1,720,962 research outputs found
Quantitative analysis of dimethylarginines in human plasma by hydrophilic liquid chromatography tandem mass spectrometry method.
No full textAmino-acids and acylcarnitines profiles obtained by Desorption Electrospray Ionization tandem mass spectrometry.
No full text
Metabolic profiling of faecal sterol excretion in a patient affected of lathosterolosis using gc/ms.
No full textA metabonomic analysis of total sterol profiles in blood cell membranes of children receiving lipid emulsions: a possible role of phytosterols of parenteral nutrition associated liver disease.
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
A metabonomic analysis of total sterol profiles in blood cell membranes of children receiving lipid emulsions: a possible role of phytosterols of parenteral nutrition associated liver disease.
No full textProfilo metabolico degli steroli fecali in una paziente affetta da latosterolosi mediane GC/MS.
No full textProfilo metabolico degli steroli fecali in una paziente affetta da latosterolosi mediane GC/MS.
No full textSterols profiling in red blood cell membranes and plasma of newborns receiving total parenteral nutrition.
No full textBackground and Objectives: Total parenteral nutrition (TPN)
is a lifesaving therapy in children with intestinal failure,
frequently complicated by liver dysfunction. Plant sterols
(phytosterols) of lipid emulsions have been supposed to
contribute to cholestasis in TPN-treated children. The present
study aimed to evaluate the plasma and red blood cell
membrane (RBCM) phytosterol levels in newborns after a
short period of TPN.
Patients and Methods: Phytosterols, cholesterol, and other
sterol levels were quantified by gas chromatography-mass
spectrometry in 15 healthy control infants, 22 patients after
TPN, and 11 patients before TPN. Sterols of lipid emulsions
were quantified.
Results: Plasma and RBCM phytosterol levels were,
respectively, on average 56mmol/L and 83mmol/g per
protein in patients after TPN, 13mmol/L and 15mmol/g per
protein in patients before TPN, and 9mmol/L and 13mmoL/g
per protein in control infants (P<0.05 for differences). The
days of TPN and the total amount of infused lipids correlated
significantly with RBCM phytosterol (P<0.05); correlations
for plasma were positive but not significant. No correlation was
observed with plasma bilirubin, g-glutamyltransferase, or
alanine transaminase.
Conclusions: Plasma and RBCM phytosterols increase
significantly in newborns after a short period of TPN. Higher
phytosterol levels were observed in some patients that could
have been due to their individual variability in phytosterol
metabolism and/or clearance. A greater accumulation of
phytosterols in membranes may induce TPN-related
cholestasis
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