1,721,025 research outputs found
Melanocytic tumors of uncertain malignant potential in childhood: do we really need sentinel node biopsy?
No full textMultiple agminated Spitz nevi of the penis
No full textA case of a 7-year-old boy with multiple agminated Spitz nevi of the outer part of the prepuce is described. The normal and electron microscopic pictures are presented.
Multiple agminated Spitz nevi of the penis
No full textA case of a 7-year-old boy with multiple agminated Spitz nevi of the outer part of the prepuce is described. The normal and electron microscopic pictures are presented.
Analysis of Cox-2 expression in Wilms' tumor.
Full text linkCylooxygenase-2 (Cox-2) inhibitors have increasingly become therapeutic
alternatives in some Cox-2-overexpressing neoplasms. As the treatment eligibility
for these drugs hinges on Cox-2 expression, Cox-2 immunostaining has recently
been widely examined in several malignant neoplasms. However, data on the
expression of Cox-2 in Wilms' tumor (WT) are limited. In this study, we examined
Cox-2 expression in 40 examples of WT to identify the prognostic impact, to
evaluate the effects on tumorigenesis, and to answer the question of whether
neoplasms with Cox-2 expression could benefit from treatment with specific Cox-2
inhibitors. Sections from paraffin-embedded tumor samples were immunostained by a
standard ABC technique using Cox-2 mouse monoclonal antibody. As in other rare
examples reported in the literature, Cox-2 immunoreactivity was analyzed and
correlated with histological features and the staging of neoplasms. However, in
contrast to other studies, we also evaluated the relation of Cox-2 positivity to
age, sex, and survival of patients. The results of this study demonstrated that
Cox-2 was ubiquitously expressed in all cases of WT and their neovasculature,
independently of the type of neoplasm (tumors with a favorable or unfavorable
histology), tissues which constitute the neoplasm (blastemal, mesenchymal and
epithelial, heterologous or non-heterologous elements), patient age, sex, or
stage of development and survival rate. Thus, Cox-2 inhibitors could be used for
treating all cases of WT. Further studies, including molecular investigations,
would be useful to confirm our hypotheses
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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