1,862 research outputs found
Costruzione di un percorso diagnostico, terapeutico, assistenziale per i pazienti con Sclerosi Laterale Amio-trofica in Regione Lombardia
No full textAmyotrophic Lateral Sclerosis (ALS) is a degenerative disease of the nervous system that affects selectively motor neurons
causing their death and thereby atrophy and paralysis of muscles innervated, with an invariably unfavourable prognosis.
ALS is included in the group of rare diseases (prevalence ≤50 cases per 100000 inhabitants), which have common
problems: difficulty in arriving at correct diagnosis and subsequently communicated the conclusion promptly to the patient,
complexity of care and therapeutic management of these patients. In Lombardy the attention to rare diseases is high
and in this context enter diagnostic, therapeutic and care paths drawn up by specialists. The construction of these documents
suggests an overall management of patients and their family and social context, requiring specific, passionate and
responsible resources for the practical application. The specific document for patients with ALS has these goals: use
for the disease a multidisciplinary approach, give at the patients all the available opportunities for treatment,
build provincial and regional health and social networks for the round care of patients, in order to clear the sense
of abandonment that they perceive. The patient’s perception of their quality of life is related more to the quality
of assistance received that to the severity of the disease or degree of disability associated
TUTELA DEL LAVORO E LIBERTA' D'IMPRESA NEI PROCESSI DI ESTERNALIZZAZIONE
No full textL’elaborato analizza le conseguenze lavoristiche della successione fra imprenditori, muovendo da una ricognizione delle varie tipologie di esternalizzazione con le relative esigenze e principali criticità.
L’indagine si concentra in primo luogo sul trasferimento d’azienda, esaminando la normativa e la giurisprudenza europee per passare poi alla disciplina di diritto interno, alle procedure sindacali e a uno specifico focus sul trasferimento delle aziende in crisi.
Successivamente l’autore si sofferma sull’appalto, prendendone in particolare considerazione gli indici di genuinità, i criteri di distinzione dalla somministrazione illecita di manodopera e la tutela delle maestranze in caso di avvicendamento fra imprese.
Da ultimo, la ricerca approfondisce le c.d. “clausole sociali”, sia di prima che di seconda generazione, valutandone la compatibilità con il diritto eurounitario e con la costituzione nonché riflettendo sui possibili rimedi in caso di loro violazione.The author analyzes the labour consequences of the succession between entrepreneurs, starting from a recognition of the various types of outsourcing with the related needs and main critical issues.
The survey focuses primarily on the transfer of businesses, examining European legislation and case-law and then moving on to internal legislation, trade union procedures and a specific focus on the transfer of companies in crisis.
The author then dwells on the contract, taking into account in particular the indications of authenticity, the criteria of distinction from the illicit administration of labour and the protection of workers in the event of turnover between companies.
Finally, the research deepens the "social clauses", both first and second generation, assessing their compatibility with European law and with the constitution and reflecting on possible remedies in case of their violation
DNA di poliomavirus in pazienti con sclerosi multipla in terapia con Natalizumab
No full textNatalizumab therapy is associated with an increased risk of progressive multifocal leukoencephalopathy (PML). Since the
prognosis of PML is extremely poor, identification of patients highly susceptible to the disease may improve outcomes.
Our paper tries to find out if new positive result or increased JCV DNA concentration in urine samples
may represent a good marker of viral reactivation. Secondary objectives are to assess the effects of therapy
on leucocyte serum levels and evaluate drug efficacy.
Every month, we evaluated leucocyte level, JCV and BKV DNA serum and urine concentration in 33 patient
with multiple sclerosis under Natalizumab treatment. We did not notice any variation in JCV DNA concentration,
nor new positive results. We noticed an increasing trend in the average BKV DNA concentration in urine.
Fifteen out of 33 patients were treated for a period of 12 months. In this subgroup we noticed an increasing trend
in leucyte serum levels and a BKV DNA new positive result in urine sample. After one year patients showed a
significant decrease in relapse rate compared to the previous year and an improvement in EDSS.
