169,885 research outputs found

    On the sub-permutations of pattern avoiding permutations

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    There is a deep connection between permutations and trees. Certain sub-structures of permutations, called sub-permutations, bijectively map to sub-trees of binary increasing trees. This opens a powerful tool set to study enumerative and probabilistic properties of sub-permutations and to investigate the relationships between 'local' and 'global' features using the concept of pattern avoidance. First, given a pattern mu, we study how the avoidance of mu in a permutation pi affects the presence of other patterns in the sub-permutations of pi. More precisely, considering patterns of length 3, we solve instances of the following problem: given a class of permutations K and a pattern mu, we ask for the number of permutations pi is an element of Av(n)(mu) whose sub-permutations in K satisfy certain additional constraints on their size. Second, we study the probability for a generic pattern to be contained in a random permutation pi of size n without being present in the sub-permutations of pi generated by the entry 1 <= k <= n. These theoretical results can be useful to define efficient randomized pattern-search procedures based on classical algorithms of pattern-recognition, while the general problem of pattern-search is NP-complete. (C) 2014 Elsevier B.V. All rights reserved

    Manoscritti miniati dalla biblioteca del duca Andrea Matteo III Acquaviva

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    Il saggio di Hermann Julius Hermann analizza le miniature della biblioteca del duca Andrea Matteo III Acquaviva d'Aragona per dimostrare il ruolo attivo avuto da questo fine intellettuale nell'ideazione delle miniature stesse, nella guida filosofico-letteraria offerta ai miniatori

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Protein-protein interaction analysis highlights additional loci of interest for multiple sclerosis

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    Genetic factors play an important role in determining the risk of multiple sclerosis (MS). The strongest genetic association in MS is located within the major histocompatibility complex class II region (MHC), but more than 50 MS loci of modest effect located outside the MHC have now been identified. However, the relative candidate genes that underlie these associations and their functions are largely unknown. We conducted a protein-protein interaction (PPI) analysis of gene products coded in loci recently reported to be MS associated at the genome-wide significance level and in loci suggestive of MS association. Our aim was to identify which suggestive regions are more likely to be truly associated, which genes are mostly implicated in the PPI network and their expression profile. From three recent independent association studies, SNPs were considered and divided into significant and suggestive depending on the strength of the statistical association. Using the Disease Association Protein-Protein Link Evaluator tool we found that direct interactions among genetic products were significantly higher than expected by chance when considering both significant regions alone (p<0.0002) and significant plus suggestive (p<0.007). The number of genes involved in the network was 43. Of these, 23 were located within suggestive regions and many of them directly interacted with proteins coded within significant regions. These included genes such as SYK, IL-6, CSF2RB, FCLR3, EIF4EBP2 and CHST12. Using the gene portal BioGPS, we tested the expression of these genes in 24 different tissues and found the highest values among immune-related cells as compared to non-immune tissues (p<0.001). A gene ontology analysis confirmed the immune-related functions of these genes. In conclusion, loci currently suggestive of MS association interact with and have similar expression profiles and function as those significantly associated, highlighting the fact that more common variants remain to be found to be associated to MS

    Food safety in collective catering: Knowledge, attitudes and correct application of GHP/GMP knowledge among foodservice workers

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    Food safety critically reliant on the behaviors adopted by foodservice personnel, involved in various stages of meal preparation, from the supply of raw food materials until its distribution to the consumer. The purpose of this work was to collect information on the level of knowledge on food safety, the correct application of the Good Hygiene Practices (GHP) and Good Manufacturing Practices (GMP) and the attitudes of the operators involved in collective catering. The survey was conducted among 15 social catering companies in Apulia (Italy) using a modified Sharif and Al-Malki (2010) anonymous questionnaire intended to assess the knowledge, attitudes and practices of the food handlers. The results highlight the need to improve both knowledge and practices regarding food hygiene and safety in order to minimize the risk of transmitting foodborne diseases. More careful planning, implementation, monitoring and evaluation of training programs for foodservice workers is required, taking into consideration the provisions of European food laws

    Correction to: Lung cancer and interstitial lung diseases: the lack of prognostic impact of lung cancer in IPF (Internal and Emergency Medicine, (2022), 17, 2, (457-464), 10.1007/s11739-021-02833-6)

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    The caption of Fig. 1 shown in the article is incomplete, the correct caption is shown below: “Fig. 1 a Correlation between interval time ‘LC diagnosis and follow up end’ and DLCO% in the three groups: UIP/IPF-LC (blue circles), SR-ILD-LC (green circles), O-ILD-LC (red circles). b Localization of lung cancer in the three groups: UIP/IPF-LC, SR-ILD-LC, O-ILD-LC. Blue columns: central cancer not in fibrotic area; green columns: peripheral cancer not in fibrotic area; beige columns: peripheral cancer in fibrotic area. c Survival in the three groups of patients: UIP/IPF-LC, SR-ILD-LC, O-ILD-LC. d Survival in patients with UIP/IPF with and without lung cancer (LC)”
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