1,721,423 research outputs found
Sperimentazione numerica sulla applicazione della decomposizione a valori singolari nella risoluzione di problemi di minimi quadrati
No full textThe spectrum of tuberculosis infection: new perspectives in the era of biologics
No full textThe risk of developing active tuberculosis (TB) is higher in patients taking immunosuppressive drugs, either as a result of reactivation of a latent TB infection (LTBI) or following a new infection with Mycobacterium tuberculosis (Mtb). We discuss the pathogenesis and spectrum of Mtb infection in light of its implication for the management of patients following biologic regimens. Among recent findings, during LTBI, Mtb can persist in the host for decades, localizing in many tissues and assuming different metabolic states that protect the bacilli from the harsh host immune defenses. Despite the strong host T cell response against Mtb, the bacilli may also replicate and multiply in vivo, and any event impairing immune function may lead to active and uncontrolled bacteria replication and active disease. The classic dichotomy between active and latent disease is being reconsidered in favor of a continuous and dynamic spectrum extending from infection to disease that can coexist in the same individual. This TB spectrum results from the dynamic interaction between the host immune system and the bacilli and can be maintained in equilibrium for decades, although treatments affecting the host immune cells may result in disease reactivation
Una estensione dell'algoritmo di Ford-Fulkerson a problemi di flusso ottimo su una rete con vincoli di fascio
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Role of nanotechnologies against infectious diseases: The paradigm of mycobacterium tuberculosis. perspectives for prevention, diagnosis and treatment
No full textTuberculosis (TB) still represents one of the most overshadowing public health issues, particularly in developing countries. The efforts that are currently being made by the scientific community are many and sprout on various fronts, but can be divided in three basic avenues: development of new vaccines for prevention, generation of new and advanced diagnostic tools, and finally improvement of the chemotherapy. An "outside-the-box" approach is hence needed to develop new and improved instruments to fight Mycobacterium tuberculosis, the causative agent of TB. Cutting-edge technologies, such as nanotechnologies, can provide innovative and powerful tools to conquer this ancient infectious disease. Here, some notable examples of how nanotechnologies have entered in infectious diseases field will be presented, discussing how the "white plague," namely the TB, can represent a paradigm of a complex infectious disease whose several aspects must be kept in consideration. Copyright © 2014 American Scientific Publishers All rights reserved
Pastores collocutores: percorsi dialogici e "velame" politico in Arcadia
Full text linkThe contribution addresses the myth of Arcadia in a formal manner (ascription to the dramatic or dialogic genre) and content (as a political paradigm), between the Middle Ages and the modern age
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