931 research outputs found
Solução numérica de escoamentos tridimensionais viscosos em qualquer regime de velocidade
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Florianópolis, 1992.Dado à inexistência de métodos matemáticos que permitam resolver escoamento reais sobre veículos aeroespaciais, como aviões e foguetes, os dois recursos de que se dispõem para projetá-los são a experimentação de modelos em túnel de vento e a simulação numérica. Embora a simulação numérica não exclua os experimentos em túnel de vento, ela permite uma redução significativa destes e, consequentemente, dos custos envolvidos num projeto, já que simulações numéricas são sabidamente muitos menos onerosas que ensaios experimentais. Um modelo numérico que permite resolver escoamentos tridimensionais viscosos e laminares, de gases perfeitos, é apresentado neste trabalho. Desta forma, contribui-se para ampliar os tipos de problemas que podem ser resolvidos através de métodos numéricos. As principais características deste trabalho são: utilizar um sistema de coordenadas naturais que se adapta a geometria do problema, emprega o arrajo co-localizado de variáveis, e, permite resolver escoamentos em qualquer regime de velocidade. A principal conclusão do trabalho é a de que o modelo numérico proposto consegue prever adequadamente a maioria dos fenômenos físicos verificados experimentalmente
Microwave assisted drying of water-based paints for wood
No full textA pilot plant for the microwave assisted drying of water-based paints for wood was designed, based on modelling results, and built. By choosing the proper combination of hot air and microwave power, it was possible to dry paints in times of an order of magnitude shorter than conventional drying. The microwave assisted drying is able to express its capabilities at its maximum when operating on UV-paints deposited at the highest surface density, while the strong interaction between microwaves and the glue used to produce plywoods may represent a limit of the proposed syste
Orazione fvnerale di Francesco Marchi : recitata nell'esequie di Benedetto Mori, celebrate alli 18 di marzo 1588 nella Compagnia di San Marco.
No full textWoodcut title ill. in border of printer's ornaments. Two decorated initials.Marchi's dedication to Cardinal Alessandro Medici is dated 19 March 1589.Mode of access: Internet.Centered on front pastedown is bookplate of Horatius (Orazio) Landau, with stamped shelving location 53060. Above it is the bookplate of U. Manganelli.Binding: modern decorated paper. Hand-written title slip mounted on front cover, with brief imprint and title written along spine
L-deprenyl as an inhibitor of menadione-induced permeability transition in liver mitochondria
No full textLa nuova geografia dell'innovazione in Italia: oltre la Terza Italia
No full textNonostante il crescente interesse nello spiegare le differenze nelle performance inno- vative delle regioni attraverso il concetto di sistemi regionali dell’innovazione (RIS), sono ancora pochi gli studi che identificano quantitativamente quali regioni possano definirsi RIS. Usando dati relativi alla Community Innovation Survey (CI), analizziamo le performance innovative delle regioni italiane per verificare se esistano dei RIS e tracciarne i cambiamenti nelle loro capacità innovative rispetto agli inizi degli anni novanta. L'analisi suggerisce che la geografia dell'innovazione in Italia è cambiata considerevolmente, soprattutto in relazione al cosiddetto modello della “Terza-Italia”, e che neanche le regioni più innovative possono essere definite RIS
Mitochondrial permeability transitions: how many doors to the house?
