1,720,964 research outputs found
Return on NFTs
Full text linkCurrently, the best known applications of blockchain technology are finance and art. In particular, the blockchain art market, born in early 2018 without fuss, went parabolic around 2021, also thanks to record-breaking sales of digital artworks associated with a Non-Fungible Token (NFT), mediated by the grand dames of auction houses Christie’s and Sotheby’s. In this contribution we merge art and finance on blockchain and explore the opportunity of buying blockchain art as a financial investment. While there exists a relatively large literature on traditional art as investment, the topic of investing in NFTs is still in its infancy. Thus, we provide methods (metrics) and tools (a Web app) to reason about opportunities, in terms of risks and returns, of investing in art on chain
Adult laryngeal hemangioma CO2 laser excision. A single institution 3-year experience (Vittorio Veneto 2001-2003).
No full textCONCLUSIONS:
Adult supraglottic hemangiomas can be treated successfully with CO2 laser excision with limited morbidity. Extended laryngeal cavernous hemangiomas involving hypopharynx should be approached with staged CO2 laser surgical procedures.
OBJECTIVES:
Hemangioma of the adult larynx is an uncommon, benign lesion characterized by thin, friable mucosa overlying the vascular stroma. The optimal surgical approach to these lesions is still controversial because only anecdotal case reports or very limited series are available. We report a 3-year, retrospective, single institution study of the results of CO2 laser treatment of supraglottic hemangiomas in adults.
PATIENTS AND METHODS:
Six consecutive cases of adult laryngeal hemangioma were treated by the first author with CO2 laser microsurgery alone.
RESULTS:
In five of six cases, no recurrences have been diagnosed (median follow-up period: 29 months). One case presented limited persistence of disease in the retro-cricoid and arytenoids at 20-month follow-up control
Paediatric laryngeal malignant nerve sheath tumour.
No full textMalignant nerve sheath tumours (MNSTs) are more frequently diagnosed in the extremities, the chest wall and the abdominal wall. Laryngeal MNST is an extremely rare occurrence, particularly in children. We treated a laryngeal recurrence of MNST in a 13-year-old boy with chemotherapy followed by horizontal supraglottic laryngectomy extended to left arytenoid and ipsilateral vocal fold and bilateral neck dissection. Four years later, hemithyroidectomy was performed for thyroid MNST recurrence. At present, 6 years after last intervention, the patient shows no evidence of recurrent disease
Leiomiosarcoma of the female breast. Report of two new cases and review of the literature.
No full textWe present the clinical, light microspcpic, and immunohistochemical features of two new cases of leiomiosarcoma of the female breast. both the patients were old (83 and 86 years) and were referred with history of long-standing breast lump. The results of the physical examination and the preoperative radiologic investigation suggested a phyllodes tumor. The patients were treated with mastectomy. The tumors measured 6 an 6.5 cm in the largest dimension, respectivelly, and were composedof fascicles of atypical, actively proliferating spindle cells, oftren intesecting hte right angles. The axillary lymph nodes wre free of tumor. Immunohistochemically, the tumor cells were positive for desmin, muscle-specific actin, and vimentin and negative fo othe markers, including keratins and hormone receptors. Focal rabdomyoblastic differentaitation was noted in one case. Follow-up at 1 year is negative for metastases or local recurrence. Our study confirms that leiomyosarcoma of the breast is a locally invasive neoplasmand that it could represent a peculiar anatomic entity among mesenchymal tumors of the breast
La diagnostica computerizzata per immagini nello studio delle adenopatie latero-cervicali in corso di car
No full textTreatment of unusual or rare laryngeal nonsquamous primary malignancies: radical (total/extended total laryngectomy) or conservative surgery?
No full textPURPOSE:
The most appropriate treatment of laryngeal nonsquamous malignancies is a controversial subject, mainly because of the limited number of cases diagnosed. Surgery, which is an obligatory choice in nearly all cases, is sometimes indiscriminately demolitive despite the relatively low locoregional aggressiveness that characterizes certain histotypes and locations. Even in extremely aggressive tumors, where the prognosis is almost invariably unfavorable because of distant metastasis, the suitability of radical surgery should be carefully assessed, especially considering the patient's remaining life quality. The aim of the present investigation was to evaluate the postsurgical oncological results in a series of consecutive patients with laryngeal nonsquamous primary malignancy.
METHODS:
We analyzed retrospectively 29 consecutive patients with laryngeal nonsquamous malignancies of whom 10 underwent total laryngectomy and 19 conservative surgery (partial laryngectomies).
RESULTS:
Of the 29 patients with of laryngeal nonsquamous malignancies, 16 were alive and free from disease after treatment, 5 died of other causes, 1 was lost at follow-up, and 7 died of the disease. Statistical analysis failed in disclosing a significantly different local recurrence rate after conservative surgery vs radical surgery after a mean follow-up period of 5.5 years.
CONCLUSIONS:
From the preliminary data emerging from the study, it seems that in nonsquamous malignancies of the larynx, the surgical approach should be the most conservative surgery possible, tailored to neoplasm extent and patient conditions. Although cervical lymph node metastases are unusual, long-term follow-up is mandatory considering the relatively high incidence of distant metastases even after years
Fibroepithelial tumor of the breast with digital fibroma-like inclusions in the stromal component: Case report with immunocytochemical and ultrastructural analysis
No full textA case of fibroepithelial tumor of the breast in a 34-year-old woman, showing digital fibroma-like inclusions in the stromal component is presented. Morphological, immunocytochemical, and ultrastructural findings indicate that the peculiar eosinophilic intracytoplasmic inclusions observed may represent tightly packed actin filaments. Although they are more frequently detected within digital fibrous proliferations of infancy, their rare occurrence at either unusual site or in adulthood has been reported. Similar inclusions have also been rarely observed in intranodal myofibroblastoma and in benign leiomyomas. These findings suggest that these inclusions may be the result of some metabolic or organisational abnormality shared by neoplastic actin-rich cells. Myofibroblastic and smooth muscle lesions are probably the commonest to show this defect
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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