1,721,130 research outputs found
Overweight in Turner syndrome: influence on growth hormone secretion and treatment.
No full textThe role of growth hormone (GH) in short stature associated with Turner syndrome (TS) is still unclear. Recently it has been suggested that overweight in TS can decrease nocturnal GH secretion and the response to GHRH stimulation test as in idiopathic obese subjects. The aim of this study was to determine the relationship between obesity, stimulated growth hormone secretion and the response to GH treatment in TS. The degree of overweight in 30 TS girls (aged 3.1-14.4 years) was correlated with the response to various GH stimulation tests (GHRH, L-DOPA, arginine, clonidine and propranolol-glucagon (PGST) and with linear growth rate during six months of GH treatment (0.6 U/kg/week). GH secretion evaluated as peak (P) and as area under curve (AUC) after GHRH was negatively correlated with the degree of adiposity expressed as % of ideal body weight (IBW) (P:r = -0.52, p 120) versus non obese patients as P (p < 0.04) and as AUC (p < 0.05); this trend was also observed after PGST (p < 0.05) but not after the other tests. After GH treatment growth velocity similarly increased in obese and non obese TS girls. No correlation was found between GH secretion and the increase in growth velocity after GH treatment. Our data confirm that overweight may be responsible for a blunted GH secretion in TS; however, it does not affect the response to GH therapy
Donne ed uomini a confronto in due settori lavorativi differenti: valutazioni delle patologie emerse
No full textFOLIA MEDIC
[Definitive body height in constitutional retardation of growth and puberty]
No full textBackground: Constitutional delay of growth and puberty (CDGP) is a frequent cause of short stature in childhood. Controversial results have been reported on the full achievement of these patients of their target height. Patients and methods: The final adult height of 20 patients with CDGP (11 male and 9 female), who did not received hormonal treatment, was compared with their target height and with the predicted adult height, by the Bayley-Pinneau method obtained before the onset of puberty. Results: A spontaneous improvement of the stature from pre-puberty to adulthood was observed in all patients (from -2.9 +/- 0.7 SDS to -1.3 +/- 0.6 SDS in male and from -2.6 +/- 0.6 SDS to -0.9 +/- 0.3 SDS in female; P < 0.001). Adult height in male (166.4 +/- 4.1 cm) at the mean age of 21 years was very close to the target height (165.7 +/- 3.9 cm) and to the predicted adult height (167.3 +/- 3.1 cm). Also in female, final height (156.6 +/- 2.0 cm) did not differ from target height (153.3 +/- 4.2 cm) and from predicted adult height (155.6 +/- 2.3 cm). Conclusions: In our experience, patients with CDGP reach their predicted adult height and achieve their genetic potential without medical treatment
Puberty in insulin-dependent diabetes mellitus (IDDM): growth, sexual maturation and final height
No full text
A Method to Discriminate Between the Candida stellata and Saccharomyces cerevisiae in Mixed Fermentation on WLD and Lysine Agar Media
No full textThis paper presents a simple method to distinguish between Candida stellata and Saccharomyces cerevisiae
yeasts during microbiological analyses. The method is based on differential yeast growth on a medium
containing cycloheximide and a medium containing lysine as only nitrogen source (lysine agar). The
cycloheximide resistance of 45 yeast strains belonging to Candida stellata, Hanseniaspora uvarum, Hanseniaspora
guilliermondii, Metschnikowia pulcherrima, Torulaspora delbrueckii, Zygosaccharomyces bailii, Kluyveromyces
thermotolerans and Zygoascus hellenicus, and 14 strains of Saccharomyces cerevisiae and Saccharomyces
bayanus on WL nutrient agar, was assayed. Cycloheximide resistance is characteristic of the species H. uvarum,
H. guilliermondii and Z. hellenicus, while for the other yeasts it depends on the strain and the concentration
of cycloheximide used. Two mg/L of cycloheximide allows selective counting of a strain of C. stellata (Cs3)
compared to one of the sensitive S. cerevisiae strain (NDA21). Similar results can be obtained on lysine agar,
but counts are reliable only with the additional spreading of a monolayer of Saccharomyces cells. The different
cycloheximide resistance of C. stellata and S. cerevisiae can be used in the microbiological analysis of mixed
cultures to monitor the individual growth of the two yeast species. This method can be applied to the study
of mixed fermentations with other non-Saccharomyces species. The modified use of lysine agar is useful to a
certain extent in the distinction of multistarter yeasts from the indigenous yeasts
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