440 research outputs found
L'isola delle verdure. Percorsi di educazione alimentare nella scuola primaria. Progetto alunni e genitori.
No full textIl progetto, calibrato per alunni delle classi seconde e terze della Scuola Primaria e relative famiglie, si pone l’obiettivo di dare un contributo alla prevenzione dell’obesità infantile e conseguenti patologie cronico-degenerative sia nel bambino che nell’adulto.
Il progetto è finalizzato ad aumentare nei bambini l’interesse per le verdure tramite un percorso ludico di tipo induttivo/deduttivo che tratta ambiti conoscitivi diversi e le famiglie degli alunni stessi sono coinvolte tramite appropriati percorsi informativi che hanno anche carattere di rinforzo per gli alunni coinvolti
Functional differences between dendritic cells derived from CD34+ bone marrow and peripheral blood stem cells
No full textBackground and Objectives. It has been previously demonstrated that dendritic cells (DCs) are characterized by an immature stage with high antigen internalization capacity, followed by a mature stage with predominantly immunostimulatory ability. The shift from the immature to the mature state can be induced in vitro by the addition of tumor necrosis factor-α (TNFα). The aim of our study was to investigate the maturation steps of DCs obtained from CD34+ cells from peripheral blood stem cells (PBSC) and bone marrow (BM). Design and Methods. DCs were generated in vitro from PBSC and BM CD34+ selected cells. The endocytic activity of the cells was measured by means of dextran-FITC uptake and alloreactivity evaluated with mixed leukocyte reactions. Immunophenotypic analysis was performed by flow cytometry. Results. We observed that DCs from PBSC, in contrast to the BM derived DCs, were never able to take up soluble antigens. Mixed leukocyte reaction (MLR) performed both on PBSC and BM CD34+ derived DCs showed an allo-stimulatory activity comparable to normal controls at day 10, but significantly higher at day 14 after the addition of TNFα. Immunophenotypic analysis showed typical dendritic markers in all the samples and, after treatment with TNFα, enhanced expression of co-stimulatory molecules. Interpretation and Conclusions. Our data seem to indicate that, in our culture conditions. BM-derived DCs could be efficiently used for pulsing with specific peptides, while PBSC-derived DC, being functionally mature, should be more suitable for gene therapy. (C) 2000, Ferrata Storti Foundation
Impacto das políticas de lazer na região do bairro Aero Rancho. Campo Grande/MS
No full textImpacto das políticas de lazer na região do bairro Aero Rancho. Campo Grande/MS / Felipe Soligo Barbosa, Luciane Coelho Rabel, Joyce Priscila Samudio da Silva, Julio Arani Pinheiro Xavier. – Campo Grande: UCDB, 2009As políticas de lazer são foco de inúmeras pesquisas e publicações no País, nos dias atuais (BARBOSA, 2008; MARCELLINO, 2002a, 2003; MARIANO, 2008; MENNEH, 2002). São eixos fundamentais de uma política de lazer: o uso do espaço urbano e a construção e animação dos equipamentos de lazer (BARBUY, 1980; MARCELLINO, 2002a; SANTOS, 1982; WILHEIM, 1976). Desse modo, é imprescindível para a democratização do lazer, mais especificamente dos conteúdos físico-esportivos, a elaboração de políticas públicas. Entretanto, não se pode deixar levar pela falácia do tarefismo, ou da política de atividades que, na maioria das vezes, acabam por constituir-se em eventos isolados e não em políticas de animação como processo. Faz-se necessário também atenção aos quatro eixos de uma política de lazer: reordenação da jornada de trabalho; reordenação do solo urbano, incluindo aí os espaços e equipamentos específicos de lazer; política de formação e desenvolvimento de pessoal para que os profissionais envolvidos trabalhem de forma coerente com os conceitos atuais e uma política de animação (MARCELLINO, 2007a).rede CEDES / M
Plio-Quaternary evolution of the central Apennines: the case of the Medium-Upper Aniene River Valley (Latium, central Italy)
No full textThe Late Pleistocene vertebrate bearing deposits at San Teodoro cave (North-Eastern Sicily): preliminary data on faunal diversification and chronology
No full textNon-generic concentrations for shape-memory alloys; the case of CuZnAl