Monitoring urine JCV DNA concentration does not seem an effective marker for viral reactivation. A
good marker could be BKV DNA urine level
Donne ed elezioni, gioie e dolori
No full textOur paper focuses on the intersection of three different dimensions: female leadership, local electoral competition, and digital communication. We wish to capture the main differences between female and male candidates in terms of digital campaigning, investigating the strategies and narratives used on the social media, the levels of interaction, the degree of personalization and intimate politics, the influence of pop politics, and the presence of gender issues. We do so by quantitively analysing Facebook posts collected over the 2016-2020 period, corresponding to five different local election campaigns. In total, our sample includes of 42 women and 70 men candidates for the office of mayor for one of the three major Italian political families (Centerleft, Center-right, 5 Star Movement), for a total of over 19,000 «election campaign» posts (i.e. published two months prior to the first election round). Through the study of different metrics and the development of an ontological dictionary, we test the existence of gender differences in local political leadership both in reference to the strategies adopted (frequency of publication, chosen themes) and in terms of digital success, that we operationalize as the number of post interactions. Our analysis suggests that there are indeed differences in the communication style and success of male and female candidates on social media, although these are often embedded and more easily appreciated within each political family
Ultra Low Carbon Vehicles: New Parameters for Automotive Design
No full textAs the influence of vehicle emissions on our environment has become better understood, the UK government has recently placed urgent emphasis on the implementation of low carbon
technologies in the automotive industry through: the UK Low Carbon Industrial Strategy. The overall objective is to offer big incentives to consumers and support for the development of infrastructure and engineering solutions. This scheme however does not consider how the development of functional and experiential user value might drive consumer demand, contributing to the adoption of low carbon vehicles (LCVs) in the mass market.
With the emergence of the North East of England as the UK’s first specialised region for the development of ultra-low carbon vehicles (ULCVs), ONE North East, as a development agency for the region's economic and business development, and Northumbria University Ideas-lab have supported a project to facilitate innovation through the collaboration of technology, research and development (R&D) and business. The High Value Low Carbon (HVLC) project aims to envisage
new user value made possible by the integration of low carbon vehicle platforms with new process and network technologies. The HVLC consortium represents vehicle manufacturers and their suppliers as well as technology based companies and through an ongoing process of design concept generation the project offers a hub for innovation led enterprise.
Whilst new technological developments in areas such as power generation, nano materials, hydrogen fuel cells, printed electronics and networked communications will all impact on future automotive design, the mass adoption of low carbon technologies represents a paradigm shift for the motorist. This paper aims to describe how the mapping of new parameters will lead to new transport scenarios that will create the space for new collaborative research on user experiences supported by innovative technologies and related services
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Matteo Maria Boiardo (1441-1494)
No full textMatteo Maria Boiardo – contemporary of Sir Thomas Malory and forerunner of Shakespeare, Spenser, Milton, Cervantes, Tolkien, and C.S. Lewis – is best known as the author of the Orlando Innamorato [Orlando in Love], a poem in ottava rima organically merging Carolingian epic and Arthurian romance. He was also a lyric and pastoral poet, playwright, and translator of classical texts into the Italian vernacular. Matteo was active in Italy during the years of 1463 throughout 1494, the year of his death
Uno sguardo all'Est. Lavoro e diritti fondamentali in Russia e negli altri Paesi della Comunità di Stati indipendenti
No full textNel contributo l'autore, dopo aver esaminato i diritti fondamentali del lavoro presenti nelle Costituzioni dei Paesi della Comunità di Stati indipendenti, si sofferma sul diritto del lavoro russo. La trattazione, a carattere diacronico, abbraccia i rami principali del diritto del lavoro: il rapporto individuale, le relazioni collettive, il mercato del lavoro. L'autore rileva una sorprendente continuità nelle linee essenziali del diritto del lavoro russo, pur nel susseguirsi di sistemi socioeconomici completamente diversi. Egli conclude che il diritto del lavoro russo appartiene saldamente alla matrice europea della materia.The contribution of the author starts by examining fundamental labour rights recognised by the Constitutions of the Countries of the Community of Independent States. Then the author focuses upon Russian Labour Law, going through the history of the main branches of the discipline: the individual relationship, industrial relations, the labour market. The article finds a surprising continuity in the essential lines of Russian Labour Law, in spite of the completely different socio-economic systems that were experimented in Russia during the twentieth century. The author concludes that Russian Labour Law clearly belongs to the European matrix of the discipline
Corpo, spazio, architettura. Fenomenologia dell’esperienza spaziale Matteo Vegetti, Fabrizia Bandi (eds.), Editrice Morcelliana, Brescia 2024
No full textThe author reviews "Corpo, spazio, architettura: Fenomenologia dell’esperienza spaziale," edited by Matteo Vegetti and Fabrizia Bandi. The book examines the philosophical underpinnings of spatial experience through a phenomenological lens, engaging with both traditional and contemporary notions of how space, body, and architecture interconnect. The author highlights the text\u27s exploration of how architects and designers might integrate phenomenological insights into their work, transforming space from mere physical dimensions into lived, experienced reality. The review appreciates the book’s thematic organization, which starts with foundational theories from Merleau-Ponty and expands through discussions on virtual spaces and the future of architecture in the digital age. Through this anthology, readers gain a comprehensive view of the architectural implications of phenomenological thought, making it a critical resource for anyone involved in the conceptualization and design of space
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