had a small score dispersion (carbon ion: median 66 and 58 (range 62–72 and 40–69)). In cases with topographic proximity of the organs at risk to the target volume, the single-field configuration scored as well as the three-field configurations. Conclusion: In summary, the three-field configurations showed the best dose distributions. A single posterior field seems to be robust and beneficial in case of difficult topographical conditions and topographical proximity of organs at risk to the target volume. A setup with two oblique posterior fields is a reasonable compromise between three-field and single-field configurations
Comparison of intensity modulated radiotherapy (IMRT) with intensity modulated particle therapy (IMPT) using fixed beams or an ion gantry for the treatment of patients with skull base meningiomas
No full textAbstract Background To examine the potential improvement in treatment planning for patients with skull base meningioma using IMRT compared to carbon ion or proton beams with and without a gantry. Methods Five patients originally treated with photon IMRT were selected for the study. Ion beams were chosen using a horizontal beam or an ion gantry. Intensity controlled raster scanning and the intensity modulated particle therapy mode were used for plan optimization. The evaluation included analysis of dose-volume histograms of the target volumes and organs at risk. Results In comparison with carbon and proton beams only with horizontal beams, carbon ion treatment plans could spare the OARs more and concentrated on the target volumes more than proton and photon IMRT treatment plans. Using only a horizontal fixed beam, satisfactory plans could be achieved for skull base tumors. Conclusion The results of the case studies showed that using IMPT has the potential to overcome the lack of a gantry for skull base tumors. Carbon ion plans offered slightly better dose distributions than proton plans, but the differences were not clinically significant with established dose prescription concepts.</p
Problems or prospects? Being a parent in the early phase of the COVID-19 pandemic in Germany
No full textBackgroundIn the early phase of the COVID-19 pandemic, many restrictions hit people in ways never seen before. Mental wellbeing was affected and burden was high, especially for high-risk groups such as parents. However, to our knowledge no research has yet examined whether being a parent was not only a risk for psychological burden but also a way to cope with the COVID-19 pandemic. MethodsAn online survey was used to collect data from 1,121 participants from April to June 2020. In addition to demographic variables, risk factors (financial burden, problems complying with COVID-19 restrictions, and pre-treatment due to mental health problems) and protective factors (emotion regulation, humor, and crisis self-efficacy) were collected. The dataset was divided into three groups: parents whose children lived at home (n = 395), parents whose children did not (no longer) live at home (n = 165), and people who were not parents (n = 561). ResultsA linear mixed effect model showed that parents had no higher burden than non-parents, and even less when children did not live at home. Expected risk factors were generally less important, and there were no differences between parents and non-parents. In contrast, parents had advantages in protective factors. ConclusionIn the early phase of the COVID-19 pandemic, it was shown that parents (with and without their children at home) were not necessarily at risk due to additional burden, but also had prospects of coping better with the situation than people without children
Early Treatment Response of a Rare Papillary Tumor of the Pineal Region after Primary Proton-Beam Therapy using the Raster-Scanning Technique at HIT
No full textGOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types
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