No full textAs is well known, the remarkable properties of many active crystalline materials, such as shape-memory alloys, originate from a symmetry-breaking martensitic phase transformation. A recent analysis (see Pitteri and Zanzotto, Acta mater., 1998, 46, 225) has shown that if a special condition on the strain parameters is satisfied, the twinning ability of a crystal undergoing a cubic-to-monoclinic transformation is considerably increased. As this feature may improve the memory behavior of cubic–monoclinic alloys, it is suggested that these predictions be tested experimentally. A procedure is given to determine explicitly which “non-generic” concentrations allow suitable alloys to produce the extra twins; which concentrations give a volume-preserving transformation are also determined (this condition guarantees self-accommodation of the martensite). As an example, the ternary CuZnAl system is considered, for which, based on the available experimental data, the non-generic concentrations are established. The work indicates that there is a scarcity of the necessary data on the mapping of lattice parameters vs concentrations in alloys with a potential for shape memory. A specific experimental program aiming at the systematic gathering of this information is proposed: building such a database may prove of considerable help in the search and synthesis of new materials with improved performance
The diagnostic and prognostic value of bone marrow immunostaining in myelodysplastic syndromes
No full textImmunohistochemistry has been introduced as a means of increasing the diagnostic accuracy of bone marrow biopsy (BMB) in myelodysplastic syndromes (MDS); more recently the possibility of coupling immunostaining with other investigational techniques has broadened the spectrum of applications to the biology and physiopathology of MDS. Using panels of monoclonal antibodies (MoAbs), various histological classifications of MDS have been proposed as an alternative to the FAB criteria. The use of Lineage-specific MoAbs has allowed a deeper insight into the dysplastic features of early hematopoietic precursors. The study of various gene products involved in the regulation of cell growth, proliferation and sensitivity to antineoplastic drugs, has revealed significant differences between MDS and morphologically-related disorders, particularly acute myelogenous leukemias (AML); these can be considered markers of a biological difference between the two groups of disorders and deserve consideration when designing therapeutic strategies for MDS, Both an increase in the percentage of cell positivity for the CD34 glycoprotein and a tendency of positive cells towards forming aggregates have been shown to be reliable predictors of leukemic transformation and survival, irrespective of the FAB subtype; furthermore, CD34 positivity has also proved to be a better prognostic factor than the presence of the abnormal localization of immature precursors (ALIP) on BMB. Finally, the simultaneous occurrence of 'large' and CD34 positive aggregates can be proposed as a means of recognizing MDS patients with an exceedingly unfavourable prognosis, and who are therefore suitable for early aggressive therapy
Oral malignancies following HSCT : graft versus host disease and other risk factors
No full textAllogenic hematopoietic stem cell transplantation (HSCT), a procedure that is widely used in the treatment of a large number of malignant and nonmalignant hematological diseases, is still associated with a wide range of complications, one of the most important of which is graft versus host disease (GVHD). The patients undergoing allogenic HSCT are also at high risk of developing secondary neoplasms, particularly leukemias and lymphomas. Solid tumors are less frequent, and the incidence appears to increase over time; the most frequent solid tumors are squamous cell carcinomas. We found that almost all studies of solid cancers occurring after transplantation are based on relatively small numbers of cases which have been monitored for short periods, and little information is available on individual cancers. In particular, reports of oral cancers in HSCT are very few. Potential risk factors associated with the development of secondary solid cancers after HSCT have been well described. They include graft versus host disease (GVHD), preoperative regimens, with either radio-chemotherapy or chemotherapy alone, conditioning regimes, immunosuppressive GVHD prophylaxis, viral infection and chronic stimulation as a result of viral antigens, antigenic stimulation from histocompatibility differences between recipient and donor, primary diagnosis, interaction of any of these factors with genetic predisposition, and other factors such as sex and age. All patients treated with HSCT should therefore be closely followed over the long term with the aim of identifying the onset of secondary tumors as early as possible. (c) 2005 Elsevier Ltd. All rights reserved
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