No full textThe inner mitochondrial membrane is famously impermeable to solutes not provided with a specific carrier. When this impermeability is lost, either in a developmental context or under stress, the consequences for the cell can be far-reaching. Permeabilization of isolated mitochondria, studied since the early days of the field, is often discussed as if it were a biochemically well-defined phenomenon, occurring by a unique mechanism. On the contrary, evidence has been accumulating that it may be the common outcome of several distinct processes, involving different proteins or protein complexes, depending on circumstances. A clear definition of this putative variety is a prerequisite for an understanding of mitochondrial permeabilization within cells, of its roles in the life of organisms, and of the possibilities for pharmacological intervention
Subendotyping of Dermatophagoides pteronyssinus–Induced Rhinitis and Its Impact on Respiratory Comorbidities
No full textBackground: The impact of delayed hypersensitivity to Dermatophagoides pteronyssinus (DP) on comorbidities of allergic rhinitis (AR) is unknown. Objective: The primary end point was to test the hypothesis that DP-induced AR could be divided into 2 subendotypes on the basis of presence or absence of a delayed-type mite sensitization detected by the positive result of atopy patch test for DP (DP-APT). The second end point was to evaluate differences in the long-term risk of respiratory comorbidities and nasal airway response to mite exposure. Methods: In a prospective observational study, we included 472 patients with DP-induced AR. A total of 343 patients had positive results of skin prick test/serum specific IgE and DP-APT and were assigned to a subendotype with both IgE- and T-cell–mediated mite sensitization (BMSS). The remaining 129 patients without delayed-type mite sensitization were included in the subendotype with only IgE-mediated mite sensitization. Nasal allergen provocation test with active anterior rhinomanometry, paranasal sinuses computed tomography scan, nasal endoscopy, and spirometry were performed. Results: At baseline, BMSS showed a larger increase in nasal airway resistance, total nasal score, and visual analogue scale score to mite exposure. During a 15-year follow-up, 56 patients developed chronic rhinosinusitis with nasal polyps, with higher incidence in BMSS than in the subendotype with only IgE-mediated mite sensitization (50 patients, 14.6% vs 6 patients, 12.4%; P < .001). BMSS also showed a higher incidence of conjunctivitis (25.7% vs 12.4%; P < .01). The rate of adult-onset asthma did not differ between groups, but patients with BMSS showed a more frequent link to chronic rhinosinusitis with nasal polyps (6 of 29 patients, 20.7% vs 0 of 10 patients, 0%). DP-APT independently predicted chronic rhinosinusitis with nasal polyps and conjunctivitis. Conclusions: Two subendotypes with significantly different clinical outcome can be identified among patients with DP-induced AR according to the presence of delayed-type mite sensitization detected by positive DP-APT result
Risk of Chronic Rhinosinusitis with Nasal Polyps in Endotypes of Dermatophagoides pteronyssinus-Induced Rhinitis
No full textBackground: Observation of the natural history of two emerging endotypes of allergic rhinitis, local-sensitization rhinitis (LAR) and dual-allergic rhinitis (DAR), compared with systemic-sensitization rhinitis (AR), could improve knowledge of the role of allergy in chronic rhinosinusitis with nasal polyps (CRSwNP). Objective: To test the hypothesis that endotypes of Dermatophagoides pteronyssinus (DP)-induced rhinitis were risk factors for CRSwNP and adult-onset asthma and to investigate whether delayed hypersensitivity to DP, assessed by atopy patch test, could be a contributing factor. Methods: We conducted a prospective observational study over 15 years on a cohort of 999 patients: 468 with AR, 333 with LAR, and 198 with DAR. The latter endotype was characterized by the coexistence of seasonal disease caused by systemic sensitization to pollen in patients with DP-induced LAR. The study design included a physical visit; ear, nose, and throat examination with anterior rhinoscopy; skin prick test; serum-specific IgE; DP-atopy patch test; nasal allergen provocation test with DP; paranasal sinuses computed tomography scan; nasal endoscopy; and spirometry. Results: During 15 years of follow-up, 194 patients developed CRSwNP with a higher rate of LAR (28.2%) and DAR (22.2%) than AR (12%). For LAR and DAR, 7.5% and 10.6% of patients developed adult-onset asthma temporally linked to CRSwNP in 68% and 71.4% of cases, respectively. A total of 858 patients with rhinitis had delayed hypersensitivity to DP. Moreover, DP-ATP was an independent predictive factor for CRSwNP and had elevated positive and negative predictive values for localized allergic disease of the nasal mucosa. Conclusions: Endotypes of DP-induced allergic rhinitis represent risk factors for CRSwNP. Patients with local-sensitization rhinitis and DAR are more at risk than those with AR. In these emerging endotypes, progression toward CRSwNP is often associated with the development of adult-onset asthma. Chronic rhinosinusitis with nasal polyps shows several possible indicators for type 2 endotype. Delayed hypersensitivity to DP is an independent predictive factor for CRSwNP
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