65 research outputs found
The Military Image in the Poetry of A. E. Housman
No full textThis thesis analyzes the military image in the poems of A. E. Housman. The first section is a brief biographical sketch which stresses those incidents of Housman\u27s life that most influenced his personality and poetry. Section two is an introduction to Housman\u27s association and contact with the military and points out influences on his military poems. Section three analyzes those military poems which have autobiographical significance for the author. The fourth section is an explanation of Housman\u27s belief that the military life is the best possible life; it also analyzes the virtues and value system of the soldier. The final section discusses the military as an escape from the misery of life, an escape either through becoming an automatonic soldier, or by reaching the ultimate in life, a brave death. All poems cited are from The Collected Poems of A. E. Housman, published by Henry Holt and Company, New York, in 1940
Housman und die Katze
No full textAls Altphiloge hat der englische Gelehrte Housman den Fortgang des Thesaurus beobachtet und dabei seine Kritik nicht versteckt. Ein Großunternehmen war ihm als Privatgelehrte suspekt, und er beschrieb diese Gemeinschaftsarbeit als 'the ergastulum at Munich’. Speziell ein kleiner Artikel, aelurus, hat ihm nicht gefallen und er lässt das deutlich merken: Everyone can figure to himself the mild inward glow of pleasure and pride which the author of this unlucky article felt while he was writing i..
Author Platforms in the Twenty-First Century: Maintaining Social Media and Self-Promoting.
No full text
A Performer\u27s Guide to Ivor Gurney\u27s The Western Playland (and of Sorrow)
No full textThe purpose of this document is to serve as a performance guide for Ivor Gurney’s song cycle, The Western Playland (and of Sorrow), a song cycle for baritone, piano and string quartet, consisting of eight songs set to the poetry of A. E. Housman. Within this performance guide an analysis of each song and poem in The Western Playland (and of Sorrow) will be explored, along with performance recommendations for each of the eight songs. Given that there were relatively few composers writing works for string quartet, piano and solo voice during the years Ivor Gurney was composing, the author feels an in-depth exploration of this song cycle necessitates the research found in this dissertation. This document contains information about the life and works of composer and poet, Ivor Gurney, and poet A. E. Housman. Appendices include: the complete solo voice works list of Mr. Gurney, his discography, transcripts of e-mail interviews with the current biography author of Mr. Gurney, and e-mail interviews with Philip Lancaster, Gurney Archivist and letters of permission
PENGARUH PERTUMBUHAN PENDAPATAN, CURRENT RATIO DAN DEBT TO EQUITY TERHADAP RETURN ON EQUITY PADA PERUSAHAAN PERKEBUNAN DI BURSA EFEK INDONESIA 2010-2017
No full textPenelitian ini mempunyai tujuan untuk mengetahui apakah terdapat pengaruh signifikan pertumbuhan pendapatan, Current Ratio dan Debt to Equity Ratio terhadap Return on Equity baik secara partial maupun simultan, pada perusahaan perkebunan di Bursa Efek Indonesia. Teknik yang digunakan dalam penelitian ini adalah purposing sampling, yaitu data diambil dari perusahaan perkebunan yang sudah terdaftar di Bursa Efek Indonesia minimal sejak 1 Januari 2010 dan perusahaan tersebut mempunyai data yang lengkap. Pengolahan data pada penelitian ini menggunakan eviews versi 10. Data yang digunakan adalah data panel, yang terdiri dari 5 perusahaan (data cross section) dan 8 tahun (data time series). Untuk menentukan model yang paling sesuai dengan penelitian ini dilakukan berbagai macam uji, yaitu : uji common effect, uji fixed effect, uji random, uji chow, uji housman dan uji lagrange multiplier. Setelah mendapatakan model yang sesuai dilanjutkan dengan uji asumsi klasik dan uji hipotesis. Hasil dari penelitian ini menunjukan bahwa pertumbuhan pendapatan dan Debt to Equity Ratio secara partial berpengaruh signifikan terhadap Return on Equity. Sedangkan Current Ratio secara partial tidak berpengaruh signifikan terhadap Return on Equity. Sedangkan secara simultan, pertumbuhan pendapatan, Current Ratio dan Debt to Equity Ratio berpengaruh signifikan sebesar 45,18%
ANALISIS CURRENT RATIO, RETURN ON EQUITY, DEBT TO EQUITY RATIO DAN PERTUMBUHAN PENDAPATAN BERPENGARUH TERHADAP RETURN SAHAM PADA PERUSAHAAN PERTAMBANGAN DI BURSA EFEK INDONESIA 2010-2014
No full textABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh CR, ROE, DER, dan pertumbuhan pendapatan terhadap return saham, baik secara parsial maupun secara simultan. Data yang digunakan adalah data panel yang merupakan gabungan dari data cross section (9 perusahaan) dan time series (2010-2014). Penelitian ini menggunakan analisis linier berganda dan dilakukan berbagai macam uji antara lain: uji common effect, uji fixed effect, uji random effect , uji chow, uji housman, uji asumsi klasik dan uji hipotesis pada model yang digunakan. Variabel independen pada penelitian ini adalah CR, ROE, DER dan pertumbuhan pendapatan. Sedangkan variabel dependen yang digunakan adalah return saham. Pada pengujian pengaruh CR, ROE, DER dan pertumbuhan pendapatan terhadap return saham digunakan model fixed effect. Hasilnya menunjukkan bahwa secara partial CR, ROE, DER, dan pertumbuhan pendapatan tidak berpengaruh secara signifikan terhadap return saham. Sedangkan CR, ROE, DER dan pertumbuhan pendapatan secara simultan berpengaruh secara signifikan terhadap return saham sebesar 33,28%. Kata Kunci : Return saham, Current Ratio, Return on Equity, Debt to Equity Ratio, pertumbuhan pendapata
