1,721,575 research outputs found
Processing effort during reading texts in young adults: text simplification, readability assessment and preliminary eye-tracking data
No full textThe paper reports empirical data about the impact of text simplification procedures supported by readability assessment measures on processing effort during reading. Sixty-six Italian native undergraduate students read original and simplified versions of TV news texts and answered a comprehension question. Accuracy data, single word-based and sentence-based measures collected by means of an eye-tracker show that reading simplified texts requires less cognitive demands than their original versions. Italiano. Il lavoro riporta dati empirici relativi all'efficacia dell'applicazione di metriche di leggibilità nella produzione di testi semplificati. Sessantasei studenti italiani madrelingua hanno letto versioni originali e semplificate dei lanci di notizie tratte da telegiornali e hanno risposto ad una domanda di comprensione. I dati sull'accuratezza e diverse metriche ottenute con l'impiego di un eye-tracker e calcolate al livello di singole parole e singole frasi mostrano che le versioni semplificate dei testi riducono significativamente il carico cognitivo dei lettori rispetto alle relative versioni originali
FREQUENCY, NUMBER AND WORD ORDER EFFECTS IN THE COMPREHENSION OF COMPLEX SENTENCES BY ITALIAN- AND GERMAN-SPEAKING PRESCHOOLERS: A PILOT STUDY
No full textEQUITY JOINT VENTURES AND NEW PARTNERSHIPS FORMATION IN TERMINAL MANAGEMENT: A STOCHASTIC ACTOR ORIENTED MODEL
No full textThe increase of equity joint ventures in the terminal container industry is an established phenomenon, which has been extensively analysed in the port management literature. However, studies have mainly focused on the expansion strategies of international terminal operators and equity venture networks at global level, neglecting their effects on port competitiveness in the domestic markets. Focusing on the Italian container terminal industry as a network system, the paper investigates the influence of endogenous and exogenous structural characteristics of terminal operators' networks on new partnerships formation. Through the application of the Stochastic Actor Oriented Model, the changes in ownership and network structure of container terminals have been analysed in two waves (2011 and 2015) in terms of: size (number of equity ties), density (propensity to build equity ties) and partners' selection (homophily and heterophily). Results show that the Italian container terminal industry is characterized by leading positions of a few players that have increased the number of equity tics. These issues are of crucial importance and deserve attention from the Port Authorities with reference to the terminals' concession policy and competition in the market
Incontinentia Pigmenti
No full textL'incontinentia pigmenti è una sindrome ereditaria X-linked, letale nel maschio, che presenta manifestazioni cutanee polimorfe, differenti a seconda delle diverse epoche della vita
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
HMGA and cancer: A review on patent literatures
No full textBackground: The high mobility group A proteins modulate the transcription of numerous genes by interacting with transcription factors and/or altering the structure of chromatin. These proteins are involved in both benign and malignant neoplasias as a result of several pathways. A large amount of benign human mesenchymal tumors has rearrangements of HMGA genes. On the contrary, malignant tumors show unarranged HMGA overexpression that is frequently and causally related to neoplastic cell transformation. Here, we review the function of the HMGA proteins in human neoplastic disorders, the pathways by which they contribute to carcinogenesis and the new patents focused on targeting HMGA proteins.
Objective: Current review was conducted to check the involvement of HMGA as a druggable target in cancer treatment.
Methods: We reviewed the most recent patents focused on targeting HMGA in cancer treatment analyzing patent literature published during the last years, including the World Intellectual Property Organization (WIPO (R)), United States Patent Trademark Office (USPTO (R)), Espacenet (R), and Google Patents.
Results: HMGA proteins arc intriguing targets for cancer therapy and are objects of different patents based on the use of DNA aptamers, inhibitors, oncolytic viruses, antisense molecules able to block their oncogenic functions.
Conclusion: Powerful strategies able to selectively interfere with HMGA expression and function could represent a helpful approach in the development of new anti-cancer therapies
New anti-cancer strategies in testicular germ cell tumors
No full textThe most common solid malignancy of young men aged 20 to 34 years is testicular germ cell tumor. In addition, the incidence of these tumors has significantly increased throughout the last years. Testicular germ cell tumors are classified into seminoma and nonseminoma germ cell tumors, which take in yolk sac tumor, embryonal cell carcinoma, choriocarcinoma, and teratoma. There are noteworthy differences about therapy and prognosis of seminomas and nonseminoma germ cell tumors, even though both share characteristics of the primordial germ cells
Further insights into testicular germ cell tumor oncogenesis: potential therapeutic targets
No full textIntroduction: Testicular germ cell tumors (TGCTs) are the most common neoplasia in the young male population, and the incidence has been constantly increasing in many parts of the world. These tumors are classified into seminomas and non-seminomas, and those divided, in turn, into yolk sac tumors, embryonal cell carcinomas, choriocarcinomas, and teratomas. Although therapeutic approaches have improved, approximately 25% of the patients relapse or, in a small number of cases, show platinum-resistant disease. Areas covered: We review several molecular targets that have recently emerged as powerful tools for both diagnosis and therapy of TGCTs. Moreover, we reviewed the most frequent deregulated pathways involved in TGCT tumorigenesis, reporting drugs that may emerge as novel therapeutic agents. Expert opinion: TGCT treatment is mainly based on platinum-derivative therapy with high cure rates. However, in the refractory patients, there are few alternative treatments. Thus, different pharmacological approaches have to be thoroughly investigated to shed new light on TGCT pathogenesis and treatment
MiRNAs and biomarkers in testicular germ cell tumors: An update
No full textTesticular germ cell tumors (TGCTs) are the leading form of solid cancer and death affecting males between the ages of 20 and 40. Today, their surgical resection and chemotherapy are the treatments of first choice, even if sometimes this is not enough to save the lives of patients with TGCT. As seen for several tumors, the deregulation of microRNAs (miRNAs) is also a key feature in TGCTs. miRNAs are small molecules of RNA with biological activity that are released into biological fluids by testicular cancer cells. Their presence, therefore, can be detected and monitored by considering miRNAs as diagnostic and prognostic markers for TGCTs. The purpose of this review is to collect all the studies executed on miRNAs that have a potential role as biomarkers for testicular tumors
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