Flow cytometry quantitation of dopamine receptor D2 loss as a sensitive measure of Huntington's Disease progression in mouse neurons
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2013.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references.Mouse models of Huntington's Disease (HD) are often used for testing potential therapeutic compounds. These experiments require substantial investments in time and resources, and have yet to produce any intervention that has made a significant impact on disease progression in the clinic. In evaluating potential therapeutics, there is an unmet need for a rapid, highly quantitative measure of disease progression in the HD mouse model brain. Such an assay would help make preclinical trials more efficient. To address this need, I have developed a novel technique for measuring the progression of transcriptional dysregulation, a phenotype with substantial similarities between mouse models and patients. Specifically, utilizing mice that drive GFP expression under the control of one such dysregulated gene (Drd2), I have improved on previous protocols for the isolation and characterization of adult neurons by flow cytometry. Drd2 is a well-studied marker of a particularly vulnerable population in HD patients, the indirect medium spiny neurons of the striatum. Using this technique, I have demonstrated the ability to accurately and rapidly quantitate Drd2 transcript levels, as measured by Drd2 GFP (D2GFP) fluorescence, in several strains of HD model mice. This D2GFP loss is particularly robust, with sufficient power to allow subtle, statistically significant alterations to be observed with very small cohorts. Furthermore, the introduction of this D2GFP transgene does not alter the classic HD pathology in these mice. Finally, I show that D2GFP dysregulation can be either induced or ameliorated genetically by delivering transgenes via adeno associated viral vectors, and that a small molecule with only subtle transcriptional effects (cystamine) fails to rescue D2GFP loss. I hope that this system can be of great utility in the validation of effective therapeutic interventions for HD.by Zachary R. Crook.Ph.D
A Comparative Analysis of Genetic and Epigenetic Events of Breast and Ovarian Cancer Related to Tumorigenesis
No full textabstract: Breast cancer persists as the most common cause of cancer death in women worldwide. Ovarian cancer is also a significant source of morbidity and mortality, as the fifth leading cause of cancer death among women. This reflects the continued need for further understanding and innovation in cancer treatment. Though breast and ovarian cancer usually present as distinct clinical entities, the recent explosion of large-scale -omics research has uncovered many overlaps, particularly with respect to genetic and epigenetic alterations. We compared genetic, microenvironmental, stromal, and epigenetic changes common between breast and ovarian cancer cells, as well as the clinical relevance of these changes. Some of the most striking commonalities include genetic alterations of BRCA1 and 2, TP53, RB1, NF1, FAT3, MYC, PTEN, and PIK3CA; down regulation of miRNAs 9, 100, 125a, 125b, and 214; and epigenetic alterations such as H3K27me3, H3K9me2, H3K9me3, H4K20me3, and H3K4me. These parallels suggest shared features of pathogenesis. Furthermore, preliminary evidence suggests a shared epigenetic mechanism of oncogenesis. These similarities, warrant further investigation in order to ultimately inform development of more effective chemotherapeutics, as well as strategies to circumvent drug resistance
Drug Resistance in Cancer: An Overview
No full textabstract: Cancers have the ability to develop resistance to traditional therapies, and the increasing prevalence of these drug resistant cancers necessitates further research and treatment development. This paper outlines the current knowledge of mechanisms that promote or enable drug resistance, such as drug inactivation, drug target alteration, drug efflux, DNA damage repair, cell death inhibition, and the epithelial-mesenchymal transition, as well as how inherent tumor cell heterogeneity plays a role in drug resistance. It also describes the epigenetic modifications that can induce drug resistance and considers how such epigenetic factors may contribute to the development of cancer progenitor cells, which are not killed by conventional cancer therapies. Lastly, this review concludes with a discussion on the best treatment options for existing drug resistant cancers, ways to prevent the formation of drug resistant cancers and cancer progenitor cells, and future directions of study
- …
